Nessmah Sultan, Nicole J Kellow et al.
Moderate habitual egg consumption (approximately 0.5–1 egg/day) is associated with improved memory, verbal fluency, and a reduced risk of dementia (HR: 0.74), although some studies report conflicting results at higher intake levels.
Mousa Nasiri, Hossein Ali Ghasemi et al.
The advanced zinc chelate compound technology (Zn-ACT) at 80 mg/kg significantly improved broiler performance, feed efficiency, antioxidant status, immune responses, and zinc utilization, while reducing fecal zinc excretion, and was comparable or superior to higher levels of supplementation and other organic zinc sources.
Alessandra da Silva Pereira, Inês Rugani Ribeiro de Castro et al.
The estimated Brazilian iron intake reference values (NRV) for children aged 7–11 months were an average requirement (AR) of 11 mg/d and a population reference intake (PRI) of 20 mg/d, and for children aged 12–23 months, an AR of 8 mg/d and a PRI of 14 mg/d, which were higher than those of the IOM and EFSA due to lower estimated iron bioavailability (7.5%) in the Brazilian diet.
Julius Mbiu, Teshale Assefa et al.
Consumer preferences, particularly for slow-darkening, fast-cooking, and biofortified varieties, are crucial for enhancing the nutritional security and marketability of common beans, necessitating integrated breeding strategies that consider genetic, biochemical, environmental, and socioeconomic factors.
Mujtaba Akram Jahangir, Muhammad Muneeb et al.
Supplementation with glycinate-based organic trace minerals in late-laying layer breeders (66–72 weeks of age) significantly enhanced eggshell breaking strength, tibial breaking strength, and hatchability, while also improving mineral absorption and reducing mineral excretion compared to inorganic sources.
Andrea Maugeri, Martina Barchitta et al.
A Mediterranean-aligned, minimally processed dietary pattern, supplemented with key micronutrients like folate, iron, vitamin D, calcium, B12, and DHA when necessary, provides significant health benefits for women of childbearing age across reproductive, metabolic, cardiovascular, and skeletal systems.
Aisha Tariq, Huma Umbreen et al.
Spinach extract-assisted iron oxide nanoparticles were significantly more effective than ferrous sulfate in improving hematological and iron-related parameters in anemic rats, with increases in hemoglobin and serum ferritin comparable to normal levels.
Yuzhou Cai, Jingxian Qian
Global breast cancer burden attributable to high red meat consumption shows rising absolute numbers despite declining age-standardized rates in high-SDI regions, with significant increases observed in low- and middle-SDI countries and younger women (25-34 years), and projections indicating continued burden increases by 2050.
Pei-Yi Chen, Eric P Skaar
Heme homeostasis is critical for bacterial survival and pathogenesis, with diverse bacterial mechanisms for heme management offering potential therapeutic targets, particularly for multidrug-resistant bacteria.
Chloe Jang, Cristiana Iosef et al.
Amino acid restriction, simulated by halofuginone, impairs human endometrial stromal cell decidualization by inhibiting key markers and disrupting TGFβ-SMAD signaling, effects that are rescued by proline supplementation.
James E Langley, Kate J Plush et al.
An additional intramuscular iron injection administered at weaning tended to improve post-weaning growth and reduce pig removals, while an injection at day seven of life improved hemoglobin concentrations but not growth.
Linlu Zhao, Jin Zhang et al.
Dietary supplementation with 20 g/d of the plant complex ALAEm in late gestation sows significantly improved sow reproductive performance, including total piglets born alive, healthy piglets, newborn litter weight, number of weaned head, and weaned litter weight at 21 days, while also enhancing serum biochemical indices and placental health by modulating the EGFR/VEGFR2-PI3K-AKT1 pathway and lipid metabolism.
Natalia Kurhaluk, Lyudmyla Buyun et al.
Phytochemicals, including flavonoids, terpenes, and phenolic compounds, are crucial for the sensory characteristics and health-promoting properties of plant-based foods, defining sensory profiles and modulating key signalling pathways (NF-κB, Nrf2, MAPK, AP-1) that regulate inflammation, oxidative stress, and cell survival, thereby reducing chronic disease risk.
Tianxi Zhang, Zhiyuan Ma et al.
Finishing lambs fed a barley-rich diet developed abnormal keratinization of the rumen, characterized by lower rumen pH, impaired tight junctions, upregulated IL-17 signaling, and downregulated protein digestion and absorption pathways.
