Anja Bruns, Josefine Nebl et al.
While all three diets provided adequate macro- and micronutrients, flexitarians showed a prevalence of cobalamin and iron deficiencies, and all groups exhibited low vitamin D intake and status, with supplementation being a key factor in mitigating deficiencies, particularly for vitamin D and cobalamin.
Mohammad Zen Rahfiludin, Septo Pawelas Arso et al.
Iron deficiency anemia in Sundanese adolescent girls at Indonesian Islamic boarding schools was associated with lower consumption of animal-based foods, not significantly affected by the plant-based diet itself.
Soojin Oh, Gareth Cave et al.
Nanoparticle technology presents a sustainable strategy for vitamin B12 fortification in food crops, improving nutrient delivery and bioavailability, particularly when integrated with hydroponic or aeroponic systems.
Raneem M Alqurashi, Aliah Aladwani et al.
A study in Taif, Saudi Arabia, found a high level of awareness (88%) regarding Vitamin B12 deficiency among the general population, although awareness of its specific effects on the nervous system was lower (50%), and a majority had not taken action to measure their B12 levels.
Serena Gandino, Agnieszka Bzikowska-Jura et al.
European human milk banks exhibit significant variability in their practices regarding vegan and vegetarian donors, with a tendency to follow national or local guidelines over international recommendations, and only a minority adopting an evidence-based approach requiring supplementation.
Khyati Garg, Venkatashiva Reddy B et al.
A concerning 19.71% prevalence of undernutrition was found among tribal lactating mothers in Guntur district, Andhra Pradesh, significantly associated with the Yenadi tribe, low education, mothers with older children, and Cesarean section delivery.
En-Jung Hsieh, Siao-Wei Liao et al.
L-DOPA oxidation products, formed at higher pH, are more potent than L-DOPA itself in inhibiting primary root growth and increasing Fe uptake and root Fe accumulation in water spinach and Arabidopsis.
Kirti Kirti, Shri Kant Singh
Five distinct dietary clusters were identified among Indian adolescents, with the "obesogenic diet" cluster showing the highest prevalence of overweight/obesity and significant associations with pre-diabetes/diabetes and lipid anomalies.
Agnieszka Białek-Dratwa, Teresa Kokot et al.
Between 2011 and 2022 in Poland's Silesian Agglomeration, women aged 20-50 showed increased consumption of breakfast, whole-grain products, vegetables, and fast-food, salty snacks, and sweets, alongside decreased consumption of dairy, meat, and fish, resulting in a rise in mean BMI and obesity prevalence.
Andrew Kien Han Wee, Rehena Sultana
In patients with type-2 diabetes mellitus, significant determinants of vitamin B12 deficiency include higher metformin daily dose, age ≥ 80 years, vegetarianism, and folate deficiency, while prescribed B12 supplementation is associated with lower odds of deficiency.
Linnea Bärebring, Christel Lamberg-Allardt et al.
Evidence is insufficient to determine if habitual or Nordic RI levels of B12 intake are sufficient to maintain adequate status for children, young adults, pregnant/lactating women, older adults, vegetarians, or vegans.
Lillie Monroe-Lord, Elgloria Harrison et al.
During the COVID-19 pandemic, American adults aged 40-100 years experienced a decline in overall nutritional quality, characterized by decreased consumption of grains, fruit, lean proteins, and dairy, and an increase in unhealthy fat, sugar, and sweet items, leading to nearly one-third of previously "not at risk" individuals shifting to "at risk" or "possible risk" nutritional categories.
Rikki A Cannioto, Kristopher M Attwood et al.
Highest adherence to cancer prevention lifestyle recommendations was associated with a 37.0% reduction in disease recurrence and a 58.0% reduction in mortality in patients with high-risk breast cancer.
Daphne Siciliani, Trond M Kortner et al.
Dietary lipid level and environmental temperature significantly affect intestinal lipid accumulation and steatosis symptoms in Atlantic salmon, influencing choline requirement, with an important interaction between these two factors.
