Tatjana Orct, Jelena Kovačić et al.
The MTHFR 677C/T polymorphism is associated with lower folate levels, altered plasma Al and Ca levels, and changes in proline, glycine, aspartic acid, and glutamic acid levels, with significant gene-diet interactions observed for trace elements, biochemical parameters, and amino acid profiles.
Ziyi Zhou, Stewart G Trost et al.
Each additional hour of prolonged sedentary behavior per day was associated with a 9% higher hazard of cancer mortality, while replacing prolonged sedentary behavior with light physical activity was associated with a 12% lower hazard of cancer mortality.
Galya Bigman, Amber S Kleckner et al.
High dietary live-microbe intake was associated with lower odds of fatigue (OR 0.60), an effect that was potentiated by higher serum 5-methyltetrahydrofolate levels.
Jacintha Domić, Pol Grootswagers et al.
This 12-week randomized controlled trial will assess the effects of a self-composed vegan diet, with or without resistance exercise, on thigh muscle volume and other health outcomes in older adults.
Marta Mazur, Artnora Ndokaj et al.
Sublingual and oral vitamin B12 administration are as effective as intramuscular injections in improving serum cobalamin levels and reducing homocysteine.
Mona Chatrizeh, Jianmin Tian et al.
Plant-based enteral nutrition (PBEN) is superior to artificial enteral nutrition (AEN) in mitigating antibiotic-induced dysbiosis, gut inflammation, bacterial translocation, and hematopoietic abnormalities in mice, and promotes microbiome recovery and improved peripheral blood profiles in critically ill children.
Ahmadreza Alipour, Mahdi Ganjkhanlou et al.
Nano-ZnO supplementation significantly improved growth performance, skeletal development, antioxidant status, intestinal barrier function, and reduced negative health scores in pre-weaned Holstein calves compared to ZnO and Zn-Lysine.
Gunawan Gunawan, Erna Winarti et al.
Mineral block supplementation resulted in the highest average daily gain (71.29 g/head/day) and economic return (3,448 IDR/head/day) in thin-tailed Indonesian sheep compared to capsule, tablet, and control groups, while maintaining stable serum mineral levels.
Suzannah Gerber, Scott C Frost et al.
Solid-state fermentation (SSF) with culinary fungi offers a scalable method to transform plant materials into nutrient-dense, minimally processed whole foods with enhanced protein, digestibility, and bioavailability, while also valorizing agricultural commodities and contributing to sustainable food systems.
Nisar Muhammad Khan, Muhammad Tahir et al.
Dietary supplementation with essential oil blends at 2 mL/kg feed significantly improved feed intake, body weight gain, feed efficiency, nutrient digestibility, and humoral immune responses in broilers, without affecting intestinal morphology or cecal microbial populations.
Analí Morales-Juárez, Jason B Reed et al.
Food insecurity in the U.S. is consistently linked to poorer diet quality, reduced nutrient intake, and higher consumption of energy-dense, nutrient-poor foods across all age groups, with specific disparities observed in fruit, vegetable, grain, dairy, and protein intake, as well as key micronutrients.
Abdulaziz A Al-Abdullatif, Maged A Al-Garadi et al.
The multi-strain probiotic RISCO-NUTRIFOUR (RNFS) improved broiler performance, upregulated intestinal immunoglobulin A, occludin, and claudin-1 gene expression, and downregulated HSP70 under heat stress, with dose-dependent effects observed.
Bi Xue Patricia Soh, Matthieu Vignes et al.
Vegan meals with lower protein quality are higher in fruit, grains, potatoes, and sugary condiments, while meals with greater proportions of legumes and pulses are associated with higher DIAAS.
Sophie L van Oppenraaij, Sjors Verlaan et al.
In Dutch adults, a higher proportion of plant-based protein in meals was associated with decreased protein quantity and quality, with only a small percentage meeting both protein recommendations and sustainability goals.
Daniele Spadaccini, Arun Chandran et al.
Adapting the Mediterranean Diet principles to South Asia requires a region-specific model that integrates local food systems, traditional practices, and metabolic risk profiles, emphasizing reduced refined carbohydrate reliance, promotion of whole grains and high-quality protein, and optimized fat choices, with long-term effectiveness dependent on complementary policy, education, and economic measures.
Raluca-Elena Alexa, Raluca Ecaterina Haliga et al.
