Sultan Aydin, Ayse Oz et al.
Sublingual methylcobalamin is an effective, safe, and non-invasive treatment for prolonged neonatal jaundice due to vitamin B12 deficiency, showing higher serum vitamin B12 levels at 1.5 months compared to intramuscular cyanocobalamin.
Emelie von Wascinski, Julijana Vracaric et al.
Pretreatment weight loss greater than 10% is consistently associated with worse survival outcomes in head and neck cancer patients, while the prognostic impact of weight loss during or after radiotherapy is inconsistent.
Cui Ma, Md Abul Kalam Azad et al.
Modifying the maternal diet of laying hens allows for the precision enrichment of eggs with omega-3 fatty acids, antioxidants, and micronutrients, potentially providing up to 150% of the RDA for Vitamin E and 50% for selenium and iodine.
Iga Pawłowska, Karolina Kuźbicka et al.
Most novel cardiovascular and antidiabetic drugs show clinically insignificant food effects on bioavailability, with exceptions including vericiguat and higher doses of rivaroxaban which are better absorbed with food, and oral semaglutide which has significantly reduced bioavailability when taken with food.
Mohd Faisal Khan, Mohammed Al-Zharani et al.
Trimester-specific nutritional counseling significantly improved maternal vitamin D status and dietary practices in Indian pregnant women, but did not show a significant association with birthweight, with gestational weight gain and overall dietary intake being more influential factors for fetal growth.
Jack C Hanna, Shikha Shikha et al.
Acute iron deprivation in *Toxoplasma gondii* triggers translational repression, proteomic changes, and a metabolic shift towards glycolysis, impairing mitochondrial function and rewiring central carbon metabolism for survival.
Alba Galafat, Isabel Del Carmen Ruiz-Rodríguez et al.
Microalgae-derived functional ingredients, particularly LB-IMMUNOboost, partially mitigated the negative impacts of high plant-based diets on gilthead seabream growth, muscle composition, and digestive function, while LB-LIVERprotect showed a more limited effect on growth and muscle but may support liver function.
Runze Guo, Rui Zhang et al.
A simple seven-item lifestyle risk score was developed and validated, showing a significant positive association with atrophic gastritis (AG) risk, where each 1-point increase in the score was associated with a 51% increase in AG risk (adjusted OR = 1.506) and a high-risk group (score ≥3) had a 3.614-fold increased AG risk compared to the low-risk group (score 0–1).
Erlend Nuland Valen, Andrew Keith Wills et al.
The PREPARED digital intervention did not lead to significant improvements in diet quality or micronutrient adequacy in young adults aged 20-35, with high loss to follow-up impacting the results.
Gladwel Kuya Sikoyo, Judith Mangeni et al.
In Siaya County, Kenya, only 19% of children under 5 met the WHO Minimum Dietary Diversity (MDD) threshold, with limited consumption of nutrient-dense foods like pulses, eggs, and flesh foods being a key factor.
Lanmei Yin, Jiaxin Chen et al.
Dietary supplementation with 240 mg/kg indole-3-acetate sodium (IAA-Na) improved jejunal morphology, enhanced nutrient absorption by upregulating nutrient transporters, and modulated inflammatory responses by reducing pro-inflammatory cytokines and increasing anti-inflammatory cytokines in weaned piglets.
Hao-Bo Jiang, Jun-Qi Zhang et al.
The gut microbiota (GM) plays a crucial role in osteosarcopenia (OS) pathogenesis through its influence on the gut-muscle-bone axis, impacting intestinal barrier integrity, systemic inflammation, metabolite production, and nutrient absorption, with potential therapeutic strategies involving diet, probiotics/prebiotics, and exercise.
Maurizio Nordio, Roberto Baldelli
A 2-month supplementation regimen of calcium, vitamin D, vitamin K2, d-chiro-inositol, and α-lactalbumin in six osteopenic patients resulted in significant increases in vitamin D and osteocalcin levels, suggesting potential benefits for bone metabolism despite stable bone mineral density T-scores.
