Guo-Sheng Zhu, Si-Yi Zhang et al.
The combination of collagen and hyaluronic acid for periocular rejuvenation demonstrated superior volume restoration and longevity compared to monotherapies, with a reduced incidence of the Tyndall effect.
Lipeng Xu, Jinze Li et al.
Ellagic acid extends lifespan and improves healthspan in *C. elegans* by enhancing stress resistance and reducing ROS accumulation, requiring the transcription factors DAF-16, HSF-1, HLH-30, and SKN-1, and an intact IIS pathway.
Jiadong Qiu, Jian Wang et al.
Both 12-form Chen-style Tai Chi (CTC12) and square dance significantly improved cardiometabolic health, physical function, and quality of life in middle-aged and older adults compared to a control group, with CTC12 demonstrating broader multidimensional benefits.
Daniela V Nickel, Franziska Jannasch et al.
Evidence is insufficient to conclude whether diet quality scores including diet diversity are linked to chronic disease outcomes due to substantial heterogeneity in conceptualization and measurement.
Caitlin R Bowman, Cara I Charles et al.
Resting-state functional organization along the hippocampal long axis shows age-related differences, with posterior signals exhibiting a distinct age trajectory and increased differentiation in frontal connections with age, but these resting-state differences have limited ability to explain age-related episodic memory decline.
Miriam Teresa López-Teros, Sara Gabriela Yeverino-Castro et al.
Higher baseline intrinsic capacity was associated with a lower risk of incident dementia over 3 years in older Mexican adults, particularly among those without baseline cognitive impairment, with locomotor function emerging as an independent predictor.
Silvia Caristia, Erica Viola et al.
A scoping review of international organization recommendations identified 554 actions across 19 policy sectors and 14 cross-sectoral strategies to promote active and healthy ageing, with health, labor, social welfare, and civil rights being the most represented sectors.
Yanan Wang, Baoying Sun et al.
Plasma miR-34a-5p demonstrates superior diagnostic and predictive performance for cognitive decline in cerebral small vessel disease patients with impaired glucose regulation compared to miR-126-3p, potentially mediating the effect of impaired glucose regulation on cognitive dysfunction through apoptosis, oxidative stress, and synaptic function pathways.
Yihua Ding, Yanhong Zhang et al.
The prevalence of sarcopenic obesity in older adults varies significantly, with a lack of standardized assessment tools and population-specific diagnostic thresholds, necessitating the development of integrated predictive tools and broader adoption of consensus guidelines.
Chenyu Yang, Noah Cook et al.
This study reveals sex-specific shared genetic architectures between Alzheimer's disease and sex hormone-related traits, indicating that higher bioavailable testosterone is associated with reduced AD risk in women, and higher BMI-adjusted SHBG is associated with reduced AD risk in men.
Dimitrios Fanourakis, Oliver Körner et al.
Preharvest environmental conditions, particularly light intensity and temperature, significantly impact nitrate levels, nutritional quality, and shelf life in greenhouse-grown lettuce, spinach, and rocket, with optimal conditions enhancing beneficial compounds and structural integrity while suboptimal conditions reduce quality and accelerate senescence.
Wanlin Zhou, Dongdong Yang et al.
A vegetarian dietary pattern is significantly associated with a 17% reduction in dementia risk (HR = 0.83, 95% CI: 0.70–0.98) in Chinese elderly individuals.
Chenglong Zhao, Liang Lyu et al.
Silicon treatment enhances muskmelon resistance to *T. roseum* by maintaining mitochondrial energy status and inducing context-specific DNA methylation in promoter regions, particularly in the CG context.
Michaela Theilmann, Sarah Gao et al.
While average episodic memory trajectories did not differ significantly across groups over seven years, individuals with HIV and suppressed viral load showed statistically significantly higher episodic memory scores than those without HIV from year 5 onwards, suggesting potential benefits of regular healthcare engagement or selective mortality.
