Research Database

Sehr niedrigNarrative ReviewMensch2025
Selected Lipidome Components and Their Association with Perinatal Depression.
Dominika Ładno, Beata Nowak et al.
Omega-3 PUFA deficiency may increase perinatal depression risk, and supplementation, particularly with EPA-rich formulations (EPA/DHA ≥ 1.5), appears beneficial for prevention, while findings regarding choline and lecithin are inconclusive, with some evidence suggesting excessive choline intake or its metabolite TMAO may contribute to depressive symptoms.
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Sehr niedrig2025
Perspective: Milk and Dairy Provide Affordable High-Quality Protein and Merit Inclusion in the Protein Foods Group.
Adam Drewnowski
Dairy foods provide affordable, high-quality protein and essential micronutrients, and compare favorably to many foods within the USDA protein foods group, meriting their inclusion.
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Sehr niedrigNarrative Review2025
Dietary interventions and nutritional strategies for menopausal health: a mini review.
Yi-Chen Liu, Zhi-Qing Guo
Dietary patterns such as the Mediterranean and plant-predominant diets, along with key micronutrients like calcium, vitamin D, and omega-3 fatty acids, are effective in reducing menopausal symptoms and preventing associated comorbidities.
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Sehr niedrigNarrative ReviewMensch2025
Ocular Manifestations of Celiac Disease: Current Evidence and Clinical Implications.
Monika Senterkiewicz, Anna Szaflarska-Popławska et al.
Celiac disease is associated with an increased risk of ocular manifestations, including uveitis (HR 1.32; 95% CI 1.10 to 1.58) and cataract (397/100,000 person-years vs. 86/100,000 person-years in the general population), as well as tear film instability, ocular surface abnormalities, altered anterior chamber depth/volume, changes in choroidal thickness and retinal nerve fiber layer, and microvascular alterations.
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ModeratRCTMensch2025
Impact of α -linolenic acid supplementation on long-chain n -3 fatty acid profiles in Western, flexitarian, vegetarian, and vegan diets.
Lea Klein, Kristin Kipp et al.
Flaxseed oil supplementation effectively increases long-chain n-3 PUFA status across various diets, with the magnitude of improvement being primarily influenced by baseline EPA concentrations, while sex, BMI, age, LA, and ARA status do not affect ALA conversion.
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Sehr niedrigMaus2025
Fraxin modulates lipid metabolism as well as gut flora to avert NAFLD.
Yang Jing, Dong Huicong et al.
Fraxin alleviates non-alcoholic fatty liver disease (NAFLD) induced by a methionine-choline-deficient (MCD) diet by suppressing FAT/CD36 expression and restoring gut microbiota homeostasis.
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Sehr niedrigNarrative Review2025
Diet and nutrition key factors for oral microbiota composition: a systematic review.
Heriberto Castro García, Vania Urias Orona et al.
Dietary patterns, particularly healthy ones like the Mediterranean and vegetarian diets, along with probiotic and prebiotic supplementation, positively modulate the oral microbiota and reduce inflammation, thereby influencing oral health.
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Sehr niedrigIn vitro2025
Effects of plant-based fermented broth on rumen fermentation, gastrointestinal development, and microbial populations in fattening lambs.
Lu Zhang, Huiwen Zhang et al.
Supplementation with a plant-based fermentation broth (FB) at a 1:500 ratio in drinking water promoted gastrointestinal development and improved microbial community structure in fattening lambs, thereby enhancing nutrient digestion and absorption.
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ModeratRCT2025
Glutamine and glutamate supplementation in sow diets during late gestation and lactation reduces farrowing duration, improves colostrum amino acid content, and enhances piglet weaning weight.
Maria Vitória S Sousa, Charles Kiefer et al.
Dietary supplementation of 10 g/kg glutamine and glutamate mixture in sows significantly reduced farrowing duration (230 vs. 309 min), increased the number of piglets born alive, and improved both colostrum amino acid concentrations and piglet weaning weights.
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Sehr niedrigMaus2025
Wubi Shanyao pills ameliorate diet-induced postmenopausal osteoporosis in mice by enhancing calcium absorption.
Xiaorui Su, Xiaohu Jin et al.
Wubi Shanyao Pills (WSP) treatment mitigated osteoporotic manifestations in a diet-induced murine postmenopausal osteoporosis model by augmenting calcium absorption through the upregulation of TRPV5 and CABP in the kidney, TRPV6 and CABP in the ileum, and VDR in the femur, leading to improved bone mass, restored calcium-phosphorus homeostasis, ameliorated systemic metabolism, and reversed anemia.
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Sehr niedrig2025
Dietary Glycine and Methyl Donors Remodel Gut Microbiota to Enhance Collagen Synthesis in Sea Cucumber ( Apostichopus japonicus ).
Dongsheng Chen, Honglin Pei et al.
Dietary supplementation with choline, betaine, or glycine significantly increases body wall collagen content in A. japonicus, with this enhancement likely mediated by gut microbiota alterations, particularly the enrichment of Achromobacter, which correlates positively with collagen levels.
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Sehr niedrigMensch2025
Bone and mineral metabolism in 2-7-year-old Finnish children and their caregivers following vegan, vegetarian, and omnivorous diets.
Suvi T Itkonen, Topi Hovinen et al.
Plant-based diets were associated with increased bone catabolism in children and accelerated bone turnover in adults, despite adequate vitamin D and calcium intake, potentially due to lower protein consumption.
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Sehr niedrig2025
Temperature regulated nutrient sensing and metabolism of amino acids in juvenile turbot ( Scophthalmus maximus L.).
Xuemin Zhang, Jiru Wang et al.
In juvenile turbot, the optimal growth temperature of 18 °C resulted in the highest mTOR signaling activity and protein deposition, despite selective intestinal amino acid transporters being upregulated at cold temperatures and plasma free amino acids being elevated at high temperatures, with high temperatures also inducing significant cellular stress and disrupting amino acid metabolism.
