Paul Fabian, Gil Blander et al.
Fish oil consumption, from whole food or supplements, may have a rejuvenating effect on PhenoAge and GrimAge acceleration, and is linked to lower triglyceride levels.
Elena Malogianni, Modhie F Alenezi et al.
Barriers to primary care access for individuals with Serious Mental Illness include stigma, lack of holistic care, fragmented communication, and inadequate clinician training, while facilitators involve patient education, trusting relationships, and structured reviews.
Todd W Dowrey, Samuel F Cranston et al.
This study established a characterized bank of longevity-specific PBMCs and iPSCs from centenarians and their offspring, demonstrating their potential for studying human longevity, aging, and resilience, including directed differentiation into cortical neurons and offering insights into mechanisms like mLOY.
Mohsen Abdel-Tawwab, Riad H Khalil et al.
The optimal dietary inclusion level of a commercial acidifier blend (CAB) for Nile tilapia fingerlings fed high-soybean diets is 4.0 g/kg feed, which significantly enhanced growth, antioxidant capacity, immune performance, and resistance to Aeromonas sobria infection.
Inge Groenendijk, Hugo H Wijnen et al.
Good pre-fracture nutritional status is associated with higher bone mineral density in older hip fracture patients, while the role of protein intake in bone health for this population remains unclear.
Nisa Buset-Ríos, Mussa Makran et al.
Opuntia dillenii demonstrates significant anti-inflammatory, lipid-modulating, cardioprotective, antidiabetic, antiproliferative, tissue-protective, and antimicrobial activities, suggesting its potential as a nutraceutical for non-communicable disease prevention and management.
David Ruiz-Ramos, José Jaime Martínez-Magaña et al.
Early-onset psychosis patients exhibit accelerated epigenetic age, which is influenced by education, comorbidity, and psychiatric admissions, and a developed methylation risk score (EOP-MRS) can predict clinical manifestations of psychosis and psychiatric comorbidity in Mexican adolescents.
Kirsten D Arendse, Grace A Baby et al.
While mHealth tools show potential for improving symptomatic cancer diagnosis in Sub-Saharan Africa, the existing literature is sparse and of low quality, highlighting significant user, tool, and structural barriers alongside facilitators that need careful consideration for effective implementation.
Jimmy Lindberg, Yuge Zhang et al.
Swedish centenarians exhibit higher polypharmacy and diagnosed diseases compared to previous decades, suggesting a deterioration in health status despite slightly improved female survival and increased home living without formal care.
Matthew Willis, Heynes Brown et al.
Temporalis Muscle Transfer (TMT) and weight implantation are common surgical techniques for lagophthalmos in leprosy patients, with TMT showing high success rates but varied complications, and weight implantation having variable success but a significant risk of implant extrusion.
Pedro Carrera-Bastos, Abel Plaza-Florido et al.
Elevated albumin levels and a prominent complement system presence in centenarians' blood proteome may contribute to resistance to autoimmunity.
Eric Weine, Samuel Pattillo Smith et al.
When genetic variants are considered independently, the accurate estimation of their effects in different contexts depends on a bias-variance trade-off, and for complex traits, considering polygenic patterns of gene-environment interaction is crucial for understanding context-dependent genetic architecture and improving prediction.
Kadriye Kurşun
Supplementation with *Moringa oleifera* leaf powder (MOLP) significantly increased body weight and upregulated MYF5 and IGF-1 gene expression in Japanese quails in a dose-dependent manner, with optimal body weight observed at 4% and 6% MOLP inclusion.
Ayman Mohammed Ismail Zafer, Alsayed Abdelhameed Shanb et al.
Treadmill training interventions are promising for improving balance and mobility in the elderly, including those with Parkinson’s disease, spinal cord injuries, and age-related balance issues, with perturbation-based treadmill training significantly reducing fall rates and dual-task treadmill training proving superior to conventional balance exercises.
Huai-Yu Wang, Yuming Huang et al.
