Research Database

Sehr niedrig2026
Soybean oil and leucine in late gestation and lactation improve maternal and offspring lipid metabolism and insulin sensitivity: insights from pig model.
Yutong Sun, Zexuan Gan et al.
Maternal supplementation with soybean oil and/or leucine during late gestation and lactation positively impacted sow and offspring lipid metabolism and insulin sensitivity, with the combination of soybean oil and leucine synergistically enhancing piglet growth, lipid metabolism, immunity, and circadian rhythm regulation.
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Sehr niedrig2026
The Impact of Feeding Organic Trace Minerals Using Advanced Chelate Technology on Reproductive Efficiency and Blood Parameters in Ghezel Ewes.
Sedigheh Vatankhah, Marziyeh Ebrahimi et al.
Supplementing the flushing diet with advanced chelate technology-based organic trace minerals (OTM) improved ewe reproductive performance compared to inorganic trace minerals (ITM), with the OTM group showing the best performance in terms of first-cycle pregnancy, lambing, and twinning rates, and a 0% abortion rate.
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Sehr niedrig2026
The olfactory receptor SNIF-1 mediates foraging for leucine-enriched diets in C. elegans .
Ritika Siddiqui, Nikita Mehta et al.
Caenorhabditis elegans utilizes the odor isoamyl alcohol (IAA), produced from leucine by bacteria, as an olfactory cue to locate leucine-rich diets, a behavior mediated by the SNIF-1 GPCR in AWC neurons.
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Sehr niedrig2026
The Concentration of Essential and Non-Essential Elements of Colostrum, Correlation with Blood Samples of calves, Estimated Daily Intakes and Supplemental Ratio.
Fulya Altınok-Yi̇pel, Hüsamettin Eki̇ci̇ et al.
Significant correlations were found between colostrum and calf blood element levels, with Ba, Cr(III), Cu, Fe, Ni, and Sr posing no health risk, while Al, As, Cr(IV), Se, and Zn might, and colostrum was insufficient for certain essential elements like Co and Cu, while providing excess Se and Zn.
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NiedrigProspektivMensch2026
Predictors of anaemia incidence and remission among adolescents: longitudinal evidence from four low- and middle-income countries.
Shuangyu Zhao, Sachin Shinde et al.
Anaemia in adolescents in low- and middle-income countries is prevalent and dynamic, with diet quality, school participation, household stability, and mental and physical health influencing its incidence and remission.
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Sehr niedrig2026
Pyridoxine requirement of Pacific white shrimp (Penaeus vannamei) fed soybean meal based diet.
Han-Se Kim, Yeonji Lee et al.
The optimal dietary pyridoxine level for Pacific white shrimp (*P. vannamei*) fed a soybean meal-based diet was estimated at 69 mg/kg, which is lower than previously reported for fish meal-based diets, and this level enhanced growth, feed efficiency, protein utilization, antioxidant capacity, immunity, digestive enzyme activity, gene expression, and gut morphology.
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ModeratSystematic Review2026
Safeguarding diet quality in a changing climate: a scoping review.
Beaula Mutonhodza, Melody Ndemera et al.
Climate change is altering the nutrient composition of crops, leading to increased sugars, antioxidants, and certain vitamins, but significant declines in protein, B vitamins (especially folate), and essential minerals like iron, zinc, and calcium, with the greatest losses observed in staples like wheat and rice.
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NiedrigProspektivMaus2026
Hydrogen-rich water attenuates radiation-induced oral mucositis in mice via antioxidant and gut microbiota-stabilizing effects: a longitudinal study.
Zixin Lan, Junyang Chen et al.
Hydrogen-rich water (HW) significantly mitigated radiation-induced oral mucositis and intestinal injury in mice by reducing inflammation, preserving gut barrier integrity, and stabilizing the gut microbiota, promoting beneficial bacteria while suppressing pathogenic ones.
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Sehr niedrig2026
Air Jet Impingement-Assisted Air Frying of Potatoes: Oil Absorption, Lipid Oxidation and Acrylamide Formation for Improved Nutritional Quality.
Ahmet Tarık Can, Selin Demirkan et al.
Air jet impingement–assisted air frying significantly reduced oil absorption (by 36.2%–38.8%) and lipid oxidation (TBARS values by 16.3%–43.4%) in French fries and potato wedges compared to deep-fat frying, while also suppressing acrylamide formation and improving energy efficiency.
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HochRCT2026
Genotype-specific responses of common bean to water deficit: mitigation by foliar-applied Fe, Zn, and Mn.
M A Wanas, Atef N Salama et al.
Integrated management of moderate deficit irrigation (D80%) and the highest foliar micronutrient rate (T3) significantly enhanced common bean performance, particularly in the Giza 6 variety, leading to improved water use efficiency, yield, and grain quality.
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Sehr niedrigMensch2026
Ontology-based dietary recommendation system for Chinese children and adolescents: development and a pilot validation study.
Zhiyu Zhang, Dongdong Xu et al.
The developed ontology-based dietary recommendation system (CADRS) significantly improved diet quality, nutritional balance, and food diversity in Chinese children and adolescents compared to actual school lunches and self-selected diets.
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Sehr niedrigRatte2026
Astaxanthin alleviates altered hepatic lipid metabolism and oxidative stress in animals fed a high-sucrose diet.
Matias Rodrigo Vargas, María Del Rosario Ferreira et al.
Astaxanthin (ASTX) from *Dilocarcinus pagei* prevents hepatic steatosis in rats fed a high-sucrose diet by enhancing fatty acid oxidation and improving oxidative status.
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NiedrigProspektiv2026
Dietary Diversity, Iron Status, and Anaemia Among Adivasi Women: Insights from the Chiguru Cohort in Chamarajanagar District, Southern Karnataka.
