Research Database

Sehr niedrigQuerschnittMensch2026
Clinically feasible biomechanical assessment of lower limb strength and postural stability in adults aged 50-75 years with moderate knee osteoarthritis: implications for technology-enabled healthy aging.
Adel Alshahrani, Ravi Shankar Reddy
Lower limb strength deficits and inter-limb asymmetry significantly contribute to postural instability in individuals with moderate knee osteoarthritis, with quadriceps strength and limb symmetry index being independent predictors of sway area.
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Sehr niedrigQuerschnittMensch2026
The Relation Between Quality of Life, Functional Impairment and Nutritional Status in Older People.
Gabriela Cristina Chelu, Cătălina Raluca Nuță et al.
In older adults, nutritional status (MNA) and functional performance are interrelated with quality of life, with lower MNA scores being associated with increased anxiety/depression and functional limitations, particularly in those aged 80 and above, while higher BMI is consistently linked to pain/discomfort across all age groups.
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NiedrigProspektivMensch2026
Myocardial fibrosis and tissue alterations predict cardiovascular outcomes in chronic kidney disease-a prospective virtual twin study design using large-scale population database.
Georgios Vavilis, Yeshe M Kway et al.
In individuals with chronic kidney disease, an increase in native myocardial T1 was independently associated with higher risks of cardiovascular death, heart failure, and atrial fibrillation.
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Sehr niedrigSystematic ReviewMensch2026
Prognostic Nutritional Index and Cancer Prognostic Outcomes: An Umbrella Review of Systematic Reviews and Meta-analyses of Observational Studies.
Zhi-Tong Li, Ming-Li Sun et al.
The prognostic nutritional index (PNI) is a significant predictor of cancer outcomes, with a higher PNI consistently associated with improved overall survival in various cancer types, although significant heterogeneity in PNI threshold definitions across studies remains a challenge.
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Sehr niedrig2026
Transcriptomic Analysis Reveals Molecular Mechanisms of Fleeing, Adhesion, and Thanatosis Patterns in Sea Cucumber Apostichopus japonicus .
Guo Wu, Hengye Wu et al.
Transcriptomic analysis of sea cucumber coelomocytes revealed distinct molecular mechanisms underlying fleeing (regulated by HTR4, HRH2, ADRA1D, and MMP14), adhesion (involving energy reallocation and potential downregulation of the longevity-regulating pathway), and thanatosis (regulated by MAPK, Rap1, and Ras pathways) stress responses.
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Sehr niedrigMensch2026
Intracellular NAD + Depletion Increases Prostanoid Production via p38/COX2 Signalling in FK866-Induced Senescent Human Umbilical Vein Endothelial Cells.
Natsuko Kitajima, Takahisa Nakajo et al.
NAD+ depletion in human umbilical vein endothelial cells increases prostanoid production via the p38/COX2 signalling pathway, leading to a senescence-like phenotype and elevated COX2-derived prostanoid production, which can be mitigated by NAD+ replenishment with NMN.
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ModeratRCTMensch2026
The Effect of Strength Training During Chemotherapy in Women With Breast Cancer on Serum Cytokine Concentrations and Skeletal Muscle Autophagy-Related Proteins.
Emelie Strandberg, Olav Vikmoen et al.
Supervised strength training during chemotherapy in women with breast cancer was associated with increased serum IL-6 and IL-17 compared with usual care, without changes in skeletal muscle autophagy- or heat-shock related proteins at the assessed time points.
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HochRCTMensch2026
A Prospective, Randomized, Active-Controlled, Evaluator-Blinded, Noninferiority Clinical Trial Examining a Non-Cross-Linked Bovine-Derived Type I/III Collagen Filler Combined with Hyaluronic Acid for Periocular Rejuvenation.
Guo-Sheng Zhu, Si-Yi Zhang et al.
The combination of collagen and hyaluronic acid for periocular rejuvenation demonstrated superior volume restoration and longevity compared to monotherapies, with a reduced incidence of the Tyndall effect.
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Sehr niedrigMensch2026
Prospective Association Between Weight Variability and Subsequent Long-Term Weight Loss in the CALERIE Study.
Branislav Jovanovic, Simar Singh et al.
Higher short-term weight variability predicted lower subsequent weight loss in adults without obesity.
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Sehr niedrigRetrospektivMensch2026
Duration of antimicrobial therapy in cardiovascular implantable electronic device associated systemic infections: a retrospective analysis.
Emily Y Xiao, Patrick T Lynch et al.
Shorter antibiotic duration (<=2 weeks) after CIED removal showed similar rates of mortality, recurrent bacteremia, and hospital length of stay compared to longer duration (>2 weeks) in patients with CIED-associated bacteremia or lead endocarditis.
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ModeratProspektivMensch2026
Genetic Predisposition to Excess Body Weight and Survival in Women Diagnosed With Breast Cancer.
Clara Bodelon, Mariah Landry et al.
In US women with nonmetastatic breast cancer, a genetic predisposition to a higher BMI was associated with a 15% increased risk of all-cause mortality.
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Sehr niedrig2026
Exploring Anti-Aging Literature via ConvexTopics and Large Language Models.
Lana E Yeganova, Won G Kim et al.
ConvexTopics, a novel topic modeling algorithm, significantly outperforms traditional methods like K-means, LDA, and BERTopic in organizing and detecting trends in biomedical research, as demonstrated by higher MaxMAP scores on benchmark and specialized datasets, including anti-aging research.
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Sehr niedrigProspektivMensch2026
Revisiting the Ross operation: early results from a new Ross program at a cardiovascular center in South America.