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Sehr niedrig2025
Limited contributions of bacteria and fungi to coral nutrition revealed by amino acid δ 13 C analysis.
Qifang Wang, Jiachen Li et al.
Coral-associated bacteria and fungi contribute minimally to *Pocillopora damicornis* nutrition, which is primarily sustained by Symbiodiniaceae translocation (70.7–93.8%) and external particulate feeding (4.8–24.8%), with the coral exhibiting trophic flexibility by increasing autotrophy from 67.1% in the cool season to 80.5% in the warm season.
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Sehr niedrigNarrative ReviewMensch2025
The Supportive Role of Plant-Based Substances in AMD Treatment and Their Potential.
Karolina Klusek, Magdalena Kijowska et al.
Plant-derived substances such as silibinin, anthocyanins, lutein, zeaxanthin, EGCG, resveratrol, chlorogenic acid, curcumin, kaempferol, baicalin, and genistein show therapeutic potential for Age-Related Macular Degeneration (AMD) by modulating oxidative stress, inflammation, and angiogenesis, although further research is needed due to limitations like low bioavailability and study design.
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Sehr niedrigRatte2025
The Effect of High-Intensity Interval Training and Mixed Probiotic Supplementation on SMOC-1 Gene Expression, Insulin Resistance, and Blood Glucose in Male Rats With Induced Diabetes.
Dorsa Ghazvineh, Marjan Dodangeh et al.
In diabetic male rats, the combination of high-intensity interval training (HIIT) and mixed probiotic supplementation synergistically reduced insulin resistance (IR) and blood glucose (BG), while HIIT alone significantly decreased secreted calcium-binding protein-1 (SMOC-1) gene expression.
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Sehr niedrig2025
Assessment of Physicochemical Properties and Consumer Preferences of Multi-Millet Extruded Snacks Using a Fuzzy Logic Approach.
Tej Bhan Singh, Ramesh Kumar Saini et al.
Multi-millet extruded snack formulation S3 (50% foxtail millet, 25% proso, 25% kodo) received the highest overall sensory acceptability rating of "Very Good" based on fuzzy logic analysis, with taste being the most critical attribute.
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Sehr niedrig2025
Enhancing Nutritional Quality and Functionality of Legumes: Application of Solid-State Fermentation With Pleurotus ostreatus .
Seyyed Mohammad Ali Noori, Mohammad Hojjati et al.
Solid-state fermentation with *Pleurotus ostreatus* significantly improved the nutritional value of lentils, chickpeas, and soybeans by increasing protein content and digestibility, enhancing antioxidant activity, and reducing antinutrients (tannin and phytate).
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ModeratProspektivMensch2025
Plasma lipopolysaccharide levels predict mortality in acutely ill children in Low- and Middle-Income Countries.
Chris A D Allen, Arya Ghate et al.
Plasma lipopolysaccharide (LPS) levels are an independent predictor of 90-day mortality in acutely ill children in low- and middle-income countries, with higher LPS levels associated with increased mortality risk.
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Sehr niedrig2025
Assessment of Purslane ( Portulaca oleracea L.) Total Oxalate Content, Ascorbic Acid, and Total Organic Acids Using Near-Infrared Spectroscopy.
Zornitsa Zherkova, Mima Todorova et al.
Culinary processing, particularly pickling, significantly reduced total oxalate content in purslane, and Near-infrared spectroscopy (NIRS) demonstrated high predictive accuracy (Rcval > 0.98, RPD > 4.04 for oxalates; Rcval = 0.99, RPD > 10 for ascorbic acid and total organic acids) for non-destructive determination of total oxalates, ascorbic acid, and total organic acids in fresh, blanched, and pickled purslane samples.
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Sehr niedrig2025
Dietary supplementation of oregano essential oil, lauric acid, and a multi-enzyme complex enhances productivity, metabolic status, and gut health in Dagu breeder hens.
Xiaotong Li, Changmin Jin et al.
The combination of oregano essential oil and lauric acid (OEA) and complex enzyme preparation (CEP) synergistically improved laying rate, feed-egg ratio, monthly total egg weight, antioxidant status, and intestinal morphology in Dagu breeder hens, while OEA alone significantly reduced broken-soft egg ratio and *E. coli* counts.
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HochRCT2025
Calcium requirements for Japanese quail in the early growth period.
Mostafa Ahmadi, Kamal Shojaeian et al.
The optimal dietary calcium requirement for Japanese quail chicks (11-24 days) is approximately 0.800% for growth and feed efficiency, with higher levels potentially beneficial for bone development and immune response.
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Sehr niedrig2025
Fava bean plant performance and fertility dynamics in Mars regolith simulant-based substrates for space farming.
Antonio Giandonato Caporale, Roberta Paradiso et al.
Green compost amendment of MMS-1 Mars regolith simulant significantly improved fava bean seed production, harvest index, and nutritional quality, making it comparable to volcanic soils, despite pure MMS-1 reducing physiological and growth parameters and seed productivity.
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Sehr niedrig2025
Cricket protein hydrolysate as a sustainable functional ingredient in dog diets: Effects on palatability, health parameters, and antioxidant shelf-life stability.
Nuttawadee Saejiem, Chaiyapoom Bunchasak et al.
While 2% cricket protein hydrolysate (CPH) significantly improves diet palatability and oxidative stability, higher inclusion levels (4-6%) reduce food intake and may cause adverse physiological changes, including eosinophilia and altered serum biochemistry.
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Sehr niedrigQuerschnitt2025
Pre-season and in-season body composition assessment by bioimpedance in professional football athletes: implications for sports nutrition, physical performance, and hormonal health.
Rand Iblasi, Mahmoud Abualsaud et al.
Professional football players in Jordan showed insufficient energy and carbohydrate intake and several micronutrient imbalances in both pre-season and in-season phases, with significantly higher protein intake during pre-season and only growth hormone (GH) levels significantly increasing in-season, while body composition and physical performance remained stable.