Joanna Nicholas, Sara Grafenauer
One-third of female pre-professional dancers in the study had a negative REDs risk score, indicating low energy availability, alongside a BMI < 20, a history of fractures, or secondary amenorrhea, with relatively low awareness of REDs and its connection to menstrual issues.
Muraleedhar S Aski, Gyan Prakash Mishra et al.
Stable and ideal lentil varieties L4076 (Pusa Shivalik) for iron and L4717 (Pusa Ageti) for zinc, with lower phytic acid, are identified as valuable donors for biofortification to combat micronutrient malnutrition.
Hermann Zbinden-Foncea, Claudia Ramos-Navarro et al.
Neither chia flour nor whey protein supplementation provided additional benefits for fat-free mass or strength gains compared to a placebo in untrained young men with a high habitual protein intake (>1.2 g/kg/day).
Dominic N Farsi, Jose Lara Gallegos et al.
Substituting 240 g/day of red and processed meat with mycoprotein for two weeks significantly reduced total cholesterol by 6.74%, LDL cholesterol by 12.3%, and waist circumference by 0.95 cm in healthy males.
Martin Světnička, Marina Heniková et al.
Czech vegan and vegetarian children show a trend towards lower urinary iodine concentration and higher anti-thyroglobulin antibody positivity compared to omnivore children, suggesting a potential risk of iodine deficiency, particularly when not using iodized salt or supplements.
Marta Delsoglio, Corbin Griffen et al.
This pilot study demonstrated that a ready-to-drink plant-based oral nutritional supplement was highly complied with, tolerated, acceptable, and safe in adult patients at risk of malnutrition, leading to increased energy, protein, and micronutrient intake, as well as improvements in body weight and BMI.
Allan Stensballe, Tue Bjerg Bennike et al.
In a murine Abcb1a-deficient colitis model, proteomic analysis revealed elevated neutrophil degranulation-associated NETs protein components from the colon to urine, and the microbiome of KO mice significantly differed from WT mice with an increase in IBD-related strains, but no significant interaction was observed between Abcb1a status and red meat intake.
Paul Henry Golding
Victor Herbert's shorter time to develop megaloblastic anaemia (4 months) compared to the author's (19 months) is attributed to Herbert's likely vitamin C deficiency, which impairs folate protection from oxidation, while the author's higher vitamin C intake (500 mg/day) ensured plasma saturation and protected folate stores.
Qibing Wang, Yang Zhao et al.
Xylo-oligosaccharides (XOS) supplementation ameliorated the adverse effects of high plant-based protein diets on weaned piglet health by improving nutrient digestibility, enhancing intestinal barrier function, increasing short-chain fatty acid levels, and reducing harmful bacterial abundance, despite not significantly affecting growth performance.
Hongxuan Fan, Yongle Wang et al.
Participants with metabolic syndrome (MetS) adhering to a high-quality or moderate-quality Mediterranean diet had significantly lower all-cause and cardiovascular mortality, and this diet could attenuate or reverse the adverse effects of sedentary behavior and depression on mortality in MetS patients.
Ogiza Palma, John Kessellie Jallah et al.
Careful nutritional planning, potentially including supplementation for specific micronutrients and protein, is essential for expectant mothers following a vegan diet to ensure optimal maternal and fetal health, although research on fetal growth and cognitive outcomes remains conflicting and requires further investigation.
Hélène Fouillet, Alison Dussiot et al.
While no single optimal plant to animal protein ratio exists for nutrition and health alone, diets with a higher percentage of plant protein (25-70%) are associated with lower environmental impact and significant health benefits, though exceeding 80% plant protein may necessitate nutrient fortification.
Zheng Wen, Jianxiong Long et al.
In the Guangxi Zhuang population, age was positively associated with anemia in both sexes, while specific dietary patterns (red meat, corn/sweet potato, fruit consumption) and body water percentage showed inverse associations with anemia, with varying effects between men and women.