Santiago Besa, Álvaro Torres et al.
The implementation of a dedicated Ross program in a high-complexity Latin American center is feasible and associated with acceptable early postoperative outcomes, including zero operative mortality and satisfactory early hemodynamic performance.
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Sehr niedrigNarrative ReviewMensch2026
Implementation of Enhance®Fitness: a scoping review using the RE-AIM framework.
Wenting Peng, Sarah McKiddy et al.
Enhance®Fitness demonstrates statistically significant improvements in physical function and psychological well-being for community-dwelling older adults, with minor adverse events, though blood pressure did not show significant improvement.
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Sehr niedrigNarrative ReviewRatte2026
Branched-chain amino acids from plants and the metabolic syndrome: pathways and pharmacological applications.
Song-Nan Wang, Yu-Xi Liu et al.
Plant-derived BCAAs, abundant in legumes, whole grains, and microalgae, show potential for metabolic syndrome prevention and treatment due to their anti-inflammatory effects, beneficial gut microbiota interactions, and association with improved metabolic health markers compared to animal-based sources.
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NiedrigRCTMensch2026
Dose-Related Effects of Different Tai Chi Styles Versus Traditional Community-Based Exercises on Cardiometabolic Health and Physical Function in Middle-Aged and Older Adults: Randomized Controlled Trial.
Jiadong Qiu, Jian Wang et al.
Both 12-form Chen-style Tai Chi (CTC12) and square dance significantly improved cardiometabolic health, physical function, and quality of life in middle-aged and older adults compared to a control group, with CTC12 demonstrating broader multidimensional benefits.
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Sehr niedrigNarrative ReviewMensch2026
The harmonies played by miR-302/367 cluster in pluripotency, reprogramming, and rejuvenation.
Melika Zamanian, Sharif Moradi et al.
The miR-302/367 cluster plays a dual role in promoting cell state transitions, such as pluripotency and reprogramming, while also mitigating aging hallmarks and potentially extending healthspan.
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Sehr niedrigProspektiv2026
Anatomical spatial-temporal distribution and multivariate risk of acute injuries in elite rugby: a cohort based on prospective surveillance.
Zhuo Chen, Xue Wang et al.
Higher training loads, the 2023/24 season, forward positions, no previous injury history, and higher temperatures were associated with elevated acute injury risk in elite male rugby players, while advanced competition stages like semi-finals and finals showed significantly higher risks.
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ModeratProspektivMensch2026
Association between the uric acid-to-albumin ratio and risk of all-cause mortality in centenarians: a prospective cohort study.
Xiaofei Liu, Hao Li et al.
Elevated uric acid-to-albumin ratio (UAR) is independently associated with a 28.7% increased risk of all-cause mortality in centenarians.
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Sehr niedrigNarrative ReviewMensch2026
Microbiota as a regulator of brain vulnerability across lifespan and disease contexts.
Maryline Santerre, Natalia Shcherbik et al.
The gut microbiota modulates neurological vulnerability through inflammatory and metabolic pathways, influencing the threshold at which neurological stress leads to disease expression, rather than being a primary cause of neurodegenerative diseases.
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Sehr niedrigNarrative ReviewMensch2026
From pathogenesis to prevention: an update on the management of obesity and its associated comorbidities in cats.
Huakai Wang, Weiwei Wang et al.
Feline obesity is a complex, multifactorial metabolic disorder that requires a shift towards managing it as a chronic disease, focusing on metabolic health, prediction, and pathogenesis for preemptive strategies.
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Sehr niedrigNarrative Review2026
Plant-based diets for human health with implications for cardiometabolic health, gut microbiome, and nutritional adequacy.
Mansour Alblaji
Well-planned plant-based diets offer significant health benefits, including reduced cardiometabolic disease risk and improved gut microbiome, and have a substantially lower environmental footprint compared to diets including animal products.
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Sehr niedrigMaus2026
YTH N6-methyladenosine RNA binding protein 2 mediated m 6 A modification of circHIPK2 promotes cellular senescence and osteoarthritis progression by inhibiting autophagy.
Dianbo Long, Zhencan Lin et al.
m6A modification of circHIPK2 by YTHDF2 promotes chondrocyte senescence and osteoarthritis progression by inhibiting autophagy via the PI3K-AKT-mTOR pathway, and circHIPK2-LNP delivery is a safe and effective therapeutic strategy for OA.
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Sehr niedrigNarrative Review2026
Intermolecular-Interaction-Driven Adaptive Remodeling: A Network Perspective on Plant Abiotic Stress Responses.
Leidi Liu, Xiangfei Cheng et al.
Plant abiotic stress responses are governed by dynamic interaction networks, not linear pathways, with stress tolerance emerging as a property of network behavior.
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HochRCTMensch2026
Ivor Lewis minimally invasive oesophagectomy versus McKeown approach: short-term benefits and mid-term equivalence in a randomized trial for oesophageal squamous cell carcinoma.
Ruipu Xiu, Ran An et al.
Ivor Lewis minimally invasive oesophagectomy demonstrated superior short-term outcomes, including reduced operative time and fewer complications, compared to the McKeown approach for mid-lower oesophageal squamous cell carcinoma, with comparable mid-term progression-free survival.
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Sehr niedrig2026
Effects of Kiperin Elixea, a multicomponent antioxidant supplement, on redox homeostasis and longevity-associated gene expression in human epithelial cell models.
Lutfiye Karcıoğlu Batur, Ahsen Pektas et al.