Micronutrient deficiencies, including iron, zinc, magnesium, calcium, vitamin D, B12, and folate, are prevalent in obesity and contribute to metabolic dysfunction and inflammation, with supplementation showing inconsistent but potentially beneficial effects depending on the nutrient and context.
Wenjun Liu, Jijun Wu et al.
Lower estimated glucose disposal rate (eGDR) is independently and linearly associated with a higher prevalence of severe abdominal aortic calcification (AAC), a finding consistent across two independent cohorts.
Samantha Yoo, Azita Montazeri et al.
Evidence linking folate status to autoimmune diseases or skeletal outcomes is limited and of weak credibility due to small sample sizes and high risk of bias in the included studies.
Shubhreet Bhullar
Fruit smoothie consumption was associated with the most favorable health outcomes, including lower hypertension, fewer mental health struggles, and higher energy levels, while fruit juice consumption was linked to poorer outcomes such as higher high cholesterol and lower sleep quality.
Osvaldo Beltrán-Osuna, Juan José López-Mayán et al.
An optimized organ-on-a-chip device provided more realistic estimations of silver and titanium dioxide nanoparticle bioavailability in foodstuffs compared to static models, with dynamic conditions showing higher bioavailability for seaweed but similar values for molluscs, highlighting the significant impact of the food matrix.
Cassandra Evans, Ross Peterson et al.
Daily supplementation with effera® at 100 mg may improve iron-related biomarkers and subjective well-being in women with chronically low iron levels unresponsive to standard iron therapy.
Tianqi Wang, Chi Zhang et al.
The LxL motif in ZIP4 acts as a zinc-responsive sorting signal that associates with the AP2 σ2 subunit, mediating clathrin-mediated endocytosis and regulating ZIP4 cell surface expression and zinc uptake.
Wanderson Dos Santos Carneiro, Carlos Eduardo de Farias Silva et al.
Pitomba fruit fractions yield nutrient-dense powders, with the peel powder (FC) being particularly rich in minerals (K, Ca, Mg) and dietary fiber, offering substantial contributions to DRIs and supporting their use as functional food ingredients.
Ningning Xia, Lulu Ding et al.
Frailty was independently associated with postoperative delirium (POD) in pancreatic cancer surgery patients and may mediate the link between poor preoperative nutritional status and POD, with a higher frailty score being a significant independent predictor of POD.
Letícia V Segre, Mariana S Bisinotto et al.
Dietary supplementation with Echium and Ahiflower oils effectively increased EPA proportions in all analyzed mouse tissues, with similar increases between the oils in liver, adipose tissue, and heart, but more pronounced increases with Ahiflower in brain, plasma, and erythrocytes, while DHA conversion was tissue-specific and generally limited.
Ross L Prentice, Lesley F Tinker et al.
Combinations of log-transformed metabolite concentrations can generate objective intake density estimates for multiple fatty acids in the diets of US postmenopausal females, with cross-validated R2 values exceeding 30% for many specific and composite fatty acids.
Luca Jokic, Isabell Pappert et al.
Wavelengths within the green gap (485-500 nm) maximized CO2 assimilation rates in Ocimum basilicum L. at high irradiances, and supplementing neutral white light with cyan or deep blue light significantly increased photosynthetic efficiency.
Phindiswa Kokisi, Felix Nchu et al.
Fermentation significantly enhances the nutritional and functional value of finger millet and soybean by reducing antinutrients, improving protein digestibility, and increasing mineral bioavailability, making them suitable for innovative fermented foods that address malnutrition and food insecurity.
Matthew J Williams, Hiral M Patel et al.
A Western-style high-phosphate diet exacerbated CKD-MBD components and negatively impacted cardiac mitochondrial function, even in the absence of overt kidney disease, highlighting the importance of early phosphate management in CKD therapy.
Menghua Yin, Qian Li et al.
Mild malnutrition was detected in 13.88% of infants aged 6-24 months attending a pediatric clinic, with food allergies, low maternal education, low birth weight, maternal pre-pregnancy thinness, frequent nighttime awakenings, and insufficient complementary feeding frequency identified as significant risk factors.
Aurélien Vigneron, Brian L Weiss et al.
PGRP-LA maintains the integrity of the peritrophic matrix in tsetse flies, which is crucial for limiting trypanosome infections.
Zhizhao Chang, Yiran Liu et al.
Protein-plus-probiotic supplementation demonstrated positive effects on physical performance, specifically muscle strength and muscular endurance, and on lean mass/muscle mass, but showed limited evidence for broad body composition changes.
