Georgios Vavilis, Yeshe M Kway et al.
In individuals with chronic kidney disease, an increase in native myocardial T1 was independently associated with higher risks of cardiovascular death, heart failure, and atrial fibrillation.
Guo Wu, Hengye Wu et al.
Transcriptomic analysis of sea cucumber coelomocytes revealed distinct molecular mechanisms underlying fleeing (regulated by HTR4, HRH2, ADRA1D, and MMP14), adhesion (involving energy reallocation and potential downregulation of the longevity-regulating pathway), and thanatosis (regulated by MAPK, Rap1, and Ras pathways) stress responses.
Guo-Sheng Zhu, Si-Yi Zhang et al.
The combination of collagen and hyaluronic acid for periocular rejuvenation demonstrated superior volume restoration and longevity compared to monotherapies, with a reduced incidence of the Tyndall effect.
Alaa M Albishi, Jawahr Alagil et al.
Cognitive function, physical performance, and balance are interrelated in midlife women, and menopausal status alone was not independently associated with these outcomes after adjustment for age and BMI.
Clara Bodelon, Mariah Landry et al.
In US women with nonmetastatic breast cancer, a genetic predisposition to a higher BMI was associated with a 15% increased risk of all-cause mortality.
Santiago Besa, Álvaro Torres et al.
The implementation of a dedicated Ross program in a high-complexity Latin American center is feasible and associated with acceptable early postoperative outcomes, including zero operative mortality and satisfactory early hemodynamic performance.
Song-Nan Wang, Yu-Xi Liu et al.
Plant-derived BCAAs, abundant in legumes, whole grains, and microalgae, show potential for metabolic syndrome prevention and treatment due to their anti-inflammatory effects, beneficial gut microbiota interactions, and association with improved metabolic health markers compared to animal-based sources.
Sandra Stuhr, Suncica Travan et al.
A high prevalence of peri-implant disease (70.4%) was observed, with cement-retained restorations and a history of periodontitis identified as significant risk factors, despite patients reporting daily cleaning and confidence in their home care.
Daniela V Nickel, Franziska Jannasch et al.
Evidence is insufficient to conclude whether diet quality scores including diet diversity are linked to chronic disease outcomes due to substantial heterogeneity in conceptualization and measurement.
Mansour Alblaji
Well-planned plant-based diets offer significant health benefits, including reduced cardiometabolic disease risk and improved gut microbiome, and have a substantially lower environmental footprint compared to diets including animal products.
Leidi Liu, Xiangfei Cheng et al.
Plant abiotic stress responses are governed by dynamic interaction networks, not linear pathways, with stress tolerance emerging as a property of network behavior.
Lutfiye Karcıoğlu Batur, Ahsen Pektas et al.
Elixea modulated redox homeostasis and longevity-associated transcriptional pathways in a cell type-dependent manner, suggesting it promotes cellular resilience and epithelial homeostasis rather than generalized proliferation.
Xiaonan Liu, Wenhao Lu et al.
JMJD3-driven epigenetic reprogramming of p16INK4a-positive cells promotes tendon regeneration by enhancing extracellular matrix synthesis, vascularization, and innervation.
Miriam Teresa López-Teros, Sara Gabriela Yeverino-Castro et al.
Higher baseline intrinsic capacity was associated with a lower risk of incident dementia over 3 years in older Mexican adults, particularly among those without baseline cognitive impairment, with locomotor function emerging as an independent predictor.
Yanzhuo Kong, Damola Adejoro et al.
Long-term stress exposure in yeast triggers aging hallmarks, including proteostasis decline and reduced energy homeostasis, which are partially reversible and involve conserved stress-response pathways across life.
Yanteng Wang, Yichen Yang et al.
The Sirt2-P300/Nur77/K310 acetylation axis is a core regulator of muscle homeostasis and regeneration, where Sirt2 promotes Nur77 deacetylation leading to its degradation and impaired Myf5 transcription, contributing to muscle aging, while P300 acetylates and stabilizes Nur77.
Jung-Chi Hsu, Umbreen Nadeem et al.