Elixea modulated redox homeostasis and longevity-associated transcriptional pathways in a cell type-dependent manner, suggesting it promotes cellular resilience and epithelial homeostasis rather than generalized proliferation.
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Sehr niedrigMaus2026
JMJD3-driven epigenetic reprogramming of p16 INK4a -positive cells promotes tendon regeneration.
Xiaonan Liu, Wenhao Lu et al.
JMJD3-driven epigenetic reprogramming of p16INK4a-positive cells promotes tendon regeneration by enhancing extracellular matrix synthesis, vascularization, and innervation.
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Sehr niedrigProspektivMensch2026
Genomic and immunological differences in endometrial cancer: a comparative study between young and old Asian patients.
Senwei Jiang, Yunhui Li et al.
Endometrial cancer exhibits conserved age-specific molecular subtypes and population-specific genomic features, with younger patients showing CTNNB1/PTEN enrichment and stemness/metabolic pathways, while older patients have TP53/ARID1A enrichment and senescence/endocrine resistance pathways.
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Sehr niedrig2026
Comparative evaluation of phytate and phytase addition on growth performance and nutrient utilization efficiency in broilers and ducks.
Shoaib Ahmed Pirzado, Zheng Aijuan et al.
Dietary microbial phytase significantly improved growth performance, nutrient digestibility, and plasma phosphorus in both broilers and ducks, with ducks showing greater improvements at higher phytate-P and phytase levels and superior nutrient retention and energy digestibility.
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Sehr niedrigNarrative Review2026
Testosterone Replacement Therapy as a Foundation for Body Composition Remodeling: Synergistic Roles of Resistance Training and Protein Intake.
Luis M Canal de Velasco, José Emiliano González Flores et al.
Testosterone replacement therapy (TRT) can lead to clinically relevant changes in body composition, increasing lean mass by approximately 1-3 kg and reducing fat mass by 1-4 kg, with these effects being amplified by resistance training and adequate protein intake.
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Sehr niedrigMensch2026
Early versus delayed enteral nutrition in septic shock: a target trial emulation study.
Peng Zhang, Ying Huang et al.
In septic shock patients, initiating enteral nutrition within 48 hours was associated with lower 28-day mortality and more ventilator-free days compared to initiation between 48-96 hours, with the benefit being greater in patients with lower vasopressor exposure.
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Sehr niedrigMaus2026
VMA21 deficiency leads to autophagic dysregulation and altered vesicle trafficking in X-linked myopathy with excessive autophagy.
Christian A Suarez, Sara K Pittman et al.
Conditional Vma21 knockout mouse models recapitulate key pathological features of X-linked myopathy with excessive autophagy (XMEA), demonstrating that Vma21 deficiency leads to autophagic dysregulation and altered vesicle trafficking, including accumulation of CD63-positive structures and C5b-9 deposition at the sarcolemma.
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NiedrigProspektivMensch2026
Comprehensive cross-sectional and longitudinal comparison of sixteen markers of biological aging from the Berlin Aging Study II.
Valentin Max Vetter, Johanna Drewelies et al.
The Allostatic Load Index (ALI) and DunedinPACE demonstrated the strongest and most consistent associations with age-associated phenotypes, both cross-sectionally and longitudinally, and significantly improved the prediction of incident Metabolic Syndrome, high cardiovascular risk, and frailty by up to 24 percentage points over 7.4 years.
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Sehr niedrig2026
Research landscape, hotspots, and evolutionary trends of knee osteoarthritis and oxidative stress: a multidimensional bibliometric analysis.
Yuhang Zhang, Erkun Yang et al.
Research on knee osteoarthritis and oxidative stress has expanded rapidly, evolving from foundational validation to mechanistic refinement and translational expansion, with a current trend towards exploring subchondral bone, gut microbiota, and cells, despite fragmented international collaboration.
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Sehr niedrig2026
Discovery and validation of key genes and potential mechanisms linked to endothelial cell senescence and carbohydrate metabolism in recurrent spontaneous abortion.
Lin Chen, Yu Shao et al.
BDH1 and PIK3C2G were identified as key genes upregulated in recurrent spontaneous abortion (RSA) that are associated with carbohydrate metabolism and endothelial cell senescence pathways, and may serve as potential diagnostic and therapeutic targets.
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NiedrigProspektivMensch2026
Stratifying prognosis in heart failure patients with reduced ejection fraction and atrial cardiomyopathy.
Jung-Chi Hsu, Umbreen Nadeem et al.
High FIND-AF risk is associated with a 2.48-fold increased risk of incident AF, ischaemic stroke, or all-cause mortality in HFrEF patients with AtCM but without baseline AF, and demonstrates superior discrimination to CHA2DS2-VASc for these outcomes.
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Sehr niedrigRatte2026
Repurposing the Antibiotic Tigecycline to Inhibit Tumor Growth and Hormone Secretion in Somatotroph Pituitary Neuroendocrine Tumors.
Zhiqian Yang, Yang Liu et al.
Tigecycline dose and time dependently suppressed GH3 cell proliferation, induced G0/G1 phase arrest, activated apoptosis, suppressed Akt/mTOR signaling, and attenuated GH synthesis and secretion.
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Sehr niedrigFallberichtMensch2026
Unexpected genetically determined immune dysregulation with liver involvement: GIMAP5 therapeutic dilemmas between targeted therapy and HSCT.
Mattia Moratti, Michele La Manna et al.