Siqi Li, Jie Cai et al.
The inflammatory burden index (IBI) was the most robust biomarker among six immune-inflammatory indices for predicting heart failure incidence and mortality, showing the strongest association with increased HF risk and mortality.
Jürgen Rehm, Daniela Correia et al.
Economic development is associated with increased life expectancy, with larger gains in lower-income countries, but rising alcohol consumption in some developing nations can negate these health benefits without effective control policies.
Dorottya Nyáry, Mónika Fekete et al.
Integrated lifestyle-based strategies incorporating bioactive-rich diets, physical activity, and optimized sleep/circadian health show promise for preserving function and promoting healthy aging by addressing the interconnectedness of inflammaging and sarcopenia, but require individualization due to high interindividual variability.
Thomas N Nitsotolis, Stelios F Assimakopoulos et al.
Chronic immune activation in people living with HIV (PLWH) on cART drives non-AIDS morbidity and mortality, leading to a 16-year reduction in comorbidity-free life expectancy, with mechanisms including gut-associated lymphoid tissue destruction, microbial translocation, and trained immunity.
Bannawich Sapapsap, Wanwarat Aree et al.
In atrial fibrillation patients with advanced chronic kidney disease, both standard- and reduced-dose apixaban demonstrated more favorable outcomes compared to vitamin K antagonists, with standard-dose apixaban showing a trend towards lower all-cause mortality.
Lorin-Manuel Pîrlog, Andreea Cătană et al.
Human longevity is a polygenic and environmentally responsive trait influenced by genetic factors like FOXO3 and APOE, and epigenetic mechanisms that link inherited susceptibility to environmental exposures, with interventions targeting shared pathways but yielding context-dependent effects.
Ihsen Abid
In GCC countries, higher death rates significantly reduce life expectancy, while renewable energy consumption and government health expenditure positively contribute to longevity, with economic growth having a modest effect and CO2 emissions negatively impacting life expectancy.
Carlo Fortunato, Francesco Piacenza et al.
A specific CpG site within the GLO1 gene (cg26053840) was associated with higher fasting glycemia, impaired kidney function, and increased systemic inflammation markers and immune mediators in hospitalized older adults.
Andrea Cavagnino, Olivier Gouin et al.
Topical application of *S. aureus* serine protease SspA to ex vivo human skin explants induced early, measurable alterations in functional permeability, structural proteins, inflammatory mediators, and proteostasis, with protein carbonylation identified as an early consequence.
Rebecca Casterton, Aitana Martinez-Cotrina et al.
Karyoptosis, a distinct form of cell death involving nuclear degeneration and expulsion of nuclear material, is induced by proteotoxic stress and regulated by p38 kinase signaling, affecting neurons in neurodegenerative disease models and showing features in post-mortem FTD and AD frontal cortex.
Adelin-Rareș Candrea, Laura Ioana Gavrilaș et al.
Berberine consistently modulates gut microbial composition across heterogeneous populations, with concurrent cardiometabolic and anti-inflammatory improvements observed in six of seven randomized clinical trials, although compositional shifts were not uniformly favorable and causality cannot be established due to methodological heterogeneity and observational nature of concurrent changes.
Ashly Hindle, Yong Chen et al.
Alzheimer's disease hippocampus exhibits disrupted homeostasis of proteins involved in synaptic integrity, autophagy, and neuroplasticity, with significant decreases in Cbln1, GluD1/2, PIST, beclin-1, BDNF, and p-cofilin, suggesting impaired synaptic function and autophagy.
Martin R Späth, Sita Arjune et al.
Short-term calorie restriction (50% of daily energy expenditure for 7 days) before living kidney donation was safe and feasible, leading to significant weight loss and molecular changes including enhanced lipolysis, reduced insulin signaling, and decreased inflammatory factors, without affecting acute kidney injury incidence or increasing adverse events.
Youngjune Bhak, Bruce Guthrie et al.