Maithili Karthik, Jai Prabhakar Sosale Chandrashekaraswamy et al.
Higher household dietary diversity was associated with lower soluble transferrin receptor (sTfR) levels, and elevated sTfR levels were strong predictors of anaemia in Adivasi women in southern Karnataka, India.
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Sehr niedrig2026
Effects of supplementation with rumen-protected methionine on growth, feed efficiency, blood parameters, and health of weaned Holstein growing calves.
Hamed Nikookalm, Farhad Foroudi et al.
Dietary supplementation with rumen-protected methionine at 2 gm/day/calf positively influenced growth performance, feed efficiency, blood parameters (reduced BUN, AST, ALT; increased RBC, HGB), and reduced diarrhea incidence in growing calves.
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Sehr niedrigMaus2026
Caspase-6 Controls Lipid and Energy Metabolism in Diet-Induced Obesity.
Abhishek Gupta, Wenjing You et al.
Caspase-6 deficiency protects against diet-induced obesity and insulin resistance by increasing lipolysis and energy expenditure through the direct cleavage of PPARγ and SP1, which suppresses ATGL expression.
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Sehr niedrig2026
Plant-derived chitosan nanoparticles: antibacterial and improved crop performance under drought stress.
Reham M Aldahasi, Hessa O Aldraiwiesh et al.
Plant-derived chitosan nanoparticles synthesized using *Adansonia digitata* extract demonstrated antibacterial activity against *E. coli*, *S. aureus*, and MRSA, and significantly enhanced *Petroselinum crispum* seed germination and growth under drought stress.
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Sehr niedrigNarrative Review2026
Exploring the potential of polyphenols in major depression: from molecular function to clinical therapy.
Shiyu Zhu, Qinming Yu et al.
Polyphenols, including curcumin and anthocyanins, show promise for treating Major Depressive Disorder (MDD) through mechanisms involving neurotransmitter pathways, inflammation, oxidative stress, and neuroplasticity, supported by preclinical data and emerging clinical evidence, though challenges like bioavailability and standardization remain.
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Sehr niedrig2026
Effect of supplemental feeding on metabolic profiles and meat quality in yaks: a non-targeted metabolomics approach.
Meisong Wang, Yayu Huang et al.
Supplemental feeding significantly improved yak meat quality by reducing shear force, cooking loss, and drip loss, while increasing polyunsaturated fatty acids and essential amino acids, attributed to enhanced amino acid, fatty acid, and glycolytic pathways.
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ModeratMetaanalyseMensch2026
Obesity and Its Association With Micronutrient Deficiency Among Mexican Children and Adolescents: A Systematic Review and Meta-analysis.
Alejandra Herrera-González, Yareni Yunuen Gutierrez-Gómez et al.
Mexican children and adolescents who are overweight or obese are significantly more likely to have vitamin D deficiency, and show some evidence of increased risk for zinc, iron, and vitamin B6 deficiencies.
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Sehr niedrigMaus2026
Methionine and choline deficiency rewires transcriptional programs to recapitulate molecular features of human MASH.
Wenjing You, Jianfei Ji et al.
Methionine and choline deficiency is sufficient to induce common proinflammatory effects and disrupt metabolic processes across hepatocytes, endothelial cells, macrophages, and hepatic stellate cells, recapitulating key molecular features of human MASH in vitro.
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Sehr niedrig2026
An RNA-sequencing analysis to determine potential upstream transcriptional regulators of essential amino acid deficiency responses in bovine mammary epithelial cells.
Boning Li, Dave J Innes et al.
Essential amino acid deficiency in bovine mammary epithelial cells activates ATF4 and interferon signaling, while down-regulating cell cycle progression and protein/DNA synthesis, with histidine deficiency primarily impacting DNA synthesis and lysine/methionine deficiencies impacting both protein and DNA synthesis.
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Sehr niedrigNarrative ReviewMensch2026
Natural products reshape osteosarcoma cell fate: promoting cell death.
Binghan Yan, Junli Chang et al.
Natural products demonstrate significant potential in modulating programmed cell death (PCD) pathways, including apoptosis, autophagy, ferroptosis, pyroptosis, and necroptosis, offering a promising therapeutic avenue for osteosarcoma treatment, although current evidence is largely preclinical.
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Sehr niedrigProspektivMensch2026
Cross-sectional observational study on prevalence and pattern of multimorbidity and its impact on geriatric outpatients in a south Indian tertiary hospital.
Shilpa Avarebeel, Michael Vassallo et al.
This study found a high prevalence of multimorbidity (66.17%) among geriatric outpatients in South India, with hypertension and type 2 diabetes mellitus being the most common conditions, and identified distinct multimorbidity clusters associated with sociodemographic and lifestyle factors.
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Sehr niedrigMaus2026
Sex-specific dynamics of MASLD reveal early hepatic and extrahepatic metabolic deterioration in females despite long-term protection.
Maria Repollés-de-Dalmau, Anna Marsal-Beltran et al.
Sexual dimorphism in MASLD is dynamic, with females exhibiting an acute metabolic and intestinal stress response and males activating compensatory pathways that transiently preserve metabolic homeostasis, a pattern that reverses long-term with males developing more severe hepatic inflammation and fibrosis.
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Sehr niedrigMaus2026
Daixie recipe ameliorates diet-induced MASH in mice via activating PI3K/AKT and Keap1/Nrf2 signaling.
Xiaoli He, Jiawen You et al.
Daixie recipe (DXR) ameliorates MASH in mice by reducing hepatic steatosis, inflammation, and oxidative stress through the activation of PI3K/AKT and Keap1/Nrf2 signaling pathways, with key active constituents including quercetin and apigenin.
