Association of Dietary Approaches to Stop Hypertension Diet With the Risk of Osteoporosis and Fracture: A Systematic Review and Meta-Analysis.

Abstract

This systematic review and meta-analysis aim to investigate the association between DASH diet and risk of osteoporosis and fracture. A comprehensive literature search was conducted in PubMed, Ovid Embase, Scopus, Web of Science Core Collection and Ovid Medline databases from inception to September 2024. Two authors performed data extraction independently and assessed the risk of bias. After a systemic search, we included a total of eight eligible studies. The six cross-sectional studies involved 17,683 individuals while the two cohort studies involved 201,062 individuals. Overall, adherence to DASH diet was not significantly associated with bone health. However, subgroup analyses revealed that adherence to DASH diet was associated with a higher level of BMD in women ( β = 0.02, 95% CI = 0.02-0.03, p < ; I 2 = 0%; τ 2 < 0.01) and individuals aged above 60 years ( β = 0.02, 95% CI = 0.01-0.03, p < 0.01; I 2 = 61%; τ 2 < 0.01). Large-scale prospective cohort studies are needed to validate our findings. Trail registration: PROSPERO number: CRD42024588891.