José Santiago Ibáñez-Cabellos, José Luis García-Giménez et al.
ELOVL2-based minimalist epigenetic clocks show promise for scalable age estimation and screening due to their simplicity and cost-effectiveness, but require further validation for clinical decision-making.
Alexandra Pislaru, Tara L Haas
Sex differences in endothelial cell biology, influenced by sex hormones, sex chromosomes, and epigenetics, lead to distinct phenotypes in areas such as nitric oxide signaling, angiogenesis, metabolism, oxidative stress response, and inflammation, impacting vascular health and disease susceptibility.
Anna Hansknecht, Martina Mankarious et al.
NSD1 deficiency in human iPSCs leads to reduced H3K36me2, global DNA hypomethylation, impaired endo-mesodermal differentiation, and accelerated epigenetic age, with NSD1 regulating endodermal differentiation via the lncRNA HIDEN and WNT signaling independently of DNA methylation.
Ye Liu, H Josh Jang et al.
Retrotransposon reactivation, particularly endogenous retroviruses (ERVs), is a pivotal event in the pathogenesis of osteoarthritis, rheumatoid arthritis, and osteoporosis, triggering immune responses and cellular senescence, and presents a promising therapeutic target.
Jung Ki Kim, Thalida E Arpawong et al.
Accelerated epigenetic aging, especially with second- and third-generation clocks, was associated with higher follow-up levels and steeper increases in GFAP and NfL in older Indian adults, suggesting utility for dementia risk stratification in resource-limited settings.
Harikrishna Reddy Rachamala, Sonia Devi Lourembam et al.
Glioblastoma stem cells (GSCs) are critical drivers of glioblastoma initiation, resistance, and relapse, exhibiting self-renewal, differentiation capacity, metabolic adaptability, and resistance to genotoxic stress, which necessitates combinatorial therapeutic approaches targeting multiple pathways and supportive niches.
Zhaojia Wang, Rui Zhao et al.
Telomere shortening drives atrial fibrillation through VCAM-1 mediated atrial electrical and structural remodeling, and inhibiting VCAM-1 reversed these abnormalities and reduced AF susceptibility.
Taylor W Hargrove, Alena Sorensen D'Alessio et al.
Adolescent exposure to structural disadvantage was associated with accelerated epigenetic aging and inflammation-related DNA methylation in early midlife, with these associations differing by race, showing a negative association for Black respondents and a positive association for White respondents.
Tingting Gong, Wei Jiang et al.
This bibliometric analysis reveals that cellular senescence is a central node linking type 2 diabetes mellitus (T2DM) and aging, with research rapidly expanding towards translational applications and aging-targeted therapeutic strategies like senolytics.
Xinyue Huang, Mengqiong Wang et al.
The transition from acute kidney injury (AKI) to chronic kidney disease (CKD) is a complex process driven by maladaptive repair mechanisms, including persistent cell cycle arrest, chronic inflammation, sustained fibroblast activation, capillary rarefaction, and dysregulated signaling pathways, leading to ongoing damage and fibrosis.
Jun Gao, Meng Yang et al.
Hepatocyte ESRRA counteracts MASLD/MASH progression by promoting lactate consumption for gluconeogenesis and mitochondrial oxidation, thereby reducing histone lactylation, with ESRRA restoration via AAV delivery ameliorating the disease.
Luisa Salvatori, Francesca Megiorni et al.
In obese patients, plasma SIRT1 levels substantially reflect subcutaneous adipose tissue SIRT1 levels, while in non-obese individuals, elevated subcutaneous adipose tissue SIRT1 may act as a local protective reservoir.
Vinicius M Fava, Monica Dallmann-Sauer et al.
Continuous antiretroviral therapy (ART) induces a progressive senescence-like pro-inflammatory state in alveolar macrophages, characterized by increased cell-cycle arrest and senescence gene priming, which is duration-dependent and independent of HIV infection, while also causing a time-independent impairment of interferon signaling that diminishes the response to viral challenge.
Fredrik Vinge, Oscar Braun et al.