Dalya Koukach, Maryam Aljumaily et al.
Dietary interventions, particularly Mediterranean and plant-based diets, show potential as complementary strategies for managing Multiple Sclerosis by improving fatigue and quality of life, though evidence for other diets and specific nutrients is inconsistent and requires further large-scale research.
Sara Pipponzi, Stefanie Primisser et al.
This study successfully demonstrated the use of a bacterial endophyte, *Methylobacterium* sp. P1-11, to produce vitamin B12 in planta, achieving levels of 1.654 μg/g dry weight without cobalt supplementation and 2.559 μg/g dry weight with cobalt supplementation in lettuce.
Svenja Fedde, Miriam Wießner et al.
Ultra-processed foods (UPFs) constituted 49% of daily energy intake across vegan, vegetarian, and omnivore diets, and their consumption was associated with lower protein, fiber, and several micronutrients, potentially exacerbating insufficient micronutrient intake, particularly in plant-forward diets.
Rebecca Simon, Kristina Lossow et al.
Both Brazil nut butter and a selenium supplement were equally effective in increasing serum selenium and SELENOP concentrations in vegans and omnivores, with a more pronounced SELENOP increase observed in vegans.
Maximilian Andreas Storz, Frieda Stübing et al.
Plant-based diets, when assessed by the Total Nutrient Index for eight potentially under-consumed nutrients, did not show poorer nutritional adequacy compared to omnivorous diets, with supplementation significantly impacting nutrient supply, especially in vegans.
Jo Pearce, Jenny Christian et al.
Maternal median iodine intake from food and supplements was 140.3 µg/d, meeting the UK RNI for women but not WHO or BDA recommendations for lactating women, and infant iodine intake from food was positively correlated with maternal total iodine intake.
Aditya R Agrawal, Navin Mair et al.
Vitamin B12 supplementation effectively reverses clinical and hematological abnormalities, including macrocytic anemia and neurological symptoms, leading to improved outcomes.
Maria Vittoria Conti, Alessandra Vincenti et al.
Adapting the Planetary Health Diet for children requires modifications to meet specific energy and nutrient needs, such as protein, iron, calcium, vitamin D, and B12, to effectively prevent childhood obesity while promoting environmental sustainability.
Tamlin S Conner, Nicola A Gillies et al.
A balanced diet containing either red meat or plant-based meat alternatives had no significant effect on psychological measures and limited physiological changes in healthy young adults.
Luwei Zhu, Xiaohan Zhang et al.
A ternary combination of essential oils, *Saccharomyces cerevisiae*, and isomaltooligosaccharides (ESI) enhanced intestinal absorptive function by increasing the villus height to crypt depth ratio and boosted immunity by elevating immunoglobulin levels and modulating cytokine gene expression in weaned piglets, with its efficacy partly dependent on farm environmental conditions.
Muna Ali Abdalla, Munshi Mohammad Sumon et al.
Combining selenium and sulfur treatments in cereals and legumes shows promise for improving protein quality, techno-functional properties, and human health benefits through biofortification, although further research is needed on specific protein fractions and functional properties.
Maharach Matra, Chaichana Suriyapha et al.
M-LEMANGOS, particularly at 4% of total substrate with 18% CP concentrate, enhanced nutrient degradability, improved rumen fermentation, and mitigated methane production.
Tuğçe Boğa, Kübra Topaloğlu Günan et al.
Four newly developed ready-to-eat biscuit formulations (for general consumption, elderly, children, and gluten-intolerant individuals) were found to be nutritionally suitable for their target groups, sensorily acceptable (scores ≥ 5), and microbiologically stable for at least 30 days, with the Biscuit for Elderly Consumption (BEC) formulation exhibiting the highest protein, fat, and dietary fiber content.
Ting-An Lin, Jianfei Pan et al.
Microplastic exposure significantly increased atherosclerosis in male mice (63% in aortic root, 624% in BCA) but not in female mice, without altering adiposity or lipid profiles, and was associated with changes in aortic cell composition and pro-atherogenic gene expression in endothelial cells.
Kara Sampsell, Camila Schultz Marcolla et al.
Fermented foods are associated with reduced risk or improved management of chronic conditions, including metabolic, cardiovascular, oncologic, and neuropsychological outcomes, and can modulate the gut microbiota, but more interventional studies are needed to establish causality and clarify mechanisms.
