Song-Yi Han, Seo-Hyun Park et al.
Galgeun-tang (GGT) improves obesity-related metabolic dysfunction by regulating glucose homeostasis, lipid metabolism, and energy expenditure across cellular, nematode, and murine models.
Božo Radić, Jelena Šuran
A standardized propolis extract (SPE) demonstrates senomorphic activity by suppressing IL-6 and transcriptionally upregulating CDK4 and p21, providing molecular insights into its clinically proven anti-wrinkle efficacy.
Yu Duan, Yingchun Luo et al.
Reduced SIRT1 leads to downregulation of HADHA via GATA4 suppression, promoting ferroptosis and contributing to age-related heart failure.
Hoon-Min Lee, Yeon-Gu Kim
Modulating autophagy with chemical additives in recombinant Chinese hamster ovary (rCHO) cells can enhance therapeutic protein production, with autophagy inducers like rapamycin generally improving cell viability and overall production with fewer adverse effects on quality compared to autophagy inhibitors, which can increase specific productivity but may negatively impact product quality attributes like sialylation.
Edinael Rodrigues de Almeida, Johnnatan Castro Cabral Gonçalves et al.
Supplementation of suckling beef calves on tropical pastures with a concentrate containing dried distillers grains (DDG) improved nutrient intake, digestibility, and metabolism, leading to increased weaning weight and average daily gain, with higher DDG inclusion reducing digestibility but not negatively impacting overall performance.
Hyo Youn Jo, Ji Seung Jung et al.
Everolimus enhances umbilical cord blood-derived mesenchymal stem cell (UCB-MSC) viability and function under high glucose conditions by inhibiting mTOR signaling, which reduces glucose influx via GLUT3 and mitigates mitochondrial reactive oxygen species (mtROS), leading to improved retinal function and structure in a diabetic retinopathy rat model.
Tatsuya Shioda, Ittetsu Takahashi et al.
ATG-18, acting independently of autophagy, is essential for gonadal longevity in neurons and the intestine, and this function is mediated by its interaction with PCK-2.
Ayşe Nur Kahve, Suhide Bilge Horzum et al.
An 8-week sustainable nutrition education program significantly improved sustainable eating behaviors and led to greater reductions in body weight, BMI, and body fat compared to traditional nutrition education in women with overweight or obesity.
Marc de Manuel, Molly Przeworski et al.
Germline mutation rates per generation are remarkably consistent across animal species, falling within approximately one order of magnitude (~10−9 to ~10−8) per base pair, suggesting strong selection pressures to minimize deleterious mutations.
Andrea Filardo, Isabella Coscarella et al.
Therapy-induced senescence in glioblastoma promotes recurrence and resistance, but senolytic drugs, particularly combinations like Dasatinib and Quercetin, show promise in eliminating senescent cells and could be enhanced with neuroprotective agents.
İskender Aksoy, Bilge Olgun Keleş et al.
Hospitalization at the index emergency department visit and higher blood urea nitrogen levels were identified as independent predictors of one-year mortality in centenarian patients, while traditional comorbidity-based frailty indices showed limited discriminatory value.
Yuwei Wu, Lili Lu et al.
CTSL proteolytically activates Notch1, leading to NICD/RBPJ-mediated induction of CUX1/p16INK4a-dependent endothelial senescence, a pathway upregulated in human atherosclerotic plaques and attenuated by endothelial CUX1 deletion in mice.
Ankush Borlepawar, Marco Neu et al.
Proteostasis, a dynamic and interconnected network crucial for cellular health, involves proactive and reactive mechanisms across cellular compartments, with its resilience to stress being a unifying concept for understanding and treating diverse human diseases including cardiovascular conditions, metabolic disorders, cancer, neurodegenerative diseases, and autoimmune conditions.
Emily A Wolfgram, Todd G Nystul
Overexpressing the autophagy gene Atg8a in early follicle cells of aged Drosophila ovaries mitigates age-related follicle cell decline, reduces DNA damage, and rescues reproductive capacity.
Xiaolong Wang, Runlu Shi et al.
This study identifies SIRT1 as a senescence-related theranostic candidate in atherosclerosis and Poliumoside as a natural SIRT1 activator with endothelial protective activity in vitro.