Iron deficiency (ID) is prevalent in primary care heart failure (HF) patients (26.7% by TSAT < 20%) and is independently associated with greater symptom severity (NYHA class III-IV), even after adjusting for multiple confounders.
Mustafa T Ardah, Pareshkumar N Patel et al.
MicroRNAs (miRNAs) are crucial regulators of brain aging, influencing key hallmarks such as genomic stability, nutrient sensing, proteostasis, autophagy, mitochondrial function, stem cell exhaustion, telomere maintenance, epigenetic regulation, and inflammatory signaling, and hold promise as biomarkers and therapeutic targets despite current challenges.
Liyne Nogay, Ananthakrishnan Vijayakumar Maya et al.
Cell cycle dynamics selectively influence H3K27ac, H3K27me3, and H3K9me3 levels at pre-existing genomic loci, with methylation levels linked to metabolic activity and acetylation levels regulated by an S-phase-dependent cycle.
May A Beydoun, Marie T Fanelli Kuczmarski et al.
Poor diet quality is associated with accelerated biological aging and increased mortality, with GrimAgeEAA identified as the strongest mortality predictor, and epigenetic mechanisms partially mediating the diet-mortality association, although this mediation is attenuated by lifestyle factors, particularly physical activity.
Jennifer Niven, Salih Kucuk et al.
Obesity imprints CD4 T cells via DNA methylation, leading to a long-lasting immune memory that persists for years after weight loss, driven by altered autophagy and immune senescence, and potentially targeted by modulating STK26 and CDKN1C.
Jonathan Gigas, Michael E Meadow et al.
The number of SIRT6 C-terminal phosphorylation sites positively correlates with species' maximum lifespan, enhancing SIRT6 interaction with PARP1 and improving resistance to oxidative stress, a mechanism that appears to have been evolutionarily selected for longevity.
Hui Wu, Gang Ning et al.
Melatonin demonstrates potential to delay Leydig cell senescence and promote endogenous testosterone synthesis by addressing multiple molecular mechanisms including oxidative stress, mitochondrial dysfunction, and the senescence-associated secretory phenotype, offering a shift from passive testosterone supplementation to active cellular repair for late-onset hypogonadism.
Maayan Insler, Maxim Shapiro et al.
DNA methylation-based epigenetic clocks, particularly DNAmAgeHannum (ρ = −0.59, p < 0.005), showed significant negative correlations with a composite physical performance score in community-dwelling adults, suggesting they can detect early physiological decline.
Sina Federmann, Michelle Westerhoff et al.
Doxorubicin treatment of endothelial progenitor cells (EPC) leads to multiple dysfunctions in their differentiated progeny, including impaired endothelial barrier function, altered cytokine response, and reduced LDL uptake, along with increased senescence.
Weronika Rzeska, Aneta Adamiak-Godlewska
Endometrial cancer incidence is significantly influenced by metabolic dysfunction, with bariatric surgery demonstrating strong evidence for risk reduction through metabolic correction, while pharmacologic interventions have not yet shown consistent preventive efficacy.
Tasnuva Binte Mahbub, Parsa Safaeian et al.
While AI has revolutionized aging research by improving data analysis, predictability, and experimental acceleration, its current applications are limited by data quality, quantity, and a lack of robust in vivo biological validation, necessitating a structured approach like the proposed AI Quality Assessment Metric (AI-QAM) for reliable translation into interventions.
Yiguang Fan, Chao Song et al.
Cardiovascular aging, a primary driver of cardiovascular diseases, is characterized by significant dysregulation of transcriptional regulatory networks involving transcription factors and epigenetic factors, leading to impaired cardiac and vascular cell function.
Chih-Ru Lin, Khanutsanan Woranam et al.
Sustained DNA damage in ATII cells from IPF patients is linked to nuclear stiffness from mechanical forces, leading to impaired DNA repair, senescence, and accelerated disease progression.
Hao Zhang, Ruida Yu et al.
Combined exercise and nutrition interventions show promising but predominantly exploratory associations with multi-layered epigenetic changes and improvements in metabolic health, muscular adaptability, inflammatory processes, and aging-related pathways, though current evidence is limited in scale and heterogeneous in design.