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Sehr niedrig2026
Influence of Dietary Supplementation with a Blend of Essential Oils, Tannins and Bioflavonoids on Milk Yield and Nutritional Properties and on Economic Sustainability of Buffalo Breeding.
Federica Dibennardo, Lorenzo Infascelli et al.
Dietary supplementation with an essential oil, tannin, and bioflavonoid blend in dairy buffaloes resulted in improved milk yield and reduced milk urea nitrogen, indicating enhanced nitrogen utilization efficiency and financial benefits.
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Sehr niedrigMaus2026
Targeting lanosterol synthase alleviates MASLD by promoting fatty acid catabolism.
Sumei Zhang, Mingcong Li et al.
Targeting lanosterol synthase (LSS) alleviates MASLD by promoting fatty acid β-oxidation and ketogenesis, leading to reduced steatosis and liver injury.
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NiedrigRCTIn vitro2026
Evaluation of Sargassum cristaefolium , Sargassum crassifolium , and Enhalus acoroides as feed additives for improving rumen fermentation and mitigating enteric methane emissions in vitro .
Nurzainah Ginting, Roni Pazla et al.
Supplementation with Sargassum cristaefolium, Sargassum crassifolium, and Enhalus acoroides at a 10% inclusion level optimizes rumen fermentation and significantly mitigates enteric methane emissions in vitro, with S. cristaefolium showing the most pronounced effects.
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Sehr niedrigMaus2026
Nuclear Galectin-1 Drives Cancer Progression through O -GlcNAcylation-Dependent Regulation of SOX2.
Woong Kim, Ye-Seal Yim et al.
Galectin-1 drives cancer progression by interacting with O-GlcNAcylated SOX2, increasing its nuclear abundance and transcriptional activity, which sustains cancer stemness and is associated with poor prognosis in gastric cancer.
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Sehr niedrigIn vitro2026
Cocoa Bean Shell as a Functional Food By-Product: Antioxidant Potential and Toxicological Thresholds in Drosophila melanogaster .
Fernanda Dos Santos Trombini, Nathália Cardoso de Afonso Bonotto et al.
In *Drosophila melanogaster*, chronic exposure to cocoa bean shell (Cascau) at concentrations of 3% and above significantly reduced survival, increased oxidative stress markers, and elevated acetylcholinesterase activity, indicating neurotoxicity and redox imbalance, while lower concentrations showed potential benefits within a narrow therapeutic window (LC50 = 7%).
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NiedrigNicht-randomisiertMensch2026
Genome-wide variation in cell-free DNA end-motif entropy predicts immunotherapy response in head and neck cancer.
Ravi Bandaru, Hailu Fu et al.
The regional motif diversity score (rMDS), a fragmentomic metric, is a biologically meaningful and clinically actionable biomarker for predicting immunotherapy response in head and neck squamous cell carcinoma (HNSCC), outperforming other metrics and improving disease-free survival.
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Sehr niedrigIn vitro2026
Evaluation of Colombian silk fibroin hydrogels functionalized with recombinant LSECtin for intervertebral disc tissue engineering.
Lyda Cenobia Caballero-Méndez, Augusto Zuluaga-Vélez et al.
Colombian silk fibroin hydrogels functionalized with recombinant LSECtin demonstrate cytocompatibility and promote chondrogenic-like differentiation of ADSCs, with rLSECtin potentially modulating SOX9, COL2A1, and ACAN expression.
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Sehr niedrigMensch2026
Lectin-Fc(IgG2a) fusion proteins binding to the cell wall of C. albicans cause structural, metabolic, oxidative, and other pleiotropic effects.
Susana Ruiz Mendoza, Claudia Rodriguez de La Noval et al.
Lectin-Fc(IgG2a) proteins exhibit direct antifungal effects against *C. albicans* by disrupting cell wall structure, inducing metabolic shifts, depleting micronutrients, causing oxidative stress, interfering with EV biogenesis, and modulating host immunity, leading to fungal elimination and enhanced host defenses.
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Sehr niedrig2026
Phytase and phosphate-solubilizing Bacteria addition improves P availability and uptake by maize in low-phosphorus red soil.
Long Zhou, Litao Zhu et al.
The combined application of organic phosphorus with exogenous phytase and phosphate-solubilizing bacteria significantly enhanced maize growth, root morphology, phosphorus availability, and uptake in low-phosphorus red soil.
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Sehr niedrigProspektivMensch2026
Evaluation of Nutritional Status in Geriatric Patients Before and After the Insertion of Complete Dentures.
Arvind K Singh, Shruti S Grover et al.
Complete denture rehabilitation significantly improved the nutritional status of completely edentulous geriatric male patients over six months, with significant increases observed in hemoglobin, serum calcium, vitamin B12, HDL, and BMI.
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Sehr niedrigFallberichtMensch2026
PD-L1-armored CD19/CD22 dual-targeted CAR-T cell co-infusion bridging to allogeneic hematopoietic stem cell transplantation achieves 7-year sustained remission in an adult patient with early relapsed, chemorefractory B-cell acute lymphoblastic leukemia: a case report.
Huan Hua, Shupeng Wen et al.
An adult patient with early-relapsed, chemorefractory B-ALL achieved a 7-year MRD-negative sustained remission following co-infusion of CD19 CAR-T and PD-L1-armored CD22 CAR-T cells, followed by allogeneic hematopoietic stem cell transplantation.
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ModeratMetaanalyse2026
The impact of supplementing quebracho and chestnut tannin extracts on the growth performance in growing and finishing beef cattle: a meta-analytical assessment.
