Centenarians-the way to healthy vascular ageing and longevity: a review from VascAgeNet.
Sabrina Summer, Maria Borrell-Pages, Rosa-Maria Bruno, Rachel E Climie et al.
Kernaussage
Centenarians, despite age-related vascular changes, often possess healthier vasculature than the average elderly due to a combination of genetic resilience, healthier lifestyles, and effective mitigation of inflammation and oxidative stress, leading to reduced cardiovascular disease risk.
Abstract
The prevalence of centenarians, people who lived 100 years and longer, is steadily growing in the last decades. This exceptional longevity is based on multifaceted processes influenced by a combination of intrinsic and extrinsic factors such as sex, (epi-)genetic factors, gut microbiota, cellular metabolism, exposure to oxidative stress, immune status, cardiovascular risk factors, environmental factors, and lifestyle behavior. Epidemiologically, the incidence rate of cardiovascular diseases is reduced in healthy centenarians along with late onset of age-related diseases compared with the general aged population. Understanding the mechanisms that affect vascular ageing in centenarians and the underlying factors could offer valuable insights for developing strategies to improve overall healthy life span in the elderly. This review discusses these key factors influencing vascular ageing and how their modulation could foster healthy longevity.
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Quelle: PubMed Central / National Library of Medicine (NLM). Apollion steht in keiner Verbindung mit NLM und wird von NLM nicht empfohlen. Evidenzgrade bewerten die methodische Studienqualität — nicht die inhaltliche Richtigkeit.
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