Namo Dubey, Shubhangi Shree et al.
Phytomelatonin enhances plant drought tolerance by modulating growth, photosynthesis, osmolyte accumulation, cellular homeostasis, and interacting with microbial communities and phytohormones, with potential for biotechnological applications.
Miriam Frosina, Samantha Maurotti et al.
Apolipoprotein E (ApoE) is a systemic regulator whose isoforms (E2, E3, E4) differentially influence lipid metabolism, inflammation, mitochondrial function, and cellular stress responses, with ApoE4 generally promoting pro-inflammatory and pro-senescent states, while ApoE2 supports lipid homeostasis and longevity.
Zhiyu Wu, Shanshan Wu et al.
A noninvasive Liver Aging Index (LAI) developed using blood, imaging, and clinical data outperformed chronological age in predicting all-cause mortality and liver-related outcomes across multiple cohorts, with genetic analyses suggesting causal associations between accelerated liver aging and these outcomes.
Liyuan Jin, Yuan Zhu et al.
The gut microbiota is associated with body weight regulation through energy metabolism, immune function, appetite control, and genetic/epigenetic interactions, with precision nutrition and AI/multi-omics offering potential but currently lacking routine clinical application evidence for weight management.
Fei-Ran Li, Qi Sun et al.
Leishmania donovani infection reprograms macrophage lipid metabolism through the Fabp4/Cd36 pathway, leading to senescence and functional heterogeneity, with M2 polarization correlating with higher parasite loads.
Zeinab Rafiee, Jessica Santiago et al.
Amyloid-beta pathology induces pTDP-43 accumulation in astrocytes and reduces the expression of TDP-43-regulated transcripts, suggesting a mechanism by which Aβ toxicity exacerbates Alzheimer's disease progression.
Zhe Qian, Huolan Long et al.
Pre-ART immune senescence, characterized by a senescent immune profile including reduced naive T cells and increased terminally differentiated T cells, is strongly associated with non-immune reconstitution (NIR) in people living with HIV (PLWHIV) receiving antiretroviral therapy (ART).
Shusen Zhu, Aura A Tamez González et al.
A streamlined, one-step dual gRNA cloning protocol combined with a pooling strategy enables rapid and efficient generation of gRNA expression vectors for high-throughput CRISPRa screening in C. elegans, significantly reducing time, labor, and reagent costs.
Xie Li, Chao Han et al.
In oral lichen planus, excessive HIF-1α expression exacerbates cellular damage by impairing autophagy-lysosomal function, and targeted inhibition of HIF-1α restores autophagy function.
Edwin Oswaldo Botia Carreño, Mona Mohamed Mohamed Yasseen Elghandour et al.
Encapsulation is a promising strategy for ruminant nutrition that protects sensitive compounds and enables controlled release, potentially improving productivity and reducing greenhouse gas emissions, but nanoencapsulation poses greater safety challenges that require further study and regulatory adaptation.
Jessica Gambardella, Antonella Fiordelisi et al.
Mitochondrial dysfunction, including impaired mitophagy, reduced respiration, and increased ROS, is an early driver of Fabry disease cardiomyopathy, and L-arginine supplementation, via NO-dependent PGC1α upregulation, restores mitochondrial homeostasis and prevents cardiac dysfunction in a mouse model.
Siti Rani Ayuti, Eun Joong Kim et al.
IGF2 is a key molecular regulator of growth, muscle development, metabolic efficiency, and production performance in livestock, with polymorphisms in its regulatory regions associated with improved growth and biotechnological advances offering ways to enhance productivity.
Yuansheng Wu, Ruixuan Ma et al.
Engineered exosomes demonstrate promise for treating orthopedic diseases by promoting osteogenesis and angiogenesis, modulating immune responses, and regulating apoptosis and autophagy, with exosome-derived biomarkers also offering potential for earlier and more sensitive detection.
Dan Yan, Tianyi Ji et al.
Fibulin-1 (Fbln1) exacerbates vascular stiffness by promoting vascular smooth muscle cell senescence and extracellular matrix remodeling through ZNF384-mediated transcriptional activation and TGF-β/Smad3 signaling.
