Shaymaa Shurrab, Amira Mobarak et al.
Long-term follow-up of two siblings with mitochondrial carbonic anhydrase VA deficiency suggests favorable growth, development, and neurological outcomes are achievable with individualized management, despite significant clinical heterogeneity observed in a literature review of 69 cases.
Hussam Al Hennawi, Muhammad Salman Sabri et al.
The presence of coronary artery calcium (CAC) is significantly associated with increased risks of major adverse cardiovascular events, all-cause mortality, myocardial infarction, and revascularization, and also promotes the initiation and continuation of preventive pharmacologic therapies and lifestyle modifications.
Qian Wang, Jianyao Xue et al.
Elevated plasma cholesterol is associated with improved sepsis outcomes, likely through promoting hepatic metabolic reprogramming.
Xia Zhou, Yun Wang et al.
Cigarette smoke-induced circFOXO3 upregulation contributes to type II alveolar cell senescence by inhibiting autophagy and interacting with E2F1, leading to lung injury.
Yusuf Aggour, Roberto Salguero-Gómez
The proposed 'Aging Onion' framework, integrating evolutionary theories of aging, suggests that the broader efficacy of caloric restriction compared to rapamycin may stem from its wider engagement of both persistent growth signaling (hyperfunction) and suboptimal somatic maintenance axes.
Xiaoya Ren, Xin Zhou et al.
The ubiquitin system, particularly deubiquitinases (DUBs) like USP20, is intricately linked to cellular aging and age-related diseases, presenting significant potential as therapeutic targets.
Liancheng Guan, Fan Yang et al.
Vitamin D receptor (VDR) signaling plays a protective role against inflammatory senescence-associated skin aging by suppressing inflammatory responses and regulating senescence pathways, with VDR modulation offering therapeutic potential for age-related skin conditions.
Ludmila Müller, Svetlana Di Benedetto et al.
Brain aging is a dynamic, interconnected systems process characterized by diverse and asynchronous cellular aging trajectories that vary across cell types and brain regions, involving altered neuronal activity, glial immune states, and vascular regulation that propagate dysfunction across networks.
Kuo-Chuan Hung, Hsiu-Lan Weng et al.
Pre-existing iron deficiency anemia is independently associated with an increased risk of recurrent acute kidney injury (HR, 1.53) and accelerated renal function decline (HR, 1.19) in critically ill patients who survive an initial AKI event.
Rahul Mittal, Farhad Alipour et al.
Immune regulation of cellular identity, driven by transcriptional and epigenetic remodeling, is a fundamental mechanism of tissue control that can lead to functional impairment and chronic disease even before cell loss, as exemplified by metabolic diseases.
Junnan Zhang, Mingyue Gao et al.
Laying hens serve as a valuable and underutilized model for studying female reproductive aging due to conserved features with humans in ovarian aging, endocrine regulation, and oxidative stress, offering a promising framework for understanding reproductive aging and identifying therapeutic targets.
Jieun Seo, Seo-Young Park et al.
Autophagy is a crucial cellular process regulated by a complex interplay of transcription factors and epigenetic modifiers, with context-dependent roles in various diseases, necessitating precision medicine approaches for therapeutic intervention.
Gwendoline Hoslett, Sara Tribble et al.
Nucleophagy, mediated by TEX264 and p97, clears cytotoxic trapped PARP1, and disrupting this pathway increases PARP1 trapping, leading to cell death and re-sensitizing PARPi-resistant cells.
Yajnaseni Chakraborti, Sunni L Mumford et al.
Minimizing postpartum weight retention was associated with a reduced risk of all-cause mortality over 50 years of follow-up, even in women with a normal pre-pregnancy BMI.
Amina Fallata, Saber Nahdi et al.
Gestational exposure to erythritol disrupts ovarian function across two generations in rats by increasing oxidative stress, suppressing autophagy and PI3K signaling, and reducing AMH levels.
