Niccolò Tesi, Marc Hulsman et al.
Most Alzheimer's disease-associated variants that increase disease risk are also associated with lower longevity odds, with a subset showing a larger effect on longevity than on Alzheimer's disease, linked to other age-related processes and enriched for endocytosis and immune signaling functions.
Eco J C de Geus
Heritability estimates for physical activity (PA) vary significantly by measurement method, sex, and age, but consistently indicate a substantial genetic contribution, with polygenic scores showing potential for tailoring interventions.
Yingjun Liu, Assunta Senatore et al.
Organotypic cerebellar slices (COCS) serve as a valid ex vivo model for mammalian brain aging, and prion exposure significantly accelerates this aging process in COCS, mouse models, and human CJD patients, suggesting a link between accelerated aging and prion-induced neurotoxicity.
Mirva Järvelä-Stölting, Laura Vesala et al.
The proteasome subunit Prosα6 negatively regulates JAK/STAT signaling in Drosophila by reducing the expression of the negative regulator Eye transformer (ET), leading to JAK/STAT pathway hyperactivation, hemocyte activation, and lamellocyte differentiation in vivo.
Ayako Tonoki, Saki Nagai et al.
The nitric oxide-soluble guanylyl cyclase (NO-sGC) pathway negatively regulates intermediate-term memory (ITM), and its age-related enhancement contributes to age-related memory impairment (AMI) in Drosophila, which can be rescued by inhibiting this pathway or reducing gycβ expression.
Evžen Korec, Lenka Ungrová et al.
Three genes, BCKDHB, FER1L6, and SERPINI2, were newly identified as associated with longevity in European bison, with specific SNPs in BCKDHB and FER1L6 being intronic and a SNP in SERPINI2 being exonic and causing an amino acid change.
Zuhao Sun, Shuang Zhao et al.
Knockdown of Sirt1 in the hippocampus of middle-aged mice led to hippocampal atrophy, impaired spatial learning and memory, increased tau hyperphosphorylation, and synaptic damage.
Cierra N Sing, Enrique J Garcia et al.
The study identifies YKL075C (AAN1) as a novel gene that regulates actin cable stability, mitochondrial function, and replicative lifespan in yeast by modulating branched-chain amino acid metabolism, and its function is independent of the TORC1 pathway.
Yujing Shao, Wenrui Zhen et al.
Dietary Enterococcus faecium NCIMB 11181 supplementation mildly alleviated Salmonella Typhimurium-induced gut injury in broiler chickens by modulating gut microbiota composition, promoting intestinal anti-Salmonella IgA production, and inhibiting intestinal cell apoptosis.
Qiao Zhu, Ping Ping et al.
Estradiol (E2) levels were negatively associated with physical function (activities of daily living and physical normality) in Chinese oldest-old and centenarian women.
Purva Jain, Alexandra M Binder et al.
Increased epigenetic age acceleration (EAA) was associated with lower odds of survival to age 90 with intact mobility and cognitive functioning among older women.
Montserrat Vega, David Castillo et al.
Four mitochondrial protein quality control mutants in *Schizosaccharomyces pombe* exhibited opposite longevity phenotypes, with increased respiration and enhanced mitophagy significantly extending chronological lifespan, while defects in these processes led to shorter lifespans.
Sheng-Han Ji, Chen Dong et al.
Centenarians exhibit relatively small blood glucose fluctuations, with lower mean blood glucose, eHbA1c, GMI, mean fasting plasma glucose, and CONGA compared to controls, and maintaining average blood glucose levels and keeping fluctuations within the normal range is conducive to longevity.
Li Chen, Karen Mei Ling Tan et al.
Newborn telomere length is influenced by a combination of heritable factors (maternal telomere length, paternal age, genetic variants) and environmental factors (maternal nutrition, cardiometabolic health, mental well-being, smoking), with sex-specific effects observed for these influences.
Valeriy Alexandrovich Agoltsov, Stepan Yurievich Veselovsky et al.
Meat from cows with brucellosis showed decreased dry matter, protein, fat, tryptophan, and protein quality indicator, along with increased ash, while milk from these cows was less fatty and had slightly lower protein content compared to healthy animals.