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Sehr niedrigNarrative Review2025
Beyond seasoning nutrients bioactive ingredients and healthcare effects of Allium vegetables.
Hafiz Ghulam Muhu Din Ahmed, Jiazhen Yang et al.
Allium vegetables, rich in organosulfur compounds and flavonoids, offer significant health benefits including antioxidant, anti-inflammatory, and antimicrobial properties, supporting cardiovascular health, metabolism regulation, and chronic disease prevention, with regular consumption (1-3 cloves garlic or 50g onions daily) linked to reduced risks of cancer and metabolic disorders.
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Sehr niedrigNarrative ReviewMensch2025
Polyphenol-Microbiota Interactions in Atherosclerosis: The Role of Hydroxytyrosol and Tyrosol in Modulating Inflammation and Oxidative Stress.
Mojgan Morvaridzadeh, Mehdi Alami et al.
Hydroxytyrosol (HTyr) and tyrosol (Tyr), phenolic compounds found in extra virgin olive oil, and the gut microbiota are interconnected in the context of atherosclerosis, with preclinical evidence supporting HTyr's vascular and metabolic benefits, though human clinical trial results are heterogeneous due to variability in dose, duration, phenolic composition, populations, and individual gut microbiota.
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Sehr niedrig2025
Biofortification of Durum Wheat Grain: Interactions Between Micronutrients as Affected by Potential Biofortification Enhancers and Surfactants.
Despina Dimitriadi, Georgios P Stylianidis et al.
S-assisted agronomic biofortification of durum wheat using sulfate micronutrients with S-amino acids and surfactants generally increased zinc and often decreased copper, while iron and manganese levels showed variable changes, and many interventions led to an overall increase in the total essential micronutrient metallome per grain.
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Sehr niedrigMensch2025
Never too late to try something new: attitudes and intention to taste foods from alternative protein sources in a sample of Italian older adults.
Maria Elide Vanutelli, Roberta Adorni et al.
Distinct factors predict intention to consume alternative protein sources in older adults, with disgust and perceived risk being key for cultured and insect-based meats, while familiarity, taste attitudes, and automatic responses are crucial for plant-based foods.
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Sehr niedrigMensch2025
Associations between dietary patterns and sarcopenia in aging populations: a community study from eastern China's Huzhou city.
Qi Zhang, Meihua Yu et al.
Dietary patterns characterized by high meat-egg intake (Pattern 2) and vegetable-freshwater aquatic intake (Pattern 3) were inversely associated with sarcopenia risk in older adults, while moderate adherence to a high dairy-low refined grain pattern (Pattern 4) was positively associated with sarcopenia risk.
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Sehr niedrigMetaanalyseMensch2025
Effect of early-life protein supplementation on childhood obesity and related metabolic outcomes: a systematic review and meta-analysis.
Rukman Manapurath, Christopher P Duggan et al.
Limited evidence suggests that protein quantity or quality during complementary feeding does not significantly impact growth or body composition in children aged 6-23 months.
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Sehr niedrigMensch2025
Fermented Food Consumption Across European Regions: Protocol for the Development and Validation of the Web-Based Fermented Foods Frequency Questionnaire (3FQ).
Emmanuella Magriplis, Sotiria Kotopoulou et al.
The validated web-based Fermented Food Frequency Questionnaire (3FQ) has been developed and pilot-tested to address gaps in fermented food intake research across four European regions, with validation for accuracy and repeatability ongoing.
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Sehr niedrig2025
Optimizing GLP-1 therapies for obesity and diabetes management.
Jarvis C Noronha, Luc F Van Gaal et al.
Integrating evidence-based nutrition (e.g., protein intake >1.2 g/kg/day distributed evenly) and physical activity (e.g., >=150 minutes/week MVPA including resistance training) with GLP-1 therapies enhances weight loss, improves body composition, and reduces visceral fat and inflammation, while proactive management of GI side effects is crucial for adherence.
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Sehr niedrigProspektiv2025
Association and optimization of the Planetary Health Diet Index with hyperuricemia.
Jia-Xin Tan, Zhen Qin et al.
The optimized PHDI-Dairy index showed a significantly stronger negative correlation with hyperuricemia risk compared to the original PHDI-US and other dietary indices, a finding validated in an independent cohort.
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Sehr niedrigNarrative Review2025
Dietary Influence on Bacterial Vaginosis.
Dhiya Ram, Pujita Julakanti et al.
Diet plays an influential role in BV susceptibility, with increased intake of nutrients such as plant-based proteins, whole grains, and dietary fibers potentially lowering the risk of BV.
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Sehr niedrigQuerschnittMensch2025
Adherence to the EAT-lancet dietary pattern among older adults in Rwanda and its association with micronutrient intake.
Theogene Habumugisha, Anna Stubbendorff et al.
Higher adherence to the EAT-Lancet diet in older adults in Kigali, Rwanda, was associated with increased intake of energy and several key micronutrients, although potential nutrient gaps, particularly in riboflavin, were identified.
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Sehr niedrig2025
Moringa oleifera Lam. leaf supplementation enhances egg quality parameters and commercial value in laying hens.
Alejandro Martínez, Tamara Vayas et al.
Supplementation with 2.5% *Moringa oleifera* leaf significantly improved egg weight (4.2% increase), albumin height (7.3% vs. 2% group), and Haugh units, and all Moringa groups enhanced yolk coloration compared to controls, without compromising production performance in commercial laying hens.
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Sehr niedrig2025
Dietary modulation of gut microbiota and functional enzymes in savannah honey bees (Apis mellifera scutellata Lepeletier).
Nolwandle N Khumalo, Linda U Obi et al.
The gut microbiota of African savannah honey bees (A. mellifera scutellata), both wild and diet-fed, is dominated by non-core bacteria, Commensalibacter and Bartonella, with diet type significantly influencing microbial diversity, composition, and predicted functional capabilities, including digestive and metabolic enzymes.
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Sehr niedrigMensch2025
Quinoa Fibre Isolated By Wet Milling as a New Ingredient for Food Enrichment: Nutritional Value and Technological Properties.