Commercial/other insurance and community social support protected against low quality of life and frailty worsening in prefrail/frail individuals, while financial dependence was a risk factor for low quality of life.
Judith R Harrison, Sonya F Foley et al.
Pathway-specific polygenic risk for Alzheimer's disease, particularly for protein-lipid complex assembly and tau protein binding, is associated with reduced white matter integrity (lower FA, higher MD) in specific cingulum tracts by mid- to late adulthood, but not in early adulthood.
Maria L Allende, Mari Kono et al.
CNS-targeted base editing using AAV-PHP.eB vectors in a mouse model of late-onset Tay-Sachs disease corrected the causative mutation, partially restored enzyme activity, significantly reduced GM2 ganglioside accumulation, mitigated neuroinflammation, delayed disease onset, and substantially extended lifespan.
Simone G Assis, Pedro H Tavares et al.
This scoping review highlights a significant increase in research on epigenetics, DNA methylation, resilience, and protective/positive factors from 2008-2019, emphasizing the interplay between epigenetics and environmental influences on mental and physical health.
Jorien L Treur, Anaïs B Thijssen et al.
Schizophrenia liability causally increases the risk of Brugada syndrome and heart rate during activity, despite limited global genetic correlation, suggesting shared immune and viral response pathways.
Wen-Tao Deng, Brooke Brothers et al.
AAV8-Y733F showed superior efficacy and similar therapeutic windows and longevity in DKO and C198R mouse models of blue cone monochromacy compared to AAV5, with efficacy declining in older mice due to cone degeneration and reduced transgene expression.
Ajmal Khan, Carson Richardson et al.
This study is the first to report associations between cigarette smoke/electronic cigarette-related volatile organic compounds and lung biological aging, with strong associations observed in cigarette smokers.
Ryo Yamamoto, Brian J Eastridge et al.
Male gender, mechanisms of injury other than fall from standing, and lower Glasgow Coma Scale score on arrival were associated with higher in-hospital mortality among centenarians, while injury severity in the extremity/pelvis was related to dependent living after injury.
Chen Huang, Jiaxi Liu et al.
While both collagen and hyaluronic acid fillers show comparable short-term efficacy for nasolabial folds correction, hyaluronic acid demonstrates significantly greater long-term dimension improvements and patient satisfaction at 6 months, despite a higher incidence of adverse events like swelling and filler displacement.
Sonopant Joshi, Mangesh Jabade et al.
Lifestyle factors including nutrition, physical activity, mental health interventions, avoidance of harmful behaviors, adequate sleep, and preventive healthcare are associated with increased longevity, improved cognitive function, enhanced physical health, and general well-being in individuals aged 50 and above.
Yunfeng Yu, Xinyu Yang et al.
This Mendelian randomization study identified four pathways where lipidome influences longevity through metabolites, with specific sterol esters, triacylglycerols, phosphatidylcholines, EDTA, and 1-arachidonoyl-gpc playing significant roles.
Priyanka Das, Ravi et al.
A screen of *E. coli* mutants identified 26 strains that extend *C. elegans* lifespan by inducing oxidative stress and activating the UPRmt, with iron homeostasis disruption and the SKN-1/SEK-1/HLH-30 pathway being crucial for this longevity effect.
Honggang Lyu, Lijun Kang et al.
Shared genetic content between depression and vitamin D levels was identified, with 13 shared loci suggesting vitamin D influences depression development through altered neurodevelopmental processes, although Mendelian randomization found no significant causal relationship.
Pihla Tommiska, Oula Knuutinen et al.
Patients undergoing burr-hole drainage surgery for chronic subdural hematoma face a high mortality risk, with circulatory diseases, accidents, and dementia being the leading causes of death, and pre-existing comorbidities significantly increasing this risk.
Rhea Chapman, Sarasa Najima et al.