Veronica Lucato, Giulia Mazzola et al.
Nostoc sp. PCC 7120 demonstrates a remarkable iron accumulation capacity, ranging from tens to tens of thousands of mgFe kgX−1, achieved through both intracellular uptake and significant extracellular biosorption, particularly evident in batch cultures.
Yang Song, Shubo Wen et al.
Early-life microbial colonization in ruminants is a dynamic process shaped by colostrum management, diet, and environmental factors, which significantly influences gut barrier function, immune maturation, and long-term milk productivity.
Jieqiong Cai, Weibin Wu et al.
Dietary supplementation with 715 mg/kg of β-hydroxy-β-methyl butyrate (M-HMB) improved growth performance in Tibetan sheep lambs by enhancing intestinal health through Ruminococcus enrichment, improved carbohydrate degradation, increased SCFA production, better antioxidant capacity, immune function, intestinal barrier integrity, and nutrient absorption, leading to greater feed utilization efficiency.
Chongshan Yuan, Xingyuan Zhu et al.
Dietary supplementation with α-linolenic acid (ALA) at levels of 0.5, 1.25, and 2 g/kg significantly improves reproductive performance in male blue foxes by enhancing semen quality, antioxidant capacity, hormone levels, and testicular development, with an optimal level suggested at 1.25 g/kg.
Haiyue Yang, Na Zhang
This randomized controlled trial will assess the efficacy, feasibility, and mechanisms of omega-3 PUFA-enriched eggs in elderly adults with metabolic syndrome by measuring longitudinal changes in fasting triglycerides, lipid metabolism, inflammation, and oxidative stress markers over 12 weeks.
Mehran Alipour, Ayoub Saeidi et al.
Twelve weeks of concurrent interval resistance-aerobic training, particularly when combined with fisetin supplementation, significantly improved inflammation resolution and metabolic control in obese men.
Gina Grimmer, Julia Muenzner et al.
Industrial yeast strains show significant variation in zinc accumulation, with *S. cerevisiae* Sa-07167 accumulating high levels of intracellular zinc coordinated to phosphate and amino acid ligands, resulting in lower bioaccessibility compared to *S. pastorianus* Nr. 42.
Jacob Raber, Thomas J Sharpton
The gut microbiome acts as a critical, modifiable mediator in the gut-brain axis, where dysbiosis and fecal transplants from aged or diseased donors are sufficient to induce cognitive impairment and neuropathological phenotypes in neurodegenerative models.
Cassandra Evans, Jaime Tartar et al.
Individuals with the FTO risk allele exhibited greater cognitive restraint, and physical activity was associated with healthier dietary behaviors, independent of FTO genotype in physically active young adults.
Zefan Huang, Liusheng Xu et al.
The CHG index was independently associated with a significantly increased risk of in-hospital mortality in heart failure patients, with each 1-unit increase associated with a 76.8% increase in mortality risk in the training cohort and a 2.716-fold increased mortality risk in the validation cohort.
Farid Hajareh Haghighi, Roya Binaymotlagh et al.
Lycopene, a potent antioxidant carotenoid, demonstrates diverse therapeutic applications in conditions such as cancer, cardiovascular disease, metabolic disorders, neuroprotection, reproductive health, and viral infections, with nanoformulations significantly improving its bioavailability and efficacy.
Gita Syahputra, Melva Louisa et al.
Zinc-chelating peptides from Holothuria scabra improved zinc status in zinc-deficient rat offspring by enhancing zinc transporter expression, with the lower dose showing comparable or superior effects to higher doses and conventional zinc sulfate.
Lukman Abiola Oluodo, Patipan Hnokaew et al.
Combined supplementation of sunflower oil and Lactiplantibacillus plantarum-R11 improved feed conversion ratio and enhanced meat tenderness and beneficial fatty acids (CLA, PUFA) in crossbred goats without adverse health effects.