Orlagh Feehan, Pamela Jane Magee et al.
A low n-6:n-3 ratio was associated with higher femur BMD, and higher ALA was associated with lower bone resorption (urinary DPD/Cr) in postmenopausal women.
Marta Kozior, Robert W Davies et al.
Whey protein isolate elicited a greater post-prandial indispensable aminoacidemia response compared to pea and fava bean protein isolates in healthy young men, with significant differences in indispensable amino acid content and digestible indispensable amino acid scores.
Manuela Neuenschwander, Julia Stadelmaier et al.
Substituting animal-based foods with plant-based alternatives like nuts, legumes, whole grains, and olive oil is beneficially associated with reduced risks of cardiovascular disease, type 2 diabetes, and all-cause mortality.
Xiaoyun Huang, Liuting Zhou et al.
Hu sheep fed TMR with 15% fermented spent mushroom substrate (RL2) exhibited superior production performance, increased essential and free amino acid content in meat, and altered rumen bacterial communities, suggesting a positive impact on production and meat quality through microbial modulation.
Oleg Zavyalov, Duskaev Galimzhan et al.
Supplementation with tested additives, except for 4-hexylresorcinol + 7-hydroxycoumarin, positively affected live weight gain and nutrient digestibility in broiler chickens, with varying effects on muscle fat content and amino acid profiles, and a general decrease in iodine and zinc in specific muscle tissues.
Melina Tsiountsioura, Gerhard Cvirn et al.
This is the first long-term trial assessing separate and combined effects of encapsulated juice powder concentrate and plant-based omega fatty acid supplements on cardiovascular health, inflammation, and ageing biomarkers in middle-aged and elderly individuals.
Katie Nicol, Eva-Leanne Thomas et al.
Substituting dairy and fish with unfortified plant-based alternatives leads to a ~97% reduction in iodine intake, risking deficiency, and fortification of these alternatives is crucial.
Anjani H Turaga
Vegetarianism is prevalent in urban Hyderabad, India, with vegetarians showing a tendency towards normal BMI and a younger age demographic, though potential nutrient deficiencies in iron, B12, and calcium require attention.
Saba Narmcheshm, Fatemeh Toorang et al.
In an Iranian hospital-based case-control study, subjects in the highest tertile of total iron intake were 46% less likely to get gastric cancer (GC) than those in the lowest (OR = 0.54, 95% CI: 0.32–0.92), while no significant association was found for heme or non-heme iron intake.
Anthony Kityo, Sang-Ah Lee et al.
High intake of processed red meat was positively associated with all-cause mortality in both men (HR 1.21, 95% CI 1.07–1.37) and women (HR 1.32, 95% CI 1.12–1.56) in a Korean adult population.
Eric Dec, James Clement et al.
Three new DNA methylation-based epigenetic clocks were developed to accurately estimate the ages of centenarians, outperforming existing clocks which tend to underestimate the ages of very old individuals.
Eloi Gagnon, Patricia L Mitchell et al.
This Mendelian randomization study found no robust evidence for a large causal impact of human gut microbiota features on cardiometabolic traits, chronic diseases, or longevity, with nominally significant associations not withstanding multiple testing correction and the strongest effects being attenuated by BMI or alcohol intake.
Thalida E Arpawong, Eric T Klopack et al.
A higher polygenic score for ADHD (ADHD-PGS) is directly associated with accelerated epigenetic aging (GrimAge), and this association is partially mediated by lower educational attainment, increased smoking, and more depressive symptoms.
Neil M Davies, Matt Dickson et al.
Two independent natural experiments (ROSLA and MR) suggest that additional education causally improves a wide range of later-life outcomes, including reduced morbidity and mortality, healthier behaviors, increased income, and improved cognitive function, with similar effect magnitudes across different educational distributions.
Zoltan Ungvari, Vince Fazekas-Pongor et al.