Arife Yilmaz, Michelle Weech et al.
Greater adherence to a dietary pattern characterized by higher intakes of fermented dairy, fruits, wholegrains, vegetables, milk, tea/coffee, nuts/seeds, and unsaturated fats/oils was favourably associated with diet quality and cardiometabolic disease risk markers in disease-free adults.
Jeffrey M Beckett, Marie-Louise Bird et al.
Web-based dietary advice for multiple sclerosis is highly diverse, often contradictory, and largely based on individual experience or unproven theories rather than robust scientific evidence.
Shaorong Li, Yaning Wang et al.
Oral sodium nitrate administration ameliorates metabolic syndrome phenotypes in mice by rebalancing macrophage polarization and function through a novel sialin-CtsL-Nrf2 pathway.
Hathairat Saengsuwan, Chaiyapoom Bunchasak et al.
10% hemp inflorescence meal (HIM) inclusion in laying hen diets resulted in no cannabinoid residues in eggs, stable production performance, and significantly improved albumen height (7.82 ± 0.29 mm vs. 6.76 ± 1.04 mm, p = 0.02), Haugh unit (86.73 ± 3.04 vs. 80.30 ± 6.93, p = 0.03), and reduced yolk-to-albumen ratio (39.02 ± 1.72 vs. 40.59 ± 0.87, p = 0.04).
Lyubov Sergeevna Grishina, Arthur Yurievich Zhigalov et al.
Machine learning effectively identified six distinct broiler groups based on mineral profiles, with cobalt, zinc, strontium, arsenic, and lithium as key differentiating biomarkers, and a Decision Tree classifier achieved 74% accuracy in predicting diet types from microbiota data.
Wenying Huo, Yiyu Lin et al.
Methionine supplementation in dairy cattle enhances gastrointestinal integrity, immune function, and milk components by modulating gut microbiota, increasing tight junction protein expression, and improving antioxidant capacity and metabolic health during the transition period.
Olga Golubnitschaja, Jiri Polivka et al.
Tear fluid multi-omics analysis identified 13 specific metabolic clusters, including significant increases in putrescine, lactic acid, and xanthine, that serve as non-invasive biomarkers for the early detection and risk profiling of ischemic stroke and related systemic pathologies.
Sabina Krupa-Nurcek, Dominika Wiśniewska et al.
Nutrition significantly impacts Hodgkin's lymphoma risk, course, and mortality, with excessive saturated fats, simple sugars, and processed meats promoting cancer, while diets rich in vegetables, fruits, fiber, and omega-3 fatty acids offer protection, and both malnutrition and obesity negatively affect prognosis.
Diego Dos Santos Baião, Davi V T da Silva et al.
L-citrulline from watermelon efficiently improves hemodynamic function by increasing plasma L-arginine, promoting vasodilation, and reducing blood pressure, peripheral arterial stiffness, and endothelial dysfunction in adults with cardiovascular disease risk factors.
Maged A Al-Garadi, Rashed A Alhotan et al.
Fibrafid supplementation, especially at 0.25%, improved breast yield, breast meat quality (higher WHC, lower CL, improved MFI), final average body weight, and feed conversion ratio in heat-stressed broilers, with benefits observed across both standard and reduced nutrient density diets.
Michelina Crosbie, James R Templeman et al.
Reformulating the crystalline amino acid (AA) reference diet (BAS63+) by increasing specific indispensable AAs improved the oxidation response by 84% in a pilot study, but in the full study, the oxidation response of the BAS diet was 7% and 60% less than peas and chicken meal (ChM), respectively, preventing the determination of methionine (Met) metabolic availability (MA) using the BAS diet as a reference, though the MA of Met in peas was 58% relative to ChM.
Omnia Y Abd-Elfadiel Hagag, Muhammed Ahmed-Hilmy El-Rayes et al.
Azolla pinnata, a fast-growing aquatic fern, serves as a sustainable and cost-effective alternative protein source in livestock feed, improving feed conversion efficiency, growth rates, and milk production in ruminants, and enhancing growth performance, egg production, and immunity in non-ruminants like poultry and fish.
Hanyu Guo, Ying Zhou et al.
A novel ferrous ion-chelating peptide, TAEDKKLIQ, isolated from chicken blood hemoglobin, demonstrated superior thermal and pH stability, digestive resistance, and iron retention compared to conventional iron supplements in the presence of dietary inhibitors, along with low cytotoxicity in Caco-2 cells, suggesting its potential as a safe and effective iron fortifier.