Si-Ying Ye, Yi Qu et al.
Defects in neutrophil efferocytosis are a key pathological mechanism in chronic inflammatory gastrointestinal diseases, and restoring efferocytosis through natural products represents a promising therapeutic strategy.
Adrian Odriozola, Adriana González et al.
The thyroid–microbiome–mitochondrial axis is a key regulator of allostatic response in athletes, where microbial metabolites and thyroid hormones reciprocally influence each other and mitochondrial function, with disruptions leading to impaired metabolic flexibility and performance.
Orapa Suteerojntrakool, Patcharapa Thaweekul et al.
Oral nutritional supplement combined with dietary counselling significantly improved weight, height, weight-for-age z-score, and fat-free mass in Thai children aged 1-6 years at risk of or with malnutrition compared to dietary counselling alone.
Guizhi Liu, Chongcong Wu et al.
N-3 PUFAs supplementation may lead to modest weight gain in pancreatic cancer patients, but the evidence is of low certainty and insufficient to support significant improvements in overall nutritional status.
Lufuno Phophi, Haley M Wilt et al.
Maternal milk bile acids activate neonatal TGR5 to promote growth and regulate IGF-1 levels, with maternal diet influencing milk bile acid composition and subsequent offspring growth.
Sirine Belaid, Vikram Raghu et al.
Pancreatic enzyme replacement therapy (PERT) does not significantly improve nutritional status or growth in patients with short bowel syndrome, and even resulted in a significant decrease in mean BMI z-scores (p = 0.03) among those with confirmed pancreatic insufficiency.
Dajeong Bong, Hyunwoo C Kwon et al.
Longevity in C. elegans is regulated by conserved pathways including reduced IIS, DR, mild mitochondrial inhibition, and germline deficiency, which converge on common downstream processes that reinforce proteostasis, RNA homeostasis, metabolic remodeling, and stress resistance.
Li Jin, Feng Gao et al.
Iron accumulation due to ZIP13 RNAi promotes tumor progression via JAK/STAT signalling, mediated by EZH2, with TET regulating iron's effect on EZH2 expression.
Ieva Sateikaite, Yasaman Samaei et al.
In young children in rural Mozambique, high phytate-to-mineral ratios (phy:Zn > 15, phy:Fe > 1, phy:Ca > 0.24) suggest significantly inhibited absorption of zinc, iron, and calcium, contributing to a high prevalence of stunting (32%) and micronutrient deficiencies.
Jennifer L Matthews, Christine Ferrier-Pagès et al.
A nutritional ecology framework, which links coral physiological requirements with environmental nutrient supply and quality, can identify mismatches impacting coral performance under stress and advance restoration practices through targeted interventions like nutrient supplementation.
Chenchen Yu, Chungang Zhang
The RSV-E PO solid dispersion significantly enhanced resveratrol's dissolution and oral bioavailability, leading to improved anti-arthritic efficacy in an AIA rat model with a favorable safety profile.
Lisha Yan, Qiong Wang et al.
Traditional thermal processing of carp scales significantly enhances protein content and generates novel bioactive peptides, leading to superior anti-inflammatory and organ-protective effects against sepsis compared to raw scales.
Ruimiao Wu, Mei Liu et al.
Polydopamine-coated Lactobacillus rhamnosus GG (LGG@PDA) significantly alleviates systemic lupus erythematosus symptoms in mice by enhancing gut survival and promoting L-methionine production, which restores macrophage efferocytosis through the upregulation of CX3CR1.
Yu Wei, Jianghong Wang et al.
The prevalence of nutritional iron deficiency anaemia in Kazakh children aged 3-14 years in Barkol County was 15.7%, with lower meat and aquatic product intake, and failure to take iron supplements identified as independent risk factors.
Xin Li, Miao Xu et al.