Evidence on sex differences in sleep wave parameters is variable, with high certainty that there are no sex differences in alpha and delta relative power in middle-to-late adulthood, and moderate certainty for several other findings, suggesting reported results may reflect unmeasured social parameters rather than biological sex.
Dessale Abate Beyene, Desalegn Getnet Demsie et al.
The pooled mean health-related quality of life (HRQoL) score among people living with epilepsy (PLWE) in sub-Saharan Africa was 63.79%, with anxiety, depression, uncontrolled seizures, comorbidities, and a family history of epilepsy being significant factors negatively impacting HRQoL.
Zoltan Ungvari, Mónika Fekete et al.
Both short (< 7 hours) and long (≥ 9 hours) sleep durations are associated with increased all-cause mortality, with short sleep increasing risk by 14% and long sleep by 34%, and long sleep showing a more pronounced effect in women.
Gonzalo Mariscal, Francisco José Tarazona-Santabalbina et al.
Fondaparinux significantly reduces VTE and DVT incidence compared to LMWHs in elective THA and hip fracture surgery, with comparable bleeding rates and greater cost-effectiveness than enoxaparin per thromboembolic event.
Rahul Kakria, James Randolph Onggo et al.
No significant differences in functional and clinical outcomes or complications were observed between suture and bony fixation for meniscal allograft transplantation.
Franziska Keßler, Maximilian Zölch et al.
Genome-wide significant SNPs for resilience indicators were identified on BTA14 for variance of deviations of observed from predicted daily milk yield, BTA5 for variance of relative daily milk yield, and BTA2 and BTA8 for autocorrelation of deviations, supporting the potential use of these indicators in selective breeding programs.
Nadia El Mrayyan, Marianne Holmgren et al.
This scoping review found a limited and sporadic landscape of predominantly non-randomised healthy-ageing interventions for older adults with intellectual disability, primarily from developed countries, highlighting significant knowledge gaps and the need for more robust, participatory research.
Ling-Ying Wang, Zi-Yi Hu et al.
Daily health behaviors significantly predict independence in older adults, with exercise, Mediterranean diet, and moderate alcohol consumption being protective, while physical inactivity, sedentary lifestyle, smoking, sleep duration extremes, low fruit/vegetable and soy intake, and high energy intake are linked to ADL impairment.
Daisuke Fujikane, Kazutaka Ohi et al.
Higher polygenic scores for educational attainment and cognitive functions (except childhood IQ) were associated with increased fruit consumption in older outpatients with lifestyle-related diseases, and these associations were supported by positive genetic correlations in an independent cohort.
Douaa Zakaria, Camillo Sandri et al.
Environment, not age, was the primary driver of gut microbiota diversity and composition in Aldabra giant tortoises, with wild tortoises showing greater diversity due to varied diets compared to captive ones.
Mohammed Alsabri, Mohammed Ayyad et al.
Head CT scans have a moderate overall positive diagnostic yield of 35.9% in pediatric patients with acute non-traumatic altered mental status, with higher yields observed in inpatient settings compared to emergency departments.
Marie Lan, Ava John-Baptiste et al.
Hypertension modification is linked to increased life expectancy, later dementia onset, and demonstrates potential for cost-effective dementia burden reduction, with full economic evaluations showing interventions either dominating the status quo or having acceptable incremental cost-effectiveness ratios.
Juhi Kumar, Kristal Ng et al.
Rapalink-1, a TOR inhibitor, prolongs chronological lifespan in fission yeast by downregulating agmatinase genes, which are part of a metabolic feedback loop that regulates TOR activity.
Motonori Kubo, Norikazu Hishikawa et al.
Replacing sedentary behavior with moderate-to-vigorous-intensity physical activity was positively associated with improved muscle strength, gait speed, skeletal muscle mass, and phase angle in older adults in a Japanese longevity region.
Yupeng Li, Xujie Wang et al.
In Chinese female centenarians, higher serum vitamin D₃ levels are inversely associated with Alzheimer's disease risk in a dose-dependent manner, with the strongest protective effect observed below 29.3 ng/mL.
