Jiahui He, Yanchi Gan et al.
Plastrum testudinis extract (PTE) ameliorates intervertebral disc degeneration (IVDD) by suppressing NF-κB mediated senescence and inflammation, leading to improved disc structure and extracellular matrix homeostasis.
Dandan Zhong, Chang Hao et al.
Podocyte-specific mPGES-2 is a key driver of renal aging and age-related osteoporosis by promoting podocyte senescence via the PGE2/EP1 signaling axis and impairing renal calcitriol and α-klotho production.
Haoran Zhong, Bowen Dong et al.
Adult *S. japonicum* worms significantly alter hepatic stellate cell miRNA expression, with hsa-miR-103a-3p being consistently downregulated and showing potential implications for liver fibrosis and hepatocellular carcinoma development and progression.
May A Beydoun, Nicole Noren Hooten et al.
Epigenetic aging markers, specifically GrimAge and DunedinPoAm, partially mediated the association between frailty and mortality, with GrimAge explaining approximately 33% of the effect in NHANES and DunedinPoAm explaining about 17% in NHANES and 9% in HRS, while first-generation clocks showed minimal mediation.
Sheng Wang, Tao He et al.
Resistant grapevine cultivars exhibit milder physiological damage and more rapid, intense, and sustained biochemical defense responses, including enhanced ROS scavenging, phenylpropanoid metabolism, PR proteins, and phenolic compounds, compared to susceptible cultivars following *Plasmopara viticola* infection.
Enrique Gabandé-Rodríguez, Manuel M Gómez de Las Heras et al.
Restoring butyrate levels through fecal microbiota transplantation or tributyrin supplementation alleviates systemic organ failure and significantly extends lifespan in mice with mitochondrial dysfunction.
Jie Li, Limin Wei et al.
LncRNA Gm44981 suppresses mesangial cell senescence and kidney aging by recruiting EZH2 to the Cdkn1a promoter, thereby enhancing H3K27me3 deposition and repressing Cdkn1a expression.
Marva Bergman, Uri Goshtchevsky et al.
Disrupting cGAS in ataxia telangiectasia (A-T) killifish models partially rescued germline differentiation, hepatic senescence, and neuroinflammation, while also improving genomic stability by restoring H3K9me3 heterochromatin and reducing micronuclei and telomere abnormalities.
Kangyuan Qu, Tengfei Zhao et al.
Supplementing high-fat diets with bile acids improved growth performance, reduced lipid accumulation and ferroptosis, and enhanced intestinal health and microbiota in Pacific white shrimp.
Wenxuan Song, Naijun Wu et al.
Exercise-derived exosomes, carrying eNAMPT, attenuate age-related metabolic dysfunction-associated steatotic liver disease by activating the NAD+-SIRT1-autophagy axis, thereby suppressing epithelial-mesenchymal transition and fibrosis.
Jia-Jing Lu, Yan-Ran Sheng et al.
IL33 deficiency or inflammation induces trophoblast senescence, leading to metabolic dysregulation and SNAP29 lactylation, which impairs autophagic flux, trophoblast invasiveness, and placental development, increasing miscarriage risk, with anti-senescence therapies showing therapeutic potential.
Angel M Charles, Christine E Rodhouse et al.
Sepsis broadly reprograms MDSC epigenomes in mice, with distinct age- and sex-associated chromatin states observed, potentially contributing to persistent immune dysfunction or trained immunity.
Anna Ronca, Federico Bellelli et al.
Mitochondrial dysfunction and chronic inflammation demonstrate the strongest associations with both self-perceived fatigue and muscle fatigability in older adults, with limited but some longitudinal evidence supporting links with genomic instability, telomere attrition, deregulated nutrient sensing, and stem cell exhaustion.
Emrah Sariyer, Eda Dokumacioğlu et al.
Oleanolic acid (OA) significantly increased SIRT1 activity in rat serum, liver, and kidney, with computational analysis showing it has a higher binding affinity to the SIRT1 allosteric site than resveratrol.
Sadatsugu Sakane, Takahiro Nishio et al.