The CAMM nanosystem achieves synergistic colitis therapy by combining hypoxia/pH dual-responsive 6-MP delivery with intrinsic ROS-scavenging Azo-MOF properties, resulting in 91.3% cumulative drug release in the colon and significant restoration of gut microbiota homeostasis.
Ana Paula Ribeiro Gaspar, Cíntia Tomaz Sant' Ana et al.
Biofortified cowpeas, particularly the BRS Aracê variety, promoted hemoglobin gain similarly to ferrous sulfate and led to beneficial metabolic changes in iron, glucose, and lipid metabolism, including improved glucose tolerance and insulin response, in anemic rats fed a high-fat/high-sugar diet.
Guido Leone, Marta Arrabito et al.
While ferrous salts are the first-line treatment for iron deficiency in children due to efficacy and cost, newer formulations and optimized dosing strategies (e.g., alternate-day dosing) improve tolerability and adherence, with intravenous iron reserved for severe cases or treatment failure.
Li-Ling Wu, Yu-Jen Liao et al.
FKBP5 deficiency protects against high-fat diet-induced MASLD and obesity by maintaining gut barrier integrity, modulating gut microbiota composition (notably increasing Blautia and Faecalibaculum), and preventing the infiltration of pro-inflammatory myeloid cells into the liver and colon.
Carolina Sousa Monteiro, Eugénia Pinto et al.
Binary mixtures of Penicillium mycotoxins (OTA:CPZ in hepatic cells and OTA:CIT in hepatic and renal cells) showed synergistic cytotoxicity at low effect levels, suggesting that current risk assessments may underestimate the toxicological impact of co-occurring mycotoxins in food.
Kaina Zhu, Yu Zhang et al.
A 12.69% protein diet supplemented with resveratrol and β-hydroxy-β-methylbutyrate synergistically improves jejunal health in Tibetan sheep by enhancing antioxidant capacity, immune response, and barrier function through the modulation of the gut microbiome and metabolome.
Nuno Gomes, Nuno Silva et al.
Higher serum vitamin D and iron levels were inversely related to alopecia, while higher intake of alcoholic and sugary beverages correlated positively with hair loss.
Katie M Hutchins, Carrie H S Ruxton
The complex fruit matrix of 100% fruit juice, particularly its polyphenol and pectin content, distinguishes it from sugar-sweetened beverages by modulating glycaemic response and providing significant vascular benefits, such as reduced blood pressure and arterial stiffness.
Georgios Marinos, Karlis Arturs Moors et al.
The study developed EcoGS, a metabolic modeling tool that predicts microbial ecological interactions, and found that increased simple sugar intake shifts gut microbiome interactions from collaborative to exploitative, while consumption of certain vitamins (B12, K1, B7) is associated with increased collaboration.
Keely Patterson, Emma N Bermingham et al.
Senior cats exhibited significantly greater intestinal permeability (LR ratio: 0.75 ± 0.160) compared to young cats (LR ratio: 0.59 ± 0.139, p = 0.004), while absorptive capacity was similar across age groups but significantly higher in male cats than female cats.
Syamsul Alam, Veni Hadju et al.
Higher genus-level Clostridium abundance was significantly and independently associated with lower weight-for-age z scores (WAZ) in 6-month-old infants (adjusted β = −0.091, P = .03).
Zeweter Abebe, Aklesia Haileyesus
Incorporating 9% fermented cauliflower leaf powder into wheat bread significantly enhances protein by 36% and fiber by 157% while reducing the carbon footprint by 7.5% and water usage by 9%, though lower substitution levels (1%–5%) are required to maintain sensory acceptability.
Yanan Zhang, Yawen Zhu et al.
Engineered live bacteria, including strains like Bifidobacterium, E. coli Nissle 1917, and Bacillus subtilis, demonstrate therapeutic potential for liver diseases by modulating the gut-liver axis, but clinical translation is hindered by insufficient validation and a lack of disease-specific standards.
Shengjie Wu, Xiaojin Jiang et al.