This study identified significant genetic factors associated with long-term condition burden and their association with lifespan, highlighting the roles of the HLA and LPA regions and suggesting a shared genetic architecture between LTC accumulation and reduced longevity.
Yuanyuan Zhao, Dongjie Du et al.
In adults with diabetes and hypertension, the TyG index demonstrated a nonlinear association with mortality, with increased risks of all-cause death above 8.9 and cardiovascular death above 9.0, and these associations were more pronounced in individuals younger than 65 years.
Imbi Smidt, Tiiu Roop et al.
Centenarians exhibit a higher diversity and relative share of culturable intestinal lactobacilli, with distinct compositional and metabolic characteristics compared to young adults, suggesting a potential role in healthy aging.
Xin Zhang, Aierpati Maimaiti et al.
Increased intrinsic epigenetic age acceleration may decrease the risk of unruptured intracranial aneurysms, and aging is causally associated with intracranial aneurysm risk.
Jinguo Liu, Liangliang Yu
Cellular senescence acts as a double-edged sword in Crohn's disease intestinal fibrosis, where acute senescence may aid tissue repair, but chronic accumulation drives inflammation and extracellular matrix deposition, leading to fibrotic strictures.
Hayley Susan Mountford, Archie Campbell et al.
Reading and spelling performance remained stable across adulthood, while phonological verbal-memory, auditory short-term memory, and working memory showed age-related declines, with females scoring higher on spelling tasks.
Hui Sun, Fei Gu et al.
FABP4 acts as an immunometabolic hub in preeclampsia, linking lipid dysregulation to inflammation and endothelial dysfunction, and holds potential as an early diagnostic marker and therapeutic target.
Swapnil G Waghmare, Meera M Krishna et al.
Conserved homologs of understudied late-onset Alzheimer’s disease risk genes causally modulate neuronal aging in a neuron-class-selective manner in C. elegans, often independently of organismal longevity.
Xinyan Gong, Xiaowei Cheng et al.
In community-dwelling centenarians, serum creatine kinase levels were independently and inversely associated with all-cause mortality in an inverse J-shaped manner.
Merve Güner, Yavuz Şahbat et al.
In centenarians with orthopedic trauma, frailty was paradoxically associated with reduced mortality, while hip fractures remained a strong predictor of mortality and higher-level care was protective.
Ryo Shikimoto, Takashi Sasaki et al.
In Japanese centenarians, higher plasma neurofilament light chain (NfL) levels were significantly associated with lower cognitive function (MMSE scores) and increased all-cause mortality.
Omnia Abdelraheem, Wafa Abu El Kheir-Mataria et al.
This scoping review identified inconsistencies in terminology and assessment methods across 162 studies on supercentenarians and semisupercentenarians, leading to the proposal of a comprehensive framework to guide a unified, supranational protocol for future longitudinal studies.
Haojie Lu, Maxime M Bos et al.
NMR-based metabolic biomarkers, particularly fatty acid ratios, were significantly and causally associated with coronary artery calcification (CAC) burden, with GlycA specifically associated with CAC in males only, and these findings were further supported by associations with coronary heart disease (CHD).
Sara Cruces-Salguero, Igor Larrañaga et al.
Centenarians exhibit delayed onset, reduced severity of some cardiovascular diseases, fewer comorbidities, lower medication use, extended survival, and more favorable biological recovery trajectories compared to non-centenarians, suggesting resilience mechanisms contributing to longevity.
Beomsu Kim, Joong-Gon Shin et al.
Chlorogenic acid (CGA) and taurine co-treatment in human skin cells identified 62 aging-related differentially expressed genes (AR-DEGs), including key regulators like TGFB2, ETS1, and EGR1, with synergistic effects observed and associations found between AR-DEGs and perceived age and skin pigmentation.
Zhiling Zhang, Huabin Su et al.