Walking, particularly brisk walking, is a powerful anti-aging intervention that significantly reduces the risk of cardiovascular diseases, hypertension, type 2 diabetes, and cancer, while also improving pain, function, sleep, and mental health, with 8,000-10,000 steps per day being strong predictors of positive health outcomes.
Sven E Ojavee, Liza Darrous et al.
74% of genome-wide significant genetic associations with age at natural menopause show age-specific effects, influencing biological pathways and health outcomes differently depending on the timing of menopause.
Abeer Qannan, Yosra Bejaoui et al.
Berardinelli–Seip congenital lipodystrophy type 2 (CGL2) patients exhibit significant epigenetic age acceleration and DNA methylation alterations, including hypomethylation of the DUSP22 promoter, suggesting a role for SEIPIN in longevity and aging.
Jin-Hyuck Jeong, Jun-Seok Han et al.
Glucose restriction in *C. elegans* extends lifespan and improves healthspan without reducing fecundity, mediated by a novel neuronal AMPK isoform (AAK-2a) that signals via neuropeptides and promotes membrane fluidity through the PAQR-2/NHR-49/Δ9 desaturase pathway.
Mariana Andrawus, Lital Sharvit et al.
Pregnancy exhibits physiological and cellular degradation mechanisms similar to aging, followed by a unique rejuvenation process postpartum, suggesting pregnancy can serve as an enhanced and effective aging model.
Michal Antkowiak, Maciej Szydlowski
Structural variants in or near six genes (ALPL, KCTD8, SGSM1, SLC12A6, RYR3, and VPS26C) were associated with body weight and obesity in Labrador Retrievers, with effects on body weight ranging from 34% to 54% of the standard deviation.
Peh Joo Ho, Iain BeeHuat Tan et al.
Site-specific polygenic risk scores can stratify the risk of developing breast, prostate, and colorectal cancers in East Asians, with higher PRS quintiles associated with increased risk for these cancers, although calibration requires improvement for clinical implementation.
Yasmine Sommerer, Valerija Dobricic et al.
A comprehensive epigenome-wide association study in Alzheimer's disease using entorhinal cortex samples identified 12 epigenome-wide significant CpG sites, including four novel loci, with some showing correlations to gene expression and accelerated epigenetic aging in AD brains.
Mai Suzuki, Siyuan Wu et al.
A strong positive correlation was found between centenarian rate and average drinking water hardness (r = 0.84; p < 0.01) in the Amami Islands, suggesting a potential beneficial effect of hard water on longevity.
Qile He, Hao-Ting Chang et al.
Higher levels of greenspace structures (LPI, Shape, Cohesion) were cross-sectionally associated with significantly lower odds of frailty in older Chinese adults, with the highest quartile showing 32-37% lower odds compared to the lowest quartile, although no significant longitudinal associations were found.
Jack C M Ng, C Mary Schooling
Genetically higher basal metabolic rate is associated with reduced parental attained age, with a stronger effect observed in women, suggesting a potential reduction in lifespan in a sex-specific manner.
Yaqun Huang, Ming-Xia Ge et al.
The transcription factor ATF7, which is upregulated in long-lived individuals, suppresses cellular senescence and systemic inflammation by inhibiting NF-κB signaling and increasing H3K9 dimethylation, thereby extending lifespan and promoting healthy aging in C. elegans.
Clare E West, Mohd Karim et al.
An integrative analysis of GWAS and co-localization identified 995 candidate genes (TargetAge set) associated with age-related multimorbidity, with 29% linked to Hallmarks of Ageing and 13% targeted by existing or investigational drugs, suggesting novel therapeutic opportunities.
Ying Jing, Yuesheng Zuo et al.
SESN1, a downstream effector of FOXO3, counteracts human skeletal muscle aging by attenuating myofiber senescence and promoting muscle regeneration, with reduced SESN1 levels in elderly serum potentially serving as a biomarker for muscle atrophy.
Daniel B Rosoff, Lucas A Mavromatis et al.
