Research Database

Sehr niedrig2026
Growth performance, blood composition, carcass characteristics, and meat quality of Ossimi and Barki fattening lambs as influenced by breed type and zilpaterol hydrochloride supplementation.
Ahmed M A Hussein, Mahmoud M Abdelsattar et al.
Zilpaterol hydrochloride supplementation improved growth performance, meat quality, hematological indices, and anabolic hormone concentrations in both Ossimi and Barki lambs, with Barki lambs showing greater improvements in carcass traits, indicating breed-specific responsiveness.
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Sehr niedrigMensch2026
Spices Beyond Antioxidants: From the Gut to the Brain.
Tatiana Diacova, David Heber et al.
Herbs and spices, rich in (poly)phenols, show potential in preventing cardiometabolic and neurodegenerative diseases, modulating the gut microbiome, and offering antioxidant and anti-inflammatory benefits, though bioavailability and habitual intake levels require further research.
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Sehr niedrigRatte2026
Early administration of renin-angiotensin system inhibitors improves survival and cardiac remodeling in heart failure with preserved ejection fraction.
Yuka Kono, Kunihiro Sonoda et al.
Early administration of RAS inhibitors (captopril or sacubitril/valsartan) significantly improves survival and prevents cardiac remodeling in HFpEF rats by suppressing inflammatory and fibrotic pathways, whereas the sGC stimulator vericiguat failed to provide similar benefits.
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Sehr niedrigMaus2026
Deficiency of glycogen synthase promotes lipid accumulation through ChREBP and AKT-mTOR1-SREBP1 axis activation in mice.
Liangkui Li, Jianan Lang et al.
Hepatic glycogen synthase (GS) deficiency promotes the progression of MASLD and metabolic dysfunction by diverting glucose flux into de novo lipogenesis via the activation of ChREBP and SREBP1 signaling pathways.
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Sehr niedrig2026
Nanoparticle delivery enhances the immunomodulatory efficacy of dietary methionine in broiler chickens.
Mehran Mehri, Mahmoud Ghazaghi et al.
Nanoparticle-conjugated methionine (nano-Met) demonstrated a relative bioavailability of 279% compared to conventional DL-methionine, significantly enhancing growth performance and humoral immune responses in broiler chickens at lower dietary concentrations.
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Sehr niedrigNarrative ReviewMensch2026
Beetroot Juice and Exercise for Clinical Health and Athletic Performance: A Narrative Review.
Eunjoo Lee, Hun-Young Park et al.
Beetroot juice supplementation consistently enhances nitrate–nitrite–NO bioavailability, leading to systolic blood pressure reductions of 5–10 mmHg and improved submaximal endurance performance (e.g., 1.9–2.8% faster time trials), though its efficacy is often blunted in highly trained athletes.
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Sehr niedrigMensch2026
Global Patterns of Mercury Speciation and Biomagnification in Sharks: Ecological Drivers and Food Safety Implications.
Ginevra Boldrocchi, Davide Spanu et al.
Deep-sea and pelagic sharks, particularly those heavily exploited and threatened, exhibit the highest mercury burdens, posing significant risks to both food safety and conservation efforts.
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Sehr niedrig2026
Optimization of dietary methionine requirements under aflatoxicosis in quail chicks using response surface modeling.
Mehran Mehri, Morteza Asghari-Moghadam et al.
Dietary methionine supplementation at levels 130–150% of NRC recommendations (6.5–7.5 g/kg) is required to counteract the negative effects of aflatoxin B₁ on growth performance, hepatic integrity, immune response, and microbial balance in quail chicks.
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Sehr niedrigMaus2026
Impact of Dietary Practices on DNA Adduct Formation by Aristolochic Acid I in Mice: Drinking Alkaline Water as a Risk Mitigation Strategy.
Hong-Ching Kwok, Jiayin Zhang et al.
Unbalanced diets (high-fat, high-sucrose, high-protein) and supplements like Vitamin C and cysteine significantly increase aristolochic acid-DNA adduct formation (up to 114%), whereas alkaline water (pH 8.8) reduces adduct levels by 30% by mitigating intestinal absorption.
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Sehr niedrigIn vitro2026
IPEC-J2 as a cellular model for studying intestinal mucus.
Frédéric Dessauge, Annie Vincent et al.
IPEC-J2 cells cultured for 14 days with 5% porcine serum and gentle agitation (5PSAg) differentiate into mucus-secreting cells, expressing MUC2 in approximately 8% of cells (comparable to in vivo goblet cell proportions), along with membrane-bound mucins, functional tight junctions, and apical microvilli, making them a suitable in vitro model for studying jejunal mucus interactions, despite an aberrant intracellular localization of MUC13.
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Sehr niedrig2026
Digestibility and transcriptomic profiling of kidney, pancreas, follicle, and uterus in laying hens supplemented with phytogenic feed additive.
Henry Reyer, Michael Oster et al.
Supplementation with a phytogenic feed additive (PFA) in laying hens significantly improved apparent ileal digestibility of crude protein (+5.7%), total amino acids (+3.1%), aspartic acid (+10.8%), calcium (+1.9%), and crude ash (+4.3%), alongside transcriptional changes suggesting enhanced immune support and nutrient metabolism in reproductive tissues.
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Sehr niedrigIn vitro2026
Cobalt mitigates zinc-starvation effects in Pseudomonas aeruginosa.
Emma Michetti, Valerio Secli et al.
Cobalt supplementation alleviates key effects of severe zinc deficiency in *P. aeruginosa*, including reduced pyocyanin production, impaired swarming motility, and enhanced sensitivity to oxidative stress, by functionally replacing zinc in proteases LasA and LasB and the transcriptional regulator Zur, and is crucial for colonization during infection.
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Sehr niedrigNarrative ReviewIn vitro2026
Traditional Chinese medicine-derived monomers improve bone metabolic imbalance and delay osteoporosis progression by regulating mitochondrial homeostasis.
Baohui Wang, Bo Dong
TCM-derived monomers show promise in improving bone metabolism by regulating mitochondrial function, reducing oxidative stress, and modulating quality control in bone cells, but current evidence is largely preclinical with limited mechanistic depth and translational validity.