Javad Ghanouni-Bostanabad, Seyyed Ali Mirghelenj et al.
Simultaneous supplementation of Spirulina Platensis and flaxseed oil in laying hen diets enhanced performance, ovarian indices, antioxidant status, and egg shelf life, resulting in eggs with improved lipid profiles rich in omega-3 fatty acids.
Manatsanun Nopparatmaitree, Juan J Loor et al.
The phytosynbiotic feed supplement, DMP, containing double-layer microencapsulated Pediococcus acidilactici V202 and Tiliacora triandra leaf extract, significantly improved broiler growth performance, nutrient digestibility, and gut health by modulating gut microbiota, volatile fatty acid levels, and intestinal morphology.
Heather M Zimmerman, Akash Liyanage et al.
Povidone-iodine and closed incisional negative pressure wound therapy are effective in improving surgical wound healing, while malnutrition, including in vegans, requires special attention, and further investigation into radiation-induced skin injury management is warranted.
Donrawee Waeyeng, Supabhorn Yimthiang et al.
Higher intake of nuts and seeds was associated with a lower likelihood of elevated kidney tubular cell injury (uNAG) in middle-aged individuals environmentally exposed to cadmium and lead, suggesting a potential protective role for these specific plant foods despite toxic metal contamination.
Li Cao, Ge Zhang et al.
Dietary chicory polysaccharide supplementation improves growth performance and colonic barrier function in weaned piglets by reshaping the gut microbiota to increase hyodeoxycholic acid (HDCA) production, which activates the HDCA-TGR5-Akt signaling axis, inhibiting the NF-κB pathway and reducing inflammation.
J L Su, G Tian et al.
A 60:40 lard-to-chicken fat blend optimized growth performance, nutrient utilization, and serum lipid homeostasis in meat ducks, attributed to a synergistic equilibrium of unsaturated to saturated fatty acids.
Eduarda Pires Costa, Mariáurea Matias Sarandy et al.
Cow's milk positively impacts bone formation by stimulating osteocalcin production (+5%) compared to transgenic and non-transgenic soy-based beverages in BALB/c mice.
Narges Milkarizi, Hanieh Barghchi et al.
Eight weeks of supplementation with *Portulaca oleracea* extract significantly reduced depression and stress symptoms in patients with non-alcoholic fatty liver disease compared to placebo.
Mochammad F Habibi, Sebastian Dorado-Montenegro et al.
Wheat arabinoxylans (AX) addition to soybean hull diets increased endogenous protein losses and reduced true ileal protein digestibility, with coarse particles potentially mitigating AX's adverse impact.
Xiaodan Zhang, Guangzhi Ma et al.
L-Ornithine-L-aspartate (OA) supplementation is superior to a physical mixture of ornithine and aspartic acid in improving broiler performance by up-regulating intestinal amino acid transporters, enhancing nutrient digestibility, modulating gut microbiota towards butyrate production, and increasing hepatic ornithine aminotransferase activity, which collectively improves protein deposition and nitrogen metabolism.
Sadegh Saffari, Mansour Torfi Mozanzadeh et al.
Dietary supplementation with 2 mg/kg selenium nanoparticles (SeN) alone or combined with 100–250 mg/kg vitamin E synergistically improved reproductive performance in Arabian yellowfin seabream female brooders by increasing selenium retention and enhancing antioxidant capacity.
Hanchi Ying, Qi Wang et al.
Nocturnal hyperglycemia in type 2 diabetes mellitus is caused by a disrupted "gut microbiota-circadian rhythm-metabolism axis," characterized by altered microbial composition, diminished circadian oscillations, impaired nocturnal hepatic gluconeogenesis suppression, and chronic inflammation.
S Ghosal, A Ghosal
Lifestyle interventions and GLP-1 receptor agonist-based therapies significantly reduced waist circumference by an average of 4.36 cm, with GLP-1RA-based therapies showing a greater reduction of 5.93 cm compared to diet-alone interventions (3.46 cm).
Arti Gupta, Vignesh D et al.
This study reveals a substantial burden of anemia, vitamin D and B12 deficiencies, and overweight/obesity among patients at a specialized nutrition center in South India, with women aged 30-44 years experiencing the highest micronutrient deficiency burden and young adults (18-29 years) representing a critical window for obesity prevention.