A multivariate genome-wide analysis identified 52 genetic variants associated with aging-related traits, including 20 novel variants, and highlighted repurposing opportunities for antidiabetic, lipid-modulating, and antihypertensive drugs for healthy aging.
Samantha N Heerschop, Argyris Kanellopoulos et al.
Optimizing diets for health and sustainability in the Netherlands, with a realistic deviation of 33% from current consumption, can reduce diet-related greenhouse gas emissions by 12-16% without compromising protein adequacy or diet quality.
Li-Xia Yu, Sha-Sha Li et al.
Despite experimental evidence suggesting beneficial renal effects and a role in CKD-MBD, inconsistent clinical findings regarding its association with kidney function, adverse outcomes, and CKD-MBD suggest that serum Klotho may not be an ideal biomarker for CKD without further well-designed research and improved assay performance.
Regina Niñoles, Carmen Maria Ruiz-Pastor et al.
Loss-of-function of the DOF4.1 transcription factor enhances seed longevity in Arabidopsis thaliana by reducing seed permeability and increasing seed storage protein accumulation, particularly cruciferins.
Zhongliang Hu, Yamei Luo et al.
Partial inhibition of the class III PI3K VPS-34 ameliorates motor aging and prolongs health span by shifting PI(3)P-PI-PI(4)P conversion, increasing PI(4)P levels essential for synaptic function.
Guoyi Yang, C Mary Schooling
Genetically mimicked ASGR1 inhibitors were associated with longer lifespan and reduced all-cause mortality, alongside effects on lipid profiles and other biomarkers, suggesting ASGR1 is a promising target for reducing cardiovascular disease risk.
I L Kuznetsova, L I Uralsky et al.
Mosaic loss of the Y chromosome (mLOY) in peripheral blood leukocytes is associated with increased risk of various cancers, neurodegenerative diseases like Alzheimer's, and all-cause mortality in men over 70.
Han Chen, Xiaoying Zhou et al.
Genetically proxied LDLR variants were associated with extended lifespan, with CETP and APOC3 inhibition also showing causal effects on increased life expectancy, suggesting these lipid-lowering drug target genes may regulate human lifespan.
Zong Chen, Zhiyou Chen et al.
This Mendelian randomization study provides evidence that overweight is causally associated with accelerated aging, indicated by decreased telomere length, increased frailty index, and increased facial aging, and also causally reduces longevity expectancy.
Liyuan Zhu, Yiran Zhu et al.
Autophagy adaptor protein p62 mediates the degradation of Linc00942, thereby suppressing DNMT3a mRNA stabilization and global DNA hypermethylation, which in turn promotes chemoresistance.
Serena Dato, Francesco De Rango et al.
Interactions between longevity-related genes, APOE genotype, and sex contribute to late-onset Alzheimer's disease risk, suggesting distinct pathways for cognitive aging.
Iuliana Popescu, Joris Deelen et al.
Lifestyle-independent gerotherapeutics targeting mechanisms like senescence and autophagy show promise for extending healthy lifespan, complementing lifestyle interventions, though challenges remain in human translation and biomarker development.
Shengjie Fan, Yingxuan Yan et al.
Nomilin, a citrus component, extends lifespan and healthspan in *C. elegans* and mice by activating PXR-mediated detoxification functions, which is linked to the IIS longevity signaling pathway.
Zhong Li, Ziqin Ding et al.
Compared to octogenarians, nonagenarians and centenarians exhibited greater prevalence of full and partial dependence in activities of daily living, a decrease in full independence, and were less likely to die in hospitals, with no significant differences in end-of-life medical expenditures.
Fabian Hellbach, Lucy Sinke et al.
This epigenome-wide association study identified significant associations between DNA methylation and the consumption of specific food groups, particularly those high in fat like nuts and seeds, cream, butter, and plant oils.
Javier Huayta, Joseph P Crapster et al.