Rene Cortese, Kylie Cataldo et al.
Intermittent hypoxia (IH) induces duration-dependent, tissue-specific epigenetic dysregulation and accelerated biological aging, with p16Ink4a-mediated cellular senescence being a primary driver of OSA-induced cardiovascular morbidity, and targeting the senescent endothelium can revert vascular dysfunction.
Ngo Cheung
Genetic liability for opioid exposure and dependence are associated with partially opposing ageing-related gene expression profiles in brain tissue, with exposure linked to reduced complement-mediated synaptic pruning and glial support, and dependence characterized by increased nutrient sensing, mitochondrial oxidative phosphorylation, and DNA repair signals.
Cristina Marcelo-Calvo, Andrés Esteban-Cantos et al.
In a pilot trial of non-diabetic older adults with HIV, 96 weeks of metformin did not result in statistically significant differences in epigenetic age compared to placebo, although the direction of change favored metformin.
Brandee Goo, Samah Ahmadieh et al.
Deletion of the histone deacetylase 9 (HDAC9) gene ameliorates aging-related adipose tissue senescence and mitochondrial dysfunction in mice, partly through the upregulation of thiosulfate sulfurtransferase (TST).
Francisco Muñoz-Carvajal, Nicole Sanhueza et al.
Age-dependent H3K9 trimethylation by dSetdb1 impairs mitochondrial UPR leading to degeneration of olfactory neurons and loss of olfactory function in Drosophila.
Zhaoli Liu, Athanasios Ziogas et al.
Chronic inflammation, particularly involving the interferon pathway, causally contributes to epigenetic age acceleration and age-related diseases, with CXCL9 showing the strongest causal evidence for epigenetic age acceleration.
Eunhwan Kim, Jae Sook Kang et al.
The circulatory system actively influences aging and rejuvenation, with blood components serving as predictors of healthspan and disease risk, and interventions like young plasma infusion and plasma dilution showing potential to partially reverse systemic aging.
Chao Jiang, Zhouting Tuo et al.
Radiotherapy-induced cellular senescence plays a dual role in cancer treatment, with acute senescence being tumor-suppressive and chronic senescence promoting recurrence, therapy resistance, and normal-tissue toxicity.
Qi Wang, Lufei Zhao et al.
A genome-wide analysis identified thirteen ZmGDS1 genes in maize, which, due to structural diversity and regulatory elements linked to senescence signals, are likely involved in leaf senescence, especially under low-nitrogen conditions.
Toshiyuki Okada, Yusuke Toyoda et al.
Activation-induced cytidine deaminase (AID) binds to the NINJ2 promoter/enhancer, inducing DNA demethylation and transcriptional upregulation, which is suggested to aid wound healing and is associated with delayed recovery from colitis in AID-knockout mice.
Luisa Malaguarnera, Vincenzo Sortino et al.
Nutritional bioactives interact with conserved molecular pathways regulating skeletal muscle homeostasis across the lifespan, but their impact is stage-dependent, with molecular improvements not consistently translating to clinically meaningful functional outcomes, necessitating integrated approaches for pediatric growth and aging muscle preservation.
Shanmugalakshmi Sadagopal, Kasey Stokdyk et al.
Rapamycin treatment during DNA/MVA SIV vaccination in rhesus macaques enhanced the magnitude and quality of postinfection CD8+ T cell responses by promoting central memory CD8+ T cell development, leading to improved viral control and survival.
T L Henechowicz, P L Coleman et al.
Polygenic scores for higher self-reported walking pace were associated with greater active music engagement across four cohorts, while polygenic scores for neuromotor phenotypes did not consistently predict it.
María Iniesta-Cuerda, Iveta Valentova et al.
SIRT1 insufficiency and aging both lead to α-tubulin hyperacetylation in the sperm midpiece, which negatively affects mitochondrial function, capacitation, and fertilization efficiency.
Brad Stanfield, Brian Leroux et al.
Once-weekly sirolimus (rapamycin) 6 mg did not enhance, and in sensitivity analyses, may have modestly attenuated short-term functional improvements from a home exercise program in older adults.