Mesothelin-Mucin 16 signaling in activated portal fibroblasts is pathogenic for cholestatic fibrosis and hepatocellular carcinoma, and targeting this pathway may offer a novel therapeutic strategy.
Sarina Abrishamcar, Stephanie M Eick et al.
Joint prenatal exposure to pesticides and psychosocial factors was associated with increased epigenetic age acceleration across early childhood, with psychosocial factors contributing the most to the total effect.
Xiaomin Wan, Wuchao Lu et al.
Immune cells and metabolites may have genetically predicted effects on fracture risk, with metabolites potentially serving as key mediators, and specific epigenetic modifications (DNA methylation) influencing fracture risk.
Su Yon Jung
Greater epigenetic aging was associated with hypertension outcomes, and African American women exhibited greater epigenetic aging acceleration than white women, with adverse social exposures partially mediating this difference and to a limited extent explaining the racial disparity in hypertension incidence.
Qiang Yang, Lilong Zhang et al.
PDRG1 acts as a clinically relevant oncogene in HCC by interacting with EZH2 to repress p21 expression, thereby suppressing cellular senescence and promoting tumor progression.
Victoria R Duke, Marc J Philippon et al.
The Zmpste24−/− progeria mouse model exhibits significantly delayed fracture healing with increased cartilage retention and decreased bone formation, alongside a dysregulated immune response and increased cellular senescence, mimicking aged mice but on an accelerated timeline.
Zhichao Lu, Yi Shuai et al.
Aging drives microglial heterogeneity in TBI, characterized by an expansion of proinflammatory NLRP3+ microglia and a decline in neuroprotective Lysozyme+ microglia, which can be reversed by inhibiting the transcription factor ELF1 with Imeglimin, leading to improved TBI outcomes and reduced mortality in aged mice.
Ayman Ali Mohammed Alameen, Hayder M Al-Kuraishy et al.
SIRT1 plays a crucial role in brain aging by regulating processes like senescence, axonal growth, and synaptic plasticity, and its dysregulation is linked to cognitive decline, with SIRT1 activators showing potential neuroprotective effects against brain aging.
Maria G Semenova, Teodoro Coba de la Peña et al.
Mutation in the rhizobial potassium transporter Smkup1 induced upregulation of stress-related genes and downregulation of autophagy genes in root nodules, suggesting a mechanism to extend nodule lifespan and nitrogen fixation duration.
Chuanqiang Liu, Fuyue Li et al.
Vascular cognitive impairment and dementia pathogenesis involves abnormal neuronal function and vascular lesions, with synaptic plasticity and epigenetic modifications, particularly DNA methylation, playing significant roles in regulating neurovascular gene expression.
Lauri Humaloja, Saara Marttila et al.
Several pro-inflammatory and some anti-inflammatory cytokines were positively associated with accelerated epigenetic aging (DunedinPACE and PCGrimAgeDev) over 4- and 11-year longitudinal follow-ups in a middle-aged population, with composite variables of systemic inflammation also showing longitudinal associations.
Jiawei Fu, Xue Leng et al.
SETD1A regulates nucleus pulposus cell glycolysis and senescence via the H3K4me3–HELZ2/PPARα–HIF1α axis, thereby driving intervertebral disc degeneration.
Vinayak Vinayak, Melike Lakadamyali et al.
Nanoscale chromatin domains (~50-200 nm) are conserved, epigenetically stratified structures that persist independently of loop extrusion machinery and are regulated by reaction-diffusion dynamics, influencing gene activity and cell state.
Miwon Ahn, Eunjin Oh et al.
Syntaxin 4 (STX4) overexpression protects islet β-cells from cytokine- or bleomycin-induced senescence by repressing senescence-related transcriptional programs and reshaping the β-cell secretome.
Takashi Sasaki, Yoshinori Nishimoto et al.
Circulating high-molecular-weight adiponectin levels increased with age into centenarian status, and in very old men, high levels predicted all-cause mortality independently of BMI.
Natsuko Kitajima, Takahisa Nakajo et al.
NAD+ depletion in human umbilical vein endothelial cells increases prostanoid production via the p38/COX2 signalling pathway, leading to a senescence-like phenotype and elevated COX2-derived prostanoid production, which can be mitigated by NAD+ replenishment with NMN.