Mingyung Lee, Luis O Tedeschi
Tannin extract supplementation was associated with increased average daily gain (ADG) in a nonlinear, dose-dependent pattern, peaking at approximately 0.30% of dietary dry matter, with positive responses also observed at 0.08% in some subsets, and these responses were context-dependent, with larger effects observed at lower protein intake and/or with monensin.
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Sehr niedrigMaus2026
B4GALT1 deficiency attenuates steatohepatitis by regulating the PPARγ/ACSL4 axis.
Youjung Chien, Ruiqi Xia et al.
B4GALT1 promotes MASLD progression by targeting lipid peroxidation in hepatocytes via the PPARγ/ACSL4 axis, and targeting B4GALT1-mediated N-glycosylation is a potential therapeutic strategy for MASLD.
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Sehr niedrigProspektivMensch2026
Innate immune profiling reveals a specific reduction of CD57 + CD62L + CD161 + NK cells in CMV-positive males with hypertension.
Xiaoqi Wang, Qiaoxi Yang et al.
Hypertension is associated with a reduction and pathogenic reshaping of CD57+CD62L+CD161+ NK cells, shifting from an adaptive to a cytotoxic phenotype.
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Sehr niedrig2026
From the field to the pot: phenological, agronomic, and cookability traits of common beans ( Phaseolus vulgaris L .) grown in contrasting climatic regions in Uganda.
Ann Ritah Nanyonjo, Yuzhou Lan et al.
Seven common bean genotypes (NAROBEAN6, SMR48, SCR60, SCR45, SCN20, KND100, SCN744) demonstrated superior performance in terms of high yield and yield components with desirable phenological traits, making them promising candidates for breeding programs and further evaluation in multi-environment trials.
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Sehr niedrigNarrative ReviewMensch2026
Gut microbiota dysbiosis-induced chronic inflammation as a driver of atherosclerosis: cellular crosstalk and host-microbe interactions.
Da Song, Huize Gao et al.
Gut dysbiosis-driven chronic inflammation is a significant and modifiable factor in atherosclerosis, linking host metabolism to disease initiation and progression through effects on gut barrier integrity, microbial metabolites, and immune reprogramming.
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Sehr niedrigMaus2026
Hongjam, an edible silkworm-derived food, attenuates steatohepatitis and fibrosis via multi-axis modulation of metabolic stress, inflammation, and fibrogenic signaling.
Hye-Rin Ahn, Seung-Won Lee et al.
Hongjam, a silkworm-derived food, attenuated liver injury and fibrosis in a mouse model of MASH by simultaneously suppressing fibrogenic signaling, inhibiting inflammation, and normalizing metabolic stress.
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Sehr niedrigSystematic ReviewMensch2026
Metabolomic profiling in phenylketonuria: a systematic review of human studies.
Arnau Gonzalez-Rodriguez, Mireia Urpi-Sarda et al.
This systematic review identified 544 metabolites that differ between PKU patients and controls across 26 studies, with the majority (60%) being upregulated in blood, including phenylalanine and related compounds, while tryptophan metabolites were predominantly downregulated.
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Sehr niedrigMaus2026
Turicibacter sanguinis is a candidate gut microbial pathobiont that promotes metabolic dysfunction-associated steatohepatitis.
Jing Guo, Zhong-Wen Xiang et al.
Turicibacter sanguinis exacerbates metabolic dysfunction-associated steatohepatitis (MASH) by dysregulating bile acid metabolism and suppressing hepatic FXR signaling, and its abundance decreases in MASH patients following treatment, correlating with improved liver injury markers.
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Sehr niedrigNarrative Review2026
A Comprehensive Review on the Anticancer Activity of Plant Peptides and Their Mechanisms of Action.
Tianyu Hou, Yuanying Wang et al.
Plant-derived anticancer peptides (PACPs) exhibit diverse structures and mechanisms, including apoptosis induction, cell cycle arrest, and immune modulation, with over 30 peptides showing efficacy in vitro and in animal models, though challenges in stability, bioavailability, and production remain.
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Sehr niedrigMensch2026
Association between DASH diet adherence and mortality in non-diabetic adults with and without chronic kidney disease.
Shang-Feng Tsai, Wei-Ju Liu et al.
Greater adherence to the DASH diet was associated with significantly lower composite cardiovascular or cancer mortality in individuals without chronic kidney disease (CKD), but no significant mortality benefits were observed in CKD participants.
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Sehr niedrig2026
Protective effect of dietary L-carnitine supplementation on follicular development in the ovary of ewes with subclinical pregnancy toxemia.
Ali Osman Turgut, Merve Pekince Özöner et al.
Subclinical pregnancy toxemia negatively impacts follicular development in ewes, and L-carnitine supplementation demonstrates a protective effect by promoting secondary follicle growth and oocyte quality.
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Sehr niedrigRetrospektivMensch2026
Neurological Outcomes of Newborn Screening-Identified Isovaleric Acidemia: A Case Series Exploring Initial C5 Acylcarnitine Levels.
Sharmila Kiss, Gary Lazarovski et al.
Despite variability in initial C5 acylcarnitine levels and metabolic decompensations, all 10 Australian patients with isovaleric acidemia detected via newborn screening had normal neurological outcomes, suggesting that initial C5 levels have minimal correlation with long-term neurological outcomes.
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Sehr niedrigMaus2026
CBP/β-Catenin Signaling in Hepatocytes Plays Pivotal Roles in MMP-7-Mediated Liver Fibrosis in a Metabolic Dysfunction-Associated Steatohepatitis Mouse Model.
Jun Imamura, Masamichi Kimura et al.