Xin Jin, Yulong Hong et al.
Palmitic acid promotes hepatocellular carcinoma progression by upregulating ZDHHC12, which palmitoylates HDAC8 at Cys244, inhibiting its lysosomal degradation and thus promoting HCC.
Melanie Haas, Beate Brandl et al.
Dietary fiber supplementation attenuated TMAO formation after beef intake in individuals with lower habitual meat consumption (<3 times/week) and significantly downregulated microbial cutC gene abundance.
Ming-Jie Duan, Maartje P Poelman et al.
Adhering to Dutch dietary guidelines, particularly by reducing processed meat consumption and increasing fruit intake, could substantially reduce the burden of non-communicable diseases and increase life expectancy in the Netherlands by 2050.
Ingrid Larsson, Jiangming Sun et al.
A diet low in fiber and high in red meat was associated with high-risk coronary plaque features, increased coronary calcification, and significant stenosis, with waist circumference, triglyceride levels, and hypertension acting as potential mediators.
Natural H S Chu
Increasing dietary fiber intake by 5 g/day was associated with an 18% lower risk of CRC-specific mortality, and high calcium intake was linked to a decreased risk of CRC, while increasing fermentable carbohydrate intake and reducing fermentable protein intake could shift the microbiome towards carbohydrate metabolism, potentially reducing adverse CRC effects in diabetic patients.
Huan Ma, Minyan Wang et al.
While the global burden of diet-related neoplasms and cardiovascular diseases has decreased from 1990 to 2021, the burden of diet-related diabetes has rapidly increased, with projections indicating a continued decline for neoplasms and CVDs but a slight increase for diabetes through 2030.
Soomin Lee, Jung Eun Lee et al.
The "seafood and vegetable" dietary pattern was associated with a reduced risk of all-cause and cardiovascular disease mortality in Korean adults.
Hajra Khurshid, Muhammad Bilal Jamshaid et al.
Iron deficiency anemia significantly modulates gut microbial diversity and microbial metabolite production, with specific anaerobic bacterial genera (Coprococcus, Anaerovoracaceae, Exiguobacterium) positively associated with anemia and branched short-chain fatty acid production, while a lack of red meat and fish consumption and high milk consumption are linked to anemia.
Yiting Tang, Yupeng Chen et al.
In 2021, dietary risks accounted for 23.61% of Type 2 Diabetes Mellitus deaths and 24.85% of disability-adjusted life-years in elderly adults globally, with significant regional and demographic disparities and an overall increase in disability-adjusted life-year rates from 1990-2021.
Giovanna Fernanda Vazzana, Alessia Romano et al.
Malnutrition is highly prevalent in children with congenital heart diseases (15–64%), where each 1-unit decrease in weight-for-age Z-score increases operative mortality by 33%, necessitating early screening and individualized nutritional support of up to 150 kcal/kg/day.
Ahmed A Saleh, Ibrahim A Elkhaiat et al.
Inclusion of cottonseed meal (CSM) in broiler diets, particularly when combined with endo-1,4-β-xylanase, improved growth performance, carcass yield, intestinal health, IGF-1 gene expression, and economic efficiency, making it a viable alternative to soybean meal.
Emmanuel Stamatakis, Nicholas A Koemel et al.
The optimal combination of moderate sleep duration, high moderate-to-vigorous physical activity, and good diet quality was associated with a 64% lower risk of all-cause mortality compared to the lowest tertiles for all three behaviours.
Xudong Zhang, Vanessa Lazaro-Camp et al.
The dual PI3K and HDAC inhibitor CUDC-907 effectively inhibits endometrial cancer growth in vitro and in vivo by restoring PR expression, reducing obesity-related factors like IGF-1, and inhibiting the PI3K/AKT pathway, showing particular efficacy in mice on high-fat diets and synergizing with progestin therapy.
Minyan Wang, Huan Ma et al.
From 1990 to 2021, neoplasms and cardiovascular diseases burden declined in China and Japan, while diabetes burden increased, with specific dietary factors like high sodium for cardiovascular disease and high red meat for neoplasms being significant risk factors.
Xiaoyun Zhou, Yiping Song et al.