Marina Pérez-Aguilera, Mireya Ruiz-Losada et al.
Drosophila p53-A and p53-E induce apoptosis transcriptionally and cell cycle-dependently, while p53-B directly activates the caspase Dronc independently of transcription and cell cycle, and all isoforms promote senescence-associated tumorigenesis via JNK activation in apoptosis-deficient cells.
Yan Ni, Yu Ma et al.
Cellular senescence and its associated inflammatory secretome, particularly IL-17A, drive epithelial-mesenchymal transition (EMT) and progression in age-related posterior subcapsular cataracts (PSC) through an IL-17A-NF-κB signaling circuit.
Victoria Norton, Julie A Lovegrove et al.
The novel 10-item SCREEN-IT tool demonstrated acceptable to good validity and reproducibility for estimating dietary fibre intake in the UK population, while being significantly quicker and more usable than existing methods.
Rana Salihoglu, Şehnaz Can et al.
Integrated transcriptomic analysis revealed that healthy aging preserves metabolic programs while Alzheimer's disease suppresses them and increases immune activity, with specific genes like TAC1, FREM3, and SLC25A46 showing opposite expression patterns in aging versus disease, consistent with an antagonistic pleiotropy framework.
Anastasia Gurinovich, Mengze Li et al.
The Saddle Point Approximation (SPA) adjustment in genome-wide association studies (GWAS) for binary phenotypes leads to more conservative p-values compared to Score tests, and using a full genetic relationship matrix (GRM) is recommended for family-based data to prevent inflation, although some tools like REGENIE and fastGWA-GLMM may be overly conservative on such datasets.
Jiaxin Zhang, Jia Quan et al.
Hyperoxia upregulates Noggin, which antagonizes BMP4 signaling, activating p53/p21-mediated senescence in pulmonary microvascular endothelial cells, contributing to alveolar developmental arrest in BPD.
Yidan Sun, June-Chiew Han et al.
A tri-axis anti-aging framework combining NMN/NR, PQQ, and EGT shows potential across multiple biological systems by synergistically targeting NAD+-dependent metabolic support, mitochondrial remodeling, and redox buffering, supported by preclinical and preliminary clinical evidence.
Ye Yu, Lei Sun et al.
Immunosenescence, characterized by the progressive loss of immune cell proliferative capacity, plays a dual role in cancer by both impairing anti-tumor immunity and, in specific contexts, exhibiting anti-tumor potential, making it a promising therapeutic target.
Yara Mohamed Taha, Mohamed Ali El-Desouky et al.
Gold nanoparticles synthesized using Raphanus sativus root extract (RRR-AuNPs) demonstrated enhanced antioxidant activity, potent antimicrobial effects against S. aureus and E. coli, and significant anticancer properties against HepG2 and Caco-2 cells, with a high selectivity index indicating safety towards normal cells.
Waheeda A Hossain, Merlin G Butler
This study identified 332 addiction-related genes, highlighting the involvement of cell cycle control, signal transduction, metabolism, protein phosphorylation, neurotrophic factors, and specifically the PI3/AKT/mTOR pathway, with AKT1, CREB1, MAPK1, MAPK3, and BDNF being prominent genes, and a significant overlap of 29 genes with alcohol use disorder.
Helen Beard, Sonia Dayan et al.
Short-term oral spermidine supplementation improved behavioral outcomes in MPS III fly models and reduced astrogliosis in MPS IIIA mouse brains, but did not impact microgliosis or lysosomal compartment size in mice.
Yen-Hung Lin, Yun-Hsun Liao et al.
Phosphatidylinositol transfer protein-1 (pitp-1) negatively regulates lifespan and healthspan in C. elegans by coordinating insulin/IGF-1 signaling (IIS) and target of rapamycin (TOR) signaling, with its reduction in neurons during early adulthood extending lifespan and improving healthspan.
Nicholas A Brennan, Xiaowen Wang et al.
Mitochondrial protein import stress causes lysosomal damage and progressive tissue atrophy in mice, independent of bioenergetic deficiency and oxidative stress.
Suzanna Shirazi, Ezaldeen Esawi et al.