Tracy A Hollander, Vidette M Juby
Routine vitamin B12 screening in adult psychiatric inpatients without physical findings or known risk factors is not clinically or economically justified, with only 2.2% of patients found to be deficient at a cost of R5780.73 per deficient patient.
Conglin Han, Dan Zhang et al.
Combined cognitive-physical interventions with multiple exercise components significantly improved memory and executive function in older adults, with interventions incorporating three or more exercise components appearing most effective for memory.
Ann C Genovese, Merlin G Butler
Fragile X syndrome (FXS), caused by FMR1 gene mutations leading to FMRP deficiency, results in neurodevelopmental, behavioral, and psychiatric challenges, with early detection and intervention significantly improving long-term outcomes.
Muhammad Rehan Sarwar, Amanda J Cross et al.
Three distinct dementia risk profiles were identified in middle-aged Australians: High Cardiometabolic Burden, High Behavioural and Psychosocial Risk, and Low Risk with Healthy Behaviours.
Mojca Železnik, Urh Grošelj et al.
The management of hypoplastic left heart syndrome (HLHS) necessitates a multidisciplinary approach that integrates medical, ethical, and psychosocial factors, yet the practical application of ethical principles in counseling and decision-making is not fully understood due to limited research and consensus guidelines.
Hamid Iqbal, Dong-Kwon Rhee
Ginseng supplementation attenuates age-related pathologies by activating Treg cells and restoring mitochondrial biogenesis through antioxidant gene regulation, contributing to a healthy lifespan.
Yunzhe Zhou, Lizhang Chen et al.
Bibliometric analysis of 2,843 publications from 2004-2024 reveals a significant increase in research on nanoparticles for gynecologic cancers, with China leading in publications and the US in influence, highlighting silver and gold nanoparticles, drug delivery, and green synthesis as key areas.
Chiyu He, Kankai Zhu et al.
High loss of adipose tissue during neoadjuvant chemotherapy is a significant prognostic factor for reduced survival in locally advanced gastric cancer, outperforming muscle loss prediction.
Anindita Tasnim Onni, Rajiv Balakrishna et al.
A diet rich in nuts, whole grains, fruits, vegetables, and fish is associated with reduced all-cause mortality, while higher consumption of red and processed meats, and sugar-sweetened beverages is linked to increased mortality.
Germán Andrés Alarcón Garavito, Katie Gilchrist et al.
Barriers to minority ethnic group participation in clinical trials include lack of minority researchers, inadequate funding in minority-serving areas, and insufficient awareness among research staff, while enablers involve patient navigators, translated materials, and community involvement.
Abdullah Alzayed
Structured transition models, particularly those involving joint clinics and transition coordinators, demonstrate improvements in self-management, adherence, patient satisfaction, and preserved lung function (FEV1) for adolescents and young adults with cystic fibrosis.
Ana Jiménez-Peinado, David Laguna-Muñoz et al.
Major depressive disorder (MDD) is associated with a significantly increased risk of respiratory illnesses, including COPD (OR 1.79) and pneumonia (OR 1.41), compared to the general population, with asthma prevalence in MDD patients doubling the worldwide mean.
Sara Cruces-Salguero, Igor Larrañaga et al.
Basque centenarians exhibit significantly lower cancer incidence and severity, with less aggressive tumors, avoidance of metastasis, and extended survival post-diagnosis compared to non-centenarians.
Shaz Raja, Ciara Barry et al.
Music therapy and music interventions demonstrate positive effects across physical, cognitive, and social domains in older adults, contributing to enhanced biopsychosocial health outcomes.
Jared V Balbona, Paul Jeffries et al.
Genetic predispositions to tobacco use causally impact multiple ageing metrics, including brain-age gap, healthspan, and telomere length, with less consistent causal effects observed for problematic alcohol use and cannabis use disorder on ageing.
Bin Yang, Guofu Zhang et al.