Sandra Aleksic, Dimpi Desai et al.
The majority of nonagenarian and centenarian men in the study exhibited preserved hypothalamic regulation of the hypothalamic-pituitary-testicular axis, with a high prevalence of testicular dysfunction compensated by a preserved hypothalamic-pituitary response.
Yiyan Cui, Zhimei Tian et al.
Guanidine acetic acid supplementation did not alter pig growth performance but modified plasma and tissue free amino acid profiles and related metabolites in a tissue-dependent manner.
Nooshin Ghodsian, Erik Abner et al.
This large EHR-based GWAS meta-analysis identified 7 genetic loci associated with NAFLD: GCKR, TRIB1, MAU2/TM6SF2, APOE, PNPLA3, LPL, and FTO, with evidence suggesting that the FTO genotype's effect on NAFLD is mediated by obesity and a potentially causal inverse association between lower LPL expression in adipose tissue and NAFLD susceptibility.
Muzi Tangyu, Michel Fritz et al.
Co-fermentation of sunflower seed milk with Propionibacterium freudenreichii NCC 1177 and Bacillus amyloliquefaciens NCC 156 yields a nutrient-rich, clean-label product with up to 17 µg (100 g)−1 vitamin B12, improved protein quality, enhanced digestibility, and better flavor.
Toby Doyle, Eva Jimenez-Guri et al.
Insect migration in *E. balteatus* is associated with significant differential gene expression in over 1500 genes involved in metabolism, muscle function, hormonal regulation, immunity, stress resistance, flight, feeding, longevity, reproductive diapause, and sensory perception.
Ken B Hanscombe, Elodie Persyn et al.
Genetic analyses support cardiorespiratory fitness (CRF) as a clinical vital sign, with genetic variants for CRF and physical activity (PA) influencing genes associated with various diseases and correlating with increased risk of conditions like coronary artery disease and type 2 diabetes, as well as obesity and shorter lifespan.
Calogero Caruso, Mattia Emanuela Ligotti et al.
While lifestyle is a stronger determinant of health and lifespan in the first eight decades, genetics becomes more important in extreme longevity, contributing up to 48% in centenarian men, with APOE and FOXO3A being consistently associated genes.
Mary K Wojczynski, Shiow Jiuan Lin et al.
The Long Life Family Study (LLFS) families exhibit healthier aging profiles and lower rates of age-related diseases compared to reference populations, with key healthy aging phenotypes demonstrating significant heritability both cross-sectionally and longitudinally.
Xing-Zhou Tian, Jia-Xuan Li et al.
Dietary supplementation with selenium-yeast (SY) improved muscle antioxidant activity, meat quality (dressing percentage, eye muscle area, tenderness, color), and fatty acid and amino acid profiles in Qianbei-pockmarked goats, with the optimal level determined to be 4.8 mg/kg under the experimental conditions.
Nicolas Perrot, William Pelletier et al.
This study identified novel genetically regulated genes, circulating proteins, and metabolites that are potentially associated with human lifespan and represent potential therapeutic targets for aging-associated diseases.
Charleen D Adams, Jorim J Tielbeek et al.
Antisocial behavior (ASB) was positively genetically correlated with COVID-19 (rg = 0.51), suggesting individuals with antisocial tendencies may have a higher risk of exposure to SARS-CoV-2.
Jocelyn L Y Tang, Anna E Hakes et al.
NanoDam identified Homeobrain (Hbn) and Scarecrow (Scro) as conserved temporal factors in Drosophila central brain and visual system progenitors, influencing cellular longevity and temporal window regulation.
Epp Sepp, Imbi Smidt et al.
The gut microbiota composition significantly differs between the oldest-old and young individuals, with the oldest-old exhibiting higher richness and diversity, a higher abundance of environmental and hereditary bacteria, and a Prevotella enterotype, while the young group has a Bacteroides enterotype and is richer in butyrate-producing bacteria.
Vinesh Naresh Shenoi, Martin I Brengdahl et al.
Paternal indirect genetic effects (PIGEs) significantly contribute to phenotypic variation in lifespan in Drosophila melanogaster, explaining 14.2% of the total paternal genetic variance in an among-population study and 22.7% when corrected.