High glucose impairs BMSC osteogenesis and proliferation while promoting adipogenesis, leading to increased cellular damage and aging, with NAD+ and α-KG levels being key implicated metabolites that can partially counteract these effects when supplemented.
Sabrina M Richter, Hoang-Long Bui et al.
Phosphorylation at Ser27 of motif A significantly increases SIRT1 activation by stabilizing motif A into a rigid, ordered conformation that enhances binding to SIRT1, primarily by altering substrate recognition (KM).
Simone Treccarichi, Mirella Vinci et al.
Trio-based whole-exome sequencing identified a de novo likely pathogenic variant (c.272dup p.(Pro92SerfsTer6)) in RAPGEF6 in an individual with psychotic disorder and mild intellectual disability, strengthening the association between RAPGEF6 and neurodevelopmental/psychiatric phenotypes.
Andrés Alarcón, Catherine Meza et al.
Piperine, a bioactive compound from *Piper nigrum*, demonstrates multitarget activity by modulating microRNA expression, DNA methylation, G-quadruplex stabilization, and transcriptional pathways, leading to apoptosis and potential therapeutic benefits in cancer and chronic diseases, despite limitations in bioavailability and the need for further clinical validation.
Carlos Anerillas, Gisela Altés et al.
A machine learning-based framework using transcriptomic and proteomic data from the SenCat catalog successfully identified conserved senescence-associated pathway alterations and robustly detected senescent cells across different human cell types and in mouse tissues in vivo.
Rubén González, Mauro Castelló-Sanjuán et al.
Enteric viral infections accelerate biological aging in Drosophila in proportion to their pathogenicity, with distinct viral strategies and host factors influencing the aging process.
Mau-Shin Chi, Huan-I Jen et al.
The combination of metformin and butyrate (MeBu) significantly attenuates chronic radiation proctitis by reducing fibrosis and modulating macrophage senescence and inflammation, with a more robust effect than either agent alone.
Behzad Varamini, Jonah O Yang et al.
Omega-3 PUFA supplementation, particularly at doses exceeding 2 g/day of EPA + DHA, shows potential for improving muscle mass, strength, and function in older adults, with enhanced benefits when combined with resistance training, and may help prevent sarcopenia through anti-inflammatory, anabolic, and mitochondrial mechanisms.
Julian Nüchel, Maryam Omidi et al.
GRASP55 is essential for lysosomal enzyme sorting at the Golgi by controlling the localization and stability of GOLPH3, LYSET, and GNPTAB, and its loss leads to missorting and secretion of lysosomal enzymes, lysosomal dysfunction, and impaired lysosomal mTORC1 signaling.
Hitomi Hidaka, Kazuma Akashi et al.
Loss of the gap junction component INX-20 in *C. elegans* markedly extends reproductive span without a significant increase in overall lifespan, operating through a pathway independent of the IIS and TGF-β pathways.
Yannick A Metzler, Hannah M Schade et al.
Machine learning analysis of the German Morningness–Eveningness Questionnaire revealed that Item 19, a self-assessment of chronotype, was the most significant predictor across all chronotypes, and an empirically derived six-item set achieved robust classification with reduced assessment burden.
Nan Xiao, Qianwen Lyu et al.
Knockout of SlBOP genes in tomato leads to defective petal abscission and delayed senescence, while knockout of PhBOP genes in petunia prolongs floral longevity and optimizes corolla morphology, demonstrating cross-species repurposing of floral persistence traits.
Wojciech M Ciszewski, Ewa Macierzyńska-Piotrowska et al.
Integrin-linked kinase (ILK) is downregulated in senescent endothelial cells, and its silencing induces a senescence phenotype, while its overexpression partially rejuvenates these cells and restores their functionality.
Mun-Ju Park, Sebin Lee et al.
Cancer-derived lactate drives extracellular matrix production in hepatic stellate cells through mTORC1-dependent pyrimidine biosynthesis, which in turn promotes ferroptosis resistance in hepatocellular carcinoma by activating the Collagen-DDR1-YAP signaling pathway.
Raghavee Neupane, Jami Rance et al.