A higher Prognostic Nutritional Index (PNI) is significantly associated with improved overall survival (OS), recurrence-free survival (RFS), and cancer-specific survival (CSS) in non-small cell lung cancer (NSCLC) patients undergoing curative surgery.
Erma Safitri, Tita Damayanti Lestari et al.
Dietary supplementation with a mycotoxin-detoxifier at 1.6 g/kg effectively restored humoral immunity to avian influenza vaccination and prevented histopathological lesions in broilers exposed to AFB1 and OTA, with antibody titers comparable to the negative control group.
Sjanie Huang, Iris Harmsen et al.
Human NPL catabolizes a broad range of sialic acids, including non-canonical forms like KDN and Neu5Gc, and its deficiency leads to the accumulation of both canonical and non-canonical sialic acids.
Qing Zhao, Wanning Li et al.
Dietary Codonopsis pilosula polysaccharides (CPP) significantly increased ileal acetic acid levels, modulated intestinal microbial diversity and composition in the duodenum and cecum, and improved intestinal barrier function (increased Claudin, Occludin, ZO-1 mRNA expression) in Hu sheep, particularly at a 0.15% supplementation level.
Ekta Patel
Dietary interventions such as the Mediterranean, low-glycemic index, and ketogenic diets, along with probiotic supplementation, significantly improve PCOS outcomes by modulating gut microbiome composition to reduce systemic inflammation, insulin resistance, and androgen levels.
Yan Jiang, Dan Xiao et al.
Probiotic therapy significantly reduces the risk of ventilator-associated pneumonia (OR = 0.67; RR = 0.74) and ICU mortality, while shortening the duration of mechanical ventilation and hospital stays in critically ill patients.
Eungyeop Lee, Jum Bum Kwon et al.
Polymeric micelles designed for oral drug delivery face significant challenges in maintaining structural integrity within the gastrointestinal (GI) environment, with evidence suggesting that only highly stable micelles (low CMC, crystalline/high-Tg cores, optimized PEG corona) might function as true nanocarriers, while others may primarily act as transient solubilizers, necessitating a critical evaluation of their complexity compared to simpler formulations like SMEDDS and ASDs.
Martina Brattini, Michelle D'Urso et al.
Bovine milk-derived extracellular vesicles (BMEVs) represent a scalable, biocompatible, and stable drug delivery platform capable of enhancing the bioavailability and therapeutic efficacy of small molecules, polyphenols, and nucleic acids across various administration routes.
Essam Menshawy, Eman N Abd Elazeez et al.
Dietary supplementation with a combination of lactic acid (1 g/kg diet) and rosemary meal (10 g/kg diet) significantly improved growth performance, intestinal morphology, antioxidant status, and immune and growth-related gene expression in Nile tilapia, demonstrating superior effects compared to individual supplementations or control.
Tahani M I Al-Hazani, Amirah S Alahmari et al.
Dietary supplementation with a combination of L-arginine (3 g/kg) and zinc oxide nanoparticles (40 mg/kg) significantly improved growth performance, antioxidant status, stress-related indicators, gut microbiota, and intestinal gene expression in heat-stressed growing rabbits.
Shankaranarayanan Jeyakodi, Arunkanth Krishnakumar et al.
Metaberine™, a novel BioSOLVE-based formulation, significantly enhanced the oral bioavailability of berberine in rats, achieving an 11.3-fold higher Cmax and a 2.6-fold higher AUC0-8 compared to conventional berberine.
Shiyi Ouyang, Ailing Chen et al.
Higher diet quality, as measured by the Chinese Dietary Guidelines Index for Children and Adolescents (CDGI-C), was significantly associated with better bone health in children and adolescents, with a 10-point increase in CDGI-C scores linked to a 0.08-unit increase in SOS Z score (95% CI: 0.04, 0.11) and a 15% reduction in the risk of low SOS (OR = 0.85, 95% CI: 0.76, 0.94).