A Alonso-Álvarez, C M Haros
Wet milling of quinoa grains successfully isolated fibre-rich fractions, with black quinoa fibre showing the highest total and insoluble fibre content (76%), highest extraction yield (20.6% d.m.), and significantly reduced phytate levels (85% reduction) leading to improved mineral bioavailability, while red quinoa fibre exhibited superior water-holding, oil-holding, and swelling capacities.
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ModeratRCT2025
Common genetic polymorphisms define one-carbon metabolite responses to different forms of choline in healthy adult males.
Nisa Butt, Jianzhang Dong et al.
Genetic variations in CHDH rs12676, BHMT rs3733890, CHKA rs10791957, and PEMT rs4646343 significantly influence individual metabolic responses to different forms of choline supplementation (choline bitartrate vs. phosphatidylcholine), leading to unique one-carbon metabolite signatures and highlighting nutrient-gene interactions.
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Sehr niedrigProspektiv2025
Dysregulated Intestinal Nutrient Absorption in Obesity Is Associated with Altered Chromatin Accessibility.
Dilhana S Badurdeen, Zhen Li et al.
A subset of obese individuals with accelerated intestinal glucose absorption (G2) exhibits a stable, transcriptionally-imprinted intestinal epithelial phenotype characterized by upregulated genes for nutrient absorption (sugar, lipid, bile acid transporters, and specific gut hormones), differential chromatin accessibility, and altered binding of master transcription factors, particularly HNF4G, which persists in long-term organoid cultures.
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NiedrigMetaanalyse2025
CO 2 Rise Directly Impairs Crop Nutritional Quality.
Sterre F Ter Haar, Peter M van Bodegom et al.
Rising atmospheric CO2 concentrations lead to a significant mean decrease of 3.2% in the nutrient content of edible crop parts across all crops and nutrients, with 77% of high-power nutrients decreasing and 15% increasing, threatening nutrient security.
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Sehr niedrig2025
The effects of Sijunzi decoction-supplemented cat food on physiological parameters and gut microbiota in healthy adult cats.
Wei Liu, Yinghao Chen et al.
Sijunzi Decoction (SJZD)-supplemented cat food significantly improved fecal scores and reduced soft stool rates, enhanced immune and antioxidant capacities, improved glomerular filtration and lipid metabolism, and positively regulated gut microbiota structure in healthy adult cats over 24 weeks.
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Sehr niedrig2025
Effects of bitter almond on production performance, antioxidant capacity and immune function of Rongde black-feathered small-sized layer strain.
Jun-Nan Chen, Yi-Fan Chen et al.
Dietary supplementation with 0.5 g/kg of bitter almond significantly improves laying rate, egg quality, antioxidant capacity, and intestinal morphology in RBSL hens, while higher doses (0.75 g/kg) may reduce egg weight.
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Sehr niedrigNarrative ReviewMensch2025
Combating Sarcopenia Through Nutrition: Anti-Inflammatory and Antioxidant Properties of Aronia melanocarpa .
Kalina Metodieva, Iliyan Dimitrov et al.
Aronia melanocarpa, rich in polyphenols, shows preclinical promise in activating antioxidant defenses, suppressing inflammation, and enhancing muscle metabolism, but further clinical trials are needed to confirm its efficacy in combating sarcopenia.
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Sehr niedrigMaus2025
Ultrafine garlic powder alleviates non-alcoholic steatohepatitis by inhibiting hepatocyte ferroptosis and modulating ERK-dependent oxidative stress.
Junhui Yu, Ningning Shao et al.
Ultrafine garlic powder (UGP) alleviates non-alcoholic steatohepatitis (NASH) by inhibiting hepatocyte ferroptosis and modulating ERK-dependent oxidative stress, demonstrating promising therapeutic potential for NASH.
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Sehr niedrig2025
Dietary Vitamin D Supplementation Improves Hair Follicle Development and Affects Fatty Acid Metabolism in Rex Rabbits.
Xiang Li, Xiaojing Wu et al.
Dietary Vitamin D supplementation at 1400–2100 IU/kg improves hair follicle density and quality in Rex rabbits by activating key signaling pathways (Wnt10b/β-catenin, Notch, SHH) and enhancing fatty acid metabolism across liver, muscle, and adipose tissues.
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Sehr niedrigMensch2025
Low Serum Levels of Zinc and Copper Are Associated With Tuberculosis.
Priyank Modi, S N Krishnagopal et al.
Serum copper levels were significantly higher in active tuberculosis (TB) patients (141.90 ± 45.27 µg/dL) compared to healthy controls (90.04 ± 58.35 µg/dL), while zinc levels were lower in TB patients (83.70 ± 59.37 µg/dL) than in controls (97.83 ± 54.18 µg/dL), resulting in a lower Cu/Zn ratio in TB patients.
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Sehr niedrigNarrative Review2025
Innovative lipid delivery systems in ruminant diets: the role of spray drying.
Thâmilla Thalline Batista de Oliveira, Thalia Catherine Sacramento Ferreira et al.
Microencapsulation, particularly spray-dried lipids, improves digestibility, nutrient utilization, and feed efficiency in ruminants, contributing to reduced environmental impacts like methane emissions, with tannins enhancing microparticle stability and rumen modulation, though in vivo assessments and economic feasibility remain key knowledge gaps.
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Sehr niedrigMaus2025
The 3xTg-AD Mouse Model of Alzheimer's Disease Exhibits Lifelong Reductions in Circulating Choline Despite Adequate Dietary Intake, With Sex-Specific Neuropathological and Behavioral Phenotypes.
Jessica M Judd, Faizan Mistry et al.
3xTg-AD mice exhibit lifelong reductions in circulating choline despite adequate dietary intake, with sex-specific neuropathological and behavioral phenotypes, including greater AD-like pathology in females and higher mortality and impulsivity in males.