Nadine Saul, Ineke Dhondt et al.
This study identified potential healthspan-related genes in C. elegans based on human GWAS data, with several genes showing specific effects on health-related phenotypes like chemotaxis, muscle integrity, and pathogen resistance, suggesting roles for human homologs WWC2, CDKN2AIP, and ACADS in health maintenance in older individuals.
Hannah-Ruth Engelbrecht, Sarah M Merrill et al.
Despite equal longevity in Mediterranean Blue Zones, oldest old men exhibit accelerated biological aging and shorter telomere length compared to women, as indicated by DNA methylation-derived predictors.
Hooriyah S Rizavi, Kayla A Chase et al.
This study identified 159 differentially modified H3K9me2 promoters in the prefrontal cortex of individuals with schizophrenia compared to controls, with 8 of 10 selected genes showing a correlation between H3K9me2 levels and mRNA expression, suggesting a functional effect on gene expression.
Donato Angelino, Francesca Pietrangeli et al.
A daily caloric restriction lapse of approximately 17-18 hours, high consumption of plant-based foods, and sustained physical activity are highlighted as important factors for the longevity of centenarians in Abruzzo.
Rubing Xue, Ke Yang et al.
Overexpression of the lysosomal enzyme NAGLU in Drosophila and human cells extends lifespan, improves stress resistance, reduces amyloid-beta deposition, and enhances lysosomal function, suggesting its potential as a therapeutic target for age-related neurodegenerative diseases.
Zhizhong Zheng, Rong Hua et al.
Gene losses, particularly in functional groups related to regressive and adaptive traits, play a significant role in the subterranean adaptations of naked mole-rats and blind mole-rats, potentially cooperating with positively selected genes.
Marco Zampiga, Luca Laghi et al.
Increasing the digestible arginine to lysine ratio in broiler chicken diets positively affected feed efficiency, likely by modulating metabolites involved in energy and protein metabolism.
Catherine Schwinger, Shakun Sharma et al.
Cobalamin deficiency was prevalent (24%) in pregnant women in early pregnancy in Bhaktapur, Nepal, whereas folate deficiency was rare (1%).
Arup Jana, Aparajita Chattopadhyay et al.
Anaemia prevalence was higher in West Bengal (64%) than Bangladesh (41%), with risk factors including sterilization use, vegetarian diet, open defecation, and groundwater use for drinking, while factors like pill/injection/IUD use, iron-rich food, safe water, sanitation, education, and economic conditions can help tackle anaemia.
Jieun Kim, Younghwa Baek et al.
In rural Korean elderly with cardiometabolic multimorbidity, higher protein intake (g/kg) is positively associated with muscle mass and strength, whereas high consumption of wheat and meat is linked to a roughly 2-fold increase in the prevalence of sarcopenic obesity.
Jahid Hasan Shourove, Fariha Chowdhury Meem et al.
In Nigerian children aged 6-59 months, higher maternal education, higher socioeconomic status, older child age (13-59 months), non-anemic maternal status, and consumption of pumpkin, carrots, squash, or sweet potatoes were associated with reduced anemia risk, while consumption of white potatoes, white yams, manioc, cassava, or other root-based foods was associated with increased anemia risk.
Lyubov V Tereshchuk, Ksenia V Starovoitova et al.
The study established that a 1.5% concentration of a binary soy phospholipid mixture with a complex HLB of 4.6 provides optimal stability for a sea buckthorn oil-in-water emulsion, achieving 99.5% colloidal stability and reducing oxidative degradation by approximately 42% over 14 days.
Alessandra Ferramosca, Vincenzo Zara
Diets rich in unsaturated fatty acids, particularly omega-3 PUFAs, and polyphenols positively impact sperm quality by enhancing mitochondrial function and reducing oxidative damage, while diets high in saturated fats and simple carbohydrates have detrimental effects.
Lu Dai, Ziad A Massy et al.