Endogenous DAF-16 spatiotemporal activity quantitatively predicts lifespan extension induced by dietary restriction, accounting for 78% of lifespan variability.
Christopher M Seabury, Johanna L Smith et al.
Genome-wide association analyses on a U.S. Holstein reproductive index identified a major quantitative trait locus on BTA6 associated with daughter pregnancy rate and cow conception rate, along with 12 additional loci influencing pregnancy probability, suggesting utility for genomic selection in dairy cattle fertility.
Fei Wu, Haidian Wei et al.
Hc-far-6, a functional orthologue of Ce-far-6, regulates larval body length in C. elegans but not fat content, and its intestinal localization and high transcription in parasitic stages suggest a role in H. contortus parasitism.
Iain Mathieson, Felix R Day et al.
This study identified 14 genetic susceptibility loci for PCOS, including three novel ones, and found largely similar genetic architecture across different diagnostic criteria, with evidence supporting shared biology between PCOS and metabolic disorders, depression, and male-pattern balding.
Mary Revelas, Anbupalam Thalamuthu et al.
Individuals with a high polygenic risk score for exceptional longevity have a significantly lower prevalence of metabolic syndrome and its components.
Hadi Tabarraei, Brandon M Waddell et al.
The CCR4-NOT subunit CCF-1/CNOT7 interacts with the transcription factor PAL-1 and is essential for the transcriptional activation of stress-protective genes in response to cadmium and acrylamide in C. elegans, partly through the co-regulator ELT-2, and its knockdown compromises stress resistance and normal lifespan.
Lingxuan Li, Shin Murakami
The ACE DD genotype is significantly associated with exceptional longevity in centenarians and long-lived individuals, despite being a risk factor for several age-related diseases.
Sara Cruces-Salguero, Igor Larrañaga et al.
Centenarians are characterized by a higher proportion of women, fewer diseases (particularly neoplasms), reduced healthcare resource utilization, and distinct biological profiles including lower glucose, hemoglobin, and triglycerides, supporting the "compression of morbidity" hypothesis.
Karin Westereng Handegård, Linn Mari Storengen et al.
Genomic heritability estimates for firework fear and noise reactivity in standard poodles were 0.28 and 0.16, respectively, with a suggestive association found on chromosome 17 near the CTNNA2 and LRRTM1 genes.
Maja Šetinc, Željka Celinšćak et al.
Genetic longevity scores, particularly the weighted GLS for age 90 (wGLS90), showed significant predictive ability for survival to advanced ages in the Croatian oldest-old population, with wGLS90 achieving 69% accuracy in predicting survival to age 90.
Weijing Wang, Jie Yao et al.
DNA methylation variants at loci within WNT3A and COL5A1 are associated with blood pressure in Chinese twins, with bidirectional causal effects observed between DNA methylation and blood pressure.
Olesya Ajnakina, Diana Shamsutdinova et al.
A polygenic predisposition to longevity was associated with reduced all-cause mortality in older adults, and the effect of APOE-ε4 on mortality from other causes was mediated by dementia diagnosis, explaining up to approximately one-third of the risk.
María Soler Artigas, Cristina Sánchez-Mora et al.
ADHD liability causally influences decreased average total household income, increased lifetime number of sexual partners, increased arm predicted mass and weight, and increased time spent watching television, with bidirectional effects observed for educational outcomes and age of first sexual intercourse.
Zulfiya G Guvatova, Anastasiya A Kobelyatskaya et al.
Russian long-livers exhibit a significantly younger epigenetic age compared to their chronological age, with an average difference of 21 years, suggesting decelerated epigenetic aging.
Laure Herreman, Paul Nommensen et al.
Protein quality, assessed by DIAAS, varies significantly between and within animal and plant protein sources, with potato and most animal proteins reaching excellent quality (DIAAS ≥ 100) for the 0.5–3-year-old scoring pattern, while many plant proteins fall into the no quality claim category (DIAAS < 75).