Hyunju Kim, Christina A Castellani et al.
Greater adherence to overall PDI, provegetarian, and healthy PDI is associated with slower epigenetic aging, as measured by GrimAge2 and PhenoAge.
Junhua Zhu, Yu Zhang et al.
Food insecurity prospectively predicted incident depression and sustained depressive-symptom burden in middle-aged and older adults, with epigenetic age acceleration (Zhang AgeAccel) accounting for a small portion of this association.
Soochi Kim, Seung Pil Pack et al.
Advances in transcriptomic and computational technologies have revealed that muscle stem cell aging is a complex process involving transcriptional dysregulation, altered cell states, and changes in tissue context, which can be explained by stochastic drift and pseudo-hierarchical erosion of high-function states.
Shahin Gavanji, Muhammad Suhail et al.
The human microbiome is integral to human biology, influencing digestion, immunity, and metabolism, with dysbiosis linked to numerous diseases including gastrointestinal, metabolic, neurological, cardiovascular, autoimmune, and oncological disorders, and also modulating drug responses.
Jordan Mazzola, Manuela Rosenfeld et al.
GHK-Cu peptide administration improves hippocampal-dependent learning in aged mice, with intranasal delivery inducing sustained suppression of aging-associated signaling and intraperitoneal administration activating acute stress-response and repair pathways.
Kaixin Liang, Mengying Hu et al.
Salvianolic acid B (SAB) effectively alleviates cellular senescence by reducing SASP expression via mTOR pathway modulation, decreasing ROS, enhancing ATP production, and ameliorating age-related muscle function decline in mice, potentially by promoting TP53INP2 expression to enhance autophagy.
Preethi Sheshadri, Maria Alicia Costa-Besada et al.
Inhibiting MTORC1 with rapamycin or restoring lysosomal pH with acidic nanoparticles rescues lysosomal and mitochondrial function in GBA1-mutant Parkinson's disease models.
Ruotong Liu, Xiang Qi et al.
Edentulism attenuated the association between high polygenic risk score (PRS) and dementia risk but amplified the association between high PRS and mortality risk, indicating that oral health status modifies the impact of genetic predisposition on dementia and mortality in older adults.
Veronica Bergo, Pavlos Bousounis et al.
The absence of MDA5 delays hematopoietic aging by reducing inflammation and improving proteostasis, leading to enhanced functional capacity in aged hematopoietic stem cells.
Abdur Rahim, Xiaomei Zhan et al.
Genomic N6medA levels increase linearly with chronological age in the human brain (Pearson correlation coefficient, 0.95), and while not statistically significant, MCI and AD patients showed a trend toward elevated N6medA, with genome-wide mapping revealing age- and AD-associated changes in N6medA distribution enriched in genes related to neuronal function and age-related neurological processes.
Ying Guo, Yuyang Miao et al.
Telomere dysfunction exacerbates intermittent hypoxia-induced cognitive deficits and nerve damage, characterized by an inflammatory transcriptomic signature, which can be mitigated by interventions targeting senescence-associated pathways like fisetin and rapamycin.
Junxin Huang, Xiaoyao Zhang et al.
The extracellular matrix protein fibrillin-1 (FBN1) drives endothelial senescence and capillary rarefaction in chronic kidney disease by upregulating ZEB1, which activates the ET-1/β-catenin signaling axis, and tubule-specific Fbn1 deletion ameliorates renal function and microvascular damage in multiple CKD models.
Julian Mutz, Lachlan Gilchrist et al.
Metabolomic ageing in mental and behavioural disorders is heterogeneous, with substance use, psychotic, affective, and neurotic disorders associated with older metabolite-predicted age, while obsessive-compulsive and eating disorders are associated with younger metabolite-predicted age, with these associations often stronger in males and individuals under 65 years.
L V Putlyaeva, T X Wu et al.
Adipogenic and osteogenic differentiation pathways of mesenchymal stem cells exhibit entirely distinct heterochromatin remodeling dynamics, with osteogenic differentiation showing less extensive remodeling compared to adipogenesis.