Sirolimus demonstrated efficacy in achieving sustained clinical remission of cytopenias in a patient with GIMAP5 deficiency (GISELL syndrome), supporting its role as a precision medical management strategy.
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Sehr niedrigNarrative ReviewMensch2026
Non-Coding RNAs as Emerging Biomarkers in HPV-Associated Cervical Precancer and Cancer: Molecular Mechanisms and Clinical Perspectives.
Matteo Terrinoni, Valerio Caputo et al.
Non-coding RNAs (ncRNAs) show promise as candidates for risk stratification, non-invasive diagnosis, treatment-response prediction, and therapeutic development in HPV-associated cervical disease, although further validation is required.
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Sehr niedrigMensch2026
Promoter hypomethylation of CDH7 : a novel epigenetic marker associated with cerebral small vessel disease.
Jeeyeon Kim, Jihye Park et al.
CDH7 hypomethylation in peripheral blood inflammatory cells was identified and validated as an epigenetic marker predictive of cerebral small vessel disease (SVD) imaging features, particularly lacunar pathology.
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Sehr niedrig2026
Dehydrocorydaline Exerts Anti-Pancreatic Cancer Effects Through the PI3K/Akt/mTOR Pathway.
Qingmeng Yu, Ruiding Li et al.
Dehydrocorydaline (DHC) exhibits anti-pancreatic cancer effects by promoting apoptosis and inhibiting proliferation, migration, and invasion, primarily through the suppression of the PI3K/Akt/mTOR and STAT3 signaling pathways.
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Sehr niedrigMensch2026
Sarcopenia-related gut microbiota in the elderly: Insights from the longevity region of Kyotango and its nutritional associations.
Takeshi Yasuda, Tomohisa Takagi et al.
Consumption of the traditional Japanese diet may contribute to sarcopenia prevention by increasing the abundance of butyrate-producing bacteria, primarily genera within the Lachnospiraceae family, suggesting a mechanistic link between Japanese dietary patterns, specific gut microbiota, and preserved muscle function in the elderly.
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Sehr niedrigRatte2026
Naringenin inhibited vascular calcification and attenuated senescence-associated changes through the p53/TOP2Aaxis.
Xiaoya Tong, Meixian Zhao et al.
Naringenin inhibits vascular calcification and attenuates senescence-associated changes by modulating the p53/TOP2A axis.
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Sehr niedrigNarrative Review2026
The microbiome-gerogene axis: a new frontier in precision geromedicine.
Jhommara Bautista, Andrés López-Cortés
The gut microbiome regulates aging through a microbiome-gerogene axis, where age-associated microbial changes influence host aging hallmarks like inflammation, immune senescence, and mitochondrial dysfunction via microbial metabolites and barrier integrity, offering a framework for precision geromedicine.
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NiedrigFall-KontrollMensch2026
Association between pace of aging estimated from blood DNA methylation and all-cause mortality: the HUNT study.
Yi-Qian Sun, Ilona Urbarova et al.
The pace of aging, estimated from blood DNA methylation, is an independent predictor of all-cause mortality, with a one-standard deviation increase in pace of aging associated with a hazard ratio of 2.42 for mortality.
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Sehr niedrigNarrative ReviewMensch2026
From the lab to lifestyle: epigenetic clocks in personalized aging and health.
José Santiago Ibáñez-Cabellos, José Luis García-Giménez et al.
ELOVL2-based minimalist epigenetic clocks show promise for scalable age estimation and screening due to their simplicity and cost-effectiveness, but require further validation for clinical decision-making.
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Sehr niedrigNarrative Review2026
Sex differences in endothelial cell biology: cellular phenotypes and molecular regulators.
Alexandra Pislaru, Tara L Haas
Sex differences in endothelial cell biology, influenced by sex hormones, sex chromosomes, and epigenetics, lead to distinct phenotypes in areas such as nitric oxide signaling, angiogenesis, metabolism, oxidative stress response, and inflammation, impacting vascular health and disease susceptibility.
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NiedrigProspektivMensch2026
Development of a nomogram for predicting incident heart failure and all-cause mortality in patients with chronic kidney disease: a 3-year follow-up study.
Yuxin Jiang, Xiaotong Song et al.
A novel dynamic nomogram integrating age, GDF-15, ferritin, lipoprotein(a), and EQ-5D score accurately stratifies the risk of incident heart failure and all-cause mortality in chronic kidney disease patients, demonstrating robust predictive ability.
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Sehr niedrigNarrative ReviewMensch2026
The effect of sodium restricted diet on the prognosis of heart failure patients: a systemic review and meta-analysis.
Ming-Hao Ma, Zhi-Cheng Yang et al.
Sodium-restricted diets in heart failure patients were associated with increased all-cause mortality (RR 1.50) and cardiac mortality (RR 2.51), with no significant difference in readmission rates, although quality of life may be improved.
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HochRCTMensch2026
Oral sodium hyaluronate improves skin hydration, barrier function and signs of aging: a randomized, double-blind, placebo-controlled trial in 150 healthy adults.
Iva Dolečková, Pavel Kušnierik et al.
Oral sodium hyaluronate (SH) supplementation at 60 mg/day and 120 mg/day significantly improved skin hydration, barrier function, and wrinkle depth in healthy adults, with the 120 mg dose showing more pronounced effects.
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Sehr niedrigIn vitro2026
NSD1 governs H3K36me2-mediated DNA methylation and drives endo-mesodermal differentiation of human iPSCs.
Anna Hansknecht, Martina Mankarious et al.