Minxiao Feng, Wenting Xu et al.
Autoimmune gastritis is a chronic CD4+ T-cell-mediated destruction of gastric parietal cells with a 3.85% global prevalence that significantly increases the risk of gastric adenocarcinoma (3–5 times) and type 1 neuroendocrine tumors (up to 10%), requiring lifelong vitamin B12 supplementation and endoscopic surveillance every 3 to 5 years based on OLGA/OLGIM staging.
Huan Zhang, Yangyang Wang et al.
Interpretable Machine Learning (IML) frameworks, such as SHAP and GNN-based attention mechanisms, transform drug discovery by converting opaque deep learning predictions into biologically actionable insights for ADME optimization, toxicity mitigation, and causal biomarker discovery.
Qianqian Chen, Fajuan Rui et al.
NFIB acts as a critical suppressor of liver fibrosis by transcriptionally repressing CCL5, thereby inhibiting hepatic stellate cell activation, oxidative stress, and the TGF-β/SMAD signaling pathway.
Angelika Krūmiņa, Aigars Reinis et al.
Pseudomonas aeruginosa utilizes a complex integration of structural virulence factors, such as the Type III Secretion System and biofilm-associated exopolysaccharides, alongside adaptive quorum sensing rewiring to transition between acute infection and chronic persistence.
Aleksandra Jaremków, Iwona Markiewicz-Górka et al.
Proper meal composition, particularly a balanced second breakfast, dinner, and supper, is associated with lower BMI, reduced body fat content, increased muscle mass, and improved body hydration in young adults.
Shynggys Sergazy, Zarina Shulgau et al.
Herbal polyphenolic mixtures show promise as multi-target modulators of oxidative stress, inflammation, and tissue remodeling in respiratory diseases, influencing pathways such as Nrf2/HO-1, NF-κB, MAPK, mitochondrial function, and profibrotic processes in preclinical studies, but face significant translational challenges including poor bioavailability, botanical variability, and limited clinical evidence.
Niamat M El-Abd, Ragaa A Hamouda et al.
Emulsified clove oil supplementation in low-energy diets positively influenced broiler performance, carcass traits, blood biochemistry, antioxidant status, and meat quality, with the emulsifier improving nutrient absorption, feed efficiency, and significantly reducing abdominal microflora by approximately 65%.
Wen Li, Junhong Miao et al.
Dietary folic acid (FA) supplementation in laying hens significantly increased egg yolk and whole egg total folate content, primarily 5-methyltetrahydrofolate (5-MTHF), with saturation observed at 5-15 mg/kg FA by week 12, without affecting laying performance or egg quality, though high doses (10 and 15 mg/kg) altered egg yolk flavor.
Stanislava Katsarova-Harrison, Gráinne Whelehan et al.
In individuals post-Roux-en-Y gastric bypass without diabetes, the addition of 2 g sodium chloride to a carbohydrate-rich meal did not significantly alter nadir postprandial plasma glucose or overall glucose homeostasis, but it did reduce peak postprandial plasma glucose (7.8 vs 8.3 mmol/L, 95% CI: -0.88 to -0.08, p = 0.02).
Huina Zhang, Peng Liu et al.
Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) significantly ameliorate NAFLD-associated steatosis, inflammation, and fibrosis by restoring impaired autophagic flux through the activation of the AMPK-mTOR-TFEB signaling pathway.
Hossein Dehghan, Sima Moghaddaszadeh-Ahrabi et al.
Supplementation with Ferula asafoetida extract and raisin pomace tannins, particularly in combination, significantly enhances equine cecal fermentation efficiency by increasing gas production, accelerating fermentation rates, and improving the digestibility of dry matter and crude protein.
Mengqing Hu, Yimiao Zhou et al.
Nano-drug delivery systems, including stimuli-responsive nanoparticles, hydrogels, and exosomes, enhance therapeutic efficacy in diabetes, IBD, and rheumatoid arthritis by providing targeted delivery, reducing systemic toxicity, and modulating immune responses such as M2 macrophage polarization and cytokine inhibition.