CBP/β-catenin signaling in hepatocytes drives MASH fibrosis through MMP-7, and inhibiting this pathway reduces fibrosis and steatosis in a mouse model, with elevated serum MMP-7 correlating with fibrosis severity in human MASH patients.
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Sehr niedrigMaus2026
Involvement of trimethylamine N-oxide in major depressive disorder via astrocytic d-Serine dysregulation.
Liwang Lin, Longyu Li et al.
Elevated plasma trimethylamine N-oxide (TMAO) levels are associated with major depressive disorder (MDD) and its symptom severity, and TMAO induces depressive-like behaviors in mice by activating astrocytic AMPK/SIRT1 signaling, leading to increased d-serine production and subsequent neuronal apoptosis.
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Sehr niedrigMaus2026
Oleic acid improves pathological changes in Aβ1-42-induced astrocytes and Alzheimer's disease mouse models through PKA/ACACB/CPT1A.
YiBo Xie, Jianan Tian et al.
Oleic acid ameliorates Alzheimer's disease pathology and cognitive impairment by restoring astrocytic fatty acid beta-oxidation through the PKA/ACACB/CPT1A pathway.
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Sehr niedrigMaus2026
Macrophage NEDD4L restrains liver fibrosis by preventing scar-associated macrophage expansion via ubiquitination of phospho-SMAD3.
Yanghuan He, Shujun Ge et al.
Macrophage NEDD4L restrains liver fibrosis by preventing scar-associated macrophage expansion via ubiquitination and degradation of phospho-SMAD3.
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NiedrigRCTIn vitro2026
Synergistic effects of Piper ornatum and lemuru fish oil on in vitro rumen fermentation, nutrient digestibility, and methane mitigation.
Mardiati Zain, Despal Despal et al.
The combination of 6% *Piper ornatum* and 4.5% lemuru fish oil resulted in the most favorable outcomes for methane mitigation, fermentation efficiency, and nutrient utilization in in vitro rumen fermentation.
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Sehr niedrigMaus2026
Dietary fish oil improves intestinal barrier function and intestinal microbiota composition and reduces systemic inflammation in a mouse model of moderate acute malnutrition.
Grace E Patterson, Elvia Yaneth Osorio et al.
Replacing corn oil with fish oil in a nutrient-deficient diet in a mouse model of moderate acute malnutrition reduced systemic inflammation, improved intestinal dysbiosis and barrier function, and decreased bacterial and LPS translocation without compromising host defense against an intestinal pathogen.
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Sehr niedrig2026
Effects of probiotic supplementation on growth and meat quality of Simmental bulls.
Yongqing Liu, Gaifang Wang et al.
Dietary probiotic supplementation at 0.2 g/kg DM improved Simmental bull growth performance and meat quality, including redness, antioxidant capacity, reduced cooking loss and shear force, and increased IMF.
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Sehr niedrigMensch2026
Associations of Dietary and Circulating Choline and Glycine With Bone Mineral Density: UK Biobank Analyses With Mendelian Randomization.
Siyu Chen, Rui Lu et al.
Circulating choline levels were associated with lower bone mineral density (BMD) in men and individuals with impaired renal function, and Mendelian randomization suggested a potential causal association between circulating choline and BMD in men.
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Sehr niedrig2026
Glycogenic hepatopathy in a primitive teleost fish model: the inductive effect of high carbohydrate diet and the alleviating role of betaine.
Jiahong Zou, Zhenwei Chen et al.
A high carbohydrate diet induced glycogenic hepatopathy in largemouth bass, characterized by increased liver glycogen accumulation without significant lipid deposition, and betaine supplementation alleviated this condition while also enhancing resistance to ammonia stress.
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Sehr niedrigNarrative Review2026
Microalgae supplementation improves goat milk composition and fatty acid profile: a meta-analysis and meta-regression.
Soumaya Boukrouh, Ihssane Mnaouer et al.
Microalgae supplementation in goat diets improved milk fatty acid profile, including increases in polyunsaturated fatty acids and n-3 fatty acids, without affecting dry matter intake or milk yield.
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HochRCTMensch2026
Effects of Omega-3 Supplementation in Sarcopenia After Bariatric Surgery: A Triple-Blind Randomized Controlled Clinical Trial.
André Vicente Bigolin, Júlia Iaroseski et al.
Omega-3 supplementation (2000 mg/day) during the perioperative period of bariatric surgery did not prevent muscle mass loss or improve muscle strength or functional performance within 105 days.
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Sehr niedrigProspektivMensch2026
Prediction of cognitive outcome and progression to dementia using ω6-PUFA/ω3-PUFA ratio.
Víctor Andrade, Luca Kleineidam et al.
The ω6-PUFA/ω3-PUFA ratio is a stronger predictor of cognitive decline and DAT progression than individual PUFAs, and maintaining a healthier ratio may preserve cognitive function and slow DAT progression.
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Sehr niedrigRatte2026
Ameliorative Effects of Lycopene and L-Carnitine on CCl 4 -Induced Liver Fibrosis Rat Model.
Adeel Shahid, Somia Shehzadi et al.
Combined Lycopene and L-Carnitine treatment effectively protected against CCl4-induced liver damage in rats by preserving hepatic histology, reducing oxidative stress, normalizing liver enzymes, and improving liver function indices.
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Sehr niedrigMensch2026
Association of socio-economic status with dietary habits and anemia prevalence in the geriatric population.
Sharanya Kandaswamy, Cibi Kannan et al.
Lower socioeconomic status (SES) and consuming a low-diversity diet are independent predictors of anemia in older adults in India, with low SES individuals exhibiting significantly higher anemia rates and lower hemoglobin levels.