NSD1 deficiency in human iPSCs leads to reduced H3K36me2, global DNA hypomethylation, impaired endo-mesodermal differentiation, and accelerated epigenetic age, with NSD1 regulating endodermal differentiation via the lncRNA HIDEN and WNT signaling independently of DNA methylation.
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Sehr niedrig2026
The quantified immune-aging dysregulation index: a large-language model-powered method for annotating and quantifying systems-level dysregulation.
George D Vavougios, Georgios Hadjigeorgiou
TENSE is a novel framework that quantifies immune-aging dysregulation from pathway enrichment analysis using an LLM to classify pathways into mechanistic categories, enabling reproducible and interpretable comparative analysis across diverse datasets.
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Sehr niedrigNarrative Review2026
Retrotransposons in Bone and Joint Diseases.
Ye Liu, H Josh Jang et al.
Retrotransposon reactivation, particularly endogenous retroviruses (ERVs), is a pivotal event in the pathogenesis of osteoarthritis, rheumatoid arthritis, and osteoporosis, triggering immune responses and cellular senescence, and presents a promising therapeutic target.
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NiedrigProspektivMensch2026
Epigenetic aging and blood based neurodegeneration markers in LASI-DAD.
Jung Ki Kim, Thalida E Arpawong et al.
Accelerated epigenetic aging, especially with second- and third-generation clocks, was associated with higher follow-up levels and steeper increases in GFAP and NfL in older Indian adults, suggesting utility for dementia risk stratification in resource-limited settings.
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Sehr niedrigNarrative Review2026
Targeting Glioblastoma Stem Cells: Therapeutic Strategies and Clinical Perspectives.
Harikrishna Reddy Rachamala, Sonia Devi Lourembam et al.
Glioblastoma stem cells (GSCs) are critical drivers of glioblastoma initiation, resistance, and relapse, exhibiting self-renewal, differentiation capacity, metabolic adaptability, and resistance to genotoxic stress, which necessitates combinatorial therapeutic approaches targeting multiple pathways and supportive niches.
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Sehr niedrigMaus2026
Telomere Shortening Drives Atrial Fibrillation Through VCAM-1 Mediated Atrial Electrical and Structural Remodeling.
Zhaojia Wang, Rui Zhao et al.
Telomere shortening drives atrial fibrillation through VCAM-1 mediated atrial electrical and structural remodeling, and inhibiting VCAM-1 reversed these abnormalities and reduced AF susceptibility.
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NiedrigProspektivMensch2026
Structural Disadvantage in Adolescence and Biological Aging in Early Midlife.
Taylor W Hargrove, Alena Sorensen D'Alessio et al.
Adolescent exposure to structural disadvantage was associated with accelerated epigenetic aging and inflammation-related DNA methylation in early midlife, with these associations differing by race, showing a negative association for Black respondents and a positive association for White respondents.
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Sehr niedrigNarrative Review2026
Investigating the research trajectory and future trends in type 2 diabetes mellitus and aging: a bibliometric analysis from 2009 to 2025 based on big data.
Tingting Gong, Wei Jiang et al.
This bibliometric analysis reveals that cellular senescence is a central node linking type 2 diabetes mellitus (T2DM) and aging, with research rapidly expanding towards translational applications and aging-targeted therapeutic strategies like senolytics.
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Sehr niedrigNarrative ReviewMensch2026
Cellular Heterogeneity During Arterial Aging.
He Xu, Paul-Lennard Mendez et al.
Single-cell RNA sequencing studies reveal that arterial aging is characterized by cellular heterogeneity across endothelial cells, smooth muscle cells, fibroblasts, and immune cells, with distinct subpopulations exhibiting senescence, extracellular matrix remodeling, and chronic inflammation.
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Sehr niedrigNarrative ReviewMensch2026
Transition from acute kidney injury to chronic kidney disease: molecular mechanisms and therapeutic interventions.
Xinyue Huang, Mengqiong Wang et al.
The transition from acute kidney injury (AKI) to chronic kidney disease (CKD) is a complex process driven by maladaptive repair mechanisms, including persistent cell cycle arrest, chronic inflammation, sustained fibroblast activation, capillary rarefaction, and dysregulated signaling pathways, leading to ongoing damage and fibrosis.
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Sehr niedrigMaus2026
Hepatocyte estrogen-related receptor α modulates a gluconeogenic-epigenetic crosstalk counteracting MASLD/MASH progression.
Jun Gao, Meng Yang et al.
Hepatocyte ESRRA counteracts MASLD/MASH progression by promoting lactate consumption for gluconeogenesis and mitochondrial oxidation, thereby reducing histone lactylation, with ESRRA restoration via AAV delivery ameliorating the disease.
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Sehr niedrigFall-KontrollMensch2026
Matched Analysis of Circulating and Adipose Tissue SIRT1 Protein Level in Human Obesity.
Luisa Salvatori, Francesca Megiorni et al.
In obese patients, plasma SIRT1 levels substantially reflect subcutaneous adipose tissue SIRT1 levels, while in non-obese individuals, elevated subcutaneous adipose tissue SIRT1 may act as a local protective reservoir.
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Sehr niedrigMensch2026
Continuous antiretroviral therapy induces progressive senescence-like reprogramming of alveolar macrophages.
Vinicius M Fava, Monica Dallmann-Sauer et al.
Continuous antiretroviral therapy (ART) induces a progressive senescence-like pro-inflammatory state in alveolar macrophages, characterized by increased cell-cycle arrest and senescence gene priming, which is duration-dependent and independent of HIV infection, while also causing a time-independent impairment of interferon signaling that diminishes the response to viral challenge.