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Sehr niedrigNarrative ReviewMensch2026
Mechanistic Analysis of Fisetin in Liver Diseases and Its Potential Therapeutic Application in IFALD-A Review of In Vitro and In Vivo Studies.
Marta Belka, Maciej Stawny et al.
Fisetin demonstrates a multifaceted hepatoprotective profile against liver diseases like IFALD by simultaneously inhibiting NF-κB-mediated inflammation, activating Nrf2 antioxidant pathways, and exerting senolytic effects, though its clinical application requires advanced delivery systems due to low bioavailability.
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Sehr niedrigFallbericht2026
Delayed Diagnosis of Primary Hyperoxaluria and Systemic Oxalosis in a Hemodialysis Patient: A Case Report and Literature Review.
Hanane Benali, Mehdi El Mansouri et al.
Primary hyperoxaluria can present atypically in late adulthood with systemic oxalosis, characterized by erythropoietin-resistant anemia, bone deformities driven by granulomatous inflammation, and multi-organ deposition including hepatosplenomegaly and lymphadenopathy.
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Sehr niedrig2026
Effects of dietary phosphorus and myo-inositol supplementation on NaPi-IIb and TRPV6 protein expression in duodenal apical membranes of laying hens from two strains.
Nataliia Shomina, Vera Sommerfeld et al.
Dietary mineral phosphorus renunciation did not affect duodenal NaPi-IIb fragment or TRPV6 expression in either hen strain, but myo-inositol supplementation modulated NaPi-IIb fragment expression in a strain-dependent manner, increasing it in Lohmann Brown-Classic hens and decreasing it in Lohmann LSL-Classic hens.
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Sehr niedrigProspektivMensch2026
Chemotherapy driven alterations in NK cell receptors and ligands in high grade serous ovarian cancer.
Pavan Kumar, Samruddhi Ranmale et al.
Standard chemotherapy in high-grade serous ovarian cancer (HGSOC) enhances anti-tumor immunity by restoring Natural Cytotoxicity Receptor (NCR) expression, reducing soluble decoy ligands, and increasing tumor cell immunogenicity, which correlates with improved progression-free survival.
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Sehr niedrig2026
Effects of salinity and broad-range antibiotics on oxalate production, transport, and degradation in Poecilia latipinna.
Felicia Vimala Rajan, Carol Bucking
Salinity acclimation in *Poecilia latipinna* leads to a coordinated host-microbe response that mitigates oxalate accumulation, involving salinity-dependent intestinal oxalate transport (upregulation of SLC26A6 and downregulation of SLC26A3) and a regionally specialized gut microbiome, with antibiotic-mediated disruption of the microbiome impairing oxalate degradation and increasing systemic oxalate stress.
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Sehr niedrigSystematic ReviewMensch2026
The potential effect of whey protein supplementation in post-bariatric surgery patients: a systematic review and meta-analysis of randomized controlled trials.
Xuehan Zhao, Tianhang Shi et al.
Whey protein supplementation after bariatric surgery significantly optimizes body composition by enhancing fat mass reduction (WMD = -2.10 kg) and preserving fat-free mass (WMD = 3.87 kg), though it has no significant effect on lipid profiles.
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Sehr niedrigQuerschnittMensch2026
Health literacy among residents in communities implementing healthy community initiatives: a cross-sectional study.
Tingjie Liu, Dan Jiang et al.
Residents in healthy community construction areas exhibited a significantly higher overall health literacy rate (65.78%) compared to the district average (53.18%), with marital status, chronic disease status, and younger age identified as key positive predictors of literacy levels.
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Sehr niedrigNarrative ReviewMensch2026
Early Life Nutrition: The First 1000 Days and Healthy Aging in Cystic Fibrosis.
Caitlin N Miles, Gillian M Nixon et al.
The first 1000 days represent a critical window for children with cystic fibrosis, where early nutritional challenges like meconium ileus and pancreatic insufficiency must be balanced against the rising risk of obesity and cardiometabolic disease through optimized breastfeeding and CFTR modulator therapy.
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Sehr niedrigProspektivMensch2026
Early-life infectious and nutritional exposures and cardiovascular risk in early adulthood in Uganda: protocol for a new round of data collection in the Entebbe Mother and Baby Study birth cohort at 21 years (EMaBS@21).
Isaac Sekitoleko, Ronald Komata et al.
The EMaBS@21 study protocol outlines a longitudinal investigation into how early-life infectious exposures, undernutrition, and socio-demographic factors program cardiovascular risk markers, such as blood pressure and lipid profiles, in a cohort of 900 Ugandan young adults.
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ModeratRCT2026
Gestational and lactational dietary supplementation with live yeast partially attenuates inflammatory responses to lipopolysaccharide challenge in newly weaned piglets.
Yuechi Fu, Abiola S Lawal et al.
Gestational and lactational dietary live yeast supplementation in sows partially alleviated the adverse inflammatory and oxidative stress effects induced by lipopolysaccharide challenge in newly weaned piglets, specifically by suppressing TLR4-mediated pro-inflammatory signaling, reducing local inflammation, and improving intestinal adherens junction protein expression.
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Sehr niedrig2026
Phytase supplementation in sorghum-based diet enhances nutrient digestibility, energy utilization, and antioxidant status of Campbell ducks.
Z Li, F Raziq et al.
Phytase supplementation (500 FTU/kg) significantly enhanced growth performance, carcass traits, nutrient digestibility, and antioxidant status in Campbell ducks fed both red and white sorghum-based diets.
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Sehr niedrigProspektivMensch2026
Divergent risk profiles for cause-specific mortality in MASLD and MetALD: a nationwide population-based study.
Hyuk Kim, Jeong-Ju Yoo et al.
MetALD is associated with a significantly higher risk of all-cause mortality (HR 2.085) compared to controls, while both MASLD and MetALD significantly increase cancer-related mortality, with risks primarily driven by metabolic factors in MASLD and lifestyle behaviors like smoking and high alcohol intake in MetALD.