Andrea Alonso-Álvarez, Claudia Monika Haros
Incorporating wet-milled quinoa fibre-rich fraction (QFi) into wheat pasta significantly increased dietary fibre and mineral content (Fe, Ca, Zn) while maintaining low phytic acid levels, suggesting improved mineral bioavailability compared to whole quinoa flour (WhQF) enriched pastas.
Marcos José Batista Dos Santos, Carlos Bôa-Viagem Rabello et al.
Partial supplementation of trace minerals (Zn, Mn, Cu) from amino acid-complexed sources (AACM) in Lohmann Brown Lite pullets from 6 to 14 weeks significantly increased tibia calcium (8.5%) and phosphorus (6.9%) content, enhanced tibia bone density (P<0.01), and elevated red blood cells and hemoglobin levels, without affecting growth performance or organ weights.
Yanling Li, Can Sun et al.
Tannins restore gut inflammatory-oxidative homeostasis in ulcerative colitis by inhibiting pro-inflammatory pathways (NF-κB/MAPK), activating Nrf2-mediated antioxidant defenses, and remodeling gut microbiota to favor beneficial taxa like Bifidobacterium.
Yuze Shi, Jinyao Zhang et al.
GSTK1 acts as a tumor suppressor in hepatocellular carcinoma by inhibiting mitochondrial fission and promoting L-carnitine metabolism through competitive binding with PGAM5 to prevent DRP1 recruitment.
Kala K Mahen, William J Massey et al.
The gut microbial metabolite trimethylamine (TMA) and its host receptor TAAR5 form a metaorganismal signaling axis that regulates host circadian rhythms, influencing clock gene expression in the olfactory bulb, metabolic hormone oscillations, and time-of-day-dependent behaviors.
Mariagrazia Turturo, Alessandro Rossi et al.
Newborn screening (NBS) for carnitine uptake deficiency (CUD) effectively identifies affected children, infants of mothers with carnitine deficiency, and heterozygous individuals, but it is associated with a high false positive rate (41.3% of recalled newborns), which can be mitigated by concurrently evaluating free carnitine (C0) and total carnitine (Ctot) values, particularly Ctot ≤19 µmol/L, which showed 100% sensitivity and 94.7% specificity for detecting true CUD cases.
Federica Fogacci, Serra İlayda Yerlitaş Taştan et al.
The D-FISH trial is designed to evaluate whether 600 IU/day of vitamin D3 derived from fish processing by-products is non-inferior to synthetic vitamin D3 in increasing plasma 25(OH)D levels over 12 weeks, using a non-inferiority margin of 5 ng/mL.
Chiara Del Prete, Alessio Ruggiero et al.
Dietary antioxidant supplementation with Oxyliver® modulated oxidative status in breeding stallions, indicated by changes in MDA, FRAP, and TAC, suggesting a positive effect on redox balance during intensive reproductive activity.
Yingxuan Chang, Le Li et al.
Sirtuin 1 (SIRT1) acts as a central metabolic-inflammatory rheostat that attenuates atherosclerosis by regulating 11 key pathways, including the deacetylation of NF-κB, p53, and PGC-1α, which collectively reduce oxidative stress, suppress inflammation, and preserve mitochondrial function across endothelial cells, macrophages, and vascular smooth muscle cells.
Miray Tonk-Rügen, Thorben Schilling et al.
The livestock microbiota-immune axis, particularly the production of natural antibodies (nAbs) against microbial glycans, serves as a critical determinant of host resilience and vector competence, offering a sustainable alternative to chemical acaricides through probiotics, selective breeding, and anti-microbiota vaccines.
Onosolesena D Idiakheua, James Odhiambo Oguta et al.
A significant association exists between nutritional status and physical function in older adults in sub-Saharan Africa, characterized by a high prevalence of various forms of malnutrition and functional impairments.