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Sehr niedrigQuerschnittMensch2026
Iron deficiency in primary care patients with heart failure: a cross-sectional study of the heart failure in Southern Sweden (HISS) cohort.
Fredrik Vinge, Oscar Braun et al.
Iron deficiency (ID) is prevalent in primary care heart failure (HF) patients (26.7% by TSAT < 20%) and is independently associated with greater symptom severity (NYHA class III-IV), even after adjusting for multiple confounders.
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Sehr niedrigNarrative ReviewMensch2026
Autophagy modulation in gynaecologic oncology: insights into immune regulation and therapeutic potential.
Mingyu Huang, Defeng Zhao et al.
Autophagy plays a dual role in gynaecological cancers, influencing tumour initiation, progression, immune regulation, and therapeutic resistance, with potential for targeted therapeutic strategies.
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Sehr niedrigNarrative ReviewMensch2026
MicroRNA-Mediated Regulation of Brain Aging Hallmarks: Implications for Neurodegeneration and Neural Recovery.
Mustafa T Ardah, Pareshkumar N Patel et al.
MicroRNAs (miRNAs) are crucial regulators of brain aging, influencing key hallmarks such as genomic stability, nutrient sensing, proteostasis, autophagy, mitochondrial function, stem cell exhaustion, telomere maintenance, epigenetic regulation, and inflammatory signaling, and hold promise as biomarkers and therapeutic targets despite current challenges.
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Sehr niedrigNarrative ReviewMensch2026
Gut microbiota in type 2 diabetes mellitus: mechanistic links between dysbiosis, insulin resistance, and chronic low-grade inflammation.
Yi Chen, Danru Jin et al.
Gut microbiota dysbiosis mechanistically contributes to type 2 diabetes mellitus by influencing insulin signalling, metabolite production, and inflammation, with altered microbial metabolic output impairing insulin responsiveness and promoting inflammation.
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Sehr niedrig2026
Cell cycle dynamics regulate H3K27 and H3K9 histone modifications in Drosophila.
Liyne Nogay, Ananthakrishnan Vijayakumar Maya et al.
Cell cycle dynamics selectively influence H3K27ac, H3K27me3, and H3K9me3 levels at pre-existing genomic loci, with methylation levels linked to metabolic activity and acetylation levels regulated by an S-phase-dependent cycle.
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Sehr niedrigMensch2026
Healthy Eating Index, Epigenetic Age Acceleration and Mortality Risk in US Adults.
May A Beydoun, Marie T Fanelli Kuczmarski et al.
Poor diet quality is associated with accelerated biological aging and increased mortality, with GrimAgeEAA identified as the strongest mortality predictor, and epigenetic mechanisms partially mediating the diet-mortality association, although this mediation is attenuated by lifestyle factors, particularly physical activity.
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Sehr niedrigMensch2026
DNA methylation-mediated memory of obesity in CD4 T lymphocytes perpetuates immune dysregulation.
Jennifer Niven, Salih Kucuk et al.
Obesity imprints CD4 T cells via DNA methylation, leading to a long-lasting immune memory that persists for years after weight loss, driven by altered autophagy and immune senescence, and potentially targeted by modulating STK26 and CDKN1C.
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Predicting the Impact of Deleterious Single-Nucleotide Polymorphisms in the p47ING1a Isoform of Human ING1 Gene.
Md Oliullah Rafi, Md Takim Sarker et al.
Six missense single-nucleotide polymorphisms (C358S, C374G, W378G, F379V, S382L, and R400P) within the PHD domain of the p47ING1a isoform are predicted to destabilize the protein, disrupt its interaction with H3K4me3 and the Sin3A/HDAC complex, thereby impairing its tumor-suppressor function.
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Sehr niedrig2026
Long-lived mammals contain more phosphorylation sites in the SIRT6 C-terminus that enhance PARP1 interaction and resistance to oxidative stress.
Jonathan Gigas, Michael E Meadow et al.
The number of SIRT6 C-terminal phosphorylation sites positively correlates with species' maximum lifespan, enhancing SIRT6 interaction with PARP1 and improving resistance to oxidative stress, a mechanism that appears to have been evolutionarily selected for longevity.
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Sehr niedrigNarrative ReviewMensch2026
From "Passive Supplementation" to "Active Repair": Melatonin Reshapes the Treatment Paradigm for Late-Onset Hypogonadism by Targeting Leydig Cell Senescence.
Hui Wu, Gang Ning et al.
Melatonin demonstrates potential to delay Leydig cell senescence and promote endogenous testosterone synthesis by addressing multiple molecular mechanisms including oxidative stress, mitochondrial dysfunction, and the senescence-associated secretory phenotype, offering a shift from passive testosterone supplementation to active cellular repair for late-onset hypogonadism.
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Sehr niedrigQuerschnittMensch2026
Epigenetics as Biomarkers of Cumulative Physical Performance in Community-Dwelling Adults: A Cross-Sectional Feasibility Study.
Maayan Insler, Maxim Shapiro et al.
DNA methylation-based epigenetic clocks, particularly DNAmAgeHannum (ρ = −0.59, p < 0.005), showed significant negative correlations with a composite physical performance score in community-dwelling adults, suggesting they can detect early physiological decline.
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Sehr niedrigNarrative ReviewMensch2026
Blue Zones, an Analysis of Existing Evidence through a Scoping Review.
Cristina Candal-Pedreira, Julia Rey-Brandariz et al.