Geoffroy Delamare, Surbhit Wagle et al.
Epigenetic mechanisms, co-encoded with synaptic patterns, play crucial roles in memory maintenance, allocation, and protection against memory loss in a recurrent neural network, challenging the sole reliance on synaptic weights for memory encoding.
Kenneth Maiese
Investigating shared cellular pathways such as cell senescence, metabolic dysfunction, oxidative stress, programmed cell death, and mitochondrial dynamics offers promising therapeutic avenues for age-related non-communicable diseases like dementia and mood disorders, which are currently inadequately treated by symptomatic approaches.
Mingyue Yao, Simin Zhang et al.
Gastrodin alleviates doxorubicin-induced cardiomyocyte senescence and apoptosis by activating the AMPK/mTOR/4EBP1 pathway and improving autophagy.
Rong Tang, Banglian Hu et al.
TPPU protects against seizures and seizure-associated comorbidities in a mouse model by inhibiting the Akt/mTOR signaling pathway and reducing neuroinflammation.
Yiqing Liu, Yunlu Liu et al.
Yiqihuoxue decoction (GSC) alleviates vascular aging in human umbilical vein endothelial cells by promoting autophagy through the coordinated regulation of the SIRT1-autophagy axis and PI3K/AKT pathway inhibition.
Jingyi Xie, Xujia Zhang et al.
In SAMP8 mice, aging led to coordinated cochlear and vestibular functional decline, synaptic vulnerability, cochlear fiber remodeling, and increased mitochondrial ultrastructural abnormalities, with mitochondrial pathology burden aligning with high-frequency hearing loss and synaptic uncoupling.
Huijuan Chen, Lingqi Xu
We identified aging-related programmed cell death signatures in heart failure and developed a tissue-based molecular diagnostic model with potential biomarker value, where STEAP3 was found to be downregulated and may contribute to ferroptosis-related injury in cardiomyocytes.
Nadya Mincheva, Adelina Petrova et al.
Inclusion of Black Soldier Fly (BSF) whole dry larvae in hens' diets linearly increased yolk color and significantly elevated levels of carotenoids (astaxanthin, β-carotene) and α-tocopherol, particularly at 6% and 9% inclusion rates, without negatively impacting hen performance.
Tsering Yangzom, Anbin Chen et al.
Nicotinamide riboside (NR) treatment attenuated astrocyte reactivity, reduced inflammatory markers, improved neuronal structure and synaptic markers, and increased mitochondrial function in POLG mutant astrocytes and organoids.
Leelavathi N Madhu, Sahithi Attaluri et al.
Intranasal administration of human iPSC-NSC-derived extracellular vesicles (hiPSC-NSC-EVs) in early Alzheimer's disease stages in 5xFAD mice mitigated multiple pathological changes, including reduced oxidative stress, improved mitochondrial function, normalized mTOR signaling and autophagy, increased hippocampal neurogenesis, and restored BDNF signaling.
Dehui Zhou, Gengsheng Yu et al.
Cadmium exposure accelerates skin aging by inducing oxidative stress, DNA damage, and mitochondrial dysfunction, leading to dermal fibroblast senescence, and SIRT1 plays a protective role by deacetylating key substrates, restoring redox balance, preserving mitochondrial integrity, and mitigating senescence.
Domickson Silva Costa, Jucimauro de Araújo Pereira Júnior et al.
Dietary supplementation of Nile tilapia with Nannochloropsis oculata and Phaeodactylum tricornutum, especially at 1% DP1% and the combined DPN1% diet, enhanced muscle PUFA content, improved immune parameters, and significantly increased resistance to Edwardsiella tarda infection.
Luana de Oliveira Leite, Mônica Leila Portela de Santana et al.
Pro-inflammatory diets were positively associated with higher adiposity (BMI, waist circumference, and waist-to-height ratio) in adolescents, particularly among girls and those older than 14 years, with no observed associations with blood pressure.
A Kathrani, K Allenspach et al.
Dietary management is a crucial component of treating canine chronic enteropathy (CE), with approximately 50% of cases responding to diet alone, and systematic diet trials can improve success rates.