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Sehr niedrig2026
Yeast polysaccharides modulate lipid metabolism and restore oviduct inflammatory and microbial homeostasis to support egg quality in Salmonella Pullorum-challenged hens.
Jianmin Zhou, Dong Dai et al.
Yeast polysaccharides improve lipid utilization and yolk pigmentation, and enhance oviduct-egg axis resistance to *S. Pullorum* by modulating host inflammation and oviduct microbial balance, thereby supporting egg quality and safety.
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Sehr niedrigIn vitro2026
Zinc bioaccessibility of foodstuffs after in vitro study in children with illnesses.
Úrsula García-Conde, Miguel Navarro-Moreno et al.
Children with gluten-related disorders, obesity, and cow's milk protein allergy exhibited significantly lower zinc bioaccessibility in the large intestine compared to healthy children, with variations observed based on food type and cooking method.
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Sehr niedrigMaus2026
Susceptibility and transcriptional characteristics of inbred C57BL/6J and outbred ICR mice in CDAHFD-induced MASH models.
Jing Zhou, Bingyi Li et al.
The choline-deficient, L-amino acid-defined, high-fat diet (CDAHFD) successfully induced MASH models in both C57BL/6J and ICR mice within 10 weeks, with ICR mice exhibiting comparable susceptibility and transcriptional profiles to human MASH as C57BL/6J mice.
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Sehr niedrigNarrative ReviewMensch2026
The Simultaneous Prevention of Multiple Diseases: A "One Ring to Rule Them All" Framework for Redox-Driven Health and Longevity.
Harold Robert Silverstein, Albert A Rizvanov et al.
Redox imbalance, characterized by oxidative stress and chronic inflammation, serves as a shared mechanistic hub linking multiple chronic non-communicable diseases, and lifestyle interventions, particularly antioxidant-rich diets, represent the most scalable approach to simultaneously influence these disease trajectories.
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Sehr niedrigMaus2026
Maternal cafeteria diet and methyl donor supplementation modulate gut microbiota and anxiety-like behavior in male offspring.
Ximena Rodríguez Gómez, Heriberto Castro et al.
Maternal methyl donor supplementation mitigated cafeteria diet-induced changes in offspring gut microbiota and was linked to microbiota-behavior associations relevant to anxiety-like responses in male mice.
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Sehr niedrigRetrospektivMensch2026
Development and validation of a model integrating clinical and metabolomic markers for gestational diabetes mellitus prediction.
Guixi Wang, Wenfeng Zhang
A prediction model integrating first-trimester clinical and metabolomic markers, particularly the SVM model, demonstrated favorable predictive accuracy (AUC 0.861) for gestational diabetes mellitus risk stratification.
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Sehr niedrig2026
A Complex Case of Ornithine Transcarbamylase Deficiency in a Patient With Severe Comorbid Conditions.
Mobeen Khan, Sardar Ahmad Rafique et al.
Early ammonia testing in infants with unexplained encephalopathy and respiratory alkalosis, coupled with a low citrulline/normal ornithine profile, can suggest partial Ornithine Transcarbamylase Deficiency (OTCD), and prompt nitrogen-scavenging therapy and protein restriction can stabilize patients and avoid dialysis.
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ModeratProspektivMensch2026
Association between meat consumption and cancer mortality in Korean adults.
In Sun Ryou, Hyun Jeong Cho et al.
Total meat consumption was not associated with overall cancer mortality, but specific meat subtypes showed varying associations with site-specific cancer mortality by sex in Korean adults, with red meat inversely associated with gastric cancer mortality in men, chicken with lower colon cancer mortality in men, processed meat with increased rectal cancer mortality in men, and organ meat with increased pancreatic and breast cancer mortality in women.
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Sehr niedrigMaus2026
PGC-1α protects against MASH via Tim23-dependent inhibition of DRP1-mediated ferroptosis.
Yanmian Zhao, Linzhong Zhang et al.
PGC-1α inhibits hepatocyte ferroptosis and attenuates MASH by upregulating Tim23 and inhibiting the Drp1-ACSL4 axis.
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Sehr niedrigQuerschnittMensch2026
American, British, and Italian Online Information on the Health Risks Associated With Eating Meat: Cross-Sectional Study.
Gianfranco Di Gennaro, Francesca Licata et al.
Italian websites on meat consumption risks were significantly less likely to be of high quality compared to British and American websites, with only 22.3% meeting the quality standards.
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Sehr niedrig2026
Effects of a second iron injection and sire line on growth performance, hemoglobin levels, antioxidative status, and whole-body iron retention in piglets.
Jannell Torres, Chanho Kwon et al.
Increasing iron injection frequency in piglets improved growth performance, hemoglobin levels, antioxidant status (plasma CAT), and whole-body iron retention, while sire line primarily influenced growth and hemoglobin but not iron retention or antioxidant status.
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Sehr niedrigProspektivMensch2026
Meat Consumption and Cognitive Health by APOE Genotype.
Jakob Norgren, Adrián Carballo-Casla et al.
Higher meat consumption was associated with better cognitive trajectories (β = 0.32) and reduced dementia risk (sHR = 0.45) in individuals with APOE ε3/ε4 and ε4/ε4 genotypes, with no such associations found in other genotypes.
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Sehr niedrigMensch2026
Burden of colon and rectum cancer attributable to a diet high in red meat in the United States, 1990-2021.
Liang Huang, Minghua Li
Although age-standardized colon and rectum cancer mortality and DALY rates attributable to high red meat intake have declined in the U.S. from 1990-2021, the burden is increasing among younger adults (25-49 years) and persistent geographic disparities remain concerning.
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ModeratRCTMensch2026
Unravelling prostate cancer risk and protective factors among urology patients in a Tanzanian population.