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HochRCT2025
Dietary zinc-di-tripeptide enhances zinc relative bioavailability and reduces fecal zinc losses compared to zinc sulfate, without compromising performance of growing pigs.
Pedro Silva Careli, Danyel Bueno Dalto et al.
Dietary supplementation with Zn-di-tripeptides (Zn-di-tripep) improved zinc (Zn) digestibility, serum and tissue Zn concentrations, and reduced fecal Zn excretion compared to zinc sulfate (ZnSO4) in pigs, demonstrating a relative bioavailability of 134% for Zn-di-tripep compared to ZnSO4.
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Sehr niedrig2025
Microwave-dried black soldier fly larvae enhance growth, intestinal health, and humoral immunity in broiler chickens: A functional feed approach.
Osfar Sjofjan, Ari Ardiantoro et al.
Dietary supplementation with 0.50%–0.75% microwave-dried black soldier fly larvae meal significantly improves broiler growth performance, ileal villus height, and humoral immune response (IgA and IgY) without adverse effects on organ weights.
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Sehr niedrig2025
Supplementation with willow containing condensed tannins shifted nitrogen excretion from urine to faeces in yearling ewes.
J P Thompson, O Cristobal-Carballo et al.
Dietary inclusion of Salix 'Beagle' (21% DM, 1.20% DM CT) in yearling ewes shifted nitrogen excretion from urine to faeces, with 19% higher faecal nitrogen excretion and 19% lower urinary nitrogen excretion compared to the control (P < 0.01), despite reducing the digestibility of dry matter, organic matter, fibre, nitrogen, and gross energy.
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Sehr niedrigRatte2025
Evaluation of the Long-Term Administration of Proton Pump Inhibitors (PPIs) in the Mineral Nutrient's Bioavailability.
Andréa Santana de Brito, Angerson Nogueira do Nascimento et al.
Prolonged omeprazole administration in rats significantly altered mineral homeostasis, leading to evidence of iron deficiency anemia (reduced circulating Fe, decreased hemoglobin, lower red blood cell counts) and changes in Cu, Ca, Mg, K, and Zn concentrations in various tissues.
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Sehr niedrigProspektivMensch2025
Iron deficiency treatment pathway in Italy: patients' perceptions of diagnosis and treatment.
Ovidio Brignoli, Rose-Marie Carneiro et al.
In Italy, an online survey of 404 patients with iron deficiency anemia/iron deficiency without anemia found high rates of self-reported symptoms (97.0%) and recurrent episodes (75.0%), with only 56.4% completing prescribed treatment, primarily due to feeling better (64.8% of non-compliant individuals).
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Sehr niedrig2025
Crosstalk between glomalin and AMF reduces cadmium uptake and leaching, enhancing pea yield and soil health.
Muhammad Usama, Muhammad Shoaib Khan et al.
Combined application of arbuscular mycorrhizal fungi (AMF) and easily extractable glomalin (EG) synergistically reduced bioavailable cadmium (Cd) in soil by 64%, Cd in pea grain by 89% (to 0.07 mg kg−1 DW), and Cd in leachates by 93% (to 0.002 mg L−1), while also improving pea grain yield by 58% and enhancing soil enzyme activities and grain nutrient content compared to untreated controls in Cd-polluted pottery soil.
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HochRCTMensch2025
Intestinal microbiome changes in response to amino acid and micronutrient supplementation: secondary analysis of the AMAZE trial.
Monica N Mweetwa, Kazi Ahsan et al.
Micronutrient and amino acid supplementation did not significantly alter overall microbial richness and diversity in adults with environmental enteropathy, although some specific genus abundance and functional pathway changes were observed within intervention arms.
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Sehr niedrig2025
Effect of areca nut extracts on growth performance, slaughtering performance, and meat quality of broiler chickens.
Juan Xu, Mengyao Li et al.
Appropriate supplementation of areca nut extracts (100–200 mg/kg) enhances broiler growth performance, meat quality, and muscle development gene expression without significant negative impacts on slaughter performance or most serum indices.
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Sehr niedrigNarrative Review2025
Human Health Applications of Calcium Montmorillonite Clay: A Systems-Based Review.
Mitchell K Ng, David J Jacofsky et al.
Calcium montmorillonite (CMM) demonstrates broad therapeutic potential across gastrointestinal, dermatologic, immune, and musculoskeletal systems by binding toxins and inflammatory compounds, with growing evidence supporting its use as an adjunctive therapy.
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HochRCTMensch2025
Effects of Diets Containing Beef Compared with Poultry on Pancreatic β-Cell Function and Other Cardiometabolic Health Indicators in Males and Females with Prediabetes: A Randomized, Crossover Trial.
Elizabeth Guzman, Indika Edirisinghe et al.
Twenty-eight days of consuming beef did not adversely affect pancreatic β-cell function, glucose homeostasis, lipoprotein lipids, or inflammation biomarkers compared to poultry in adults with prediabetes.
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Sehr niedrigMensch2025
Iron intake and iron status of Swedish adolescents with diets of varying climate impact.
Elinor Hallström, Josefin Edwall Löfvenborg et al.
Swedish adolescent girls with higher dietary climate impact, lower red meat, and lower heme iron intake had a higher risk of iron deficiency (ID), while boys with higher dairy intake had a higher risk of ID.
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Sehr niedrig2025
Schizochytrium Supplementation in Compound Feed: Effects on Growth, Metamorphosis, Intermediate Metabolism, and Intestinal Health of Bullfrogs ( Lithobates catesbeianus ).
Hao Ding, Yinglin He et al.
Dietary Schizochytrium meal supplementation at 15.00 g/kg significantly promoted bullfrog tadpole growth (23.78% increase in WGR), metamorphosis, and intestinal health, with an optimal level estimated at 13.27 g/kg.
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Sehr niedrigProspektivMaus2025
Wheat-Based Protein Slows Disease Progression in Pkd1 Knockout Mice.
Randee Sedaka, Jifeng Huang et al.