Jaewang Lee, Ji Hyeon You et al.
GLP-1 receptor agonist therapy induces chronic energy flux constriction, shifting metabolism towards lipid substrates and elevated oxidative throughput, which can lead to a "redox bottleneck" when oxidative demand exceeds NAD⁺/NADPH buffering capacity, impacting long-term metabolic stability.
Seán R Millar, Ivan J Perry et al.
Greater adherence to an overall plant-based diet (oPDI) and a healthier plant-based diet (hPDI) is associated with fewer depressive symptoms and greater well-being in middle- to older-aged adults.
Wiliana Júlia Ferreira de Medeiros, Claudivan Feitosa de Lacerda et al.
The invasive vine Cryptostegia madagascariensis exhibits a resource-acquisitive strategy with higher nutrient concentration, photosynthesis, and growth under flooding, while the native palm Copernicia prunifera employs a resource-conservative strategy with morphological root adaptations, indicating the invasive vine poses a significant threat to native palm regeneration.
Qi Yang, Juan Liu
Diets rich in plant-based foods (fruits, nuts, vegetables, legumes, cereals, fish) were inversely associated with cardiovascular disease risk in older adults, while higher consumption of edible oil, meat, and alcohol was positively associated with increased risk.
Ting Yu Lu, Jiao Wang et al.
Higher adherence to the planetary health diet (PHD) was linearly associated with lower all-cause and cardiovascular disease mortality, but not cancer mortality, in Chinese individuals aged 50 and older, and was associated with a lower heart age in women only.
Shu-Yi Li, Jason Leung et al.
Adherence to the MIND diet may mitigate the detrimental effects of long-term PM2.5 exposure on all-cause and respiratory mortality in older adults, while overall diet quality (DQI-I) or anti-inflammatory diets (DII) showed no protective effects.
Sharon F. Daley, Melissa R. Hinson
The Mediterranean diet positively impacts endothelial function across microvascular, brachial, and carotid arteries, with effects mediated by molecular and genetic changes.
Yuan Wang, Lijuan Han et al.
Dietary magnesium potassium sulfate supplementation significantly enhanced Tibetan sheep meat quality, with 0.25% PMS being optimal for meat quality (improving pH24h, a*, intramuscular fat, and PUFAs) and 0.30% PMS being best for carcass fat percentage.
Elizabeth Edwards, Tsun Lok Morris Tsang et al.
Australian hospital nutrition standards demonstrate strong alignment with the Australian Dietary Guidelines but show variable alignment with European Society for Clinical Nutrition and Metabolism guidelines, with notable gaps in macronutrient distribution, diet definitions, foodservice governance, and monitoring.
Hongwei Ma, Mengen Xu et al.
Bacillus licheniformis BL-01 alleviates DSS-induced ulcerative colitis in mice by repairing the intestinal barrier, regulating gut microbiota, and modulating its metabolism.
Yongliang Zhang, Xixi Dai et al.
Dietary compound probiotics mitigated lipopolysaccharide-induced intestinal and hepatic injury, and growth impairment in Lohmann Pink chickens by enhancing intestinal barrier integrity and hepatic antioxidant capacity, and suppressing the TLR4/NF-κB inflammatory pathway.
Juliana B Nunes, Thalles H F de Souza et al.
Oral administration of LASSBio-1736 loaded into bovine serum albumin nanoparticles (LASSBio-1736n) significantly enhanced gastrointestinal stability, intestinal permeability, and in vivo leishmanicidal efficacy in a hamster model, leading to an 85.48% reduction in splenic parasite burden compared to the standard treatment Glucantime.
Ruhi K Shah, Justin J Lin et al.
Traumatic brain injury (TBI) significantly disrupts gastrointestinal (GI) function through neuroinflammation and autonomic dysregulation, leading to a range of GI pathologies that can impede neurological recovery and are influenced by the brain-gut axis.
Huijing Li, Huiqiong Li et al.
Molecular-weight-optimized Astragalus polysaccharides (APS), particularly a combination of high and low molecular weight fractions, show promise in modulating gut microbiota and mitigating cisplatin-induced acute kidney injury by restoring microbial homeostasis and enhancing gut barrier function.