Yecheng Xu, Jing Zhao et al.
Iron deficiency suppresses intestinal stem cell proliferation and promotes their differentiation into enterocytes, which is linked to alterations in the Notch signaling pathway.
Ziling Yang, Huigui Guo et al.
Deleting specific bacterial genes (ΔcrcB, ΔpurE, and ΔyojI) in E. coli significantly inhibits C. elegans reproductive fitness by inducing a 'high metabolism, low proliferation' state in the host, affecting spermatogenesis without impacting locomotion or lifespan.
Luisa Ladel, Bethsebie Sailo et al.
Higher-order chromatin structures (HOCS) are crucial in human development, aging, and cancer, with disruptions in their organization leading to diseases and offering potential therapeutic targets.
Xianwen Wang, Qihang Huang et al.
Sepsis impacts lymphocyte subsets differently in elderly and pediatric patients due to their distinct baseline immune states (immunosenescence vs. immunoimmaturity), leading to divergent pathways of immune dysfunction and recovery potential, although both extremes can converge on an immunoparalysis-like phenotype.
Yuru Tang, Xiao Gao et al.
This study provides genetically informed evidence that biological aging (telomere length and multivariate aging indices), modifiable lifestyle factors (BMI and smoking initiation), and specific immune phenotypes are linked to increased susceptibility to COVID-19 and sepsis.
Josephine R Paris, Tom L Jenkins et al.
The European lobster genome assembly is 1.76 Gb with high completeness, and the divergence between the European and American lobster species is estimated at 26 Mya, with identified gene family expansions related to neurofunction, immunity, and telomere biology.
Bruno César Feltes
Aging is a species-typical, time-dependent remodeling process shaped by evolutionary trade-offs and environmental context, not a pathology, and classifying it as a disease lacks scientific basis and may hinder effective research and interventions.
Ida Autio, Aino Saarinen et al.
Healthier eating over a long follow-up period was associated with decelerated epigenetic aging, and this effect was particularly pronounced in individuals with low levels of physical activity.
Gretchen T Clark, Yue Zhao et al.
Aging disrupts renal circadian rhythms, leading to sex- and time-of-day-dependent senescence phenotypes and increased transcriptional variability, with the uncoupling of Bmal1 and Cdkn1a expression identifying distinct senescent-like and profibrotic cell populations.
Simon Sanwald, Thomas Kammer et al.
No significant associations were found between the DNA methylation of NR3C1, SLC6A4, or OXT genes and depression diagnosis or symptom change in patients treated for depression.
Huiling Yan, Wenhui He et al.
Peritoneal dialysis-associated peritonitis caused by non-fermenting Gram-negative bacteria (NF-GNB) is associated with more comorbidities, poorer nutritional status, and significantly worse short-term (lower cure rate, higher treatment failure) and long-term (higher all-cause mortality) clinical prognosis compared to peritonitis caused by fermenting Gram-negative bacteria (F-GNB).
Peng Wan, Yimin Zheng
NF-κB acts as a dynamic signaling hub integrating mechanical stress, innate immunity, and metabolic cues to drive osteoarthritis progression through cartilage degeneration, altered chondrocyte fate, and inflammation, with therapeutic strategies requiring context-dependent precision.
Hiroshi Kobayashi
Endometrial cancer arises from the dysregulation of pathways essential for reproduction and tissue homeostasis, such as PI3K–AKT–mTOR and p53, which, under modern environmental pressures and aging, are redirected towards tumorigenesis, representing an evolutionary trade-off between early-life benefits and late-life costs.
Ngo Cheung
Transcriptome-wide association studies across opioid use disorder, alcohol misuse, cannabis use disorder, and anxiety suggest a cross-disorder architecture involving partially antagonistic modules of neuroimmune pruning, glutamatergic plasticity, and aging-related stress responses, rather than a single liability continuum.
Zhi Wen, Min Yu et al.
Immune cell senescence disrupts the osteoimmune microenvironment, leading to enhanced bone resorption and suppressed bone formation, thereby playing a significant role in the pathogenesis of chronic bone diseases like osteoporosis, osteoarthritis, rheumatoid arthritis, and diabetes-related bone disease.
