Emanuela Talamonti, Anna M Pauter et al.
Impairment of systemic DHA synthesis via Elovl2 deficiency leads to hyperactive pro-inflammatory M1 macrophages and M2 macrophages that lose their anti-inflammatory phenotype and gain M1-like characteristics, effects which are reversed by DHA supplementation.
Masoud Isanejad, Jaakko Mursu et al.
Higher total protein and animal protein intake were associated with increased lean mass and appendicular lean mass in elderly women, particularly those who maintained their weight and received vitamin D and calcium supplementation.
Nadja B Kristensen, Mia L Madsen et al.
Danish vegans show better compliance with macronutrient recommendations (lower saturated fat and sugar, higher fiber) than omnivores, but frequently fail to meet micronutrient targets for vitamin D, iodine, and selenium, even when using supplements.
Bridget Ann Knight, Beverley M Shields et al.
Higher maternal BMI at 28 weeks gestation was independently associated with lower serum B12 levels in a non-diabetic White British obstetric cohort, replicating findings from Indian studies.
Alfonso Clemente, Maria C Arques et al.
This study identified induced and natural variants of pea seed protease inhibitors (TI1 and TI2), including a double null mutant in Pisum elatius (JI 262) with significantly reduced trypsin and chymotrypsin inhibitory activity, offering potential for improving seed protein quality through breeding programs.
Katrin Kuhnt, Stefanie Weiß et al.
Daily intake of echium oil (EO) containing stearidonic acid (SDA) is more effective than linseed oil (LO) for increasing blood EPA and DPA, but neither oil maintains blood DHA status without fish/seafood consumption.
Mahmoudreza Hadjighassem, Behnam Kamalidehghan et al.
Oral alpha-Linolenic acid (ALA) consumption significantly increased plasma BDNF and MDA levels in healthy adults, with a greater increase in BDNF observed in women.
Prakash P Mansara, Rashmi A Deshpande et al.
Low n6/n3 fatty acid ratios selectively decrease breast cancer cell viability and growth, induce lipid peroxidation, upregulate tumor suppressor SMAR1, downregulate tumor activator Cux/CDP, and activate p21WAF1/CIP1, suggesting a potential strategy for breast cancer prevention and management.
Anna-Liisa Elorinne, Georg Alfthan et al.
Long-term vegan diets were associated with lower concentrations of vitamin B12, vitamin D, iodine, and selenium, but also with more favorable fatty acid profiles and higher polyphenol concentrations compared to non-vegetarians.
Rafal W Wojciak
Two-day food restrictions significantly decreased iron levels and negatively impacted mood and well-being in healthy women, with higher depression symptom scores observed after the study period.
Vasken L Keleshian, Matthew Kellom et al.
Dietary n-3 PUFA deprivation worsened NMDA-induced changes in rat brain lipid metabolism and inflammatory markers, while n-3 PUFA supplementation did not ameliorate these effects.
Krithiga Shridhar, Preet Kaur Dhillon et al.
Indian vegetarian diets generally meet Recommended Dietary Allowance (RDA) levels for macro- and micro-nutrients with less fat and lower calories, but vitamin B12 bioavailability is a concern.
Reilly T Enos, Kandy T Velázquez et al.
Reducing the omega-6:omega-3 ratio using only alpha-linolenic acid in a high-fat diet did not effectively attenuate obesity, insulin resistance, or related inflammatory outcomes in mice, although a 1:1 ratio did improve certain fatty acid profiles and reduce macrophage infiltration in adipose tissue.
Yanni Papanikolaou, James Brooks et al.
A significant number of U.S. adults do not meet recommendations for omega-3 fatty acid intake, suggesting that supplementation in addition to food sources may be necessary.
David Vauzour, Noemi Tejera et al.
Anthocyanin intake did not significantly affect EPA or DHA status or FADS2 gene expression across cell, rodent, and human models, suggesting their benefits are unlikely to be related to n-3 PUFA status.
Anne M J Gilsing, Matty P Weijenberg et al.
The NLCS-MIC established a cohort over-represented with individuals at the lower end of the meat consumption spectrum, showing that confirmed vegetarians and pescetarians had more favorable dietary and lifestyle characteristics compared to regular meat consumers, although prevalent cancer cases were highest in these groups, with a significant portion adopting their diets post-diagnosis.
Lies Pottel, Michelle Lycke et al.