Federica Perillo, Federica Mascaretti et al.
Cancer-related malnutrition in colorectal cancer patients is associated with increased tissue-infiltrating neutrophils, altered T cell phenotypes with increased exhaustion markers, and distinct tumor-associated microbiota patterns, including enriched genera like Bacteroides, Prevotella, and Parabacteroides, which correlate with higher NLR.
Zhi Wang, Nuo Li et al.
Intestinal mucosal barrier injury is a complex, multifactorial condition impacting multiple organ systems, and a multidisciplinary approach integrating insights from various fields is crucial for understanding and treating it.
Richard Atinpoore Atuna, Fortune Akabanda et al.
Spontaneous fermentation significantly alters the techno-functional and biochemical properties of Ghanaian staple flours, with specific improvements in water/oil absorption, reduced phytic acid, and varied impacts on viscosity and polyphenol content, enhancing their suitability for complementary foods.
S Sugiharto, F R Handayani et al.
Enzyme supplementation enables higher inclusion of agro-industrial byproducts in broiler diets, leading to improved performance, nutrient digestibility, gut health, economic benefits, and reduced environmental impact, while also mitigating antinutritional factors.
Damilare O Famakinde, Ciaran Lonergan et al.
Fish food (FF) and artificial snail gel (SG) diets significantly improved Biomphalaria glabrata growth, survival, and fecundity compared to fresh lettuce (FL), associated with upregulation of genes related to immunity, growth, and reproduction, and enrichment of short-chain fatty acid-producing bacteria.
T P Timberlake, S Sapkota et al.
Insect pollinators are directly responsible for 44% of farming income and over 20% of vitamin A, folate, and vitamin E intake in smallholder communities in Nepal, with declines in pollinator species anticipated to exacerbate poverty and micronutrient deficiency.
Samantha Jane Meredith, Kate A Sheppard et al.
Adherence was significantly lower for a new porridge-based oral nutritional supplement compared to a standard drink-based supplement in hospitalised older adults, primarily due to disliked texture and larger volume, with 71% liking the drink-based supplement versus 45% for the porridge.
Oana Stoia, Paula Anderco et al.
Artificial intelligence (AI) and machine learning (ML) offer a promising framework for optimizing antimicrobial therapy in complex gastrointestinal and renal infections by enabling resistance prediction and individualized treatment, but clinical implementation faces significant regulatory, validation, and oversight challenges.
Haosheng Xie, Mingxuan Zhang et al.
Kidtal + Ca (KDTCa) significantly promotes longitudinal bone growth and improves bone microarchitecture in calcium-deficient rats by elevating serum IGF-1 levels and enhancing growth plate endochondral ossification, demonstrating superior efficacy compared to calcium citrate alone.
Ewelina Polak-Szczybyło, Jacek Tabarkiewicz
In obese individuals, body composition, lifestyle, and dietary components significantly influence adiponectin, resistin, and the adiponectin-resistin index, with resistin correlating positively with body fat and adiponectin/AR index correlating negatively with lean body mass and positively with anticoagulant use, while negatively with NSAID/Vitamin D3 use and simple carbohydrate intake.
Moh Sofi'ul Anam, Budi Prasetyo Widyobroto et al.
Combined organic selenium and zinc supplementation significantly modulated ruminal microbial composition in vitro, increasing Bacteroidetes and Proteobacteria while decreasing Firmicutes, Patescibacteria, and Euryarchaeota at the phylum level, and increasing Prevotella, Ruminococcus, and Prevotellaceae UCG-003 while decreasing Lachnospiraceae XPB1014 group, Christensenellaceae R-7 group, Butyrivibrio, and Ruminococcus gauvreauii group at the genus level.
Jeannine Baumgartner, Renée Blaauw et al.
In iron-deficient children with virally suppressed HIV, 12 weeks of daily oral iron with galacto-oligosaccharides (GOS) resulted in a 39% greater relative increase in serum ferritin (P=0.053) and significantly lower incidence of fever and rhinorrhoea compared to iron with placebo.
Michael Hoppe, Ann-Sofie Sandberg et al.
Sourdough fermentation significantly enhances non-heme iron absorption from whole grain rye bread by degrading phytate, with absorption being 2.8 to 3.5 times higher in dephytinized bread compared to high-phytate bread.
Weiyong Wang, Yong Ruan et al.