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NiedrigRCTMensch2026
Mediterranean diet adherence is associated with mitochondrial microproteins Humanin and SHMOOSE; potential role of the Humanin-Nox2 interaction in cardioprotection.
Roberto Vicinanza, Vittoria Cammisotto et al.
High adherence to the Mediterranean Diet is associated with significantly higher levels of mitochondrial-derived peptides Humanin and SHMOOSE and lower markers of oxidative stress (sNox2-dp and 8-iso-PGF2α) in patients with atrial fibrillation.
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Sehr niedrigNarrative ReviewMensch2026
Potential Links Between Aging, Mitochondrial Dysfunction, and Drug Transporter Function-Molecular Mechanisms and Pharmacokinetic Implications.
Patryk Rzeczycki, Oliwia Pęciak et al.
Age-related mitochondrial dysfunction drives a regulatory shift in gastrointestinal transporters (notably reducing BCRP and P-gp efficiency) through pathways like AMPK and SIRT1, leading to increased drug bioavailability and higher toxicity risks in elderly patients.
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Sehr niedrigNarrative ReviewMensch2026
Multitarget Actions of Pentacyclic Triterpenic Acids in Alzheimer's Disease: Mechanistic Insights.
Niti Sharma, Seong Soo A An
Pentacyclic triterpenic acids (PTAs) exhibit multimodal neuroprotective effects in Alzheimer's disease models by targeting various pathological pathways, including antioxidant, anti-inflammatory, anti-amyloidogenic, mitochondrial-protective, and synaptic regulatory mechanisms, leading to improved learning and memory in preclinical studies.
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Sehr niedrigMaus2026
Enhanced Salmonella mortality in naturally resistant, immunocompetent male mice is associated with an altered systemic immune response.
Aliyah N Bennett, Allysa L Cole et al.
Male 129X1/SvJ mice exhibit significantly higher mortality (3% vs 38% survival at 14 days) and bacterial burden compared to females, a susceptibility linked to a maladjusted immune response characterized by elevated IL-10 and insufficient IL-27 levels.
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Sehr niedrigNarrative ReviewMensch2026
Ribosome Biogenesis and Translational Control in Skeletal Muscle Atrophy and Hypertrophy: Mechanisms and Therapeutic Perspectives.
Miaomiao Xu, Xiaoguang Liu
Ribosome biogenesis, regulated primarily by the mTORC1/Pol I signaling axis, serves as a critical rate-limiting determinant of muscle plasticity, where its expansion is required for hypertrophy and its early suppression drives muscle atrophy in aging, disuse, and disease.
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HochRCT2026
The effects of reduced protein diet supplemented with arginine plus glutamine-glutamate on growth performance, diarrhea incidence, blood metabolites, nutrient digestibility, and nitrogen utilization in nursery pigs.
Lucas Medina Teixeira, Jansller Luiz Genova et al.
Reducing dietary crude protein (CP) from 22.5% to 18.0%, even with arginine plus glutamine–glutamate (AGG) supplementation, linearly decreased feed efficiency (G:F) by 0.015 for each 1.0% CP reduction and compromised growth performance, but significantly reduced diarrhea incidence by 3.55% points per 1.0% CP reduction and nitrogen excretion in nursery pigs.
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Sehr niedrig2026
Growth performance and bone zinc concentration in broiler chickens with dietary supplementation of organic zinc.
Hansol Kim, Tuoying Ao et al.
10 mg/kg organic zinc was sufficient for maximizing growth performance in broilers, while at least 16.5 mg/kg was required to maximize skeletal zinc deposition, effectively replacing 40 mg/kg inorganic zinc for comparable outcomes.
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Sehr niedrigNarrative Review2026
Emerging strategies in senotherapeutics: from broad-spectrum senolysis to precision reprogramming.
Weidong Zhang, Shijie Song et al.
Next-generation senotherapies, including CAR-T cells, PROTACs like DT2216, and microbiome modulators, are evolving to overcome the toxicity and inconsistent efficacy of first-generation senolytics by shifting toward tissue-precision targeting and immune-based clearance.
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Sehr niedrigNarrative Review2026
From diet to brain repair: natural bioactive compounds in post-ischemic stroke recovery.
Fan Bu, Zicheng Zhang et al.
Natural bioactive compounds such as resveratrol, curcumin, and omega-3 fatty acids target multiple pathways including oxidative stress, inflammation, and neurogenesis to support post-ischemic stroke recovery, though clinical efficacy remains limited by low bioavailability and inconsistent trial results.
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Sehr niedrigNarrative ReviewMensch2026
The interplay of dietary sugar, chronic inflammation, and bladder cancer: mechanistic insights, evidence, and prevention strategies.
Larisa Tratnjek, Aleksandar Janev et al.
High dietary sugar intake is linked to increased bladder cancer risk through mechanisms involving metabolic dysregulation, gut microbiota imbalance, chronic inflammation, and oxidative stress.
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Sehr niedrigNarrative Review2026
Rhythms of life: melatonin, nutrition, sleep, and antioxidant strategies for healthy aging.
Cristina Manuela Drăgoi, Ion-Bogdan Dumitrescu et al.
Age-related melatonin decline acts as a mediator of physiological aging, but its restoration through timed supplementation and dietary chronobiotics—such as tart cherries, kiwifruit, and tryptophan—can mitigate oxidative stress, improve sleep architecture, and preserve circadian integrity.
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Sehr niedrigMaus2026
Metal uptake systems underpin Enterococcus faecalis virulence in both non-diabetic and diabetic wound infection models.
Debra N Brunson, Ling Ning Lam et al.
The ability to acquire essential trace metals is critical for *E. faecalis* wound infection, with diabetic mice exhibiting higher bacterial burdens and impaired nutritional immunity, particularly iron restriction, compared to normoglycemic mice.
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Sehr niedrigMensch2026
Bioactive aporphines and flavonoids from a fermented beverage target metabolic inflammatory pathways in obesity and type 2 diabetes.
Xiurong Wu, Yang Qiu et al.