Jérémie Prévost, Sarah J Medina et al.
Both monkeypox virus infection and MVA-BN vaccination lead to declining antibody levels over time, raising concerns about waning immunity and potential reinfection, and suggesting a need for booster doses.
Haiyun Chen, Qinghe Geng et al.
A novel Vdr-spermidine-DNMTs signaling axis is essential for preserving granulosa cell function and maintaining ovarian health, where age-related decline in Vdr leads to GCs aging and ovarian decline, but spermidine and SAM supplementation can counteract these effects.
Holly E Holmes, Kamal Srivastava et al.
Supplementation with nicotinamide riboside and pterostilbene (NRPT) for 7 days safely reduced the frequency and severity of undesirable menopause transition symptoms in symptomatic women, accompanied by a significant increase in the urinary E2/E1 ratio.
Jennifer Nhieu, Fatimah Najjar et al.
CRABP1 signalosomes modulate diverse signaling pathways in a cell type-specific manner, maintaining cellular and organ health, particularly during aging, with disruption contributing to age-related diseases like thyroid dysfunction.
Xiaoyu Zhang, Ai Guan et al.
Elevated homocysteine and reduced methionine/methylation levels are associated with worse cognitive performance and accelerated cognitive decline in Alzheimer's disease patients.
Niloufar Mansooralavi, William E Lowry
MECP2 deficiency impairs DNA repair, leading to genotoxic stress and senescence, which drives the metabolic and neuronal deficits observed in Rett Syndrome.
Guanglei Chen, Yunzhi Chen et al.
Metabolic reprogramming in COPD leads to protein lysine acylation modifications, such as lactylation and succinylation, which regulate inflammation, senescence, and tissue remodeling, suggesting potential targets for biomarkers and therapeutic interventions.
Ruxia Qiu, Dong Zhang et al.
Immunosenescence, a maladaptive immune remodeling, serves as a unifying mechanism linking frailty and multimorbidity by eroding physiological reserve and promoting disease clustering.
Jamaji C Nwanaji-Enwerem, Dennis Khodasevich et al.
Short-duration spaceflight significantly alters methylation-derived biomarkers of aging and immunity, with notable bidirectional shifts in certain proteins and enrichment in pathways related to endopeptidase activity and cell aggregation.
Haobo Jiang, Yuting Zhang et al.
Osteosarcopenic obesity (OSO) is an immunometabolic disorder driven by chronic inflammation, trained immunity, and senescence, originating from visceral adipose tissue and systemically affecting muscle and bone through a vicious cycle of immune dysregulation.
Yanxia Shang, Yanfeng Shang
Resistance and combined exercise training demonstrate more consistent anti-inflammatory benefits in older adults with sarcopenia compared to aerobic exercise, by suppressing pro-inflammatory pathways and modulating immune responses.
Christopher J Shore, Marc F Österdahl et al.
The COVID-19 pandemic accelerated epigenetic ageing rates (GrimAge acceleration: p=0.002, β=0.99) in individuals between Spring 2020 and Spring 2021, regardless of SARS-CoV-2 infection status.
Shimeng Wang, Jingtian Mu et al.
Oxidative stress-induced senescent macrophages promote squamous cell carcinoma invasion via glutamine metabolic reprogramming and IL-1β secretion, which can be effectively targeted by blocking IL-1β.
Kai-Le Li, Chen Wang et al.
roX1 and roX2 lncRNAs promote heterochromatinization in intestinal stem cells, leading to gene silencing, stem cell hyperplasia, and reduced lifespan in female Drosophila under stress conditions.
Cornelia M Weyand, Jörg J Goronzy
Aging profoundly impacts the human immune system, leading to a decline in its structural integrity and functional resilience, characterized by compromised hematopoietic stem cells, reduced adaptive immune function, and increased susceptibility to infections and autoimmune diseases, while also promoting chronic inflammation and tissue degeneration.