Taylor Guthrie, Jade Eccles-Smith et al.
Pregnant women post-bariatric surgery frequently did not meet micronutrient supplement recommendations, leading to common deficiencies in iron, vitamin B12, vitamin A, and vitamin D, with the relationship between intake and deficiency being unclear.
Ahmed Bargheet, Gaute Hovde Bø et al.
Probiotic supplementation with Bifidobacterium in Tanzanian infants led to increased Bifidobacterium colonization, reduced pathobionts like ESBL-E, and decreased antibiotic resistance genes and mobile genetic elements by altering gut metabolomics towards lactate and pyruvate production.
Li Wang, Wiola Mi et al.
An A2 β-casein infant formula with high sn-2 palmitate and CPP significantly reduced saturated fatty acid excretion, decreased fatty acid calcium soap formation, improved calcium, iron, and zinc absorption, and regulated cortisol levels, with benefits comparable to human milk.
Linda Ndeshipandula Lukolo, Martin Shapi et al.
Despite challenges such as insufficient food quantity and nutritional inadequacy, the Khomas Regional Council's food support program positively impacted the health and well-being of people living with HIV by leading to observable weight gain, improved physical health, reduced treatment defaulting, and enhanced psychosocial well-being.
Sandra Etumah Ifie, Reuben Samson Dangana et al.
Maize is a crucial global food source providing macronutrients, micronutrients, and phytochemicals, with biofortified varieties and genetic/agronomic interventions essential for improving nutritional quality and addressing deficiencies, despite challenges like low mineral bioavailability due to phytates.
Narisa Rueangsri, Uraiporn Booranasuksakul et al.
While the intervention group showed within-group improvements in BMD T-scores at the right arm, pelvis, and right leg, no significant between-group differences in BMD were detected compared to the control group after 12 weeks.
Adriana Alviter-Plata, Niousha Ahmari et al.
Loss of bone marrow β1/β2-adrenergic receptors protects against diet-induced obesity by reprogramming host-microbiota interactions, leading to reduced lipid absorption and altered fecal lipid profiles.
Evangelia N Kerezoudi, Sue McKay et al.
Low-dose chicory root-derived rhamnogalacturonan-I (chRG-I) supplementation beneficially modulated the gut microbiome, protected the intestinal barrier, and enhanced systemic immune readiness in healthy adults.
Zhihui Chen, Yang Zhao et al.
A dietary methionine-to-cysteine ratio of 0.53%:0.37% (HMCR) optimizes broiler growth performance by positively influencing hypothalamic neurodevelopment, PKA signaling, GH secretion, and ileal morphology through IP3R and PI3K pathways.
Bin Liu, Yuejian Mao et al.
B. lactis Ca360 demonstrated the most pronounced enhancement of calcium, iron, and zinc absorption in a Caco-2 cell model, indicating a multi-pathway promotion effect and identifying it as a functional probiotic strain with significant potential.
Saleh A Alsanie
The integration of multi-omics technologies with non-thermal food processing presents a transformative opportunity for personalized nutrition by enabling tailored interventions and enhancing nutrient bioavailability.
Mateusz Labudda, Anna Rybarczyk-Płońska et al.
Cruciferous vegetables, rich in glucosinolates and their hydrolysis products like isothiocyanates and indoles, show promise in cancer prevention through mechanisms including enhanced detoxification, apoptosis induction, and modulation of epigenetic pathways, with epidemiological studies generally supporting an inverse correlation between consumption and cancer risk.
Yuli Frita Nuningtyas, Muhammad Halim Natsir et al.
Postbiotics derived from lactic acid bacteria, Bacillus spp., and Saccharomyces cerevisiae consistently enhance broiler gastrointestinal health and performance, with category-specific benefits and greater efficacy under stress conditions, making them suitable alternatives to antibiotic growth promoters.
Soon Lee, Stephanie Dubrof et al.
Maternal DHA supplementation increased offspring gut microbiota diversity and claudin-1 protein levels, which were correlated with specific brain network activations, suggesting a role in regulating the gut-brain axis.
Fumi Oono, Keiko Wada et al.