Okinawa, Ogliastra, and Nicoya are demographically and epidemiologically well-characterized Blue Zones, though some exhibit a recent decline in their longevity advantage, while other regions like Ikaria, Martinique/Guadeloupe, Cilento, a Dutch municipality, and Rugao require further investigation, and Loma Linda and Menorca lack sufficient scientific evidence.
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Sehr niedrigMaus2026
Endothelial progenitor cell susceptibility to DNA damaging and DDR-modulating compounds determines endothelial differentiation accuracy.
Sina Federmann, Michelle Westerhoff et al.
Doxorubicin treatment of endothelial progenitor cells (EPC) leads to multiple dysfunctions in their differentiated progeny, including impaired endothelial barrier function, altered cytokine response, and reduced LDL uptake, along with increased senescence.
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Epigenetic regulation of cardiac physiology and pathophysiology: biological sex matters.
Omid M T Rouzbehani, Marta W Szulik et al.
Epigenetic mechanisms play a critical role in cardiac physiology and pathophysiology, with biological sex significantly influencing disease susceptibility, progression, and therapeutic responses, often conferring a protective advantage in females compared to males.
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Sehr niedrigNarrative Review2026
Metabolic Amplification in Endometrial Carcinogenesis: Biological Rationale and Translational Limits of Precision Chemoprevention.
Weronika Rzeska, Aneta Adamiak-Godlewska
Endometrial cancer incidence is significantly influenced by metabolic dysfunction, with bariatric surgery demonstrating strong evidence for risk reduction through metabolic correction, while pharmacologic interventions have not yet shown consistent preventive efficacy.
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Sehr niedrigNarrative ReviewMaus2026
A comprehensive review of artificial intelligence as a catalyst in aging research: insights, gaps and future perspectives.
Tasnuva Binte Mahbub, Parsa Safaeian et al.
While AI has revolutionized aging research by improving data analysis, predictability, and experimental acceleration, its current applications are limited by data quality, quantity, and a lack of robust in vivo biological validation, necessitating a structured approach like the proposed AI Quality Assessment Metric (AI-QAM) for reliable translation into interventions.
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Sehr niedrigNarrative Review2026
Transcriptional regulation in cardiovascular aging.
Yiguang Fan, Chao Song et al.
Cardiovascular aging, a primary driver of cardiovascular diseases, is characterized by significant dysregulation of transcriptional regulatory networks involving transcription factors and epigenetic factors, leading to impaired cardiac and vascular cell function.
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Ballroom dance and balance ability in older adults: a serial mediation model of fear of falling and physical self-efficacy.
Dongquan Gao, Xiaojie Sun et al.
Ballroom dance was positively associated with balance ability in older adults, with physical self-efficacy acting as the largest mediator, followed by fear of falling, and a serial pathway involving both.
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Stiffness-dependent alveolar type II cell senescence in idiopathic pulmonary fibrosis.
Chih-Ru Lin, Khanutsanan Woranam et al.
Sustained DNA damage in ATII cells from IPF patients is linked to nuclear stiffness from mechanical forces, leading to impaired DNA repair, senescence, and accelerated disease progression.
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Sehr niedrigSystematic ReviewMensch2026
Exercise and nutrition as epigenetic regulators of gene expression: an exploratory scoping review with bibliometric analysis.
Hao Zhang, Ruida Yu et al.
Combined exercise and nutrition interventions show promising but predominantly exploratory associations with multi-layered epigenetic changes and improvements in metabolic health, muscular adaptability, inflammatory processes, and aging-related pathways, though current evidence is limited in scale and heterogeneous in design.
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Intermittent Hypoxia Mimicking Sleep Apnea Induces Systemic and Tissue Specific Epigenetic Changes and p16-Mediated Cellular Senescence Underlying Vascular Dysfunction.
Rene Cortese, Kylie Cataldo et al.
Intermittent hypoxia (IH) induces duration-dependent, tissue-specific epigenetic dysregulation and accelerated biological aging, with p16Ink4a-mediated cellular senescence being a primary driver of OSA-induced cardiovascular morbidity, and targeting the senescent endothelium can revert vascular dysfunction.
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ModeratMetaanalyse2026
Opposing Ageing-Related Transcriptomic Profiles Distinguish Opioid Exposure Liability From Dependence Liability.
Ngo Cheung
Genetic liability for opioid exposure and dependence are associated with partially opposing ageing-related gene expression profiles in brain tissue, with exposure linked to reduced complement-mediated synaptic pruning and glial support, and dependence characterized by increased nutrient sensing, mitochondrial oxidative phosphorylation, and DNA repair signals.
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Sehr niedrigNarrative ReviewMensch2026
From Longevity Genetics to Precision Interventions: Integrating Nutrigenomics and Epigenetic Mechanisms of Ageing.
Lorin-Manuel Pîrlog, Andreea Cătană et al.
Human longevity is a polygenic and environmentally responsive trait influenced by genetic factors like FOXO3 and APOE, and epigenetic mechanisms that link inherited susceptibility to environmental exposures, with interventions targeting shared pathways but yielding context-dependent effects.
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HochRCTMensch2026
Metformin and epigenetic age in non-diabetic older people with HIV in Madrid (METFORAGING): a double-blind, randomised, placebo-controlled, pilot trial.
Cristina Marcelo-Calvo, Andrés Esteban-Cantos et al.
In a pilot trial of non-diabetic older adults with HIV, 96 weeks of metformin did not result in statistically significant differences in epigenetic age compared to placebo, although the direction of change favored metformin.
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Peripheral immune cell subsets as potential predictors of benefit from immune checkpoint blockade therapy in small cell lung cancer.