Dietary supplementation with 8 mg/kg canthaxanthin (CX) significantly improved egg production rate by 23.8% and reduced feed conversion ratio by 15.3% in Huaixiang laying hens under heat stress, while also mitigating intestinal oxidative damage and improving intestinal morphology and nutrient absorption.
Zhuo Song, Xiuci Yan et al.
20(S)-protopanaxadiol prolongs lifespan and enhances stress resistance in Caenorhabditis elegans by targeting the insulin receptor and activating the DAF-16/FOXO pathway, leading to increased expression of antioxidant and detoxification genes.
Scheine Leite Canhada, Álvaro Vigo et al.
Ultra-processed foods (UPFs) overall and their subgroups were associated with an increased risk of cardiometabolic and mental health outcomes, with specific subgroups like sweetened beverages and processed meats showing significant associations with various conditions.
Wenjun Zhu, Paba Edirisuriya et al.
Supplementation with Clostridium cochlearium 2316 significantly mitigated high-fat diet-induced obesity and metabolic dysfunction by reducing body weight gain by 17.3%, improving glucose homeostasis (89.4% HOMA-IR reduction), and increasing basal metabolic rate and energy expenditure.
Qianqian Du, Jiachen Zheng et al.
Low-molecular-weight chondroitin sulfate-iron complex (LCS-Fe) significantly enhanced oral bioavailability in mice (Cmax 415.16 ± 109.50 μg/mL) and exhibited superior anti-inflammatory effects in LPS-induced macrophages compared to unmodified chondroitin sulfate (CS) and high-molecular-weight chondroitin sulfate-iron complex (CS-Fe), by reversing LPS-induced metabolic changes, particularly in valine, leucine, and isoleucine biosynthesis.
Chun-Yik Lew, Yi-Teng Tang et al.
Shikonin, a naphthoquinone phytochemical, exhibits potent anticancer activity by inducing diverse regulated cell death pathways (apoptosis, necroptosis, ferroptosis, pyroptosis), suppressing metastasis, and disrupting tumor metabolism, and it synergizes with conventional therapies to overcome resistance, although its clinical translation is limited by poor bioavailability, dose-dependent hepatotoxicity, and a lack of modern clinical trials.
Deeksha Rana, Renuka Aggarwal et al.
Formulating products with Kodo millet and chickpea significantly increases crude protein (up to 18.31 g/100 g) and lysine content compared to traditional cereal controls, meeting up to 79.5% of the daily lysine requirement for children while remaining cost-effective and sensory-acceptable.
Tanja Kongerslev Thorning, Anne Raben et al.
The review of meta-analyses and RCTs indicates that dairy consumption is associated with a reduced risk of obesity, type 2 diabetes, cardiovascular disease, and colorectal cancer, while showing no association with all-cause mortality and providing nutritional advantages over plant-based alternatives.
Andres V Ardisson Korat, Ecaterina Duscova et al.
Midlife intake of high-quality carbohydrates and dietary fiber were favorably associated with healthy aging, while refined carbohydrate intake was unfavorably associated.
Bruna O de Vargas, Saba Vaezi et al.
The study successfully developed and implemented a practical, scalable method for evaluating different protein sources within plant-forward diets, demonstrating high participant acceptance and adherence to both meat- and plant-protein-distinct diets that reduced ultra-processed foods, total and saturated fats, and sodium while increasing fiber.
Golnaz Shambayati, Mojtaba Mohammadzadeh Vazifeh et al.
Probiotic garden cress produced using Bifidobacterium bifidum demonstrated resistance to simulated gastrointestinal conditions, retained probiotic properties for 3 days, and showed increased Vitamin C and fat content without negatively impacting organoleptic properties or growth rate.
Meaghan E Kavanagh, Andreea Zurbau et al.
Greater adherence to the Portfolio dietary pattern was inversely associated with a lower risk of cardiovascular disease (CVD), coronary heart disease (CHD), and all-cause mortality in a racially diverse US adult cohort, with greater reductions observed in the non-White group for CVD and CHD mortality.
Stephen R Robinson, Malav S Trivedi et al.
Aerosolised vitamins A, B12, and D, and inhaled iodine, show evidence of pulmonary absorption and systemic delivery, with some studies demonstrating efficacy in restoring micronutrient levels and, for magnesium, improving peak expiratory flow rate in asthmatic children and adults.
Xichao Sun, Liwen Zhang et al.