In older adults with advanced chronic kidney disease, higher trimethylamine N-oxide (TMAO) was associated with increased all-cause mortality (multivariable HR: 1.46; 95% CI: 1.17, 1.83), while higher 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF) was independently associated with reduced risk of all-cause mortality (HR: 0.79; 95% CI: 0.71, 0.89) and kidney replacement therapy initiation (HR: 0.80; 95% CI: 0.71, 0.90).
Efrat Monsonego Ornan, Ram Reifen
A postnatal growth model in young rats demonstrated a more sensitive and physiologically accurate assessment of protein quality for alternative proteins compared to PDCAAS and DIAAS, particularly under protein restriction.
Stine Weder, Markus Keller et al.
Vegan children in Germany (1-3 years) exhibited more favorable micronutrient intake and fat quality compared to vegetarian and omnivorous children, although all groups had inadequate intake of vitamin D and iodine without supplementation, and vegan and vegetarian children required special attention for vitamin B2, vitamin B12, calcium, and iron.
Hechun Liu, Feng Wang et al.
Perilla oil supplementation decreased fasting blood glucose, while fish oil supplementation reduced serum triglyceride levels in type 2 diabetic patients, with distinct effects on erythrocyte fatty acid composition and glycolipid metabolism.
Fateen Ata, Ammara Bint I Bilal et al.
Optic neuropathy, presenting as gradual bilateral vision decrease, was the initial presentation in 87.5% of the reviewed VitB12 deficiency cases with ophthalmological involvement, and timely VitB12 replacement can prevent permanent optic nerve damage.
Evangelia Damigou, Rena I Kosti et al.
Unprocessed lean white meat is generally neutral or beneficial for cardiometabolic risk, particularly when replacing red meat, whereas processed poultry or poultry with skin is associated with an increased risk of type 2 diabetes, hypertension, and weight gain.
Nick W Smith, Anant C Dave et al.
Plant-based beverages (PBB) are generally not nutritionally equivalent to bovine milk, being more expensive, lower in protein (except soy), and exhibiting significant nutritional variability, with soy PBB being the closest substitute but still having issues with sedimentation, calcium bioavailability, and protein quality.
Sushruti Kaushal, Tanu Priya et al.
In anemic pregnant women in Himachal Pradesh, India, iron deficiency (serum ferritin <15 ng/mL) was the most prevalent cause (50%), followed closely by vitamin B12 deficiency (48.8%) and folate deficiency (33.72%), with a significant proportion exhibiting multiple nutrient deficiencies.
Jenny Ruedlinger, Vicente Cid-Ossandón et al.
In a Chilean population, high processed meat intake was associated with male sex, younger age, being employed, risky alcohol intake, unhealthy weight, and other unhealthy dietary patterns, and was linked to a 2.28 times higher prevalence of cardiovascular disease and a higher prevalence of diabetes, with obesity partially mediating these associations by 5.0% and 13.9%, respectively.
Masoud Isanejad, Behnam Tajik et al.
Dietary alpha-linolenic acid (ALA) and total omega-3 polyunsaturated fatty acids (PUFA) were positively associated with better physical function measures in older women, while EPA and DHA were not significantly associated with physical function or muscle mass.
Tiina Pellinen, Essi Päivärinta et al.
Partial replacement of animal protein foods with plant protein foods led to marked decreases in the intake and status of vitamin B-12 and iodine, with no changes observed in iron status.
Jessie L Ellis, J Philip Karl et al.
Dietary vitamin K amount, more than form, influences murine gut microbial community composition, with females appearing more responsive, and dietary vitamin K is remodeled to bacterial menaquinones in vivo by murine gut microbes.
Małgorzata A Desmond, Jakub G Sobiecki et al.
Vegan diets in children were associated with a healthier cardiovascular risk profile but also with increased risk of nutritional deficiencies (B-12, iron, 25(OH)D) and lower bone mineral content and height, while vegetarian diets showed less pronounced nutritional deficiencies but a less favorable cardiometabolic risk profile compared to omnivores.
Wilhelm Stoffel, Inga Schmidt-Soltau et al.
Dietary supplementation with arachidonic acid (AA) and docosahexaenoic acid (DHA) restored fertility in infertile FADS2-deficient mice by remodeling gonadal membrane lipidomes, reassembling functional gap junction networks, and reconstituting the blood-testis barrier.