Centenarians achieve immune equilibrium through remodeling of cytotoxic immune lineages (NK, CD8+ T, γδ T cells) and fine-tuning of inflammatory responses, rather than generalized immunosuppression, with specific genetic loci identified as potential targets for interventions.
Kelun Zhang, Bing Wang et al.
Nutritional status significantly impacts cancer outcomes in rural Chinese women, with dietary transition, food insecurity, and metabolic dysregulation contributing to poorer survival through various biological pathways, necessitating integrated nutrition care within the healthcare system.
Chad Yanyatan, Karthik Mohanraj et al.
V14™ delays age-dependent mobility decline in C. elegans and induces transcriptional changes related to metabolism and stress responses, while AG1® negatively impacts mobility.
Lu Pu, Zhiliang Zuo et al.
ERG forms nuclear condensates via liquid-liquid phase separation (LLPS), which alters chromatin and reduces senescence-related gene expression, thereby attenuating cellular senescence.
Gwanwoou Yun, Ronchen Liu et al.
Mortality following traumatic injury in *Drosophila* exhibits substantial additive genetic variation and condition-dependence, with genotypes having higher mortality also showing lower viability, fecundity, and lifespan.
Wataru Matsunaga, Takahiro Ishikawa et al.
The combination of microneedling and liposomal vectors synergistically enhanced non-viral SIRT1 gene delivery to human skin equivalents, resulting in a ~357-fold increase in SIRT1 mRNA expression, while topical application of naked plasmid DNA also showed significant, albeit lower, efficacy (~70-fold increase).
Flavien Delhaes, Justine Falciola et al.
This study identified 37 proteins in centenarians that exhibit expression levels similar to younger individuals, suggesting a signature of successful aging associated with pathways of programmed cell death, metabolic enzymes, extracellular matrix stability, immune responses, and neurotrophic signaling.
Hee-Sook Lim, Hansol Park et al.
A senior-friendly diet was associated with statistically significant improvements in utility weight (0.053) and quality-adjusted life expectancy (0.655) among older adults in South Korea.
Huanjie Huang, Tianshu Gui et al.
Forkhead box O (FOXO) transcription factors are crucial for cellular resilience and longevity, with their function influenced by intrinsically disordered regions (IDRs), isoform specificity, and context-dependent activation, highlighting the need for further research into these areas for promoting healthy aging.
Czeslaw Ducki, Monika Jach et al.
Vitamin D is not a universal psychiatric treatment, but its relevance is context-dependent, particularly in early neurodevelopmental vulnerability, inflammatory/metabolic depression, psychosis liability, severe mental illness with nutritional deprivation, and frailty/multimorbidity, with clinical management focusing on identifying high-risk patients and correcting deficiency according to established medical guidance.
Xiang Meng, Xuting Song et al.
The zebrafish model validates the pro-repair and regenerative effects of plant-derived compounds by modulating conserved mechanisms such as inflammation, oxidative stress, and autophagy, with potential for translation into clinical benefits.
Xiangjiao Yi, Junyan Li et al.
Combined phthalate exposure, particularly mono-n-butyl phthalate (MBP), is associated with reduced skeletal muscle mass, mediated by inflammation and oxidative stress, with DBP/MBP potentially activating the TNFα/NF-κB axis leading to muscle atrophy and pyroptosis.
Ruiyu Wu, Xiao Yang et al.
A three-month Chinese Medical Nutrition Therapy (CMNT) intervention led to diabetes remission maintained for three years in 75% of participants with normal BMI, without ongoing structured intervention, and was associated with improved quality of life and reduced complications.
Samuel L Battalio, Bonnie Spring et al.
Interventions targeting diet and activity can lead to collateral improvements in stress and, to a lesser extent, sleep, with the stress/sleep intervention showing statistically larger improvements in sleep duration compared to the diet/activity intervention.
Rıdvan Erten, Mehmet Poyrazer
In older US adults, a greater difference between lumbar spine and total hip T-scores was associated with higher all-cause mortality in women, but not in men, while the total hip T-score was the strongest single-site predictor for mortality in both sexes.