Xinran Feng, Ying An et al.
Polygonati Rhizoma (PR) mitigates oxidative stress-induced senescence in periodontal ligament stem cells (PDLSCs) by reducing oxidative damage and suppressing the senescence-associated secretory phenotype (SASP) via the NF-κB pathway, performing comparably to metformin.
Aijing Yang, Beibei Zhang et al.
Blueberry anthocyanins (BA) significantly ameliorate radiation-induced intestinal injury (RIII) by modulating gut microbiota composition and associated metabolites, with its protective effects confirmed to be dependent on gut microbiota regulation through fecal microbiota transplantation experiments.
Yantao Zhang, Zhenxing Zhu et al.
LRRK2 activates the cGAS–STING pathway, leading to increased HMGB1 production and subsequent induction of chondrocyte senescence, thereby accelerating osteoarthritis progression.
Lucimar Aguiar da Silva, Vinícius Parzanini Brilhante de São José et al.
The extruded BRS 305 sorghum-based beverage, rich in phenolic compounds, improved fecal and blood metabolites, oxidative balance, and cardiometabolic markers in adults with excess body weight.
Souradipta Ganguly, Betul Gunes et al.
Reversing hepatic fibrosis through dietary intervention in a mouse model of MASLD restored left ventricular function and improved survival, identifying mitochondrial dysfunction and fibroinflammatory remodeling as key drivers of MASLD-associated heart failure with preserved ejection fraction.
Anna Plym, Anqi Wang et al.
A 451-variant polygenic risk score (PRS) may influence prostate cancer survival, with stronger associations observed in the 65-74 years age group at diagnosis when excluding PSA-linked variants.
Tatjana Ábel, Diána Gellért et al.
Women with type 2 diabetes mellitus experience disproportionately higher cardiovascular risk due to a complex interplay of metabolic phenotypes, dietary exposures, and genetic susceptibility across their life course, necessitating sex-aware precision nutrition strategies.
Tomás Alarcón, Javier A Menendez et al.
A spectral dimension reduction approach applied to a mathematical model of chromatin modifications reveals that metabolic cofactors like SAM and acetyl-CoA can serve as early warning signals for epigenetic tipping points, with reduced acetyl-CoA levels specifically decreasing the robustness of hyperacetylated epigenetic landscapes.
Tetiana Poliezhaieva, Yuting Li et al.
An aging-associated decline in phosphatidylcholine (PC) synthesis is a conserved driver of mitochondrial dysfunction, and dietary supplementation with PC or choline can restore mitochondrial integrity and metabolic resilience.
David Bar-Or, Jason Williams et al.
Osteoarthritis can be understood as a systems failure in inflammation regulation and resolution, driven by interconnected factors including aging-related redox decline, dysregulated mediator transport, kinase-phosphatase imbalance, and defective resolution pathways.
Sonja Dähn, Christian Zimmermann et al.
Dietary allyl-isothiocyanate (AITC) did not improve survival or enhance host defense in Drosophila melanogaster fed a high-sucrose diet, and in some cases, exacerbated mortality, particularly in infected females.
Xingshun Zhu, Fengmei Zhang et al.
Cardiovascular disease is increasingly understood as a chronic immunometabolic disorder driven by persistent low-grade inflammation, influenced by factors such as age-related genetic immune changes (CHIP), innate immune memory, trained immunity, thrombo-inflammatory processes, and neuroendocrine stress signaling.
Xiaoyue Li, Caiqi Shen et al.
The RLIM-MDM2-p53 signaling axis drives oxidative stress-induced stem cell dysfunction by promoting MDM2 ubiquitination and degradation, leading to p53 stabilization, autophagy suppression, and accelerated senescence, ultimately impairing wound healing.
Emily J Leptich, Priyadharshini Vijayakumar et al.
INS-17 acts as a nutrient deprivation signal that regulates associative behaviors in *C. elegans* by signaling through DAF-2 and influencing stimulus valence processing, independent of lifespan regulation.
