Transcriptional regulation in cardiovascular aging.
Yiguang Fan, Chao Song, Fangnan Feng, Qing Xun et al.
Kernaussage
Cardiovascular aging, a primary driver of cardiovascular diseases, is characterized by significant dysregulation of transcriptional regulatory networks involving transcription factors and epigenetic factors, leading to impaired cardiac and vascular cell function.
Abstract
Cardiovascular diseases (CVD) stand as the primary cause of mortality and form the most prevalent disease category. Numerous studies have demonstrated that aging serves as a crucial pathogenic factor in the progression of CVD. Nevertheless, the molecular mechanisms underlying cardiovascular aging have not been fully elucidated. Research in various aging models has consistently shown that aging is attributed to the dysfunction of a complex transcriptional regulatory network that maintains the body's health, tissue homeostasis, and stress resistance. Transcription factors and chromatin regulatory factors are involved in almost all cellular activities, and an increasing amount of evidence indicates that as key regulatory elements, transcription factors and chromatin regulators control cellular senescence by regulating the transcription of related genes. Therefore, the aim of this review is to summarize the specific role of transcriptional regulation in the mechanism of cardiovascular aging, providing new strategies for the treatment of CVD.
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Quelle: PubMed Central / National Library of Medicine (NLM). Apollion steht in keiner Verbindung mit NLM und wird von NLM nicht empfohlen. Evidenzgrade bewerten die methodische Studienqualität — nicht die inhaltliche Richtigkeit.
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