Methionine deprivation, but not restriction, impairs prepubertal spermatogenesis by inducing mitochondrial dysfunction, oxidative stress, and DNA damage, which activates the CHK2-p53/p21 apoptotic pathway in germ cells.
Marappan Gopi, Govinthasamy Prabakar et al.
Maternal supplementation of organic zinc (Zn-methionine) to broiler breeders significantly increased fertility and hatchability, particularly at 60 mg/kg, and improved offspring intestinal histo-morphological attributes (villi length, diameter, absorptive surface area), but did not affect offspring growth performance (body weight, feed intake, feed efficiency) under standard feeding conditions.
Seokju Kang, Youri Jin et al.
In older adults with sufficient energy intake, frailty was inversely associated with total protein intake (OR, 0.67; 95% CI, 0.46–0.97), animal protein intake (OR, 0.59; 95% CI, 0.43–0.82), and plant protein intake (OR, 0.68; 95% CI, 0.50–0.92), while in those with deficient energy intake, only plant protein intake was inversely associated with frailty.
Mingyu Wang, Yifan Chen et al.
Lactate alleviates DSS-induced jejunal damage in piglets by activating the Wnt/β-catenin pathway, which restores villus height, promotes Lgr5+ stem cell proliferation, and reduces epithelial apoptosis.
Tim Zerback, Christian Koeder et al.
A daily multinutrient supplement containing 82 µg of vitamin B12 significantly improved vitamin B12 blood biomarkers in healthy vegans, while no clear positive impact was observed for other examined vitamins and choline, and vitamin A status remained poor.
Ángela Alcalá-Santiago, Noelia M Rodríguez-Martín et al.
Well-planned plant-based diets can achieve comparable sustainability and nutritional adequacy to a healthy Mediterranean diet, with attention required for specific micronutrients like vitamin D, iodine, and vitamin B12, while also substantially reducing environmental impact.
Alexandru S Barcan, Joseph L Humble et al.
Supplementation with *Boletus edulis* extract (BEE) in an *in vitro* Atlantic salmon gut model significantly increased microbial diversity, enhanced amino acid absorption and crude protein digestibility (p<0.05 for 10% BEE), and reduced ammonia production (p<0.001 for 10% BEE) compared to control.
Marina Heniková, Anna Ouřadová et al.
Vegan diets are associated with better cardiometabolic profiles, particularly lower LDL and total cholesterol in both children and adults, but low iodine status is a concern that warrants attention.
Anna Stubbendorff, Silke Kern et al.
Adherence to the EAT-Lancet diet in older adults was associated with a more favourable nutrient profile, improved metabolic health markers (lower glucose and triglycerides, higher HDL-cholesterol), and did not lead to widespread micronutrient inadequacy.
Katarzyna Hencel, Matthew J Sullivan et al.
The study developed a high-throughput, simple, and cost-effective assay using E. coli B834 (DE3) that can detect and estimate vitamin B12 levels down to 50 pM.
Isabelle Mulkerrins, Anine Christine Medin et al.
Youth in Sweden, across all dietary patterns studied (vegan, lacto-ovo-vegetarian, pescatarian, and omnivorous), face challenges in meeting micronutrient recommendations, with particular concerns for vitamin D and selenium, and specific risks for calcium, vitamin A, B12, and potassium depending on the diet.
Lu-Ran Wang, Dong-Xu Liu et al.
A computer simulation analysis, including network pharmacology and molecular docking, revealed that vitamins A, C, D, E, and K exert multi-potential benefits in periodontitis prevention and treatment through anti-inflammatory, antioxidant, and bone regeneration effects by modulating common core targets such as ESR1, PPARG, and GSK3B.
Martina Tosi, Veronica Maria Tagi et al.
Newborn vitamin B12 deficiency in this cohort was primarily linked to inadequate maternal dietary intake, even among omnivorous diets, highlighting the need for comprehensive maternal nutritional assessment and supplementation from pre-conception.
Mingyang Cui, Zhe Wang et al.
Procyanidin and roxadustat synergistically ameliorate renal anemia in mice, with the combination leading to superior improvements in hematological parameters, reduced kidney injury, fibrosis, and inflammation, enhanced iron mobilization and absorption, and procyanidin mitigating roxadustat-induced thrombopoiesis.
Emel Oz, Fatih Oz
Artificial intelligence (AI) reframes ingredient substitution as a systems-level optimization problem, integrating machine learning, graph-based modeling, natural language processing, and ontology-aware systems to balance sensory, functional, nutritional, and socio-regulatory constraints in food formulation.