Patrick Tamatey, John W Boney et al.
Dietary supplementation with 25-hydroxyvitamin D3 and canthaxanthin, with or without copper and gluco-oligosaccharides, consistently increased yolk color in broiler breeder hens from 30 to 41 weeks of age, but showed only limited and transient improvements in albumen height, Haugh unit, shell thickness, lay rate, and feed conversion ratio, with no significant improvements in fertility or hatchability.
Bailey Smith, Kailey Myers et al.
Estrogen signaling through the GPER pathway remains functionally resilient in aging female vasculature, enhancing nitric oxide-dependent dilation and modulating vascular tone even as classical ERα and ERβ pathways decline.
Buheliqiemu Yushanaji, Xiao Zhang et al.
Supplementation with *Lactobacillus acidophilus* in yellow-feathered broilers did not significantly improve overall growth performance, but a moderate dose (10 g/kg) increased apparent nutrient digestibility during days 22-42, enhanced beneficial gut microbiota (higher *Lactobacillus*, lower *E. coli* counts), and improved duodenal villus height.
Zhuohang Li, Jiamin Zhang et al.
Ultrasound-assisted curdlan curing significantly improved water-holding capacity by 14.0% and reduced cooking loss by 15.4% in rabbit meat compared to the control, leading to enhanced water retention across various cooking methods.
Wenlin Zhou, Longya Si et al.
A DDS-guided, tiered dietary diversification intervention significantly increased dietary diversity levels (Total DDS: Cohen's d = 1.72 at 2 months) and improved nutritional status (MNA-HF scores: Cohen's d = 0.56 at 2 months; BMI increase: Cohen's d = 0.52 at 2 months) in elderly chronic heart failure patients able to eat orally.
Katia D'Ambra, Roberta Trovato et al.
Dietary inclusion of hazelnut skin or hazelnut skin green extract in finishing pig diets did not negatively impact growth performance or carcass traits, but reduced cholesterol content in the Longissimus thoracis muscle (HSD: -7.56%, HSED: -12.10%) and increased thigh yield in the HSED group.
Rafael A Casuso
Age-related skeletal muscle decline is driven by a bidirectional disruption of the crosstalk between the sarcoplasmic reticulum and mitochondria, where impaired calcium signaling and chronic endoplasmic reticulum stress lead to bioenergetic deficits, anabolic resistance, and maladaptive mTORC1 hyperactivation.
Adrian S W Tordiffe
Lymphoplasmacytic gastritis in captive cheetahs is a bile acid-driven chemical injury caused by the mismatch between frequent captive feeding and their natural feast–fast ecology, leading to duodenogastric reflux and mucosal stress.
Romain Meer, Joyce Y Xu et al.
Six-month supplementation with 350 mg/day of magnesium citrate did not significantly improve calciprotein crystallization (T50) or carotid-femoral pulse wave velocity (cfPWV) in older individuals with type 2 diabetes and medial arterial calcification.
Laura E Marchese, Sarah A McNaughton et al.
While no direct associations were found between plant-based diet indices and health outcomes, significant indirect effects suggest that fat mass mediates the relationship between diet quality and cardiovascular risk, with healthy plant-based diets reducing risk and less healthy plant-based diets increasing risk through their respective impacts on body fat.
Synara C Lopes, Vitória K Felix Monteiro et al.
Apolipoprotein E (ApoE) deficiency or structural impairment increases vulnerability to methylmercury (MeHg)-induced oxidative and metabolic dysfunction, with ApoE2 and ApoE3 forming stable Hg–S bonds with MeHg, while ApoE4 does not, suggesting reduced mercury retention capacity.
Bin Yang, Jiaojiao Hou et al.
This systematic review and meta-analysis found no significant overall association between DASH diet adherence and BMD, osteoporosis risk, or hip fracture risk, but indicated a positive association with BMD in women and individuals over 60 years old.
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