Nutrient elements significantly modulate plant responses to cadmium (Cd) stress by influencing Cd bioavailability, uptake, binding, complexation, cellular stability, antioxidant defense, signaling, and gene expression, offering powerful tools for reducing Cd in food crops and improving phytoremediation through optimized fertilization and advanced biotechnologies.
Anne J Wanders, Samantha N Heerschop et al.
Replacing all animal meat with plant-based meat alternatives in the Dutch diet led to a decrease in utilizable protein adequacy from 93% to 86%, with protein adequacy being influenced by total protein content, lysine content, and protein digestibility of the alternatives.
Saydul Md Safwa, Nikitha Modupalli et al.
Dual-stage ultrasound-assisted extraction (UAE-UIP) significantly increases rice bran protein yield (65.7%) and improves functional properties like solubility and emulsifying capacity, although it reduces protein purity and amino acid scores compared to conventional alkaline extraction.
Martina Tosi, Matteo Domenico Marsiglia et al.
The use of a slow-release phenylalanine-free protein substitute in PKU patients significantly improved insulin sensitivity, as evidenced by a reduction in HOMA-IR (2.0 to 1.4, p=0.0099) and an increase in QUICKI (0.6 to 0.7, p=0.0404), while maintaining stable plasma phenylalanine levels and nutritional status.
Daniela Viktoria Nickel, Rasmus Wibaek et al.
In this Ethiopian cohort, high maternal adherence to a vegetarian food pattern was significantly associated with higher neonatal fat mass (33.5 g), while an animal-source food pattern was primarily linked to higher fat-free mass (53.1 g).
Grace Austin, Jessica J A Ferguson et al.
While plant-based diets (PBDs) in Australians offer superior profiles for fibre, magnesium, and saturated fat compared to regular meat-eating diets, they are associated with significantly higher risks of inadequacy for vitamin B12, iodine, calcium, and long-chain omega-3 fatty acids.
Wentao Gui, Petr Paral et al.
MCL1 regulates mTORC1 signaling and cellular bioenergetics independently of its anti-apoptotic role, controlling HK2 levels and contributing to tumor promotion, while MCL1 inhibitors suppress mTORC1, leading to cardiotoxicity that can be ameliorated by dietary leucine supplementation.
Rui Chu, Mingming Li et al.
Exercise interventions significantly increased serum IGF-1 levels in older adults with frailty and/or sarcopenia (SMD = 0.42, 95% CI: 0.23–0.60, p < 0.0001), with combined training (SMD = 0.60) and resistance training (SMD = 0.35) being more effective than aerobic training alone (SMD = 0.01).
Mauricio Moel, Girish Harinath et al.
Intermittent low-dose rapamycin administration over 48 weeks was relatively safe in healthy, normative-aging adults and was associated with significant improvements in lean tissue mass and pain in women, with no significant changes in visceral adiposity.
Yuge Zhang, Shunsuke Murata et al.
Centenarians exhibit lower age-specific disease incidence rates and lifetime risks for most major diseases (stroke, myocardial infarction, cancers) compared to non-centenarians, indicating they delay and avoid diseases, with hip fracture being the notable exception of higher lifetime risk.
Jessica Eastwood, Saskia van Hemert et al.
Acute probiotic supplementation led to faster reaction times on cognitively demanding executive function trials, and chronic supplementation improved cognitive biases related to reactivity to sad mood, including hopelessness, rumination, and aggression, in healthy older adults.
Di Wang, Congkang Jia et al.
A lower prognostic nutritional index (PNI) is strongly associated with higher mortality rates in patients with acute myocardial infarction (AMI), with a pooled hazard ratio of 0.91 (95% CI: 0.85–0.91; p < 0.0001), although no significant relationship was observed between PNI and major adverse cardiovascular events (MACE).
Hossein Haghir, Mohammad Javad Yazdanpanah et al.
Facial and body acupuncture significantly reduced frown lines and improved subject satisfaction and social functioning in women aged 30-59 compared to a waitlist control group, with minor adverse effects reported.
Lingling Bao, Youquan Wang et al.
Adequate energy intake was associated with significantly lower 28-day mortality among high-risk critically ill patients, but this association was not confirmed in randomized controlled trials or by trial sequential analysis, and adequate protein intake did not significantly reduce mortality in either high-risk or low-risk patients.
Taline Lazzarin, Raquel Simões Ballarin et al.
Nut inclusion in the CKD diet may offer benefits for oxidative stress, inflammation, and all-cause mortality, with walnut intake appearing safe for electrolyte balance, though evidence is limited by study bias and heterogeneity.