SIRT1 in osteoblasts upregulates DAAM2 via EZH2 acetylation, promoting chemokine secretion that activates CD4+ CTLs to eliminate senescent osteoblasts, thereby preventing age-related bone loss and osteoporosis.
Gang Wang, Shengjie Pan
An integrated 6-month intervention combining narrative therapy and resilience training significantly improved psychological and nutritional recovery, reduced complications and inflammation, and increased 2-year disease-free survival (89.2% vs. 75.3%) and overall survival (93.1% vs. 81.6%) in patients undergoing intersphincteric resection for low rectal cancer compared to standard care.
Shunsuke Murata, Yuge Zhang et al.
Centenarians independent of formal long-term care were more likely to have avoided stroke, dementia, and hip fracture earlier in life compared to dependent centenarians, with health differences becoming apparent primarily after exceeding average life expectancy but visible from around age 80.
James Pierzchalski, Nance Cunnigham et al.
While SCD risk is elevated in male PLWH, viral load suppression and CD4+ counts ≥200 cells/mm3 likely reduce SCD risk towards general population levels, though SCD risk in women with HIV remains unknown.
Ali Alghubayshi, Mohammad A Alshabeeb et al.
This study identified simvastatin, allopurinol, omalizumab, canakinumab, and etanercept as promising repurposed drugs, and olfactory receptor gene clusters, TRIM genes, SIDT2, and CADM3 as novel drug targets for sickle cell disease in the Saudi population.
Xindi Wei, Longfei Zhuang et al.
The presence of natural teeth was associated with a 38.4% increased likelihood of becoming a centenarian compared to being completely edentulous, after adjusting for various demographic and health factors.
Sabrina Summer, Maria Borrell-Pages et al.
Centenarians, despite age-related vascular changes, often possess healthier vasculature than the average elderly due to a combination of genetic resilience, healthier lifestyles, and effective mitigation of inflammation and oxidative stress, leading to reduced cardiovascular disease risk.
Alessandra Zonari, Lear E Brace et al.
The OS-01 topical formulation significantly improved skin barrier function and hydration, reduced systemic inflammatory markers like IL-8, and showed a trend towards slowing biological aging compared to a control moisturizer over 12 weeks.
Sten Kajitani, Wesley Chorney et al.
While definitions of structural valve deterioration (SVD) varied, cumulative evidence suggests a trend toward superior long-term durability of porcine bioprostheses compared to bovine bioprostheses in mitral valve replacements, with porcine valves more prone to regurgitation and bovine valves to stenosis, particularly in younger patients.
Xiaohuan Tan, Guiping Jiang et al.
Low-frequency vibration training (LFVT) significantly improved walking speed and waist-to-hip ratio in older adults compared to a control group.
Siyu Bing, Weida Liu et al.
Declining self-reported health showed a graded association with increased cardiometabolic multimorbidity prevalence in Chinese older adults, with "bad" SRH associated with a four-fold elevated risk compared to "good" SRH.
Vaibhav Vats, Rai Dilawar Shahjehan et al.
In older patients with NSTE-ACS, an invasive strategy significantly reduced the risk of myocardial infarction (MI) and revascularization, but increased the risk of severe bleeding, with no significant difference in all-cause mortality or cardiovascular mortality.
Melis Cobandag, Natasha Sigala
Non-pharmacological treatments for auditory verbal hallucinations (AVHs) in schizophrenia spectrum disorders (SSDs) showed an overall medium, statistically significant effect size of -0.298, with AVATAR therapy demonstrating the strongest evidence for efficacy.
Yongjie Tu, Xiaoguang Lin et al.
Digitalized Traditional Chinese Exercises significantly improved functional mobility, balance, global cognition, and quality of life in older adults, with longer intervention durations yielding greater benefits, although grip strength and depression were not significantly improved.
Yuan Yuan, Su-Ping Wang et al.