FH03FS, a sterilized fermented beverage containing bioactive aporphines and flavonoids, demonstrates potential for combating obesity and type 2 diabetes through a multi-target mechanism involving metabolic and inflammatory processes, as supported by phytochemical profiling, network pharmacology, molecular docking, and molecular dynamics simulations.
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Sehr niedrigNarrative ReviewMensch2026
Mechanistic Modulation of Autophagy by Bioactive Natural Products: Implications for Human Aging and Longevity.
Maroua Jalouli, Abdel Halim Harrath et al.
Bioactive natural products, including specific polyphenols, alkaloids, terpenoids, and carotenoids, promote healthy longevity by precisely modulating autophagy through the activation of AMPK, SIRT1, and TFEB pathways and the inhibition of mTORC1.
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Sehr niedrigRatte2026
Molecular insights into the protective role of nano-naringin in mancozeb-induced testicular damage and infertility.
Eman I Hassanen, Sara S Elbagwry et al.
Chitosan-coated naringin nanoparticles (NARNPs) significantly outperform free naringin in mitigating mancozeb-induced testicular toxicity by restoring sperm quality, testosterone levels, and steroidogenic gene expression while reducing oxidative stress.
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Sehr niedrigMensch2026
Micronutrient intake and predictors of adequacy in female collegiate dancers consuming low-energy diets.
Samantha Brooks, Ann Frost et al.
A majority of female collegiate dancers fail to meet RDA/AI for iron (80%), vitamin D (69%), calcium (67%), omega-3s (63%), and folate (59%), with adequacy primarily predicted by higher total energy intake and the use of dietary supplements.
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Sehr niedrigNarrative ReviewMensch2026
The Role of Ketogenic Diet and β-Hydroxybutyrate in the Prevention of Muscle Catabolism and Sarcopenia in Aging Populations: Mechanisms, Evidence, and Clinical Perspectives.
Claudia Venturini, Giulia Matacchione et al.
β-Hydroxybutyrate (βOHB) acts as a signaling molecule that preserves muscle mass and function by inhibiting HDACs, reducing oxidative stress and inflammation, and enhancing mitochondrial biogenesis and mTORC1 signaling.
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Sehr niedrigNarrative ReviewMensch2026
Spices and Essential Oils in Food Preservation: From Natural Additives to Active Packaging Systems.
Olena Stabnikova, Viktor Stabnikov et al.
Spices and their essential oils (EOs) demonstrate significant potential as natural antimicrobial and antioxidant agents for food preservation, enhancing food safety, inhibiting microbial growth, reducing oxidative degradation, and extending shelf life across various food products, with advanced delivery systems further improving their efficacy and application.
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Sehr niedrig2026
Divergent jejunal cis- and trans-eQTLs and their microbiome associations following a diet lacking mineral phosphorus supplements in laying hens.
Yosef A Abitew, Henry Reyer et al.
The study identified 114 miR-eQTLs and 123 mRNA-eQTLs in laying hens, revealing that phosphorus utilization is governed by strain-specific genetic architectures where LB hens exhibit strong cis-regulation of key transporters like CALB1 and SLC34A2, while LSL hens rely more on trans-regulatory mechanisms, both of which are significantly correlated with specific gut microbiota such as Lactobacillus and Turicibacter.
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Sehr niedrig2026
Do fermented herbal extracts affect pig behavior, health and productivity? An on-farm study.
Natalia Nöllenburg, Barbara Metzler-Zebeli et al.
Supplementation with a 1% fermented herbal extract significantly reduced tail tissue loss during rearing (7.2% vs. 38.8%) and decreased respiratory symptoms during fattening, although it did not significantly impact productivity or slaughterhouse pathologies.
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Sehr niedrigMaus2026
Alcohol consumption in metabolic dysfunction-associated steatotic liver disease (MASLD): understanding the gut-liver crosstalk for clinical translation.
Raquel Benedé-Ubieto, Olga Estévez-Vázquez et al.
Combined alcohol and Western diet synergistically exacerbates steatotic liver disease by disrupting the gut-liver axis, leading to increased intestinal permeability, hepatic inflammation, and impaired lipid metabolism, with gut dysbiosis playing a causal role.
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Sehr niedrigMaus2026
Spatial transcriptome mapping identifies Ppara-Anxa2 cross-talk in microplastic-induced hepatotoxicity.
Woncheol Jung, Hassan Abushukair et al.
Polyethylene (PE) microplastic exposure induces significant hepatotoxicity and exacerbates diet-induced steatohepatitis in mice by disrupting lipid metabolism and nuclear receptor signaling, with spatial transcriptomics revealing inflammatory hotspots characterized by reduced cellular diversity and a key Ppara-Anxa2 axis, particularly active in pericentral hepatocytes, as a critical mechanism in the liver's response.
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Sehr niedrigMaus2026
A Molecular and Functional Investigation of the Anabolic Effect of an Essential Amino Acids' Blend Which Is Active In Vitro in Supporting Muscle Function.
Lorenza d'Adduzio, Melissa Fanzaga et al.
The Gunaminoformula (GAF) essential amino acid blend demonstrated high intestinal bioavailability (over 50% for all EAAs) and significantly enhanced muscle cell metabolism by activating Akt-mTORC1-GSK3 and AMPK pathways, leading to a 200.6% increase in functional glucose uptake.
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Sehr niedrigNarrative ReviewMensch2026
Gastrointestinal Journey of Human Milk Oligosaccharides: From Breastfeeding Origins to Functional Roles in Adults.
Yosuke Komatsu, Megumi Furuichi et al.
Human milk oligosaccharides (HMOs) exert region-specific benefits across the gastrointestinal tract by inhibiting pathogen adhesion in the upper GI tract and acting as selective prebiotics and barrier enhancers in the lower GI tract, with clinical evidence supporting their safety and efficacy in improving IBS symptoms and microbiota composition in adults.
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ModeratRCT2026
Dietary supplementation with 25-hydroxycholecalciferol is more effective than cholecalciferol in improving reproductive performance in aged duck breeders.