Ying Wang, Chunli Dong et al.
Polystyrene nanoplastics exposure in young mice significantly increased inflammatory markers and cellular senescence, decreased antioxidant gene expression, and disrupted oral-gut microbiome homeostasis, thereby accelerating aging.
Ke Zhou, Ping Lu et al.
The gut microbiome significantly influences anticancer drug resistance through mechanisms like drug biotransformation, immune modulation, and tumor microenvironment alteration, necessitating personalized microbiome interventions and the development of less susceptible therapies for precision oncology.
Jianbo Cheng, Jing Li et al.
Casein enzymatic hydrolysate (CEH) alleviates Salmonella Typhimurium-induced enteritis in adult mice by modulating the gut microbiota to increase lactate, which activates a GPR81-Wnt3A-ISC axis, promoting intestinal repair and regeneration.
Abdullah T Aslan, Yukiko Ezure et al.
Early appropriate antimicrobial therapy (EAAT) within 24 hours of blood culture sampling was associated with a significantly lower hazard of 14-day and 28-day all-cause mortality in patients with hospital-acquired bloodstream infections caused by Gram-negative bacteria, including those with carbapenem-resistant Gram-negative bacteria.
Song Li, Yanjiang Liu et al.
Dietary spermidine significantly mitigates radiation-induced intestinal injury by activating the Nrf2 pathway, enhancing intestinal barrier integrity, reducing inflammation, and reshaping the gut microbiota towards beneficial bacteria.
Valeria Calcaterra, Hellas Cena et al.
Dietary polyphenols show promise for pediatric obesity and cardiometabolic prevention, supported by mechanistic evidence and observational/early clinical findings, but direct clinical application is limited by conceptual controversy, methodological weaknesses, and insufficient pediatric-specific evidence, suggesting that promoting polyphenol-rich dietary patterns within lifestyle interventions is the most evidence-based approach.
Xinuo Ma, Feng Wang et al.
The C-reactive protein-triglyceride-glucose index (CTI) is an independent predictor of all-cause mortality in chronic heart failure patients across different ejection fraction subtypes, with higher CTI levels indicating increased mortality risk, particularly in HFpEF.
Abigail A Harrington, Timothy J Nickels et al.
Calcineurin signaling is a major driver of echinocandin tolerance and persistence in *C. glabrata* and *C. albicans*, and its inhibition with FK506 can improve echinocandin efficacy by reducing these mechanisms.
Melkamu B Beyene, Renuka Visvanathan et al.
This study provides the first comprehensive genetic analysis of intrinsic capacity (IC), demonstrating its heritability (25.2% in UKB, 19.5% in CLSA) and identifying 38 independent SNPs across 10 genomic loci, with a polygenic score significantly associated with higher IC scores.
İbrahim Demir, Bilge Ecemiş et al.
Quantitatively assessed apical myocardial fibrosis burden independently predicts cardiac mortality in LVAD recipients, even after accounting for competing non-cardiac risks.
Zengxun Ni, Zineng Zhou et al.
This study computationally identified ESR1, PIK3CA, and MTOR as core targets for dauricine's anti-hypoxic mechanism, supported by molecular docking and molecular dynamics simulations, suggesting dauricine as a potential multi-target candidate for hypoxia intervention.
Takashi Ono, Takuya Iwasaki et al.
Cataract and uveitis were significantly linked to poor visual acuity in patients aged 100 years and older, with cataract surgery improving visual acuity.
Amos Stern, Michal Linial
CatBoost models accurately predicted Alzheimer's disease risk using UK Biobank data, achieving a ROC-AUC of 0.773, particularly in females, with the ApoE-ε4 gene being the strongest genetic risk factor, and vascular dementia models showing even higher predictive performance.
Grecia Abigayl Turrubiates-Hernandez, Jose Eduardo Mares-Gil et al.