Higher adherence to eight diet quality indices was associated with lower all-cause and cardiovascular disease mortality in a Japanese population, with the Alternate Healthy Eating Index-2010 showing particularly strong and consistent associations.
Shamil Rakhmatullin, Marina Kurilkina et al.
Dietary quercetin supplementation at 5 mg/kg optimally improved growth performance, feed efficiency, and immune balance in Arbor Acres broiler chickens without increasing pathogenic bacteria, while higher doses (10-15 mg/kg) led to an increase in Campylobacterota.
Ziyi Luo, Shunyao Zhu et al.
Gastrodia elata polysaccharides (GEPs) exert cardiovascular effects primarily through gut microbiota fermentation, which generates bioactive metabolites that modulate host pathways, thereby resolving the bioavailability-efficacy paradox.
Minna Luo, Hang Xiao
The co-consumption of black pepper and dietary lipids synergistically enhances carotenoid bioavailability, with a human clinical trial showing a 6.1-fold increase in total plasma carotenoids when both were consumed together compared to a control.
Linda M Beckett, Ellie Ketcham et al.
Colostrum enhances jejunum DNA fractional synthetic rate, villi growth, and cellular proliferation in neonatal gilt piglets compared to milk replacer, with the most significant stimulation observed at higher intake levels.
Vasileios Gkanis, Dimitrios Papaconstantinou et al.
Perioperative calcium combined with vitamin D is the most effective strategy for preventing post-thyroidectomy hypocalcaemia and reducing intravenous calcium use, with combination therapy significantly reducing clinical hypocalcaemia (OR 0.31), biochemical hypocalcaemia (OR 0.27), and intravenous calcium requirements (OR 0.15) compared to no supplementation.
Khuzin Dinislam, Anas Shamsi et al.
Dietary polyphenols, found in fruits, vegetables, tea, and coffee, show therapeutic potential and modulate NF‐κB signaling by suppressing its activation, inhibiting kinases, reducing oxidative stress, and modulating epigenetic and redox-sensitive pathways, thereby playing a role in preventing inflammation-driven non-communicable diseases, particularly cancer.
Karishma Sen, Anita Sakarwal et al.
The synthesized flavone demonstrates significant neuroprotective potential against diabetes-associated neurodegeneration by mitigating oxidative stress, improving lipid profiles, normalizing HOMA indices, and regulating key neurodegenerative and metabolic genes in rat brain tissues.
Viera Karaffova, Dagmar Mudronova et al.
Dietary drone brood homogenate (DBH) supplementation in pigs significantly upregulated intestinal barrier genes, enhanced phagocytic capacity and oxidative burst activity, and increased the CD4+:CD8+ ratio, suggesting improved gut barrier function and immunostimulatory effects.
Xinna Wang, Hang Chen et al.
The primary threat of ultra-processed foods (UPFs) stems from the industrial collapse of their physical food matrix, initiating a systemic cascade of dysregulation that impacts eating behavior, gastrointestinal function, metabolism, gut microbiome, and leads to chronic inflammation.
M J Duque-Correa, C Meloro et al.
Intestine length scales hyper-allometrically with body mass in amphibians, with an exponent between 0.39 and 0.53, similar to other vertebrates.
Shuai Wang, Pengxiang Bai et al.
Yeast culture supplementation reduces ETEC-induced diarrhea in neonatal livestock by 40% to 60% through mechanisms that strengthen the intestinal barrier, modulate immunity, and improve gut microbiota homeostasis.
Joe Dare Nyefene, Patricia Glago
Incorporating 10% corn chaff into wheat cakes significantly improved fiber content and mineral composition, maintained consumer acceptability, and resulted in a shelf life of 4 days at room temperature and 7 days refrigerated.
Limenew Abate Worku, Rakesh Kumar Bachheti et al.
Ethiopian fermented foods and beverages, including milk products, beverages like Tella and Tej, and staple foods like Injera and Kocho, offer enhanced flavor, shelf life, and nutrient bioavailability through microbial activity, but face challenges in standardization, documentation, and commercialization.
Silvia Molino, María M Piskorz et al.