Elevated Controlling Nutritional Status (CONUT) scores are significantly associated with increased risks of all-cause mortality (HR = 1.57), cardiovascular mortality (HR = 1.53), and heart failure readmission (HR = 1.35) in patients with heart failure.
Stephen Simmons, Soban Sadiq
Adjunctive aripiprazole showed consistent and statistically significant reductions in fasting triglycerides and variable but often significant weight loss in patients taking olanzapine for schizophrenia, while psychiatric symptom control remained stable.
Konstantinos Prokopidis, Alyssa N Varanoske et al.
Exercise combined with a hypocaloric diet may have inconsistent benefits for thigh intermuscular adipose tissue, while exercise alone without a caloric deficit does not alter intermuscular or intramuscular adipose tissue.
Yiyi Xu, Jiner Chen et al.
High adherence to healthy dietary patterns was associated with a reduced risk of ovarian cancer (RR = 0.91; 95%CI: 0.85–0.98) and improved ovarian cancer survival (RR = 0.85; 95% CI: 0.76–0.95).
Teppei Abiko, Shin Murata et al.
Pain Neuroscience Education with physical activity (PNE-PA) resulted in significantly greater improvements in physical function (Chair Stand in 30 s, step count) and psychological outcomes (Pain catastrophizing scale, Fear-avoidance beliefs questionnaire) compared to biomechanical treatments in older women with chronic low back pain.
Zhihe Chen, Xueyan Wu et al.
Genetically proxied SGLT2 inhibition was associated with increased father's attained age, improved cognitive function, and higher intelligence, with these effects being mediated by specific brain imaging-derived phenotypes.
Gong-Hua Li, Yu-Hong Li et al.
Replication and ROS-induced senescence share a common metabolic signature of decreased lipid metabolism and downregulated mevalonate pathway, while irradiation and oncogene-induced senescence show more heterogeneity, and enhancing the mevalonate pathway can reverse senescence-associated metabolic alterations and increase lifespan in C. elegans.
Dairine Dempsey, Maria Hall et al.
Prader-Willi syndrome is associated with significantly reduced life expectancy, severe impairment in quality of life, and substantial economic costs, impacting patients, caregivers, and healthcare systems, with hyperphagia being a major contributor to mortality and caregiver burden.
Kumi Watanabe Miura, Takuya Sekiguchi et al.
The 12-week PICMOA intervention did not significantly improve cognitive function or psychological well-being in older adults with subjective cognitive concerns, although a negative effect on categorical fluency was observed in participants unfamiliar with smartphones.
Natasha Dowell, Shayma Begum et al.
Bone cement demonstrates superior audiological success compared to incus interposition and is comparable to partial ossicular replacement prostheses (PORPs) for ossicular chain reconstruction, with sustained benefits in longer-term follow-up.
Maheshvari N Patel, Nayan Patel et al.
Plant-based iron, particularly when combined with vitamin C, significantly improved hemoglobin levels and other hematological markers in adults with iron deficiency anemia, with no adverse events reported.
Jessica R Kennedy, Caitlin O Blain
Macroalgal degradation is highly variable, with increased temperature accelerating decay, brown algae exhibiting higher recalcitrance than red algae, and pre-treatment significantly increasing recalcitrance estimates, while larger litterbag mesh sizes slow degradation.
Umile Giuseppe Longo, Giovanni Intermesoli et al.
A standardized protocol for diagnosing metal hypersensitivity in joint arthroplasty, including test selection and timing, is absent, leading to significant variability in reported outcomes and hindering clinical decision-making.
Hamidreza Raeisi-Dehkordi, Mojgan Amiri et al.
This meta-analysis found that higher total testosterone was associated with lower all-cause mortality in men, while higher sex hormone-binding globulin was associated with higher all-cause mortality in women, with dose-response relationships observed for endogenous sex steroid hormones and mortality.
Yici Yan, Jing Yuan et al.
Bispecific antibody combined with chemotherapy significantly improves progression-free survival, overall survival, and overall response rate in solid tumor patients compared to chemotherapy alone, with notable benefits observed in specific subgroups and increased risks of certain adverse events.