Fidelis Charles Bugoye, Richard Biegon et al.
Dietary and lifestyle factors, particularly increased red meat and alcohol intake, were significantly associated with higher prostate cancer incidence, while increased soya, coffee, and tomato intake, and not being married were associated with lower incidence in a Tanzanian population.
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Sehr niedrig2026
Chemical inhibition of INO1 reduces phytic acid in rice and wheat grains for enhanced micronutrient bioavailability.
Tatsuki Akabane, Satoshi Kamino et al.
Chemical inhibition of INO1 in rice and wheat grains significantly reduced phytic acid content by up to 31% and 47% respectively, without negatively impacting yield, seed quality, or germination, thereby enhancing micronutrient bioavailability.
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Sehr niedrigMensch2026
Exploring significant gender disparities in esophageal cancer risk: Insights from Mendelian randomization analysis and global burden of disease data.
Jiale Cui, Rong Zhang et al.
Significant gender disparities in esophageal cancer risk are likely due to the direct causal effects of smoking and elevated male testosterone levels, with TP53 potentially mediating the relationship between testosterone levels and esophageal cancer risk.
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HochRCTMensch2026
Choline and betaine concentrations in plasma discriminate levels of dietary choline intake in healthy adults: analysis of a double-blind randomized crossover controlled feeding study.
Isis Trujillo-Gonzalez, David A Horita et al.
Plasma choline and betaine concentrations effectively discriminate low dietary choline intake from adequate intake under controlled feeding conditions, with a combined analysis yielding an AUC of 0.85.
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ModeratQuerschnittMensch2026
Dietary Behavior Clustering and Cardiovascular Risk Markers in a Large Population Cohort.
Mauro Lombardo, Giovanni Aulisa et al.
Distinct behavioral eating profiles are strongly associated with body composition and cardiovascular-related eating patterns, with structured/mindful eaters exhibiting healthier anthropometrics and greater adherence to cardioprotective food preferences, while disordered eaters showed unfavorable profiles.
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NiedrigSystematic ReviewMensch2026
Effects of Animal-Based Foods on Metabolic Outcomes in Adults with MASLD and Comorbidities: A Systematic Review of Randomized Controlled Trials (2020-2026).
Joanna Michalina Jurek, Katarzyna Zablocka-Slowinska et al.
Freshwater fish consumption and daily intake of probiotic yogurt, particularly when fortified with vitamin D, are associated with improvements in metabolic, anthropometric, and hepatic outcomes in adults with MASLD, while high-saturated-fat animal products like ghee can exacerbate cardiometabolic issues.
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Sehr niedrigNarrative ReviewMensch2026
A comprehensive review of the physiology and evidence base to guide the use of ergogenic and medical supplements for enhanced cycling performance.
Andrew Rowland, Sophie Edwards et al.
Supplements can enhance cycling performance through ergogenic (direct) and medical (indirect) mechanisms, with Group A supplements demonstrating strong evidence for efficacy and safety, while Group B offers targeted benefits in specific contexts, and medical supplements support overall health and training consistency.
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HochRCTMensch2026
Effects of Minimally Processed Red Meat within a Plant-Forward Diet on Biomarkers of Physical and Cognitive Aging: A Randomized Controlled Crossover Feeding Trial.
Saba Vaezi, Bruna O de Vargas et al.
Incorporating minimally processed pork into a plant-forward diet in older adults improved insulin sensitivity and HDL cholesterol compared to a lentil-based diet, while both diets supported cognitive-related metabolic health and neurochemical markers.
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Sehr niedrigMaus2026
Neuroprotective mechanisms of Thai traditional brain tonic Phy-Blica-O against LPS-induced neuroinflammation: Inhibition of NF-κB in microglia and mice.
Thammarat Kaewmanee, Palanivel Ganesan et al.
Phy-Blica-O (PBO) inhibits LPS-induced neuroinflammation in vitro and in vivo by suppressing the NF-κB signaling pathway and reducing iNOS, COX-2, and pro-inflammatory cytokine expression.
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Sehr niedrig2026
Assessment of safety profile and anti-obesity effects of innovative plant-based food formulations in a zebrafish diet-induced obesity model.
Justyna Magdalena Hermanowicz, Sandra Budziak et al.
The plant-based food formulations F1, F2, and F3 were found to be safe in zebrafish and significantly reduced body weight, glucose, total cholesterol, triglycerides, and visceral fat accumulation in a diet-induced obesity model.
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Sehr niedrigSystematic ReviewMensch2026
Effects of dietary supplements on cognitive outcomes and physiological biomarkers in mild cognitive impairment: a systematic review and network meta-analysis.
Xiaolong Wang, Shan Jiang et al.
PUFA supplements demonstrated the greatest cognitive benefit in individuals with mild cognitive impairment (MCI), with a significant reduction in Aβ42 and Aβ40 levels, although evidence is limited by study quality and heterogeneity.
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Sehr niedrig2026
The colostrum chronicles: identifying porcine milk oligosaccharides in colostrum and investigating their role in litter performance.
Georgina O Smith, Márton Lengyel et al.
While PMO concentrations in sow colostrum are highly individual and no PMO significantly impacted piglet body weights, higher 2'-fucosyllactose (2'FL) concentration may reduce pre-weaning mortality, and lacto-N-neotetraose (LNnT) concentration was negatively associated with litter size, suggesting potential for supplementation in piglet milk replacers.
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Sehr niedrigMaus2026
Induction of TFEB promotes Kupffer cell survival and reduces lipid accumulation in MASLD.
Mandy M Chan, Sabine Daemen et al.