A plant-based wheat-gluten diet mitigates kidney function decline, inflammation, and cyst growth in male Pkd1KO mice compared to an animal-based casein diet, while lysine supplementation accelerates cyst growth and metabolic stress without inducing inflammation.
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Sehr niedrigProspektivMensch2025
Iron insight: exploring dietary patterns and iron deficiency among teenage girls in Sweden.
Anna Stubbendorff, Beata Borgström Bolmsjö et al.
Vegetarians/vegans and pescatarians were significantly more likely to be iron deficient than omnivores, with vegans/vegetarians having a 5.95 times higher odds of iron deficiency compared to omnivores.
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NiedrigProspektivMensch2025
The Role of Dietary Supplements in Modulating Menopause Onset: A Comprehensive Analysis of Nutritional and Lifestyle Influences on Menopause Timing.
Shekhinamary Jebaraj, Valentine Nlebedim
Regular use of fish oil, vitamin B-complex, antioxidant mixtures, and vitamin C supplements was associated with a later age at natural menopause, while smoking, red meat consumption, and lower educational attainment predicted earlier menopause.
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Sehr niedrigProspektivMensch2025
The Effect of a Lecture-Based Educational Intervention to Improve the Nutrition Knowledge and Behavior of Plant-Based Seventh-Day Adventists Living in the United Kingdom.
Robert K Janko, Irmgard Haussmann et al.
An expert-led lecture intervention significantly improved nutrition knowledge and motivated supplement use, particularly for Vitamin B12, among UK-based Seventh-day Adventists following plant-based diets.
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Sehr niedrigSystematic Review2025
Urinary metabolites as biomarkers of dietary intake: a systematic review.
Mariah Kay Jackson, Bing Wang et al.
Urinary biomarkers show potential for assessing intake of broad food groups like citrus fruits, cruciferous vegetables, whole grains, and soy foods, but may struggle to distinguish individual foods.
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Sehr niedrigMensch2025
Trends in diet structural composition and quality among adults in Beijing, China (2010-2022).
Ningsu Chen, Liyu Huang et al.
Between 2010 and 2022, Beijing adults exhibited a significant dietary shift towards lower carbohydrate and higher fat intake, alongside a move from plant-based to animal-sourced foods, resulting in persistent nutritional imbalances and suboptimal diet quality.
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NiedrigSystematic ReviewMensch2025
Dietary Intake Trajectories from Early Life and Associated Health Outcomes: A Systematic Review.
Miaobing Zheng, Seon Y Park et al.
Dietary intake trajectories from infancy or early childhood are associated with various health outcomes, including dental caries, adiposity, cardiometabolic markers, neurocognitive development, liver function, and gut microbiota, from early childhood up to adulthood.
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ModeratProspektivMensch2025
Risk of hypothyroidism in meat-eaters, fish-eaters, and vegetarians: a population-based prospective study.
Catharina J Candussi, William Bell et al.
A vegetarian diet was associated with a moderately higher risk of hypothyroidism after controlling for BMI, with lower iodine intake observed in vegetarians and vegans compared to meat-eaters.
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ModeratRCTMensch2025
Dietary climate impact correlates ambiguously with health biomarkers- a randomised controlled trial in healthy Finnish adults.
Merja Saarinen, Tiina Pellinen et al.
Replacing animal-sourced proteins with plant-sourced proteins significantly reduced the dietary climate impact in healthy Finnish adults, with the PLANT group (70% plant-sourced protein) showing a 39% lower daily climate impact (2.10 kg CO2 eq.) compared to the ANIMAL group (70% animal-sourced protein).
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Sehr niedrig2025
Untargeted metabolomic analysis of dietary rumen-protected choline supplementation in fattening lambs.
Jinyan Yun, Airong Zhu et al.
Rumen-protected choline supplementation (5 g/kg DM) significantly modulates the serum metabolome of fattening lambs by upregulating 125 metabolites, primarily enhancing glycerophospholipid and amino acid metabolism pathways which correlate with increased hot carcass weight and slaughter rates.
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Sehr niedrigNarrative ReviewMensch2025
Role of Nutrition in the Management of Chronic Liver Disease.
Matt Pelton, Sarah Abdel-Meguid et al.
Malnutrition, sarcopenia, and frailty are highly prevalent in chronic liver disease (CLD) and liver cirrhosis (LC) and necessitate individualized nutritional management, with various assessment tools and evidence-based recommendations available for caloric, protein, sodium, and vitamin supplementation tailored to CLD etiology and complications.
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Sehr niedrigNarrative ReviewRatte2025
Medicine-food homology bioactives in Parkinson's disease: multi-target oxidative-stress modulation and translation to dietary supplements.
Meng Wang, Yizhu Zhang et al.
Medicine-food homology (MFH) compounds demonstrate preclinical promise for modulating oxidative stress in Parkinson's disease through multi-target mechanisms, suggesting potential as adjunctive dietary supplements pending clinical validation of efficacy and long-term safety.
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Sehr niedrig2025
Milk fat globule membrane supplementation in formula modulates the gut microbiome and metabolic status of piglets and normalizes intestinal development.
Zonghan Zhou, Bin Liu et al.
Supplementing infant formula with milk fat globule membrane (MFGM) improves jejunal morphology, reduces pathogenic bacteria like Pasteurella, and normalizes serum metabolic profiles—particularly betaine and aromatic amino acids—to more closely resemble breastfed piglets.
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Sehr niedrigNicht-randomisiertMensch2025
Effect of a Mediterranean Diet Adapted to the Mexican Population on Indicators of Metabolic Risk in Patients With Obstructive Sleep Apnea: Protocol for a Randomized Controlled Trial.
Gittaim Pammela Torres San Miguel, María de la Luz Sevilla González et al.
This study aims to evaluate an adapted Mediterranean diet versus standard nutritional treatment for metabolic risk indicators in Mexican OSA patients, with the expectation that the Mediterranean diet group will show a higher proportion of cardiometabolic indicators in control.