Inger Aakre, Marianne Sandsmark Morseth et al.
Norwegian women exhibited insufficient iodine status from pregnancy through 18 months post-partum, with median urinary iodine concentrations consistently below WHO thresholds and reaching a nadir of 57 μg/L at 6 weeks post-partum.
Giuditta Pagliai, Ilaria Giangrandi et al.
Dietary interventions such as olive oil, ancient grains, low-calorie, low-FODMAP, and vegetarian diets, along with specific supplements like Vitamin D and Magnesium, show promise in reducing fibromyalgia symptoms, though evidence is currently limited by small sample sizes and study design.
Vivian Pedrinelli, Rafael Vessecchi Amorim Zafalon et al.
None of the 100 analyzed homemade canine and feline diets were nutritionally complete, with significant deficiencies in essential minerals and protein persisting regardless of the number of ingredients, the presence of supplements, or the use of vegetarian/vegan formulations.
Carmen-Antonia Mocanu, Tudor Petrisor Simionescu et al.
Low-protein diets (0.55–0.6 g/kg-day) and supplemented very-low-protein diets (0.28–0.43 g/kg-day) are effective and nutritionally safe interventions that significantly postpone kidney replacement therapy, improve metabolic markers like FGF 23, and increase long-term survival in patients with chronic kidney disease.
Yawei Fu, Yadong Wang et al.
Omega-3 PUFAs significantly impact the intestinal microbiota, host-microbiome interactions, and host immune system, offering a feasible approach to maintaining gut health by modulating gut immunity via gut microbes.
Hélène Chevallier, Florent Herpin et al.
The Synadiet three-grade model (A, B, C) provides a nuanced framework for botanical health claims, as demonstrated by the attribution of a Grade B claim to Trifolium pratense for contributing to lower LDL-cholesterol in postmenopausal women at doses of 50–80 mg/day.
Francis Feldman, Mireille Koudoufio et al.
Clinical evidence indicates that polyphenol supplementation effectively improves lipid profiles by reducing triglycerides, total cholesterol, and LDL-C while increasing HDL-C, with the most consistent benefits observed in patients with type 2 diabetes and metabolic syndrome.
Canan Kop-Bozbay, Ahmet Akdag et al.
Low protein diets reduced dressing percentage and water holding capacity in broilers, while BCAA blends did not improve performance or breast yield under summer conditions.
Ralf Jäger, Javier Zaragoza et al.
Co-administration of plant protein with a multi-strain probiotic significantly increased post-prandial blood concentrations of essential amino acids (EAAs) and branched-chain amino acids (BCAAs) in physically active men.
Shuai Yuan, John A Baron et al.
Genetically predicted lifelong higher serum calcium concentrations were associated with lower odds of longevity and increased risk of cardiovascular disease, while serum 25-hydroxyvitamin D showed no such associations.
Bergita Ganse, Anne Kristin Braczynski et al.
Athletes aged 100 years and older experience an accelerated rate of performance decline, particularly in the 100-m sprint, with no performance plateau observed after 90 years.
Shihui Fu, Ping Ping et al.
Centenarian longevity in oldest females was inversely associated with nutritional status (GNRI) and abdominal obesity, and positively associated with sex hormones (prolactin, progesterone, estradiol) and bone turnover markers (osteocalcin, β-crossLaps, PTH).
Dengying Liu, Zhenliang Chen et al.
The integrated haplotype score (iHS) and runs of homozygosity (ROH) analyses identified selection signatures in Shanghai Holstein cattle, revealing genes associated with immunity, reproduction, and adaptation to their environment.
Sanghee Park, David D Church et al.
Consumption of Hayward green kiwifruit with a beef meal accelerates the appearance of essential amino acids into the peripheral circulation in older individuals compared to Hort 16A gold kiwifruit.
Renate H M de Groot, Rebecca Emmett et al.
Non-dietary factors including age, female sex (under 50), wine consumption, and TAG form are positively associated with n-3 LCPUFA levels, while genetics, BMI (under specific conditions), and smoking are negatively associated, with inconclusive evidence for other factors.
Michael J Watts, Daniel R S Middleton et al.