Miguel A Galindo-Campos, Max Hardy-Werbin et al.
Early post-treatment increases in specific peripheral immune cell subsets, such as CD8+CD103+Ki67+ and CD4+Ki67+ T cells, predict improved survival in small cell lung cancer patients treated with chemotherapy and immune checkpoint blockade therapy.
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Sehr niedrigMaus2026
Histone Deacetylase 9 Gene Deletion Ameliorates Aging-Related Adipose Tissue Senescence and Mitochondrial Dysfunction in Mice.
Brandee Goo, Samah Ahmadieh et al.
Deletion of the histone deacetylase 9 (HDAC9) gene ameliorates aging-related adipose tissue senescence and mitochondrial dysfunction in mice, partly through the upregulation of thiosulfate sulfurtransferase (TST).
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Age-dependent H3K9 trimethylation by dSetdb1 impairs mitochondrial UPR leading to degeneration of olfactory neurons and loss of olfactory function in Drosophila .
Francisco Muñoz-Carvajal, Nicole Sanhueza et al.
Age-dependent H3K9 trimethylation by dSetdb1 impairs mitochondrial UPR leading to degeneration of olfactory neurons and loss of olfactory function in Drosophila.
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Interferon-related inflammaging links epigenetic age acceleration to multimorbidity.
Zhaoli Liu, Athanasios Ziogas et al.
Chronic inflammation, particularly involving the interferon pathway, causally contributes to epigenetic age acceleration and age-related diseases, with CXCL9 showing the strongest causal evidence for epigenetic age acceleration.
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Epigenetic Age Acceleration Is Associated With HIV Infection Independently of Inflammation.
James K Gibb, Joshua M Schrock et al.
Among young adults with HIV and detectable viremia on ART, epigenetic age acceleration was more strongly associated with HIV infection than with systemic inflammation, with shifts in blood T-lymphocyte composition contributing to epigenetic aging.
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Sehr niedrigNarrative ReviewMensch2026
Blood as the mirror and modulator of aging: mechanistic insights and rejuvenation strategies.
Eunhwan Kim, Jae Sook Kang et al.
The circulatory system actively influences aging and rejuvenation, with blood components serving as predictors of healthspan and disease risk, and interventions like young plasma infusion and plasma dilution showing potential to partially reverse systemic aging.
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Sehr niedrigNarrative ReviewMensch2026
The Implications of Radiotherapy-Induced Cellular Senescence for Cancer Treatment and Tumor Microenvironment Modulation.
Chao Jiang, Zhouting Tuo et al.
Radiotherapy-induced cellular senescence plays a dual role in cancer treatment, with acute senescence being tumor-suppressive and chronic senescence promoting recurrence, therapy resistance, and normal-tissue toxicity.
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Identification and Analysis of the ZmGDS1 Gene Family in Maize.
Qi Wang, Lufei Zhao et al.
A genome-wide analysis identified thirteen ZmGDS1 genes in maize, which, due to structural diversity and regulatory elements linked to senescence signals, are likely involved in leaf senescence, especially under low-nitrogen conditions.
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Activation-induced cytidine deaminase promotes DNA demethylation and expression of the Ninjurin-2 gene.
Toshiyuki Okada, Yusuke Toyoda et al.
Activation-induced cytidine deaminase (AID) binds to the NINJ2 promoter/enhancer, inducing DNA demethylation and transcriptional upregulation, which is suggested to aid wound healing and is associated with delayed recovery from colitis in AID-knockout mice.
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Sehr niedrigNarrative ReviewMensch2026
From Growth Trajectory to Functional Decline: Age-Contextualized Nutritional Strategies for Muscle Vulnerability. A Narrative Review.
Luisa Malaguarnera, Vincenzo Sortino et al.
Nutritional bioactives interact with conserved molecular pathways regulating skeletal muscle homeostasis across the lifespan, but their impact is stage-dependent, with molecular improvements not consistently translating to clinically meaningful functional outcomes, necessitating integrated approaches for pediatric growth and aging muscle preservation.
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Coadministration of rapamycin with a DNA/MVA SIV vaccine improves memory CD8+ T cell response.
Shanmugalakshmi Sadagopal, Kasey Stokdyk et al.
Rapamycin treatment during DNA/MVA SIV vaccination in rhesus macaques enhanced the magnitude and quality of postinfection CD8+ T cell responses by promoting central memory CD8+ T cell development, leading to improved viral control and survival.
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Telomere Dysfunction and Proteostasis Decline Define Distinct Pathways of Cellular Senescence in the Human Respiratory Tract.
Céline Coquette, Kamar Bouchoucha et al.
Proteostasis decline, indicated by increased SA-β-Gal activity and lysosomal content, emerges as early as age 40 in nasal epithelial cells and correlates with olfactory decline, suggesting proteotoxic stress may play a more prominent role in driving age-associated tissue dysfunction in the upper respiratory tract, while telomere dysfunction-induced foci (TIF) increase significantly only in individuals aged 75 and older in the airway epithelium.
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Thermal Stress Disrupts Gut Microbiota, Induces Oxidative DNA Damage, and Modulates Immune and Stress-Related Gene Expression in the Red Sea Urchin ( Loxechinus albus ).
Katalina Llanos-Azócar, Juan Manuel Estrada et al.
Elevated temperatures significantly reduced food consumption, decreased gut microbial diversity, increased oxidative DNA damage, and upregulated stress and immune response genes in the red sea urchin (Loxechinus albus).
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