Jianwei Zhou
A higher Diuretic Intensity Score (DIS) was associated with lower 28- and 90-day all-cause mortality in hospitalized heart failure patients across two independent cohorts.
Aaron Park, Nolan Martin et al.
Transvenous lead extraction patients with a patent foramen ovale (PFO) had a significantly higher mortality rate (5.41% vs. 0%) compared to those without a PFO, although stroke incidence was not statistically different.
Irene Boateng, Thomas Phillips et al.
A greater comorbidity burden in patients with chronic kidney disease was associated with increased mortality and worse health-related quality of life, but not with the progression of kidney disease.
Björn Zethelius, Mats Talbäck et al.
Age and sex alone were better predictors of 5-year mortality than NMI, CCI, or ECI alone, but adding NMI to age and sex provided a modest improvement in predictive performance, while CCI and ECI were less informative.
Yanqiong Li, Lixia Yang et al.
A higher Comprehensive Health Assessment Score (CHAS), integrating lifestyle, physical function, metabolic health, and comorbidity/medication adherence, was strongly associated with reduced cardiac and all-cause mortality in U.S. adults with coronary heart disease, with lifestyle factors and comorbidity/medication management being the strongest predictors.
Antonia Kleeberg, Thomas Luft et al.
The Endothelial activation and stress index (EASIX) independently predicts short- and long-term mortality in acute ischemic stroke patients and improves risk stratification beyond established clinical scores.
Biagio Sassone, Marco Zuin et al.
A zero-contrast strategy for cardiac resynchronization therapy implantation is feasible, safe, and effective in chronic kidney disease patients, leading to better renal preservation compared to procedures using contrast.
Galadriel Pellejero-Sagastizabal, Patricia Esteban et al.
Circulating granzyme A (GzmA) concentration and activity were significantly elevated in patients with secondary peritonitis compared to healthy controls, and each doubling of baseline GzmA was associated with a 2.52-fold increase in the odds of in-hospital mortality.
Joan Ern Xin Tan, Mattias Wei Ren Kon et al.
Structured, dietitian-supported, and Mediterranean-style dietary interventions improve diet quality, sustainable weight control, and quality of life among breast cancer survivors.
Chukwudi Nwogu, James Stupin et al.
In patients with acute ischemic stroke who experienced recurrent symptoms after thrombolysis, dual antiplatelet therapy (DAPT) did not demonstrate a significant advantage over aspirin monotherapy (AM) in reducing recurrent ischemic stroke, symptomatic intracranial hemorrhage, or 90-day mortality.
Vu Manh Tan, Pham Xuan Hung et al.
Holter-derived mean heart rate robustly predicted in-hospital mortality in acute heart failure patients, with a heart rate > 100 bpm significantly increasing mortality compared to < 70 bpm (31.3% vs. 4.8%).
G Chad Hughes, Michael D Dake et al.
At 3 years, the TBE device demonstrated durable outcomes for nondissection descending thoracic aortic disease, with 99% LSA branch patency, 1% lesion-related mortality, and minimal complications.
Omar Almaadawy, Naydeen Mostafa et al.
The association between cardiac amyloidosis and increased all-cause mortality post-TAVR in aortic stenosis patients is dependent on the definition of cardiac amyloidosis used, with screening-based cohorts suggesting an increased risk while analyses of confirmed cases do not.
Qiong Wu, Jian Peng et al.
Drug-induced liver injury (DILI) is a strong independent predictor of in-hospital mortality in tuberculous meningitis (TBM), significantly improving mortality risk prediction, with a borderline trend towards age-related effect modification.
Xinrui Yin, Shijia Du
Elevated pan-immune-inflammation value (PIV) is associated with adverse cardiovascular outcomes in patients with acute coronary syndrome undergoing percutaneous coronary intervention, with moderate certainty evidence supporting associations with long-term all-cause mortality and angiographic no-reflow/slow-flow.