Metformin demonstrates cytoprotective effects on retinal pigment epithelial cells by reducing oxidative stress and improving mitochondrial function, potentially offering therapeutic benefits for age-related macular degeneration, although its inhibition of mitochondrial complex I may be detrimental under severe mitochondrial dysfunction.
Kepu Zheng, Leiyang Dai et al.
Human liver cirrhosis is characterized by a progressive suppression of regulated cell death programs, including autophagy and necroptosis, in liver macrophages, leading to distinct macrophage states and identifying potential diagnostic and therapeutic targets.
Katalina Llanos-Azócar, Juan Manuel Estrada et al.
Elevated temperatures significantly reduced food consumption, decreased gut microbial diversity, increased oxidative DNA damage, and upregulated stress and immune response genes in the red sea urchin (Loxechinus albus).
Tao Zhang, Zhetan Ren et al.
The interaction between DNA methylation and innate immunity is a critical mechanistic foundation in IBD pathogenesis and progression, characterized by a dynamic interplay that exhibits stage-specific characteristics during initiation, progression, and relapse, contributing to sustained inflammation and memory.
Fengling Liu, Hanyu Liu et al.
Research on the intersection of diabetic kidney disease (DKD) and sarcopenia has shown a significant increasing trend over the past two decades, with shared molecular pathways identified in oxygen/hypoxia response, energy metabolism, and insulin signaling.
Marco Di Filippo, Giovanni Paolino et al.
Sulforaphane (SFN) demonstrates photoprotective effects against UV-induced skin damage and carcinogenesis across various models, primarily by activating the Nrf2 pathway, although further clinical studies are needed to confirm its efficacy and translational relevance.
Ziqi Chen, Jiantao Guo et al.
Constitutive HDAC3 expression in pregranulosa cells is essential for maintaining the ovarian reserve by epigenetically suppressing ferroptosis, with loss of HDAC3 disrupting iron homeostasis and causing mitochondrial dysfunction.
Xiuhong Chen, Huilong Liu et al.
Cellular senescence, while a tumor-suppressive mechanism, has a dual role in cancer, potentially promoting tumor progression and recurrence through the senescence-associated secretory phenotype (SASP) and escape mechanisms, necessitating advanced therapeutic strategies.
Robin Cristofari, Leyla R Davis et al.
King penguins transitioning to a sedentary, food-stable zoo lifestyle experience accelerated epigenetic ageing, with an estimated age acceleration between 2.63 and 6.48 years, driven by pathways related to cell growth and nutrient sensing.
Melissa C Orenduff, Emily K Woolf et al.
Caloric restriction induced distinct, time-dependent shifts in carbohydrate and lipid metabolism, with early reductions during weight loss followed by stabilization or compensatory responses during weight maintenance.
Amarjeet Shrama, Yanlin Zi et al.
Sirtuin 2 (SIRT2) inhibits global protein synthesis by deacetylating Rheb at K151, promoting its degradation and subsequently inhibiting the mTORC1 pathway, a mechanism implicated in preventing cardiac hypertrophy.
Qiming Yin, Joshua Stevenson-Hoare et al.
Older epigenetic age at baseline and after 8 years, as well as steeper epigenetic aging trajectories, were consistently associated with increased cancer risk in older adults, independent of chronological age and lifestyle factors.
Mengfei He, Lulu Liang et al.
EZH2 interacts with STAT3, enhancing its phosphorylation and lysine methylation, which drives podocyte injury and senescence in diabetic nephropathy.
Valentin Max Vetter, Marit Philine Junge et al.
DunedinPACE was the strongest and most consistent predictor of all-cause mortality among 14 consensus biomarkers, and a minimal set including muscle mass, standing balance, and DunedinPACE predicted mortality with high accuracy, comparable to a full model.
Hadar Parnas, Joanna Bartman et al.
Recurrent intermittent fasting in mice leads to sustained cytoprotective gene expression and enhanced genome stability through β-hydroxybutyrate signaling and chromatin remodeling, resulting in reduced DNA damage accumulation and accelerated repair.
Kumiko Uemura, Shunya Hiro et al.