Admission serum ferritin levels can predict severe disease and adverse outcomes in hospitalized pediatric patients, with a cut-off of 385 ng/mL indicating a 3.2-fold higher probability of death.
Hailin Du, Yamei Sun et al.
In selected patients with postoperative gastrointestinal bleeding after open-heart surgery, those undergoing endoscopic intervention had significantly lower 30-day (26.5% vs. 49.8%) and 1-year (33.8% vs. 57.1%) all-cause mortality rates compared to those who did not receive endoscopic intervention.
Paula Etayo-Urtasun, Mikel Izquierdo et al.
Structured exercise significantly improved parasympathetic modulation (RMSSD, pNN50) and sympathovagal balance (LF/HF ratio) in older adults, with a significant increase in long-term adaptability (SD2).
Enrico Sella, Elena Carbone et al.
A systematic review identified 26 instruments assessing views of aging in older adults, with only a few specifically addressing cognitive changes, and most instruments demonstrated psychometric limitations across various measurement properties.
Parag N Jain, Beryl C Zhuang et al.
Young adults with congenital heart disease who underwent multiple childhood surgeries (Fontan group) showed significantly accelerated epigenetic aging (GrimAge, PhenoAge, DunedinPACE) compared to controls, with inflammation markers (IL-6, CRP) contributing to these differences.
Pingkui Jin, Yanjie Geng et al.
Elevated circulating GDF-15 levels at admission were significantly associated with a 2.82-fold increased risk of mortality in patients with acute heart failure.
Qian Liu, Fan Yang
Hobby engagement is consistently associated with a lower risk of functional disability progression, a higher likelihood of recovery from severe disability, and reduced mortality risk among those with severe disability, leading to significantly longer functional and total life expectancy across diverse global populations.
Jurjen F Krommenhoek, Wendy Beekman et al.
Andexanet alfa use in the Netherlands was associated with a 4.6% 30-day cumulative incidence of thrombotic events, which was lower than in clinical trials, but a 34% 30-day all-cause mortality rate, reflecting the poor prognosis of the patient population.
Soraya Doustmohamadian, Marjan Momeni et al.
Individuals with a metabolically healthy abdominal obese (MHAO) phenotype did not show significantly elevated risks of type 2 diabetes, cardiovascular disease, or all-cause mortality compared to metabolically healthy, non-abdominally obese controls, although abdominal adiposity itself was associated with adverse changes in blood pressure and cholesterol levels.
Yasushi Iwamoto, Hiroshi Kusunoki et al.
This exploratory study found that in two Japanese municipalities, older adults (65-89 years) showed lower all-cause mortality with more COVID-19 vaccine doses, while younger adults (20-49 years) showed higher mortality with five or more doses, and those aged 50-64 showed higher mortality with six doses, though causality cannot be established due to data limitations.
Sun-Young Kang, Jeong-Soo Gim et al.
Lipid-associated epigenetic signatures are highly conserved across mammals, play a role in tissue identity and aging, and blood methylation serves as a reliable proxy for internal metabolic tissue evolution.
Ayman Alqurain, Omer H Al-Hasani et al.
Dietary sodium restriction is effective for hypertension, but strict sodium restriction (<1.5 g/day) is not supported for reducing mortality or hospitalization in established heart failure, with moderate restriction potentially improving symptoms while aggressive restriction could be harmful.
Jordi Morwani-Mangnani, Fatih A Bogaards et al.
Combining insulin resistance metabotype with the MetaboHealth score identified differential responses in body composition, particularly fat loss, in insulin-resistant adults based on baseline immune-metabolic health status, with individuals in the highest MH tertile experiencing fat loss irrespective of diet or metabotype.
Hidayat Arifin, Ruey Chen et al.
The Malnutrition Screening Tool (MST), Malnutrition Universal Screening Tools (MUST), and Nutritional Risk Screening 2002 (NRS-2002) demonstrate good accuracy in detecting malnutrition in patients with chronic diseases, with MST showing a higher area under the curve (AUC).