The study generated new crop composition data for Tanzania and Western Kenya, revealing significant risks of deficiency for calcium, zinc, and iodine in both regions, and selenium in Kenya, highlighting the need for localized data to inform interventions.
Andrea J Glenn, Effie Viguiliouk et al.
Vegetarian dietary patterns were associated with reduced coronary heart disease (CHD) mortality and incidence, but not overall cardiovascular disease (CVD) or stroke mortality, although the certainty of this evidence is rated as very low.
Derek D Headey, Giordano Palloni
Children of lactovegetarian mothers were less likely to be stunted or wasted, while children of vegan mothers were at increased risk of stunting, with frequent dairy consumption by mothers predicting lower risks of stunting and wasting in their children.
Gro-Ingunn Hemre, Erik-Jan Lock et al.
Atlantic salmon fed plant-based diets require adjusted B-vitamin supplementation, with updated recommendations for niacin, riboflavin, cobalamin, folate, pyridoxine, and pantothenic acid, while biotin and thiamine levels were found to be sufficient.
Kristin Hamre, Nini H Sissener et al.
Atlantic salmon fed diets high in plant ingredients did not show increased requirements for vitamin C, E, or selenium, with current recommendations for alpha-tocopherol (150 mg kg−1) and selenium (0.3 mg kg−1) being sufficient, although higher vitamin C supplementation (above 190 mg kg−1) is advised for optimal immune function and stress resistance.
Yohannes Seyoum, Christèle Humblot et al.
Despite predominantly plant-based diets and a high proportion of underweight girls, anemia (8.7%) and clinical iron deficiency (8.7%) prevalence was low in rural Ethiopian adolescent girls, though 41% had marginal iron stores, suggesting high iron intake possibly from soil contamination.
Angélica Gallego-Narbón, Belén Zapatera et al.
Spanish vegetarians in this study generally had sufficient vitamin B12 and elevated folate status, though subclinical vitamin B12 deficiency (detected by MMA) was present in 11% and hyperhomocysteinaemia in 32%, with a higher risk in non-supplement users.
Xiaoyang Sheng, Junli Wang et al.
Fortified cereal and meat interventions improved vitamin B12 status and may enhance cognitive levels in toddlers in poor rural China, where vitamin B12 deficiency was common due to low dietary intake.
Aneel Kapoor, Mukhtiar Baig et al.
Vegetarians in this study showed a significantly higher prevalence of Vitamin B12 deficiency (51% vs. 3%) and a greater frequency of neuropsychiatric and neurological problems, including depression, paresthesias, peripheral neuropathy, and psychosis, compared to omnivores.
Purab Pal, Karen Hales et al.
A flaxseed-supplemented diet increases 2-methoxyestradiol and docosahexaenoic acid, which induce apoptosis and decrease angiogenesis in ovarian tumors through p38-MAPK dependent and independent pathways, respectively.
Muhammad Awidi, Hisham Bawaneh et al.
Iron deficiency anemia is a significant health problem in adult and adolescent women in Jordan, with menstrual blood loss being the most significantly associated cause.
Aiping Fang, Keji Li et al.
In Chinese adolescent boys consuming plant-based, low-calcium diets, calcium intake below 300 mg/d was associated with shorter adult stature, while intake above 400 mg/d did not lead to taller adult stature, and intake over 570 mg/d was linked to faster height growth but not absolute adult height; no significant associations were found in girls.
Yankho Kaimila, Oscar Divala et al.
Consumption of animal-source protein is associated with increased height-for-age z scores in rural Malawian children aged 12–36 months.
Sindhu Kashyap, Nirupama Shivakumar et al.
The true ileal indispensable amino acid digestibility of hen's egg white protein, whole egg, and cooked meat in healthy humans was found to be 86.3% ± 4.6%, 89.4% ± 4.5%, and 92.0% ± 2.8% respectively, with significant differences observed between protein sources, particularly between egg white and meat protein.
Leanne Hodson, Francesca L Crowe et al.
Plasma phosphatidylcholine (PC) n-3 fatty acids (FA) are sensitive biomarkers of intake, with fish oil increasing EPA, DPA, and DHA, and flaxseed oil increasing ALA, EPA, and DPA within 14 days across a range of intakes.