Nurzhan Sarsembayeva, Gulmariya Ikramzhan et al.
Dietary supplementation with zeolite or vermiculite combined with E. coli 39-SN significantly improved the nutritional composition of African sharptooth catfish muscle, with zeolite+probiotic enhancing protein and essential amino acids, and vermiculite+probiotic increasing fat content and energy value.
Yalçın Mert Yalçıntaş, Mikhael Bechelany et al.
Bovine colostrum and its bioactive components, particularly lactoferrin and exosomes, demonstrate significant anticancer potential by inhibiting tumor growth, inducing apoptosis, and reducing chemotherapy-induced toxicity across various cancer types.
Maryann R Rolands, Fabio Mainardi et al.
Optimal protein and nutrient quality in plant-based meals can be achieved with specific ratios of protein food groups, requiring at least 30% from soy-based or animal protein sources.
Jelena Meinilä, Jyrki K Virtanen
Strong and probable evidence links the consumption of red and processed meat to an increased risk of colorectal cancer, cardiovascular disease mortality, coronary heart disease, and stroke, with processed meat specifically increasing colorectal cancer risk by 16% per 50 g/day.
Omar Aguillón-Hernández, María Teresa Viana et al.
Combined dietary supplementation of 1% methionine and 1% taurine synergistically enhanced growth performance (e.g., final weight increased by 233.4%) and reduced whole-body cholesterol content (by 78%) in Totoaba macdonaldi juveniles fed low-fishmeal diets.
Samantha Nikita Heerschop, Sander Biesbroek et al.
Current diets in healthy European adults do not raise immediate concerns for utilizable protein intake, although females in Germany show a higher prevalence of inadequacy.
Siti Rani Ayuti, Sangsu Shin et al.
The ACTA1 gene is a critical regulator of skeletal muscle development, fiber composition, and meat quality in livestock, and optimizing its expression through genetic selection, nutrition, and biotechnology can enhance muscle yield, meat quality, and feed efficiency.
Jun Huang, Kaidi Ma et al.
Maternal proline supplementation during the critical fetal myogenesis phase (gestation days 20-114) significantly enhances offspring skeletal muscle mass, cross-sectional area, and oxidative fiber development in piglets, mediated by STAT3-CCND1 signaling and improved mitochondrial function.
Luise Ehlers, Anika Kasprick et al.
Bach2-deficient C57BL/6N mice spontaneously developed autoimmune pancreatitis (AIP) and were protected against high-fat diet (HFD)-induced fatty liver disease.
Natsu Sugama, Emily T Lew et al.
Supplementation of cultivated pork fat cell culture media with thiamine-HCl, L-methionine, or myoglobin significantly modulated the volatile organic compound (VOC) profile upon heating, increasing specific aroma compounds such as 4-methyl-5-thiazoleethanol (milky), methional (potato-like), and various lipid degradation products like γ-nonalactone (coconut-like) and (E, E)-2,4-decadienal (deep fat aroma), respectively.
Hanlu Zhang, John W Cone et al.
Human fecal inoculum is crucial for accurately predicting in vitro protein fermentation potential relevant to humans, as significant differences in fermentation kinetics were observed compared to porcine inoculum, although Rmax values were comparable.
Kai-Meng Shang, Hany M Elsheikha et al.
The chicken gut microbiome exhibits widespread bile salt deconjugation capacity, with 80.17% of reconstructed genomes carrying BSH genes, but limited complete secondary bile acid synthesis, and this bile acid-microbiota axis is spatially variable and significantly altered by *Salmonella typhimurium* and *Eimeria tenella* infections.
Eun-Young Kwon, Ji-Won Kim et al.
Setaria viridis ethanol extract mitigates sarcopenic obesity in high-fat diet-induced mice by activating the AMPK and IGF-1/Akt/mTOR signaling pathways, leading to reduced adiposity, increased skeletal muscle mass, and improved metabolic profiles.
Eileen Bailey, Jérôme Wojcik et al.
Microalgal-derived omega-3 fatty acid oil significantly increased total plasma phospholipid DHA and EPA to a level nutritionally non-inferior to fish-derived omega-3 fatty acid oil (GMR = 111% with 94–132% CI for total DHA+EPA), despite differences in EPA:DHA ratios and doses.
Diriba B Kumssa, Tristan Dew et al.