Valentín Pérez-Mellado, Ana Pérez-Cembranos
The *Podarcis pityusensis* population on Vaixell Islet exhibits large body size, high density, and remarkable longevity, with growth best described by the Gompertz model, indicating intense intraspecific competition and adaptation to extreme islet conditions.
Burcu Tekin, Rafig Gurbanov
The gut microbiota undergoes significant taxonomic and functional remodeling during aging, characterized by reduced microbial diversity, loss of beneficial bacteria, and altered metabolic pathways, which are associated with inflammaging and age-related diseases, suggesting its potential as a biomarker for biological aging.
Mónica Margarita Barón Castro, Angelica María Montoya García et al.
Nursing training practices at the studied university align with regional guidelines for adults and older adults, demonstrating the acquisition of essential competencies for comprehensive care and supporting healthy aging policies, with a notable focus on interventions for individuals from subsidized health regimes and lower socioeconomic strata.
Gioi Spinello, Erica Gobbi et al.
Older adults perceive digital health tools as emotionally distant and impersonal, preferring in-person interactions and social support, and are more receptive to hybrid models that integrate digital tools with human contact for promoting healthy aging.
Hoda G Mohammed, Hassnaa O Mohammed
A collaborative intervention targeting pragmatic language skills in children with ODD and psychological flexibility in their mothers led to significant reductions in ODD symptom severity, with effects maintained at a 1.5-month follow-up.
Marwa Ezz El-Din Ibrahim, Mihriban Elçiçek et al.
Non-thermal processing technologies (HPP, PEF, US, CP) are superior to thermal processing for preserving and enhancing the functional potential of Green Leafy Vegetables (GLVs), improving food safety, releasing bioactive compounds, and maintaining sensory properties, which is crucial for preventive medicine and personalized nutrition in aging populations.
Yingqi Yao, Lin Zhu
A disconnect exists between the public's superficial understanding of sports nutrition foods and their actual utilization, negatively impacting athletic performance, with a need for improved cognition, targeted product development, and industry standards.
Seyed Amirhossein Vahhabzadeh Mousavi, Maryam Salehian et al.
For older adults, improvements in sleep medication use, daytime dysfunction, and fatigue were associated with improvements in functional recovery from acute hospitalization to 4-week follow-up.
James L Dorling, Corby K Martin et al.
A smaller decrease in physical activity energy expenditure during prolonged calorie restriction was associated with improvements in grip strength, insulin resistance, HDL-C, and physical activity time in individuals without obesity.
Jinfeng Li, Terukazu Sanui et al.
Severe periodontal inflammation induces a "senescence-primed" status in helper T cells, which can exacerbate rheumatoid arthritis through a novel cellular mechanism.
Daisy Fancourt, Lehané Masebo et al.
Arts and cultural engagement (ACEng) and physical activity (PA) were associated with slower epigenetic aging, with comparable effect sizes, particularly in adults aged 40 and above, and these effects were observed on second- and third-generation epigenetic clocks.
Juliana Helena Castro E Silva, Davide Marangon et al.
The GPR17 agonist Galinex (GAL) promotes oligodendrocyte maturation and myelination capacity under inflammatory conditions by partially restoring terminal maturation-associated features and oligodendrocyte morphology.
Chuang Shen, Yifan Yin et al.
Maintaining high dietary diversity with regular physical activity was associated with optimal cognitive function, while physical inactivity was an independent risk factor for cognitive decline that favorable dietary habits could not fully offset.
Vadym Lykhach, Natalia Bevz et al.
Supplementing replacement gilt diets with 0.10% "Imunochasnyk" significantly improved growth performance, feed efficiency, and survival rate, alongside enhanced intestinal morphology.
Gabriela Cristina Chelu, Cătălina Raluca Nuță et al.