Yating Li, Yongyan Jin et al.
Dietary supplementation with 25-hydroxycholecalciferol (25-OH-D3) is more effective than cholecalciferol (VD3) in improving egg production, hatchability, and ovarian development in aged duck breeders, with a relative bioavailability of 211% based on plasma concentrations.
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Sehr niedrig2026
Microencapsulated Ganoderma lucidum extract improves antioxidant capacity, intestinal morphology, and nutrient digestibility in free-range laying hens under tropical conditions.
Tonglian Buwjoom, Piyaphat Petwattanapha et al.
Microencapsulated Ganoderma lucidum extract (MGE) significantly mitigates heat stress in laying hens by improving antioxidant capacity (reducing MDA by up to 47%), enhancing intestinal morphology and nutrient digestibility, and producing eggs with lower cholesterol and superior polyunsaturated fatty acid profiles.
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Sehr niedrigMensch2026
Effects of Oil Properties on Stability Behavior of High-Energy-Density Fat Emulsions.
Xianmin Xu, Wei Zeng et al.
The stability of high-energy-density emulsions is primarily determined by oil chain length and unsaturation, with medium-chain fatty acids (MCFAs) providing the highest stability (TSI 0.35) through smaller particle sizes, higher zeta potentials, and superior rheological properties compared to long-chain fatty acids.
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Sehr niedrig2026
Ultra-processed foods and cardiometabolic risk: from evidence to policy.
Hayley M O'Neill
Evidence from randomized controlled trials and observational studies confirms that high ultra-processed food (UPF) intake drives excess calorie consumption (approx. 500 kcal/day) and increases risks for obesity, type 2 diabetes, cardiovascular disease, and all-cause mortality.
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Sehr niedrigFall-KontrollMensch2026
Nutritional status, dietary antioxidant capacity, and dietary diversity in patients with newly diagnosed hematological malignancies: a case-control study.
Busra Nur Koyuncu, Merve Yilmaz et al.
Patients with newly diagnosed hematological malignancies exhibit significantly higher rates of malnutrition (61.8% per GLIM) and lower dietary total antioxidant capacity (3.85 vs. 8.68 mmol/day) compared to healthy controls.
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Sehr niedrigNarrative ReviewMensch2026
Adult Neurogenesis in Neurodegenerative Diseases: Mechanisms of Dysregulation in Alzheimer's and Parkinson's Disease.
Magdalena Dębiec, Marcin Rojek
Adult neurogenesis, crucial for brain plasticity and regeneration, is significantly impaired in Alzheimer's and Parkinson's diseases due to factors like inflammation, oxidative stress, and signaling pathway disturbances, which inhibit new neuron proliferation, differentiation, and survival, thereby contributing to cognitive dysfunction.
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NiedrigProspektivMensch2026
Genome-Wide Variations of End Motif in Cell-Free DNA Fragments Distinguish Immunotherapy Responders from Non-Responders in Head and Neck Cancer: A Multi-Institute Prospective Study.
Ravi Bandaru, Hailu Fu et al.
The regional motif diversity score (rMDS), a novel cfDNA fragmentomic metric, effectively distinguishes immunotherapy responders from non-responders in HNSCC, with a machine learning classifier achieving robust predictive performance (AUC 0.89–0.99) and correlating with improved disease-free survival.
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Sehr niedrigNicht-randomisiertMensch2026
Gut Microbiota Changes Following Aerobic Exercise in Malnourished Octogenarians: An Assessor-Blinded Intervention Study Stratified by Nutritional Status.
Huizhi Yang, Jiahao Li et al.
After a 12-week aerobic exercise intervention, malnourished octogenarians exhibited higher post-intervention microbial richness and diversity compared to healthy octogenarians, with distinct taxonomic and predicted functional profiles, although causality remains uncertain due to the absence of a control group.
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Sehr niedrig2026
Lack of gastric acidification reduces postprandial energy expenditure and protein digestion but not growth in Astyanax mexicanus.
Patrícia Gomes Ferreira, Hugo Flávio et al.
The absence of gastric acidification in *atp4a*-null *Astyanax mexicanus* significantly reduces post-prandial energy expenditure and protein digestibility, leading to altered carcass mineral and lipid composition, although growth rate is not significantly affected over an 8-week trial.
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Sehr niedrig2026
Apple pomace and hempseed cake can reduce methane intensity (CH₄/DMI) and alter the rumen microbiome in dairy cows: a shotgun metagenomic approach.
Abdolvahab Ebrahimpour Gorji, Benchu Xue et al.
In a 24-day study, apple pomace (AP) and hempseed cake (HC) significantly lowered methane intensity (CH4/DMI) in dairy cows by inducing microbial and functional shifts in the rumen, without negatively impacting feed intake or milk yield.
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Sehr niedrig2026
Specific regulation of muscle protein metabolism in broilers by dietary fermented cottonseed meal.
Lianqing Wei, Yun Xu et al.
Supplementation with fermented cottonseed meal (FCM) at 6% enhanced protein synthesis and inhibited protein degradation in broiler muscles, with greater effects observed during the early-growth phase.
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Sehr niedrigMaus2026
Dietary Taurine Enhances Intestinal Digestion, Absorption, and Villus Morphology in Mice.
Jingxia Kong, Jianjun Chen et al.
Dietary taurine supplementation enhances intestinal digestion, absorption, and epithelial renewal in mice, improving baseline intestinal physiology and conferring resilience against acute inflammatory injury by upregulating intestinal stem cell markers.
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Sehr niedrigIn vitro2026
Investigation of the enzyme-inhibitory, antibacterial, and anticancer properties of metal phthalocyanines.
Meryem Topal, Fevzi Topal et al.
The synthesized phthalonitrile derivative and its metal phthalocyanines demonstrated varied antibacterial activity, inhibited both acetylcholinesterase and butyrylcholinesterase with notable potency from InPc and CuPc, and exhibited high cytotoxicity against MCF-7 breast cancer cells, with CuPc being the most potent.
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HochRCTMensch2026
Determinants of Infant and Young Child Feeding Practices of Children With Severe Acute Malnutrition in Agrarian and Pastoralist Settings of Ethiopia.