Rishi Chowdhary, Manjeet Kumar Goyal et al.
Sarcopenia is an increasingly prevalent condition in MASLD and a powerful independent predictor of adverse hepatic and cardiovascular outcomes in non-cirrhotic disease.
Qinggang Ge, Libo Zheng et al.
Human umbilical cord mesenchymal stem cells (hUC-MSCs) are safe and well-tolerated in patients with mild-to-moderate ARDS, with the middle dose showing promising therapeutic effects, including significant improvements in oxygenation and reductions in lung injury scores.
Anni Ylinen, Stefan Mutter et al.
Multimorbidity, defined as the coexistence of two or more chronic conditions, is prevalent in 60.4% of individuals with type 1 diabetes and is strongly associated with a significantly increased risk of all-cause mortality (HR 6.01), with each additional condition further elevating this risk.
Wolfgang Kopp
Chronic diseases arise from the persistent activation of a shared stress-response network, involving sympathetic and RAAS signalling, metabolic overload, oxidative stress, and innate immune pathways converging on intracellular hubs, leading to multimorbidity.
Zhenwei Zhai, Junyu He et al.
The prognostic nutritional index (PNI) at discharge is a practical bedside tool for estimating long-term all-cause mortality in survivors of pneumonia-induced sepsis, with lower PNI tertiles associated with significantly higher mortality risk.
Peng Tian, Liping Wang et al.
Frailty in patients aged 75 years or older undergoing percutaneous coronary intervention is associated with significantly increased risks of in-hospital mortality (RR = 3.16), all-cause mortality (RR = 2.51), bleeding (RR = 2.26), and stroke (RR = 1.90), although the evidence quality is low.
Yu-Wei Liu, Yung-Kuo Lee et al.
Glycosylation-related gene (GRG) based molecular stratification identifies clinically distinct lung adenocarcinoma subtypes associated with immune regulation, tumor stemness, and differential therapeutic responses, with a developed Glyco.marker system predicting prognosis and identifying vulnerabilities to specific drug classes.
Ya-Dong Li, Le-Lan Gong et al.
Higher consumption of ultra-processed food was associated with a 10% higher risk of all-cause mortality, a 9% higher risk of circulatory system diseases mortality, a 20% higher risk of nervous system diseases mortality, and a 28% higher risk of mortality from other causes, with no association found for cancer mortality.
Hatem Ahmed, Imad Alabdul Razzak et al.
In anticoagulated patients, vonoprazan use was associated with significantly lower rates of gastrointestinal bleeding, all-cause mortality, and blood transfusions, as well as modestly higher hemoglobin levels compared to proton pump inhibitors over one year.
Mao Ye, Suqi Lv et al.
Elevated red blood cell distribution width-to-albumin ratio (RAR) levels at admission are independently associated with increased 28-day all-cause mortality in sepsis patients, with a non-linear dose-response relationship observed.
Minmin Wu, Junhan Chen et al.
Higher plasma levels of copper, lead, and strontium were significantly associated with increased all-cause mortality in patients post-myocardial infarction, and an environmental metal risk score derived from these metals improved risk stratification beyond the GRACE score.
Klaus J Stark, Martina E Zimmermann et al.
Elevated high-sensitivity cardiac troponin T (hsTnT) levels are associated with increased cardiovascular and non-cardiovascular mortality risk in older adults, particularly in those with prevalent cardiovascular disease.
Wenwen Diao, Shunxiong Tang
Vigorous occupational physical activity and total vigorous physical activity were associated with a reduced risk of Parkinson's disease, while adherence to physical activity recommendations in general was linked to lower all-cause mortality in adults aged 40 and older.
Boke Chen, Di Wu et al.
Smoking is an independent risk factor for all-cause, COPD-specific, and CVD mortality in COPD patients in Sichuan, with a dose-response relationship observed for consumption, duration, and age of onset.