Echium oil supplementation in head and neck cancer patients undergoing radio(chemo)therapy effectively increased erythrocyte EPA and GLA levels but did not significantly reduce weight loss or improve other nutritional parameters compared to placebo.
Jeannine Baumgartner, Cornelius M Smuts et al.
Combined provision of iron and alpha-linolenic acid (ALA) to double-deficient rats improved reference memory and increased hippocampal DHA compared to iron or ALA alone, suggesting iron enhances ALA conversion to DHA and benefits cognition.
Sadanand Naik, Vijayshri Bhide et al.
Regular milk intake improved vitamin B-12 status and reduced homocysteine levels in vitamin B-12 deficient Indian lacto vegetarians.
Jonathan P Arm, Joshua A Boyce et al.
Dietary supplementation with borage and echium seed oil combinations in mild asthmatics increased circulating 20-22 carbon PUFAs (DGLA, EPA, DPA) without increasing AA levels, and this was associated with reduced leukotriene production by inflammatory cells.
Luigi Fontana, Remi M Adelaiye et al.
A 7% protein diet resulted in significant inhibition of tumor growth in human xenograft models of prostate (70%) and breast (56%) cancer compared to a 21% protein diet, associated with reduced IGF-1, mTOR activity, cell proliferation, and specific epigenetic markers.
Tina H T Chiu, Hui-Ya Huang et al.
A Taiwanese vegetarian diet is strongly associated with a reduced prevalence of diabetes and IFG in men and women, even after controlling for confounders and risk factors.
Sabine Rohrmann, Kim Overvad et al.
High consumption of processed meat is associated with a moderately increased risk of early death, particularly from cardiovascular diseases and cancer, and reducing consumption to less than 20 g/day could prevent over 3% of all deaths.
Patrícia Borges Botelho, Karina da Rocha Mariano et al.
Echium oil supplementation improved plasma lipid profile and attenuated hepatic steatosis in LDLr KO mice, potentially through mechanisms different from EPA and DHA, possibly related to the lower N-6/N-3 FA ratio in the liver.
Faqir Muhammad Anjum, Muhammad Faizan Haider et al.
Supplementing broiler diets with extruded flaxseed meal increased omega-3 fatty acid content in meat but negatively impacted growth performance, oxidative stability, and sensory properties of meat products, with 10% being the maximum level before significant negative effects.
Simon J Evans, Alan R Prossin et al.
Serum PUFA profiles correlate with personality factors and suicidal history in bipolar subjects, with specific ratios of n-3 fatty acids and FADS2 activity associating with personality factors linked to suicidal risk, and lower serum arachidonic acid observed in suicide attempters.
Sophie Guez, Gabriella Chiarelli et al.
This case highlights that standard prenatal vitamin B12 supplementation may be insufficient for vegan mothers, potentially leading to severe infant deficiency with persistent neurological damage despite treatment, and emphasizes the need for B12 and iron assessment in infants with unexplained severe anemia.
Asmita Kulkarni, Kamini Dangat et al.
Excess maternal folic acid without vitamin B12 led to reduced placental global DNA methylation, which was restored to control levels by omega-3 fatty acid supplementation in vitamin B12-deficient rats.
Paul F Davis, Marlies K Ozias et al.
Diet-induced reduction in brain docosahexaenoic acid (DHA) in female rats alters dopamine receptor density, with effects differing by reproductive status, and these changes are similar to those observed in rodent depression models.
Afsaneh Keramat, Bhushan Patwardhan et al.
Osteoporosis in postmenopausal women from Iran and India is associated with several common risk factors, including lower education, longer menopause duration, earlier menopause age, bone/joint problems, lower weight/BMI, and history of fracture, while calcium supplementation, HRT, exercise, and specific dietary consumptions act as protective factors, with no significant differences in risk factor associations between the two populations.
Kein medizinischer Rat. Die dargestellten Studien dienen der wissenschaftlichen Information und ersetzen keine ärztliche Beratung. Bei gesundheitlichen Fragen wende dich an eine approbierte Ärztin oder einen Arzt.
Quelle: PubMed Central / National Library of Medicine (NLM). Apollion steht in keiner Verbindung mit NLM und wird von NLM nicht empfohlen. Evidenzgrade bewerten die methodische Studienqualität — nicht die inhaltliche Richtigkeit.
Inhalte werden ausschließlich aus Open-Access-Quellen mit kommerziell nutzbaren Lizenzen (CC0, CC BY, CC BY-SA) indexiert. CC BY-ND wird für bearbeitete Inhalte nicht genutzt.