Mohammed Areb, Lieven Huybregts et al.
Caregiver literacy, caregiver dietary diversity, access to improved water, older child age, and community engagement were positively associated with selected infant and young child feeding practices among children with severe acute malnutrition, while caregiver depression, household food insecurity, and mobility restrictions were linked to poorer practices.
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Sehr niedrig2026
25-Hydroxyvitamin D 3 supplementation improves growth performance and alleviates weaning stress in calves by modulating intestinal microbiota and metabolic pathways.
Wei Zhu, Xinyu Liu et al.
Dietary 25-hydroxyvitamin D3 supplementation significantly improved calf growth performance, starter intake, and antioxidant capacity, while reducing inflammatory response and intestinal permeability, by modulating intestinal microbiota and metabolic pathways.
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Sehr niedrigNarrative ReviewIn vitro2026
In vitro digestion models in food chemistry: advancements, challenges, and applications in nutrient bioaccessibility and bioavailability.
Farhang Hameed Awlqadr, Mohammed N Saeed et al.
In vitro digestion models, when integrated with advanced analytical instruments and absorption simulators, offer a cost-effective and reproducible alternative to in vivo studies for assessing nutrient release, transformation, and absorption, though standardization and microbiome representation remain key challenges.
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Sehr niedrigQuerschnittMensch2026
Plasma Amino Acids as Correlates of Serum Insulin-Like Growth Factor 1, Linear Growth, and Fat-Free Mass: A Cross-Sectional Study among Ugandan Children with Stunting.
Anni Larnkjær, Joseph Mbabazi et al.
In stunted children, most plasma amino acids were positively associated with serum IGF-1, but only a few were associated with linear growth (HAZ) or fat-free mass (FFM), and animal-source food intake was not a strong correlate of plasma amino acids.
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Sehr niedrig2026
Countering the negative effects of dietary soybean (SB) meal in Nile tilapia with organic acid salts.
Abeer Awad, Hanan A Ghetas et al.
Supplementation with sodium propionate and sodium butyrate, particularly in combination, effectively counteracted the negative effects of high soybean meal diets in Nile tilapia, leading to improved growth, feed efficiency, digestive enzyme activities, antioxidant status, intestinal morphology, and modulated gene expression.
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Sehr niedrigRatte2026
Bioavailability of Ferric Pyrophosphate and Ferric Orthophosphate with/without Extrusion and/or Citric Acid and/or Trisodium Citrate in Rats and In Vitro INFOGEST Digestion and Caco-2 Cell Model.
Jiejia Zhang, David B Akinbo et al.
Formulations of micronized ferric pyrophosphate (μFePP)/ferric pyrophosphate (FePP) with a high molar ratio of citric acid (CA) and trisodium citrate (TSC) are promising for rice fortification, with high ratio FePP and μFePP being superior to high ratio ferric orthophosphate (FePO4) in increasing hepatic iron concentrations in rats.
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Sehr niedrigMensch2026
Modelling the impact of dietary diversity on child nutrition in Pakistan: a machine learning analysis with Shapley Additive exPlanations and Boruta interpretability.
Muhammad Shahid, Jiayi Song et al.
Adequate dietary diversity (consuming five or more food groups) is protective against malnutrition in children under five in Pakistan, while consuming fewer than five food groups is a significant risk factor.
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Sehr niedrigQuerschnittMensch2026
Food sources of choline and their contribution to choline adequacy in U.S. older adults.
Asuka Suzuki, Jessica E Keller et al.
Whole eggs and egg-based dishes were the primary contributors to choline intake in U.S. older adults, with higher consumption observed in the quartile with the highest choline adequacy.
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HochRCTMensch2026
Polyphenols increase circulating lipids but improve LDL particle quality and reduce LDL oxidation in postmenopausal women: metabotype- and age-dependent effects in a randomised, placebo-controlled crossover trial.
María García-Nicolás, María Paula Jarrín-Orozco et al.
Polyphenol supplementation in postmenopausal women increased total cholesterol, LDL-cholesterol, and triglycerides in an age-dependent manner, but improved LDL particle quality and reduced oxidized LDL, with the extent of oxidized LDL reduction varying by gut microbiota metabotype.
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Sehr niedrigMensch2026
Development of a blueprint for plant-derived hospital meals: a multidisciplinary co-creative study.
M A van Bree, H M Kruizenga et al.
Fully plant-derived hospital meals can provide adequate, palatable, and cost-effective protein for clinical use, although trade-offs exist between protein quality, taste, cost, and portion size.
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Sehr niedrig2026
Butyrate combined with niacin enhances intestinal barrier function repair in weaned piglets infected with ETEC by promoting colonic metabolism and antimicrobial peptide expression.
Qingsong Tang, Rui Zhen et al.
Dietary supplementation with a 100:2 ratio of coated butyrate and niacin (BN2) improved growth performance, colonic metabolism, and colonic barrier function in weaned piglets, alleviating ETEC-induced dysfunction by regulating antimicrobial peptide expression via H3K27ac promotion.
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Sehr niedrigMetaanalyseMensch2026
Health Effects of Plant-Based Diets in People with Overweight or Obesity: A Systematic Review and Meta-Analysis.
Ildikó Csölle, Viktória Cseh et al.
Plant-based diets may offer modest improvements in BMI, LDL cholesterol, and HbA1c for individuals with overweight or obesity, but the evidence is limited and of low to very low certainty, with most outcomes showing little to no difference compared to omnivorous diets.
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Sehr niedrigNarrative ReviewMensch2026
Intermittent Fasting and Androgen Receptor Signaling in Prostate Cancer: Metabolic Crosstalk and Therapeutic Implications.
Grażyna Gromadzka, Maria Bendykowska
Intermittent fasting (IF) shows promise as a metabolic intervention in prostate cancer (PCa) by modulating androgen receptor (AR) signaling and tumor metabolism, potentially enhancing sensitivity to AR-targeted therapies, with preclinical studies indicating reduced AR expression and signaling, though clinical evidence remains preliminary and requires further investigation.