Tingyuan Zhang, Fan Zhang et al.
In Chinese ICU patients with carbapenem-resistant Gram-negative bacilli (CR-GNB) infections, colistimethate sodium (CMS)-based treatment achieved an 82.5% clinical response and 72.8% microbiological eradication, with an acceptable safety profile and a low incidence of adverse events, although baseline renal function may affect the occurrence of CMS-associated acute kidney injury.
Chen Wang, Xing Guo et al.
Intravenous polymyxin B sulfate (PMB) and colistimethate sodium (CMS) showed comparable efficacy in treating pulmonary infections, but PMB was associated with a shorter hospital stay, less hematotoxicity, and a more favorable cost profile.
Murat Karamanlıoğlu, Oral Menteş et al.
The TAPSE/sPAP ratio was independently associated with adverse clinical outcomes and mortality in patients with Type 2 Respiratory Failure, reflecting impaired right ventricular–pulmonary arterial coupling.
Premysl Velek, Marije J Splinter et al.
Counting co-occurring diseases is as accurate as multimorbidity indices for predicting all-cause mortality in the general population.
Jheng-Yan Wu, Yu-Min Lin et al.
Tirzepatide (TZP) use was associated with a significantly reduced risk of a composite outcome including all-cause mortality, major adverse liver, cardiovascular, and kidney events compared to thiazolidinediones (TZDs) in adults with MASLD.
Yuanyuan Wang, Bingya Lv et al.
Atrial functional mitral regurgitation (AFMR) is common in patients with HFpEF and ESRD undergoing hemodialysis and is significantly associated with increased all-cause mortality and worsening cardiac function, with even mild AFMR increasing mortality risk, and plasma ANP levels may serve as a potential diagnostic biomarker.
Magnus Scheer, Hanno Witte et al.
Postoperative tranexamic acid was associated with a lower rate of revision surgery for chronic subdural hematoma recurrence compared to surgery alone, although it did not significantly impact hematoma volume reduction.
Emilien Van Weydevelt, Ziyad Alrajhi et al.
Outcomes after fenestrated and branched endovascular aortic repair (F/BEVAR) were similar in patients ≤65 years compared to older patients at 24 months, despite younger patients experiencing a higher rate of branch-related secondary reinterventions.
Masafumi Kurajoh, Tetsuo Shoji et al.
Blood type A was associated with significantly lower all-cause and cardiovascular mortality risk compared to blood type O in hemodialysis patients.
Benjamin Vögeli, Patrick Badertscher et al.
The CHA2DS2-VA score is strongly associated with all-cause and cardiovascular mortality in ICD patients with IHD and DCM, but does not predict ventricular arrhythmia.
Adarsh Annapareddy, Tarun Jayakumar et al.
Robotic-assisted total hip arthroplasty achieved significantly greater accuracy and consistency in acetabular cup inclination and anteversion compared to manual impaction, with robotic placement substantially reducing deviation from planned orientation.
Junhui Chen, Jiaming Cao et al.
Mild hypothermia combined with decompressive hemicraniectomy was associated with a higher rate of good functional outcomes (mRS 0-2) and lower 30-day mortality compared to decompressive hemicraniectomy alone in patients with malignant MCA infarction, although it also led to significantly more shivering, bradycardia, and electrolyte disturbances.
Jiwen Che, Na Liu et al.
The developed Cog-Free tool, utilizing routine health examination data without cognitive testing, achieved a significantly higher area under the curve (AUC) of 0.86 compared to three established cognitive-testing-free dementia risk tools, demonstrating its potential as an effective pre-screening and risk stratification tool.
Yanzhuo Kong, Damola Adejoro et al.
Long-term stress exposure in yeast triggers aging hallmarks, including proteostasis decline and reduced energy homeostasis, which are partially reversible and involve conserved stress-response pathways across life.
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