Reactive microglia (DAM) and astrocytes (DAA), characterized by significant heterogeneity and influenced by factors like inflammation, lipid metabolism, epigenomics, and cellular senescence, play crucial roles in psychiatric disorders, neurodegeneration, and aging, with emerging AI-driven multi-omic approaches offering new avenues for therapeutic discovery.
Shan Zhu, Jennifer Q Zhou et al.
Inhibition of p38 MAPK reduces the expression of profibrotic genes (α-SMA and Col3A1) in lung fibroblasts by decreasing H4K16 acetylation enrichment at their promoter regions, a mechanism more sustained in near senescent/senescent cells.
Yi-Wei Liu, Jing-Tao Zou et al.
Local delivery of OSK factors via AAV vectors mitigates osteoarthritis progression by partially reprogramming chondrocytes, exerting anti-inflammatory and anti-apoptotic effects, preserving chondrocyte phenotype, attenuating epigenetic aging through DNA methylation modulation, and promoting fibrocartilage hyalinization, with TET2 playing a crucial role in mediating these beneficial effects.
Chukwuemeka E Ogbu, Stella C Ogbu et al.
Accelerated biological aging, assessed using various validated measures, was consistently associated with increased MASLD/NAFLD risk, greater fibrosis severity, and higher mortality across 19 observational studies.
Jiatong Shan, Jian Hua Tay et al.
Cross-sectional analyses in older Asian adults revealed significant positive associations between smoking history and accelerated epigenetic aging, while weekly physical activity and daily cognitive engagement were associated with slower aging.
Xin Liu, Yuanyuan Ma et al.
Maternal dietary restriction in rats leads to impaired growth and dyslipidemia, characterized by reduced triglycerides and elevated total cholesterol and HDL-C, with recombinant human IGF-1 treatment failing to improve growth but effectively reducing elevated HDL-C.
Dimitrios Diamantidis, Konstantinos Nikolettos et al.
While advanced paternal age is associated with changes in sperm epigenetics and DNA integrity, its independent clinical impact on assisted reproduction outcomes like fertilization, blastocyst formation, and aneuploidy is small after accounting for maternal and laboratory factors.
Ang Li, Xianglu Xiao et al.
Isoginkgetin (ISO) protects against ALS motor neuron degeneration by inhibiting GSK-3β, leading to mTORC1-independent TFEB nuclear translocation, enhanced lysosomal function, and amelioration of ALS-like pathology.
Erica L Vieira, Perla El-Ahmad et al.
Older adults with major depression exhibited significantly lower counts of endothelial progenitor cells (EPCs) and very small embryonic-like stem cells (vSELs) compared to non-depressed individuals, with vSEL count negatively correlating with depressive symptom severity.
Anne K Bozack, Javier Perez-Garcia et al.
The nasal microbiome is associated with small-to-modest variation in the nasal epigenome in adolescents, with 45 differentially methylated loci identified between microbiome clusters and specific bacterial genera like Propionibacterium and Corynebacterium linked to DNA methylation levels and epigenetic aging.
Jianfeng Yu, Mingzhuang Hou et al.
A combinatorial formulation of nicotinamide mononucleotide (NMN) and apigenin (API), termed "N + A," alleviated cellular senescence, promoted musculoskeletal regeneration, and improved musculoskeletal integrity in aged mice by preserving NAD+ levels, activating mitochondrial SIRT3, and modulating gut microbiota-derived phytosphingosine (PHS).
Jasper David Feldkamp, Nele Schmitt et al.
Cancer therapies can induce long-lasting molecular changes resembling physiological aging in cancer survivors, with epigenetic alterations being the most mature biomarker, showing consistent acceleration and strong associations with treatment, lifestyle, and health conditions.
Rodolfo Fernando Rivera, Maria Teresa Sciarrone Alibrandi et al.
Vascular calcification in chronic kidney disease is reframed as a spectrum of five distinct yet interconnected toxin-driven phenotypes—inflammatory-oxidative, mineral-metabolic, epigenetic-senescent, endocrine cross-talk, and integrated toxic continuum—offering a translational framework for precision-guided intervention through biomarker-based stratification and mechanism-matched therapies.
Jessica Kasamoto, John González et al.