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Sehr niedrigNarrative ReviewMensch2026
Nutritional Monitoring During Gender-Affirming Hormone Therapy: Body Composition and Metabolic Implications.
Martina Tosi, Fabrizia Lisso et al.
Gender-affirming hormone therapy induces significant, sex steroid-related changes in body composition and metabolism that are not adequately captured by conventional assessment models derived from cisgender populations, necessitating a multidimensional, longitudinal framework for nutritional management with distinct priorities for transgender men and transgender women.
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Sehr niedrigNarrative ReviewRatte2026
From Parallel Programming to Bidirectional Crosstalk: The Brain-Kidney Axis in Cardiovascular-Kidney-Metabolic Syndrome.
Chien-Ning Hsu, You-Lin Tain
Cardiovascular–kidney–metabolic (CKM) syndrome is a life-course disorder driven by persistent oxidative stress and maladaptive brain–kidney crosstalk, necessitating integrated strategies including early-life reprogramming, nutritional optimization, microbiome modulation, and pharmacological therapies for effective management.
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Sehr niedrigNarrative ReviewIn vitro2026
Impact of Nutrition on Embryo Production in Cattle: Mechanistic Insights.
Ramanathan Kasimanickam, Vanmathy Kasimanickam
Nutrition is fundamental to cattle embryo production efficiency, with adequate energy, macronutrients, micronutrients, and metabolic stability supporting follicular development, oocyte competence, and embryo survival, while negative energy balance and oxidative stress limit assisted reproductive technology outcomes.
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ModeratProspektivMensch2026
Association of plant-based diet with cardiometabolic multimorbidity trajectory: A prospective study in UK Biobank.
Shimin Chen, Chao Chen et al.
Higher adherence to plant-based diets (PDI) and healthy plant-based diets (hPDI) is associated with a reduced risk of transitioning from cardiometabolic disease-free status to first cardiometabolic disease (FCMD) and cardiometabolic multimorbidity (CMM), while hPDI and unhealthy plant-based diets (uPDI) are associated with mortality risk.
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Sehr niedrigFall-KontrollMensch2026
Determinants of low birth weight babies delivered at paropakar maternity and Women's hospital: A case-control study.
Sadiksha Pokhrel, Paras Kumar Pokharel et al.
Maternal educational status, per capita income, parity, hemoglobin level, period of gestation, pre-pregnancy weight, history of chronic medical illness, illness during pregnancy, and vegetarian diet were identified as independent risk factors for low birth weight in babies delivered at Paropakar Maternity and Women’s Hospital.
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ModeratRCTMensch2026
Randomised feasibility trial of a remotely delivered holistic UK employee programme combining tailored sleep hygiene, diet, and physical activity counselling for weight management: a mixed-methods evaluation.
Andrea Du Preez, Danae Marshall et al.
This feasibility trial suggests that a remotely delivered sleep-enhanced intervention (SEI) integrating sleep, PA, and diet may support multi-behavioural change, showing potential benefits in eating behaviour, objective PA, sleep hygiene, and anxiety, although rapidly introducing multiple behavioural components may hinder long-term adherence.
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Sehr niedrig2026
The Impact of Nutrition Education Based on the PRECEDE-PROCEED Model on Improving the Nutritional Status and Growth Status of 7-12-Year-Old Malnourished Children in Kermanshah.
Fatemeh Maleki, Shaghayegh Sharifi Soltani et al.
Nutrition education based on the PRECEDE-PROCEED Model significantly improved malnourished children's knowledge, attitude, self-efficacy, and behavior, leading to enhanced dietary intake and improved Weight for Age Percentile (WFA) and BMI for Age Percentile (BFA), but not Height for Age Percentile (HFA) in the short term.
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Sehr niedrigIn vitro2026
Investigation Into the Variations in the Interactions Between Different Selenium Sources and Gut Microbiota.
Meiyu Yuan, Yihong Li et al.
The molecular characteristics of polysaccharides significantly influence the bioavailability, microbial community composition, and metabolic pathways of selenium, with positively charged polysaccharides like chitosan (CS) and chitosan quaternary ammonium salt (HACC) enhancing microbial utilization of selenium nanoparticles and promoting beneficial gut microbiota and short-chain fatty acid production.
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NiedrigProspektivMensch2026
Healthy dietary patterns, longevity genes, and life expectancy: A prospective cohort study.
Yanling Lv, Jing Song et al.
Greater adherence to five healthy dietary patterns (AHEI, AMED, hPDI, DASH, DRRD) was consistently associated with reduced all-cause mortality and prolonged life expectancy, irrespective of genetic predisposition to longevity.
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Sehr niedrig2026
Embryonic nano lauric acid delivery modulates lipid metabolism, oxidative balance, and gut morphogenesis in broiler chicks.
Mostafa Mohamed Soliman, Saad N El-Shater et al.
In ovo injection of 2.5 mg/egg nano-lauric acid (NLA) improved serum lipid profiles, hepatic antioxidant defenses, growth-related gene expression, and intestinal development in broiler chicks, while a higher dose of 5 mg/egg negatively impacted hatchability and induced metabolic stress.
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Sehr niedrig2026
Supplementing Lactobacillus brevis metabolite modifies carcass performances, characteristics of meat, taste-related compounds and fatty acid profiles of heat stressed Chikso cattle.
Farouq Heidar Barido, Puruhita et al.
Supplementing rumen-protected Lactobacillus brevis metabolites (LBMs) to heat-stressed Chikso steers significantly improved growth performance (average daily gain and weight gain) and enhanced meat quality, including increased protein content, reduced cooking loss, suppressed lipid oxidation, and improved freshness indicators, while also reducing saturated fatty acids and increasing EPA.
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Sehr niedrigNarrative Review2026
The Rise of Plant-Based Proteins: Consumer Perception and Challenges.
Batuhan Inanlar, Esra Capanoglu
Plant-based foods offer significant health and sustainability benefits, with a growing market, but face challenges in consumer perception (taste, price, neophobia), regulatory labeling restrictions, and nutritional limitations compared to animal proteins.