Several wild edible fruit (WEF) species in Ethiopia are rich in essential minerals (Ca, Fe, Mg, Se, Zn), often surpassing levels in cultivated fruits, with a 100g serving of certain WEFs providing up to 40% of recommended nutrient intakes for adolescent boys.
Jessika Lamarre, David R Wilson
Ring-billed gull chicks can bioconvert ALA into shorter-chain derivatives and some EPA and DPA, but have a limited ability to convert ALA into DHA, potentially making them vulnerable to n3-LCPUFA deficiencies on urban diets.
Anne E Sanders, Jianwen Cai et al.
A diet rich in arachidonic acid (AA) was associated with higher odds of painful temporomandibular disorder (TMD), while n-3 supplement intake was associated with lower odds of TMD.
Andreja Čanžek Majhenič, Alenka Levart et al.
Plant-based cheese substitutes available in Slovenia generally exhibited poor nutritional value and average sensory quality compared to semi-hard dairy cheeses, containing significantly less protein and calcium, more salt, and a less favorable fatty acid profile with higher atherogenic and thrombogenic indices.
Jie Wang, Shiqian Ran et al.
Dietary supplementation with Schizochytrium sp., flax seed, or a mixture significantly altered goat milk lipid molecular species, with the mixed supplementation showing the most pronounced increase in DHA-TG and DHA-GPL, elevating them by over 10-fold and 4-fold, respectively.
Samantha Hartwig, Scarlett Burron et al.
Supplementation with camelina oil (CAM), flaxseed oil (FLX), or canola oil (OLA) at 0.37 g/kg BW for 8 weeks increased skin n-3 fatty acid composition and decreased n-6 fatty acid composition and the n-6:n-3 ratio in horses, with no significant differences in immune or inflammatory responses observed among the treatments after 16 weeks.
Shengnan Wang, Zihui Jin et al.
Dietary interventions, including the Mediterranean diet, calorie restriction, unsaturated fatty acids, fibers, and polyphenols, show promise in reducing circulating ceramide levels, which are implicated in various diseases.
Piyaradtana Homyok, Wunpen Sonsamrong et al.
Targeted lipid nanoparticles loaded with tuna oil can enrich chicken meat with n-3 PUFA, but the enrichment efficiency was lower than using crude tuna oil directly, with no negative effects on liver, muscle, or kidney functions.
Kristen N Gilley, Jenifer I Fenton et al.
Serum omega-3 polyunsaturated fatty acids (PUFAs) and, to a lesser extent, omega-6 PUFAs were favorably associated with systemic lupus erythematosus (SLE) patient-reported outcomes, while monounsaturated fatty acids (MUFAs) and saturated fatty acids (SFAs) were unfavorably associated, with docosahexaenoic acid (DHA) showing consistent favorable associations across disease activity, pain, and sleep quality.
Renny Fatmyah Utamy, Ambo Ako et al.
Feeding a legume-based green concentrate (GC), particularly GC with 30% legume inclusion (GC30), significantly mitigated negative energy balance (NEB) in postpartum Holstein Friesian cows, leading to enhanced milk yield (15.88 kg/d), improved feed conversion efficiency (1.10), increased daily profit (10.99 USD/d), reduced blood BHB (0.91 mmol/L) and milk BHB (0.43 mmol/L), and elevated IGF-1 (50.27 ng/mL) and estrogen (104.36 ng/mL).
Aitana Vázquez-Fernández, Francisco F Caballero et al.
In older adults with multimorbidity, higher total protein intake was associated with a decreased risk of frailty (HR for tertile 3 vs. tertile 1: 0.66; 95% CI: 0.45, 0.96), with higher fish protein intake specifically decreasing the risk of progression from multimorbidity to frailty (HR per 1-SD increment: 0.81 [95% CI: 0.68, 0.97]), and higher plant protein intake decreasing the risk of progressing from multimorbidity to mortality (0.86 [0.75, 0.98]), but higher total, plant, and animal protein intake increased the risk of progression from frailty to mortality (HR for 1-SD increment in total protein: 1.38 [1.05, 1.81]).
Qianwei Wang, Yucheng Han et al.
Targeted gut microbiome interventions, including probiotics, prebiotics, and plant-based diets, show potential for managing end-stage renal disease by modulating short-chain fatty acid metabolism and suppressing pathogens, though efficacy varies with host factors and kidney replacement therapy modalities.
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