Three novel epigenetic clocks trained on a small subset of CpGs consistently altered by senescence, age, and mortality did not show a reduction after senolytic treatment, and in some cases, accelerated.
Yue Xu, Ziyi Wang et al.
H3K36me3 deficiency in intestinal stem cells leads to an altered epigenetic state, impacting lipid metabolism and promoting cell senescence, which can be alleviated by metabolic intervention.
Daniel Stein, Christian Gallrein et al.
SIRT6 deficiency leads to hyper-translation without enhanced protein folding capacity, resulting in misfolded protein accumulation, aggregates, and neurodegeneration, which can be alleviated by reducing protein synthesis rates.
Àngela Llop-Hernández, Sara Verdura et al.
Senolytic efficacy in therapy-induced senescence is determined by a layered circuit involving mitochondrial bioenergetic heritage, acquired flexibility, and a mitochondria-inflammatory SASP crosstalk, with functional readouts of metabolic flexibility and SASP predicting efficacy.
Hsin-Yun Chang, Sarah E McMurry et al.
Heat hormesis in C. elegans extends lifespan in wild-type but not germline-less mutants, suggesting a germline-dependent mechanism involving transient disruption of reproduction, and identifies conserved regulators like HSF-1, SNPC-4, ELT-2, FOS-1, DPY-27, and MARS-1.
Zeenat Farooq, Vladimir Ilievski et al.
HKDC1 expression in the brain is crucial for cognitive function and neuroprotection, with its decline due to aging-induced chromatin changes reducing TFEB regulation, leading to mitochondrial dysfunction, senescence, and neuroinflammation.
Teng Gao, Chen Weng et al.
MitoDrift, a probabilistic framework modeling mitochondrial DNA inheritance, enables high-precision lineage inference and quantitative lineage-state analysis from single-cell multiome data, accurately reconstructing clonal relationships and resolving clonal dynamics in human tissues across health and disease.
Giray Eryilmaz, Yilmaz Yucehan Yazici et al.
mRNA priming induces an ISG-dim state in myeloid cells driven by type I IFNs, while mRNA boosting and Ad26.COV2.S vaccination induce an ISG-high state involving type I and type II IFNs, with Ad26.COV2.S triggering the most robust IFN response.
Fujia Xie, Cheng Xi et al.
Senescent endothelial cells are central commanders of atherosclerotic plaque development and instability, orchestrating pro-atherogenic behavior of immune cells and VSMCs via SASP and EVs, with the RBP4 axis linking metabolic disease to vascular senescence.
Jiahuan Gong, Jingxuan Xu et al.
Skeletal muscle fibrosis is driven by excessive extracellular matrix deposition, primarily collagens, following failed regeneration, with TGF-β/Smad and YAP/TAZ pathways playing central roles, and potential therapeutic strategies involve targeting these pathways, modulating immune responses, and regulating ECM metabolism.
Jun Yong Oh, Jae-Byoung Chae et al.
Targeted delivery of the senolytic agent ABT-263 to senescent retinal pigment epithelial (RPE) cells using Bst2-functionalized nanoparticles (B-Z-PON) effectively eliminates these cells, restores RPE function, and improves visual outcomes in aged and senescence-induced mouse models.
Sophia C Whitley, Ruiling Zhong et al.
mTOR/let-363 functions cell-intrinsically within C. elegans neurons to promote age-associated ectopic neurite sprouting from the soma, without extending lifespan.
Baiwei Mao, Zhihuang Zheng et al.
Tubular AMD1 restrains p53/p21-dependent senescence and promotes adaptive repair after kidney injury by preserving polyamine homeostasis, and spermidine supplementation can mitigate this deficiency to promote renal repair.
Lei Chen, Lingxin Zheng et al.
FGF21 promotes PINK1-mediated mitophagy to attenuate cardiac hypertrophy, and mismatched FGFR1 expression may lead to FGF21 resistance in heart failure.
Jianhuang Huang, Qixiu Wang et al.
Cellular senescence-associated genes GAPDH, CCND1, and HBEGF are linked to M2 macrophage polarization and inflammatory cytokine secretion in meningioma, potentially contributing to an immunosuppressive tumor microenvironment.
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