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Sehr niedrigNarrative ReviewMensch2026
The role of gut microbiota-immune-endocrine crosstalk in the pathogenesis of osteoporosis.
Xingwen Xie, Xin Chen et al.
The gut microbiota–immune–endocrine interactive system is crucial in osteoporosis pathogenesis, where dysbiosis promotes bone loss by exacerbating inflammation, compromising the gut barrier, and disrupting hormonal signals.
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Sehr niedrigNarrative ReviewMensch2026
B vitamins intake and cancer risk: a structured narrative review of evidence on riboflavin, pyridoxine, cobalamin and folate.
Alexander Bertuccioli, Chiara Maria Palazzi et al.
Vitamin B6 shows potentially protective associations, particularly for gastrointestinal cancers, while folate's effects are context-dependent and vitamin B12 associations are inconsistent, with current evidence not supporting high-dose B-vitamin supplementation for primary cancer prevention.
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Sehr niedrig2026
Yeast culture derived from Jiang-flavor Baijiu distiller's grains enhances immune function and gut health in geese.
Pan Tao, Fei Zhang et al.
Dietary supplementation with 6%-10% yeast culture derived from Jiang-flavor Baijiu distiller's grains (JBGC) improved immune function, antioxidant capacity, and gut health in Magang geese by promoting villus growth, stabilizing tight junctions, and modulating immune responses.
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Sehr niedrigRatte2026
Multi-target litholytic strategy toward calcium oxalate stone therapy: a fundamental study.
Shasha Xia, Kaiwen Shen et al.
MTCLS demonstrated superior in vitro dissolution efficacy for calcium oxalate stones compared to citrate and showed acceptable short-term biosafety in an animal study without significant adverse effects.
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Sehr niedrig2026
Evaluating poultry by-product meal, tomato pomace, and azolla with or without Natuzyme supplementation as sustainable alternatives to fish meal for Nile tilapia (Oreochromis niloticus).
Ahmed M Kamel, Manal M Mahmoud et al.
Poultry by-product meal (PBM) is a cost-effective and comparable alternative to fish meal (FM) for Nile tilapia, with azolla also showing potential, while tomato pomace showed less favorable results unless supplemented with enzymes.
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Sehr niedrigSystematic ReviewMensch2026
Long-term effects of plant vs. animal protein supplementation on body composition, muscle strength, physical performance, and cardiometabolic risk factors in adults:a systematic review and meta-analysis of randomized controlled trials.
Mohammed Ahmed Yimam, Justin Roberts et al.
Long-term supplementation with plant-based protein, primarily soy, did not result in statistically significant differences compared to animal-based protein in body composition, muscle strength, physical performance, or cardiometabolic risk factors in adults.
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NiedrigProspektivMensch2026
Spatio-temporal patterns and prediction of colorectal cancer mortality in Chinese cancer registration areas: A nationwide study based on multiple models.
Yu Zhao, Xiaoshuang He et al.
Colorectal cancer mortality in Chinese cancer registration areas showed an upward-downward-upward trend from 2005 to 2018 and is predicted to generally rise from 2019 to 2035, with persistent urban-rural, gender, and regional inequalities.
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Sehr niedrigProspektivMaus2026
Association between maternal iron deficiency and delayed neonatal auditory maturation and altered cochlear synaptic energy metabolism: analysis from a mother-infant observational study, mouse models, and cochlear explants.
Yi Zhao, Rui Hou et al.
Non-anemic maternal iron deficiency is associated with delayed neonatal auditory maturation, characterized by prolonged auditory brainstem response latencies and altered cochlear synaptic energy metabolism, as evidenced by human observational data and supported by mouse models and cochlear explant experiments.
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Sehr niedrigNicht-randomisiertMensch2026
Changes in MoCA scores with sequential administration of Trikatu Cūrṇa and Brahmi Ghṛta in mild cognitive impairment: an exploratory single-arm clinical study.
Saurav Sharma, Devipriya Soman et al.
The sequential administration of Trikatu Cūrṇa and Brahmi Ghṛta significantly improved overall cognitive scores (MoCA) by an average of +5.63 points in participants with mild cognitive impairment, with a large effect size (Rosenthal’s r = 0.879) and no reported adverse events.
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Sehr niedrigQuerschnittMensch2026
Association of Long-Term Proton Pump Inhibitor Use With Nutrient Deficiencies: A Retrospective Cross-Sectional Study.
Sarah Nafea, Chinenye Iguh et al.
Long-term proton pump inhibitor (PPI) use was associated with a high prevalence of vitamin B12, magnesium, and calcium deficiencies, with significant differences observed based on the type of PPI used.
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HochRCT2026
Efficacy of dietary onion powder (Allium cepa L.) as a phytogenic feed additive: Effects on growth performance, blood biochemistry, gut morphology, and immune function in broiler chickens.
Qiu Zhong, F Raziq et al.
Dietary supplementation with onion powder (4 g/kg feed) significantly improved growth performance, gut morphology, serum biochemical profiles, and immune responses in broiler chickens.
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Sehr niedrigNarrative Review2026
Clinical evidence for microbial-derived polyphenol metabolites in health and disease: a scoping review.
Jennie Brown, Lydia Norby-Adams et al.
Specific microbial-derived (poly)phenol metabolites (MPMs) are recurrently associated with cardiometabolic, inflammatory, neurological, and gastrointestinal health outcomes, with urolithins and phenolic acid derivatives showing the most consistent links, although substantial heterogeneity in study design limits definitive conclusions.
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HochRCTMensch2026
Maternal supplementation of vitamin B 12 in predominantly vegetarian pregnant women improves their vitamin B 12 status and the neurodevelopment of their infants: the MATCOBIND multicentric double-blind randomised control trial.
Jitender Nagpal, Manu Mathur et al.
Daily 250 µg vitamin B12 supplementation in vegetarian pregnant women significantly improved infant mental developmental quotients (DQs) and maternal B12 status compared to a 50 µg dose, with a more pronounced effect in Indian infants.
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