Current allele distribution of the human longevity gene APOE in Europe can mainly be explained by ancient admixture.
Daniel Kolbe, Nicolas A da Silva, Janina Dose, Guillermo G Torres et al.
Kernaussage
Current APOE allele distributions in Europe are primarily shaped by ancient admixture events, with selection playing a role in early population differentiation, leading to significant frequency differences between Western Hunter-Gatherers and early farmers for ε4 and ε3 alleles.
Abstract
Variation in apolipoprotein E (APOE) has been shown to have the strongest genetic effect on human longevity. The aim of this study was to unravel the evolutionary history of the three major APOE alleles in Europe by analysing ancient samples up to 12,000 years old. We detected significant allele frequency shifts between populations and over time. Our analyses indicated that selection led to large frequency differences between the earliest European populations (i.e., hunter-gatherers vs. first farmers), possibly due to changes in diet/lifestyle. In contrast, the allele distributions in populations from ~4000 BCE onward can mainly be explained by admixture, suggesting that it also played an important role in shaping current APOE variation. In any case, the resulting allele frequencies strongly influence the predisposition for longevity today, likely as a consequence of past adaptations and demographic processes.
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Quelle: PubMed Central / National Library of Medicine (NLM). Apollion steht in keiner Verbindung mit NLM und wird von NLM nicht empfohlen. Evidenzgrade bewerten die methodische Studienqualität — nicht die inhaltliche Richtigkeit.
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