In older adults, nutritional status (MNA) and functional performance are interrelated with quality of life, with lower MNA scores being associated with increased anxiety/depression and functional limitations, particularly in those aged 80 and above, while higher BMI is consistently linked to pain/discomfort across all age groups.
Emelie Strandberg, Olav Vikmoen et al.
Supervised strength training during chemotherapy in women with breast cancer was associated with increased serum IL-6 and IL-17 compared with usual care, without changes in skeletal muscle autophagy- or heat-shock related proteins at the assessed time points.
Branislav Jovanovic, Simar Singh et al.
Higher short-term weight variability predicted lower subsequent weight loss in adults without obesity.
Emily Y Xiao, Patrick T Lynch et al.
Shorter antibiotic duration (<=2 weeks) after CIED removal showed similar rates of mortality, recurrent bacteremia, and hospital length of stay compared to longer duration (>2 weeks) in patients with CIED-associated bacteremia or lead endocarditis.
Lana E Yeganova, Won G Kim et al.
ConvexTopics, a novel topic modeling algorithm, significantly outperforms traditional methods like K-means, LDA, and BERTopic in organizing and detecting trends in biomedical research, as demonstrated by higher MaxMAP scores on benchmark and specialized datasets, including anti-aging research.
Wenting Peng, Sarah McKiddy et al.
Enhance®Fitness demonstrates statistically significant improvements in physical function and psychological well-being for community-dwelling older adults, with minor adverse events, though blood pressure did not show significant improvement.
Melika Zamanian, Sharif Moradi et al.
The miR-302/367 cluster plays a dual role in promoting cell state transitions, such as pluripotency and reprogramming, while also mitigating aging hallmarks and potentially extending healthspan.
Zhuo Chen, Xue Wang et al.
Higher training loads, the 2023/24 season, forward positions, no previous injury history, and higher temperatures were associated with elevated acute injury risk in elite male rugby players, while advanced competition stages like semi-finals and finals showed significantly higher risks.
Xiaofei Liu, Hao Li et al.
Elevated uric acid-to-albumin ratio (UAR) is independently associated with a 28.7% increased risk of all-cause mortality in centenarians.
Maryline Santerre, Natalia Shcherbik et al.
The gut microbiota modulates neurological vulnerability through inflammatory and metabolic pathways, influencing the threshold at which neurological stress leads to disease expression, rather than being a primary cause of neurodegenerative diseases.
Huakai Wang, Weiwei Wang et al.
Feline obesity is a complex, multifactorial metabolic disorder that requires a shift towards managing it as a chronic disease, focusing on metabolic health, prediction, and pathogenesis for preemptive strategies.
Dianbo Long, Zhencan Lin et al.
m6A modification of circHIPK2 by YTHDF2 promotes chondrocyte senescence and osteoarthritis progression by inhibiting autophagy via the PI3K-AKT-mTOR pathway, and circHIPK2-LNP delivery is a safe and effective therapeutic strategy for OA.
Ruipu Xiu, Ran An et al.
Ivor Lewis minimally invasive oesophagectomy demonstrated superior short-term outcomes, including reduced operative time and fewer complications, compared to the McKeown approach for mid-lower oesophageal squamous cell carcinoma, with comparable mid-term progression-free survival.
Senwei Jiang, Yunhui Li et al.
Endometrial cancer exhibits conserved age-specific molecular subtypes and population-specific genomic features, with younger patients showing CTNNB1/PTEN enrichment and stemness/metabolic pathways, while older patients have TP53/ARID1A enrichment and senescence/endocrine resistance pathways.
Shoaib Ahmed Pirzado, Zheng Aijuan et al.
Dietary microbial phytase significantly improved growth performance, nutrient digestibility, and plasma phosphorus in both broilers and ducks, with ducks showing greater improvements at higher phytate-P and phytase levels and superior nutrient retention and energy digestibility.
Luis M Canal de Velasco, José Emiliano González Flores et al.