Zhaoyin Su, Yifeng Lin et al.
Preoperative malnutrition is significantly associated with poorer overall survival in patients undergoing abdominal tumor surgery, with a pooled hazard ratio of 1.61 (95% CI: 1.49–1.73).
Mats Borjesson, Margareta Kristenson et al.
The Swedish model of health dialogues, a combined individual- and community-based primary preventive program for CVD, is associated with reduced CVD and all-cause mortality (moderate level of evidence) and improvements in biological CVD risk factors and diet (moderate level of evidence).
Hanife Altınışık, Merve Nezir
Low, medium, and high concentrations of hydrogen peroxide (18%, 25%, and 40%) used in in-office bleaching did not significantly differ in their efficacy, longevity, tooth sensitivity, or impact on oral health-related quality of life over a 6-month period.
Amani N Alansari, Salma Mani et al.
Primary anastomosis in NEC neonates is associated with a significantly lower risk of mortality (RR = 0.61; 95% CI: 0.42 to 0.88) and comparable overall complication rates to stoma formation.
Ju Youn Jung, Je-Yeon Yun et al.
Comorbid depression significantly increases 1-year mortality risk in advanced cancer patients with lower proactive positivity, but not in those with higher proactive positivity.
Jennifer Yee Man Tang, Hao Luo et al.
Combining lifestyle education with resistance and aerobic exercise, delivered through different sequences, improved frailty, fitness (grip strength and arm curl), and quality of life in older adults with frailty or prefrailty over 18 months.
Li-Ning Peng, Pei-Lin Lee et al.
The 12-month multidomain intervention led to less grey matter volume reduction in the left inferior temporal lobe and improved cognitive function and HDL-C levels in older adults, with distinct effects on brain structure and physical performance observed between urban and rural participants.
Ze-Yuan Liu, Ben Liu
High nutritional risk index (NRI) and geriatric nutritional risk index (GNRI) predict superior overall survival (HR = 1.78) and distant metastasis-free survival/progression-free survival/recurrence-free survival (HR = 1.95) in esophageal cancer patients, while low NRI/GNRI is associated with more lymph node metastasis, deeper tumor invasion, and advanced tumor stage.
Claudia M Groot Kormelinck, Debby L Gerritsen et al.
The intervention did not reduce the inappropriateness of psychotropic drug use in nursing home residents with dementia, but it did reduce overall usage, particularly of anxiolytics and antidepressants, at 16 months.
Shuyue Wang, Lixia Song et al.
Nucleotide supplementation significantly reduced DNA methylation age by 3.08 years and improved insulin sensitivity (reduced HOMA-IR) in older adults over 19 weeks, with no severe adverse events reported.
Passant H Hassanein, Abdel Wahab M Samaha et al.
Chemo-mechanical caries removal agents (Brix 3000 and Papacárie Duo) were more effective than hand excavation in reducing cariogenic bacteria, minimizing pain, and improving restoration longevity in immature permanent molars, with Papacárie Duo showing a superior clinical success rate compared to Brix 3000 and hand excavation.
Yuya Watanabe, Kazuki Hyodo et al.
A 12-week web-based aerobic dance exercise program significantly improved maximal walking speed in older adults, with a trend towards increased light-intensity physical activity.
Eric R Reed, Kevin B Chandler et al.
A cross-platform analysis of serum proteins identified 80 proteins associated with extreme old age, conserved between mass spectrometry and aptamer-based assays, highlighting pathways such as blood coagulation, IGF signaling, ECM organization, and the complement cascade.
Xin Tong, Ross Blanc et al.
One dose of Ad26.preF + SpreF elicits a long-lasting, functionally potent humoral response characterized by sustained IgG3 production, strong FcγR engagement, and long-lasting opsinophagocytic functions, which is not further enhanced by a booster at 12 months.
Ravi B Parikh, William J Ferrell et al.
Machine learning (ML) presentation strategies significantly improved prognostic accuracy among medical oncologists for patients with metastatic non-small-cell lung cancer, particularly when using absolute or reference-dependent estimates, but did not alter recommendations for palliative care or advance care planning.
Oam To-Aj, Apithai Bumrungpanictarworn et al.
Structured competitive table tennis training significantly improved the quality of life in older adults across physical, psychological, and social domains compared to recreational play.
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