Elena García-Maldonado, Alexandra Alcorta et al.
A daily 250 mg algal DHA supplement from *Schizochytrium sp.* was effective and bioavailable in increasing serum DHA levels across omnivorous, lacto-ovo vegetarian, and vegan adults.
Daniel Kolbe, Nicolas A da Silva et al.
Current APOE allele distributions in Europe are primarily shaped by ancient admixture events, with selection playing a role in early population differentiation, leading to significant frequency differences between Western Hunter-Gatherers and early farmers for ε4 and ε3 alleles.
Katja M Hoedjes, Hristina Kostic et al.
A single naturally occurring SNP in Eip75B has causal pleiotropic effects on fecundity and egg-to-adult viability, with the 'G' allele leading to a significantly higher egg-laying rate and egg-to-adult viability compared to the 'T' allele.
Natassia Robinson, John Casement et al.
Anti-cancer treatments in childhood cancer patients induce consistent DNA methylation changes that are retained in adult survivors and associated with adverse health outcomes.
Zaray Rojas Conzuelo, Roger Robyr et al.
The NutriOpt algorithm successfully formulated plant-based food mixtures with protein quality (PDCAAS) over 100, comparable to animal-based proteins, by optimizing ingredient combinations based on amino acid profiles and digestibility.
Thibault Teissier, Eric Boulanger et al.
Inflammageing and immunosenescence are complexly intertwined, driven by immune system ageing, senescent cells, and a shift towards pro-inflammatory processes, with strategies like spermidine treatment, mTOR inhibition, and senolytic therapies showing significant promise in mitigating these age-related declines.
Antoine Daunay, Lise M Hardy et al.
French centenarians and semi-supercentenarians (CSSC) and their offspring (NCO) exhibit significantly younger DNA methylation-based ages (DNAmage) compared to a general population control group (CG), suggesting decelerated epigenetic and biological aging in these exceptionally long-lived individuals and their relatives.
Hannah Chandler, Richard Wise et al.
A consistent negative influence of additive genetic Alzheimer's disease risk on cerebral perfusion across the lifespan was demonstrated, and this effect was related to regional expression of proximal Alzheimer's disease risk genes.
He Li, Minhong Ren et al.
Longevity individuals exhibit longer LTL (particularly in the very old), good hepatic function, lower triglycerides, and lower inflammation levels, with LTL stabilizing or slightly increasing in individuals aged 90 and above.
Louis-Hippolyte Minvielle Moncla, Samuel Mathieu et al.
Nineteen blood proteins were found to be causally associated with heart failure, with ABO, BAG3, and FLT4 remaining significant after Bonferroni correction, and several identified proteins and pathways showing potential as therapeutic targets.
Evžen Korec, Lenka Ungrová et al.
Four genes (TDRP, FBXO25, MC2R, and FBXL21) were found to be associated with longevity in purebred Cane corso dogs, with specific alleles and genotypes linked to extended lifespan.
Mattias Winant, Kurt Buhler et al.
Homothorax (Hth) and Extradenticle (Exd) are identified as key regulators of dilp2, -3, and -5 expression in Drosophila Insulin-Producing Cells (IPCs), with the Retinal Determination Gene Network (RDGN) also playing a repurposed role in regulating Insulin/IGF signalling (IIS).
Rounak Dey, Wei Zhou et al.
The developed GATE method is a scalable and accurate approach for genome-wide survival association analysis of time-to-event phenotypes in large biobanks, demonstrating improved performance and accuracy, especially under heavy censoring and for low-frequency variants, compared to existing methods.
Peng-Cheng Hai, Dong-Xiao Yao et al.
Centenarians and centenarian offspring did not exhibit healthier BMI, blood pressure, or plasma lipids compared to offspring spouses.
Siying Li, Wenye Fan et al.
Frailty prevalence in Chinese older adults significantly increases with age, shows a slight increase over time periods, and generally decreases across birth cohorts, with age being the strongest influencing factor.
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