Hana Kahleova, Rebecca Fleeman et al.
A 16-week low-fat vegan diet significantly reduced body weight by 6.5 kg and fat mass by 4.3 kg, with the replacement of animal protein by plant protein accounting for over half of the fat mass reduction and correlating with improved insulin sensitivity.
Yueru Li, Yinghui Rong et al.
Stearidonic acid (SDA) suppresses adipocyte differentiation and lipid accumulation in 3T3-L1 cells by down-regulating adipogenic transcription factors and lipid accumulation genes, with higher concentrations leading to more significant reductions in triglyceride levels and gene expression.
Anne Lise Brantsæter, Helle Katrine Knutsen et al.
Children, adolescents, adults, and ovo-lacto vegetarians in this Norwegian sample had adequate iodine intake based on median urinary iodine concentration (UIC), while the elderly, pregnant women, non-pregnant women of childbearing age, and vegans had inadequate iodine intake, with 89% of pregnant women and 95% of vegans having UIC below WHO cut-offs.
Jingjing Li, Zhennan Gu et al.
Dietary α-linolenic acid (ALA) efficiently increases n-3 LCPUFAs in vivo and significantly reduces prostate weight in mice, comparable to fish oil supplementation, by increasing n-3 LCPUFAs and decreasing arachidonic acid.
Fenglei Wang, Huijuan Liu et al.
Early introduction of complementary foods (3-6 months) was significantly associated with a higher risk of anemia and lower hemoglobin concentration in children aged 4-6 years in China.
Agnieszka Pluta, Paweł Stróżecki et al.
Six-month omega-3 acid supplementation (2 g/day) significantly decreased urinary MCP-1 excretion in CKD stages 1-3 patients and healthy individuals, without affecting CRP, serum MCP-1, or WBC counts.
David Rogerson
Vegan diets can be nutritionally adequate for athletes with careful planning, but may require attention to energy intake, protein quality and quantity, and specific micronutrients like B12, iron, zinc, calcium, iodine, and n-3 fatty acids, with supplementation often being necessary.
Jadwiga Ambroszkiewicz, Witold Klemarczyk et al.
Prepubertal children on vegetarian diets exhibit lower ferritin, lower hepcidin, and higher sTfR levels compared to omnivorous children, suggesting a higher prevalence of subclinical iron deficiency despite comparable iron intake and hematologic parameters.
Małgorzata Sikorska-Wiśniewska, Adriana Mika et al.
Dialysis patients exhibit significantly lower n-3 PUFA content, including ALA, which further decreases with time on dialysis, and strong positive correlations were found between n-3 PUFA (DHA and EPA) and body fat percentage.
Jakub G Sobiecki, Paul N Appleby et al.
Striking differences in nutrient intakes were observed between meat eaters and vegans, with intermediate values for fish eaters and vegetarians, and while overall compliance with population dietary goals was high, potential inadequacies in vitamin B12, iodine, and possibly zinc and selenium were highlighted for vegetarian and especially vegan diets.
N Wright, L Wilson et al.
A community-based whole food plant-based diet intervention resulted in significantly greater BMI reduction at 6 months compared to normal care (3.9 kg m−2 difference, P<0.0001), with sustained BMI reduction and a trend towards significant cholesterol reduction at 12 months in the intervention group.
Trond M Kortner, Michael H Penn et al.
Dietary supplementation with bile components or lecithin did not improve performance or gut health in Atlantic salmon, and in some cases, negatively impacted growth and intestinal function.
Nick van Wijk, Martin Balvers et al.
Combined supplementation of dietary crude lecithin and DHA-containing oils synergistically increases plasma and red blood cell n-3 PUFA levels, including DHA and EPA, by enhancing DHA's systemic availability.
Rodrigo Valenzuela, Francisca Echeverria et al.
Hydroxytyrosol (HT) supplementation prevents high-fat diet-induced metabolic alterations in desaturase activities, oxidative stress, and n-3 LCPUFA content in mice, restoring desaturase activity, reducing oxidative stress, and maintaining n-3 LCPUFA levels.
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