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Sehr niedrigRatte2025
Therapeutic potential of canagliflozin in DEN/TAA-induced renal cancer: mechanistic insights into NLRP3/IL-6/STAT3 and AMPK signaling and oxidative stress regulation.
Rehab F Abdel-Rahman, Mahdi H Alsugoor et al.
Canagliflozin demonstrates dose-dependent anti-carcinogenic efficacy against DEN/TAA-induced renal cancer by activating the AMPK pathway and suppressing the NLRP3/IL-6/STAT3 inflammatory axis, leading to significant improvements in kidney function markers and oxidative stress levels.
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Sehr niedrigMaus2025
Vascular dementia increases levels of methylenetetrahydrofolate reductase and cystathionine β-synthase in female patients and changes gene expression of acetylcholine and glutamate clathrin-sculpted transport vesicles.
Sanika M Joshi, Abbey McKee et al.
Vascular dementia (VaD) is associated with an increased demand for one-carbon metabolism, characterized by significantly elevated levels of MTHFR and CBS in female patients and increased ChAT across both genders, alongside spatial transcriptomic evidence of disrupted synaptic transport and glutamatergic signaling.
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HochRCTMensch2025
Resistance training increases myofibrillar protein synthesis in middle-to-older aged adults consuming a typical diet with no influence of protein source: a randomized controlled trial.
Marie Korzepa, Jonathan I Quinlan et al.
In middle-to-older aged adults, a 10-day dietary intervention with either predominantly animal-derived or plant-derived protein did not affect daily myofibrillar protein synthesis rates, but resistance exercise training did increase these rates regardless of protein source.
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Sehr niedrig2025
Characterizing probiotic profiles using genomic and metabolomic insights into chicken cecum-derived Bacillus subtilis YB-1 14246.
Jiajun Yang, Ying Li et al.
*B. subtilis* YB-114246 possesses abundant nutritional genes, produces high levels of riboflavin and digestive enzymes (cellulase, amylase, protease, lipase), and its metabolites, particularly riboflavin, correlate with improved laying performance in aged hens.
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NiedrigSystematic ReviewMensch2025
Arthrospira platensis and Chlorella vulgaris Consumption on Iron Status: A Systematic Review of In Vivo Studies.
Alexandra Lacurezeanu, Dan Cristian Vodnar
Arthrospira platensis and Chlorella vulgaris consumption significantly improve iron status and hematological parameters in both animal and human models, with A. platensis showing stronger erythropoietic effects and C. vulgaris demonstrating enhanced antioxidant defenses, and both are considered safe with no significant adverse effects reported.
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Sehr niedrigQuerschnittMaus2025
Mechanical Stimulation Induces Yap Mediated OCTN2 Transcription to Enhance Carnitine Metabolism in Sarcopenia.
Yahong Lu, Yu Bai et al.
Mechanical stimulation from exercise activates the Yap/Tead4 pathway to upregulate the OCTN2 transporter, thereby maintaining carnitine homeostasis and mitochondrial function to prevent sarcopenia.
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Sehr niedrigMaus2025
NEK7 couples SDHB to orchestrate respiratory chain electron transport homeostasis that impedes liver fibrosis.
Zhenzhen Sun, Le Sun et al.
NEK7 localizes to hepatocyte mitochondria, binds to succinate dehydrogenase complex iron sulfur subunit B (SDHB) to maintain complex II spatial stability and electron transport homeostasis, and its deficiency induces reverse electron transfer (RET), increasing reactive oxygen species (ROS) and promoting liver fibrosis, while NEK7 overexpression alleviates liver fibrosis.
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Sehr niedrigMaus2025
Folic Acid Supplementation Attenuates Hepatic Steatosis by Enhancing Choline Availability and Remodeling Fatty Acid Profiles in Mice Fed a High-Fat Diet.
Eva Kranenburg, Ruslan Kubant et al.
Tenfold folic acid supplementation significantly attenuates high-fat diet-induced hepatic steatosis by reducing hepatic triacylglycerol concentrations by 46% and increasing hepatic choline availability through the upregulation of the PEMT and CDP-choline pathways.
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Sehr niedrigMensch2025
Perceived motivators and barriers to consuming a plant-based diet: a qualitative research study.
Jiaqi Yang, Lauren Bernard et al.
Motivators for adopting a plant-based diet include animal welfare, environmental concerns, health, and culture, while barriers involve lack of inclusiveness, insufficient nutrition education, and limited product availability, with social influences and access to affordable, healthy foods acting as significant facilitators.
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Sehr niedrigIn vitro2025
"Hot" alkaline hydrolysis of UiO-66 to enhance quercetin loading, in vitro release, antioxidant, and anti-inflammatory properties.
Ruimiao Chang, Huichun Wang et al.
The UiO-66-BH-100@QU system demonstrates enhanced quercetin release, improved antioxidant and anti-inflammatory activities, and good biocompatibility, offering a promising approach for delivering poorly soluble natural active ingredients in functional foods.
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ModeratSystematic Review2025
Efficacy of dietary supplements as an adjunctive therapy for polycystic ovary syndrome: an umbrella meta-analysis.
Rutong Wang, Kongwei Huang et al.
This umbrella meta-analysis of 46 randomized trials found that nutritional supplements, particularly myo-inositol, probiotics, and omega-3 fatty acids, show promise in improving metabolic and reproductive outcomes in women with polycystic ovary syndrome (PCOS).
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Sehr niedrigNarrative ReviewMensch2025
Synergistic Effects of Exercise and Nano-Curcumin Supplementation in Women with Lifestyle-Related Diseases: A Scoping Review.
Nafih Cherappurath, Muhammed Navaf et al.
Combining nano-curcumin supplementation with structured exercise offers superior benefits for women with lifestyle-related diseases compared to either approach alone, improving oxidative stress, inflammation, cardiometabolic risk factors, and physical performance.
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HochRCTMensch2025
Nutritional and health benefits of a partial substitution of red and processed meat with non-soy legumes: a 6-week randomized controlled trial in healthy working-age men.