Testosterone replacement therapy (TRT) can lead to clinically relevant changes in body composition, increasing lean mass by approximately 1-3 kg and reducing fat mass by 1-4 kg, with these effects being amplified by resistance training and adequate protein intake.
Peng Zhang, Ying Huang et al.
In septic shock patients, initiating enteral nutrition within 48 hours was associated with lower 28-day mortality and more ventilator-free days compared to initiation between 48-96 hours, with the benefit being greater in patients with lower vasopressor exposure.
Christian A Suarez, Sara K Pittman et al.
Conditional Vma21 knockout mouse models recapitulate key pathological features of X-linked myopathy with excessive autophagy (XMEA), demonstrating that Vma21 deficiency leads to autophagic dysregulation and altered vesicle trafficking, including accumulation of CD63-positive structures and C5b-9 deposition at the sarcolemma.
Valentin Max Vetter, Johanna Drewelies et al.
The Allostatic Load Index (ALI) and DunedinPACE demonstrated the strongest and most consistent associations with age-associated phenotypes, both cross-sectionally and longitudinally, and significantly improved the prediction of incident Metabolic Syndrome, high cardiovascular risk, and frailty by up to 24 percentage points over 7.4 years.
Yuhang Zhang, Erkun Yang et al.
Research on knee osteoarthritis and oxidative stress has expanded rapidly, evolving from foundational validation to mechanistic refinement and translational expansion, with a current trend towards exploring subchondral bone, gut microbiota, and cells, despite fragmented international collaboration.
Lin Chen, Yu Shao et al.
BDH1 and PIK3C2G were identified as key genes upregulated in recurrent spontaneous abortion (RSA) that are associated with carbohydrate metabolism and endothelial cell senescence pathways, and may serve as potential diagnostic and therapeutic targets.
Zhiqian Yang, Yang Liu et al.
Tigecycline dose and time dependently suppressed GH3 cell proliferation, induced G0/G1 phase arrest, activated apoptosis, suppressed Akt/mTOR signaling, and attenuated GH synthesis and secretion.
Mattia Moratti, Michele La Manna et al.
Sirolimus demonstrated efficacy in achieving sustained clinical remission of cytopenias in a patient with GIMAP5 deficiency (GISELL syndrome), supporting its role as a precision medical management strategy.
Jeeyeon Kim, Jihye Park et al.
CDH7 hypomethylation in peripheral blood inflammatory cells was identified and validated as an epigenetic marker predictive of cerebral small vessel disease (SVD) imaging features, particularly lacunar pathology.
Qingmeng Yu, Ruiding Li et al.
Dehydrocorydaline (DHC) exhibits anti-pancreatic cancer effects by promoting apoptosis and inhibiting proliferation, migration, and invasion, primarily through the suppression of the PI3K/Akt/mTOR and STAT3 signaling pathways.
Takeshi Yasuda, Tomohisa Takagi et al.
Consumption of the traditional Japanese diet may contribute to sarcopenia prevention by increasing the abundance of butyrate-producing bacteria, primarily genera within the Lachnospiraceae family, suggesting a mechanistic link between Japanese dietary patterns, specific gut microbiota, and preserved muscle function in the elderly.
Xiaoya Tong, Meixian Zhao et al.
Naringenin inhibits vascular calcification and attenuates senescence-associated changes by modulating the p53/TOP2A axis.
Jhommara Bautista, Andrés López-Cortés
The gut microbiome regulates aging through a microbiome-gerogene axis, where age-associated microbial changes influence host aging hallmarks like inflammation, immune senescence, and mitochondrial dysfunction via microbial metabolites and barrier integrity, offering a framework for precision geromedicine.
Yi-Qian Sun, Ilona Urbarova et al.
The pace of aging, estimated from blood DNA methylation, is an independent predictor of all-cause mortality, with a one-standard deviation increase in pace of aging associated with a hazard ratio of 2.42 for mortality.
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