TFEB induction promotes Kupffer cell fitness under lipid stress during MASLD, leading to improved liver steatosis and portal filtration by enhancing lysosomal lipolysis, mitochondrial fatty acid oxidation, and reducing oxidative stress and ferroptosis.
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Sehr niedrigNarrative ReviewMensch2026
Dietary Nutrients, Gut Microbiota, and Cardiac Function: From Metabolic Mechanisms to Clinical Applications.
Lucia Scisciola, Manuela Giovanna Basilicata et al.
Gut microbiota-derived metabolites, including TMAO and PAGln, are associated with adverse cardiovascular outcomes, while SCFAs and indoles may offer protection, though findings are heterogeneous due to various factors and require further mechanistic and interventional studies.
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NiedrigQuerschnittMensch2026
Low anemia but high dyslipidemia prevalence in Brazilian schoolchildren: a nutritional transition profile.
Ana Carolina Marques Ciceri, Syang Ândrea de Oliveira et al.
This study in Brazilian schoolchildren aged 5-8 years found a low prevalence of anemia but a high prevalence of dyslipidemia, with inflammation (CRP) being a strong independent predictor of functional iron availability (Ret-He), irrespective of nutritional status.
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Sehr niedrigMaus2026
EMMPRIN deficiency alleviated metabolic-associated steatohepatitis progression via regulation of the UBA52-MCT1 axis.
Linying Lai, Baoyuan Huang et al.
EMMPRIN promotes MASH progression by downregulating UBA52, which impairs K63-linked ubiquitination and stability of MCT1, leading to lactylation-dependent metabolic reprogramming, lipid accumulation, inflammation, and fibrosis.
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Sehr niedrigProspektivMensch2026
Validation of a semi-quantitative Food Frequency Questionnaire for dietary assessment among adults in Northwest China.
Jing Huang, Huinan Zhang et al.
The developed food frequency questionnaire (FFQ) for adults in Northwest China demonstrates good reproducibility and acceptable relative validity for ranking nutrient intakes, but tends to overestimate absolute intakes.
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Sehr niedrigMaus2026
Targeted Mitochondrial ECSIT Overexpression Attenuates MASH by Increasing OTUD3 Expression.
Yuqing Jiang, Tingting Tong et al.
Mitochondrial ECSIT overexpression alleviates MASH phenotypes by increasing OTUD3 expression, which stabilizes SIRT3 via deubiquitination, thereby inhibiting mtDNA oxidation and steatosis-induced metabolic disorders.
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ModeratSystematic ReviewMensch2026
From nutritional intervention to immune modulation: a multi-database bibliometric and topic modeling study of vitamin D in inflammatory bowel disease.
Kun Wang, Xingyu Zhu et al.
Research on vitamin D in inflammatory bowel disease (IBD) has shown a steady increase in output since 2006, with emerging trends focusing on the gut microbiome, immunomodulation, and micronutrients, while core themes include vitamin D deficiency, gut microbiota, inflammatory response, and diet.
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NiedrigProspektiv2026
A lipidomic based metabolic age score for monitoring the effects of lifestyle and diet on metabolic disease risk.
Tingting Wang, Habtamu B Beyene et al.
The environmentally adjusted metabolic age score (EAmAge) demonstrates stronger and more consistent associations with Alzheimer's disease, cardiovascular disease, and mortality compared to an unadjusted model, suggesting it is a more informative marker of intrinsic metabolic ageing.
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Sehr niedrigQuerschnitt2026
Participation in Healthy Ageing Centres in Bosnia and Herzegovina Is Associated with Increased Physical Activity, Social Interactions, and Life Satisfaction Among Older People: A Cross-Sectional Study.
Daniela Pamias-Lopez, Tara Keck
HAC attendance is associated with higher life satisfaction, increased physical activity (measured by MET hours per week), and greater social engagement among older people in Bosnia and Herzegovina.
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HochRCTMensch2026
Contrasting dietary patterns remodel gut microbial function and generate multi-omic signatures associated with cardiometabolic markers.
Jordan Stanford, Emily C Hoedt et al.
Two weeks of contrasting dietary patterns altered gut microbial metabolic function, with pathways responding more consistently than taxonomy, and multi-omic integration identified diet-discriminating features and 77 significant associations between microbial genes/metabolites and cardiometabolic markers.
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Sehr niedrigNarrative ReviewMensch2026
Hypomagnesemia: A Clinical and Nutritional Update.
Anastasia Papagiannidou, Maria Mitropoulou et al.
Magnesium is a critical cofactor for over 600 enzymes, and its deficiency (<0.6 mmol/L) is a modifiable risk factor for cardiometabolic, neurological, and musculoskeletal diseases, with supplementation showing significant benefits such as reducing HbA1c by 0.5–0.7% and systolic blood pressure by 2–8 mmHg.
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Sehr niedrigRatte2026
From data mining to experimental validation: ST36 and CV12 as core acupoint combination for acupuncture in functional dyspepsia.
Jialin Jia, Zhen Zhong et al.
Electroacupuncture at ST36 and CV12 significantly improved digestive function, nutritional status, reduced duodenal eosinophil and mast cell infiltration, and increased Claudin-1 and Occludin expression in functional dyspepsia rats.
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Sehr niedrigNarrative Review2026
The gut microbiome in colorectal anastomotic leakage: from mechanisms to precision.
Songlin Sun, Feng Long et al.
Dysbiosis during the perioperative period, characterized by the expansion of collagenolytic pathobionts like *Enterococcus faecalis*, *Fusobacterium nucleatum*, and *Alistipes onderdonkii*, compromises anastomotic healing after colorectal cancer resection, while a metabolically active, short-chain fatty acid-producing commensal community is crucial for preventing anastomotic leakage.
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