Yu Ni, Qian Yao et al.
Higher Dietary Inflammatory Index (DII) scores, indicating pro-inflammatory dietary patterns, are significantly associated with increased risks of cardiovascular disease (CVD) incidence [HR = 1.23, 95% CI (1.14–1.33)] and mortality [HR = 1.29, 95% CI (1.24–1.35)].
Elisa Carta, Alice Riccardi et al.
High cognitive reserve is associated with better cognitive performance, particularly in executive functions, even in the oldest-old (90-105 years old).
Mojgan Yazdanpanah, Nahid Yazdanpanah et al.
Metabolites from the glycerophosphocholine and fatty acid families play a causal role in the timing of female reproductive longevity, with increasing levels of most associated metabolites linked to later age at menarche and menopause.
Ander Saenz-Antoñanzas, Maider Muñoz-Culla et al.
Metallothioneins (MTs), particularly MT1 and MT3, are highly expressed in astrocytes within the hippocampus of centenarians and very old individuals, and their expression is crucial for maintaining astrocytic homeostasis and potentially protecting the aging brain.
Giulia Scarparo, Madison Sankovitz et al.
Invasive Vespula pensylvanica colonies in Hawaii exhibit polygyny with multiple, generally unrelated queens, leading to prolonged lifespans and stable queen assemblages, with the number of queens early in the season predicting colony persistence.
Päivi Herranen, Kaisa Koivunen et al.
A polygenic score for hand grip strength (PGS HGS) predicts a reduced risk for several noncommunicable diseases and mortality, with individuals in the highest quintile showing a 5%-23% decreased risk compared to the lowest quintile.
Sandeep Acharya, Shu Liao et al.
A multi-omics integration pipeline identified 64 significant genes and 13 enriched modules associated with cardiovascular risk traits in the Long Life Family Study, with 29 genes and 3 modules replicated in the Framingham Heart Study cohort.
Han Chen, Xinyu Tang et al.
Genetic variants associated with PCSK9, CETP, APOC3, LDLR, and LPL drug targets are linked to increased lifespan, while variants for CETP and LPL are associated with reduced hypertension risk, and variants for LPL are linked to reduced risks of T2D and NAFLD, and variants for ANGPTL3, LDLR, LPL, and APOB are associated with reduced risks of several cancers.
Yu Guo, Guojuan Ma et al.
Alzheimer's disease causally accelerates epigenetic aging (GrimAge) and negatively impacts exceptional longevity, with shared genomic loci identified for both associations, while other neurodegenerative diseases did not show such causal effects.
Imad Abugessaisa, Ri-Ichiroh Manabe et al.
Cap Analysis of Gene Expression (CAGE) profiling identified differentially expressed lncRNAs and antisense RNAs, including OVCH1-AS1, between non-frail and frail old adults, with PYGL highlighted as a key hub gene through Weighted Gene Co-expression Network Analysis (WGCNA).
Yunsung Lee, Astanand Jugessur et al.
Polygenic scores (PGSs) of telomere length (TL) alleles explained 6.6% of TL variance in parents and 5.2% in newborns, with maternally transmitted alleles having a greater impact on newborn TL, especially in girls.
Francine Grodstein, Bernardo Lemos et al.
A genome-wide association study of cortical epigenetic clock age in older individuals identified 13 independent loci, with the strongest association at rs4244620, which is annotated to CD46 and shows colocalization with CD46 expression in oligodendrocytes and association with cognitive decline and Parkinsonian signs.
Ewa Matczyńska, Robert Szymańczak et al.
Whole-exome sequencing (WES) analysis, supported by the newly created Polish genomic reference database (POLGENOM), enabled molecular diagnosis in 64.94% of referred inherited retinal dystrophy (IRD) patients, identifying causative variants for rare diseases like Wagner syndrome and treatable conditions like RPE65 mutations.
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