A tannin-rich phytocomplex significantly improved gastrointestinal and psychological symptoms in IBS-D patients, with associated improvements in gut barrier function, microbial metabolism, and normalization of hydrogen breath tests.
Wenyan Yan, Xinyuan Sun et al.
Betaine alleviates oxidative stress induced by non-esterified fatty acids (NEFA) in mammary epithelial cells of dairy cows and enhances milk protein synthesis through the Nrf2-JAK2/STAT5/mTOR signaling pathway.
Paloma Eduarda Lopes de Souza, Adiel Vieira de Lima et al.
Supplementation with microencapsulated organic acids and phenolic compounds modulated productive performance, egg quality, and intestinal physiology in laying hens, with higher inclusion levels (500 g/t) generally associated with more favorable responses.
Saleh A Alsanie
Probiotic-enriched functional foods offer significant potential for improving gut health and disease prevention through enhanced probiotic viability and delivery, but require careful strain selection, matrix matching, optimized storage, regulatory harmonization, and clinical validation for widespread public health integration and equitable accessibility.
Michitaka Funayama, Akihiro Koreki et al.
Higher parenteral dextrose intake during refeeding in anorexia nervosa is associated with electrolyte deficiencies, particularly in magnesium and calcium.
Alessandra B Silva Rischiteli, Artur Francisco Silva-Neto et al.
Dietary xanthan gum supplementation in rats induced moderate-grade inflammation and altered the colon gut barrier by increasing Claudin 2 levels, while also modifying the relative abundance of Elusimicrobiota at the highest dose.
Natalia Ksepka, Kamil Wysocki et al.
Combined astaxanthin and kokum supplementation showed synergistic hepatoprotective effects in mice with diet-induced NAFLD by increasing fatty acid unsaturation, reducing lipid peroxidation, and normalizing lysosomal activity.
Linglian Kong, Xinran Zhang et al.
Dietary glycerol monolaurate (GML) supplementation alleviated necrotic enteritis in broilers by improving intestinal barrier function, reducing inflammation and oxidative stress, modulating gut microbiota, and consequently improving growth performance.
Masatomi Shimizu, Ayako Daizo et al.
Compared to an SFA-rich diet, a PUFA-rich diet in mice was associated with increased lipid-peroxidation linked adducts and greater mtDNA damage in vivo, correlating with membrane n-6 PUFA enrichment.
Jiman Kang, Digvijay Patil et al.
N-acetylcysteine (NAC) dampens neutrophil-driven inflammation and restores lipid membrane homeostasis in steatotic livers subjected to ischemia-reperfusion injury (IRI) by attenuating inflammatory gene expression, reducing neutrophil accumulation, suppressing LCN2 expression, restoring phosphatidylcholine abundance, and preserving sphingomyelin.
Igor Fernando Dos Santos, Carla de Moraes Salgado et al.
A leucine-rich diet partially mitigated the negative impacts of cancer on pregnancy in rats, improving placental activity and reducing fetal weight loss and resorption rates.
Zhenzhen Ji, Zhiqiang Miao et al.
Dietary Eucalyptus globulus oil (EGO) supplementation, particularly at 200 mg/kg, improved broiler growth performance (increased ADG, decreased F/G), enhanced serum antioxidant capacity, and positively modulated immune and barrier gene expression in the jejunum and lung of broilers from 1 to 21 days of age.
Jianyu Zhang, Sepideh Torabi et al.
This study identified putative QTL for soybean seed protein quantity and quality traits on chromosomes 1, 2, and 15, including novel loci, using a modified QTL-seq approach.
Xiaohua Su, Jindi Yang et al.
Probiotic supplementation in women with gestational diabetes modulated gut microbiota, increased short-chain fatty acid production, enhanced insulin sensitivity, and reduced inflammation, demonstrating therapeutic potential for GDM management.
Wenbo Liu, Yuanyuan Zhang et al.
Thiolated chitosan/alginate/Emodin nanoparticles (TCS/ALG/Emodin-NPs) significantly improved renal function, reduced kidney injury and fibrosis, modulated gut microbiota, and enhanced intestinal barrier function in a chronic kidney disease mouse model, outperforming free emodin.
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