Sarah E McGovern, Gaoya Meng et al.
Broad epigenetic shifts, particularly decreased H3K4 methylation, in the aging Drosophila retina contribute to widespread alterations in rhythmic gene expression.
Eimear McGlinchey, Sarah Pape et al.
While evidence is sparse and inconsistent, exercise, social connectedness, and cognitive stimulation show some promise for improving or maintaining cognition in adults with Down syndrome, with cardiovascular risk factors also showing associations with cognitive outcomes.
Zhan-Tao Feng, Yue-Yan Zhang et al.
Combined interventions of bioactive compounds and exercise show synergistic effects in preclinical models and some human studies, improving hippocampal neurogenesis, synaptic plasticity, and cognitive function in aging and neurodegenerative disorders, although robust clinical evidence for disease modification is still limited.
Xiangdong Sun, Jiaqi Duan et al.
The fungal polysaccharide KQS-1 rescues senescent-like Treg dysfunction in allergic asthma by epigenetically reprogramming FOXP3 and IL10 via Dectin-1 signaling, leading to amelioration of airway inflammation in a mouse model.
Zheng Shi, Cuilan Hu et al.
Cancer-associated fibroblasts (CAFs) are key drivers of tumor microenvironment remodeling post-radiotherapy, mediating radioresistance through immunosuppression, paracrine signaling, exosome communication, and stromal remodeling, even after high-dose irradiation.
Mercedes Diaz-Baena, Lucia O Pareja et al.
The major phosphatase activity in common bean embryonic axes was identified as a purple acid phosphatase, PvPAP26, which is ubiquitously expressed and highly expressed in cotyledons during active nutrient mobilization after germination.
Masaru Tanaka, Sachio Tsukada et al.
Lactobacillus paragasseri ameliorates age-dependent thermotaxis decline in C. elegans by suppressing AWC hyperactivity, an effect dependent on the DAF-16 transcription factor and heat-labile bacterial components.
Salah Mhamdi, Karim Chamari et al.
Aging is increasingly recognized as a modifiable process, not an inevitable decline, with scientific breakthroughs and lifestyle interventions offering potential to decelerate or partially reverse biological aging and extend healthspan.
Valeria López-Sebastiani, Karen V Quiroz-Cornejo et al.
Micronutrient balance is essential for brain health, with deficiencies and excesses impacting neurotransmission, synaptic remodeling, energy metabolism, and neuronal integrity, leading to cognitive and emotional consequences across the lifespan, and physical activity amplifies the positive effects of adequate micronutrient intake.
Lauren Bodilly, Sarah Weiner et al.
Maternal low-fat and high-fat diets significantly decrease survival in neonatal mice with *Staphylococcus epidermidis* sepsis, independent of bacterial burden, and alter serum cytokine profiles and the metabolome in offspring.
Don Benjamin, Michael N Hall
Between 2022 and 2025, 14 new mTORC1 substrates and 3 new mTORC2 substrates were identified, with many new targets involved in autophagy and cancer.
Meini Li, Jingyue Zhang et al.
Ectoine attenuates H2O2-induced cellular senescence in human keratinocytes and endothelial cells by downregulating the p53/p21 and p16 pathways and reducing oxidative damage.
Sourav Chakraborty, Thomas J Nickel et al.
Ancestral exposure to bisphenol A (BPA) in medaka fish leads to transgenerational alterations in the liver transcriptome and epigenome of unexposed descendants, resulting in premature hepatic aging characterized by downregulated mitochondrial genes and hypermethylated key regulatory genes.
Lu Bai, Fan Wang et al.
Iron overload disrupts M0 macrophage redox balance and inflammatory polarization, impairing hematopoietic stem cell function through the Nrf2/Keap1/HO-1 pathway, an effect that can be reversed by activating this pathway with TMC.
Norihisa Kato, Yongshou Yang et al.
Vitamin B6 acts as an indirect antioxidant by enhancing the production of PLP-dependent metabolites—including carnosine, taurine, H2S, and GABA—which collectively activate the Nrf2 signaling pathway to mitigate oxidative stress and inflammation.
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