Sari Bäck, Essi Päivärinta et al.
Partially substituting red and processed meat with non-soy legumes for 6 weeks in healthy working-age men led to improvements in cardiovascular disease biomarkers and weight, while maintaining short-term nutritional adequacy of iodine, iron, and vitamin B12.
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Sehr niedrigQuerschnittMensch2025
Gender Differences in Protein Consumption and Body Composition: The Influence of Socioeconomic Status on Dietary Choices.
Mauro Lombardo
In Italian adults, men consumed significantly more meat and processed meat than women across all socioeconomic levels and body composition categories, while women, particularly those with low fat-free mass, consumed more soy, with high consumption of meat, processed meat, and dairy being associated with higher BMI, and high consumption of eggs and soy with higher fat-free mass.
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Sehr niedrigNarrative ReviewMensch2025
CYP24A1 in Small Intestinal Vitamin D Metabolism and Clinical Implications.
Agnieszka Nowacka, Maciej Śniegocki et al.
CYP24A1 is a crucial local regulator of vitamin D signaling in the small intestine, and its dysregulation is implicated in various gastrointestinal disorders, including inflammatory bowel diseases, celiac disease, and colorectal cancer, by compromising epithelial barrier function, immune modulation, and nutrient transport.
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HochRCT2025
Effects of ginkgo leaf extract on growth performance, nutrient utilization, blood biochemical parameters, meat quality, fatty acid profiles, and gene expression in growing rabbits.
Qi Lu, Rui Chen et al.
Dietary supplementation with Ginkgo leaf extract (GLE) improved growth performance, nutrient utilization, meat quality, n-3 polyunsaturated fatty acid concentrations, and antioxidant activity in growing rabbits, with an optimal supplementation level of 4 g/kg.
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Sehr niedrig2025
Elucidating the Nutritional Profile and Biochemical Characterization of High-Energy Nutritional Bar Formulated with Sukkari Date Paste and Mixed Nuts.
Hassan Barakat, Hani A Alfheeaid et al.
Nut-rich Sukkari date-mixed nut bars (DNB1-DNB2) optimized protein, essential amino acid balance, mineral density, and antioxidant capacity, while date-rich variants (DNB4-DNB5) enhanced natural carbohydrates, and a 60:40 date-to-nut ratio (DNB3) provided an optimal balance of phenolic recovery, antioxidant activity, and sensory appeal.
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Sehr niedrigMensch2025
Sex-differences in endotoxemia and trimethylamine N-oxide according to the diet and type 2 diabetes status in coronary heart disease patients: from the CORDIOPREV study.
Helena Garcia-Fernandez, Javier Arenas-Montes et al.
The presence of type 2 diabetes mellitus (T2DM) abolishes the sex-based advantages in endotoxemia, TMAO levels, and carotid atherosclerosis markers observed in non-diabetic patients with coronary heart disease, while dietary interventions (Mediterranean and low-fat) significantly reduce LPS levels specifically in those with newly diagnosed T2DM.
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Sehr niedrigNarrative Review2025
The influence of dietary and supplemental omega-3 fatty acids on the omega-3 index: A scoping review.
Meghan Dempsey, Michelle S Rockwell et al.
Interventions involving over 1,000 mg/d of combined DHA and EPA or solely DHA for at least 12 weeks were effective in raising the omega-3 index (O3i) to the recommended level of ≥8%, with triglyceride formulas showing greater bioavailability.
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Sehr niedrigMaus2025
Somatic loss-of-function mutations in CIDEB reduce hepatic steatosis by increasing lipolysis and fatty acid oxidation.
Qiyu Zeng, Satish Patel et al.
Cideb deletion protects against fatty liver disease by increasing beta-oxidation and reducing neutral lipid storage, mediated by ATGL and PPARa activation, with potential therapeutic implications for MASLD.
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NiedrigQuerschnitt2025
Dietary risk factors and cancer mortality burden from 1990 to 2021: a comparative study of China and global regions with varying sociodemographic development levels based on the Global Burden of Disease database.
Chunxiu Zhao, Qian Ruan et al.
China's diet-attributable cancer mortality decreased from 9.9% to 6.3% between 1990 and 2021, driven by reduced vegetable deficiency and increased red meat consumption, with sex-specific patterns observed.
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Sehr niedrigProspektivMensch2025
Biomarkers Linked to Malnutrition Identified According to GLIM Criteria Among Older Community-Dwelling Adults: Results from the ilSIRENTE Study.
Hélio José Coelho-Júnior, Riccardo Calvani et al.
In older adults, GLIM-defined malnutrition was positively associated with a cluster of blood markers related to kidney function (urea, c-terminal agrin fragment, and potassium; OR = 1.647, p = 0.039) and negatively associated with clusters reflecting anemia (hemoglobin, hematocrit, and red blood cell count; OR = 0.567, p = 0.022) and nutrient availability (calcium, albumin, total protein levels, and HDL cholesterol; OR = 0.607, p = 0.035).
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Sehr niedrigNarrative ReviewMensch2025
Practical Considerations for the Diagnosis and Management of Isovaleryl-CoA-Dehydrogenase Deficiency (Isovaleric Acidemia): Systematic Search and Review and Expert Opinions.
Eva Thimm, Anselma Riederer et al.
Early diagnosis of isovaleric acidemia via newborn screening significantly improves neurocognitive outcomes and reduces neonatal mortality (3.8% vs. 18.7% in clinically diagnosed cases), while management requires a combination of leucine restriction, L-carnitine, and L-glycine supplementation.
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NiedrigQuerschnittMensch2025
Association between dietary B vitamins intake and age-specific blood pressure: A cross-sectional study in American adults.
Xianfeng Li, Zhiqiang Nie et al.
Dietary B-vitamin intake is significantly associated with blood pressure in an age-dependent manner, where vitamins B1, B2, B6, and folate generally show protective effects against hypertension (particularly in older adults), while high intake of vitamin B12 and choline is associated with increased hypertension risk.
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