High FIND-AF risk is associated with a 2.48-fold increased risk of incident AF, ischaemic stroke, or all-cause mortality in HFrEF patients with AtCM but without baseline AF, and demonstrates superior discrimination to CHA2DS2-VASc for these outcomes.
Hua Ji, Ying Tang et al.
The study elucidates the ILF2–NPM1–NF-κB axis in diabetic foot ulcer pathogenesis, where ILF2 destabilizes NPM1 mRNA, reducing NPM1 accumulation and subsequent NF-κB activation, thereby suppressing inflammatory senescence and promoting wound healing.
Matteo Terrinoni, Valerio Caputo et al.
Non-coding RNAs (ncRNAs) show promise as candidates for risk stratification, non-invasive diagnosis, treatment-response prediction, and therapeutic development in HPV-associated cervical disease, although further validation is required.
Yihua Ding, Yanhong Zhang et al.
The prevalence of sarcopenic obesity in older adults varies significantly, with a lack of standardized assessment tools and population-specific diagnostic thresholds, necessitating the development of integrated predictive tools and broader adoption of consensus guidelines.
Yu Zeng, Meng Gao
Circular RNAs (circRNAs) are multifaceted regulators of hepatic lipid metabolism through mechanisms including miRNA sponging, RNA-binding protein interaction, and peptide translation, showing promise as diagnostic biomarkers and therapeutic targets for metabolic liver diseases, although significant challenges remain in their clinical translation.
Marina Russo, Gianluca Conza et al.
Osteoporotic bone exhibits significantly reduced Gal-1 and increased Gal-3, miR-22, and miR-21, with serum showing reduced Gal-1 and miR-22 and increased miR-21, suggesting a co-dysregulation pattern of these biomarkers in osteoporosis.
Yuxin Jiang, Xiaotong Song et al.
A novel dynamic nomogram integrating age, GDF-15, ferritin, lipoprotein(a), and EQ-5D score accurately stratifies the risk of incident heart failure and all-cause mortality in chronic kidney disease patients, demonstrating robust predictive ability.
Ming-Hao Ma, Zhi-Cheng Yang et al.
Sodium-restricted diets in heart failure patients were associated with increased all-cause mortality (RR 1.50) and cardiac mortality (RR 2.51), with no significant difference in readmission rates, although quality of life may be improved.
George D Vavougios, Georgios Hadjigeorgiou
TENSE is a novel framework that quantifies immune-aging dysregulation from pathway enrichment analysis using an LLM to classify pathways into mechanistic categories, enabling reproducible and interpretable comparative analysis across diverse datasets.
Aleksandr Martynenko
Ethnonutrigerontology (ENuG) is proposed as an integrative framework conceptualizing nutrition as a cultural-biological regulator of ageing, linking culturally patterned dietary models to biological ageing mechanisms and functional resilience.
Lele Ling, Sining He et al.
Electroacupuncture (EA) ameliorates high-fat, high-sugar diet-induced premature ovarian insufficiency (POI) by inhibiting METTL3-mediated m6A methylation of Beclin 1 mRNA, thereby suppressing excessive granulosa cell autophagy and restoring ovarian function.
Chenglong Zhao, Liang Lyu et al.
Silicon treatment enhances muskmelon resistance to *T. roseum* by maintaining mitochondrial energy status and inducing context-specific DNA methylation in promoter regions, particularly in the CG context.
He Xu, Paul-Lennard Mendez et al.
Single-cell RNA sequencing studies reveal that arterial aging is characterized by cellular heterogeneity across endothelial cells, smooth muscle cells, fibroblasts, and immune cells, with distinct subpopulations exhibiting senescence, extracellular matrix remodeling, and chronic inflammation.
Yuanjia Shi, Jing Zhang et al.
PCSK9 promotes atherosclerosis progression by activating the FOXO3a autophagy pathway, and this process can be inhibited by COS, which reduces PCSK9-induced macrophage injury and atherosclerosis.
A M Taylor, K L Matzeller et al.
A high saturated fat diet (30% coconut oil) in female Drosophila melanogaster reduced lifespan and climbing ability, uniquely induced structural neurodegeneration, increased oxidative stress, and impaired autophagic flux, suggesting metabolic stress and autophagy disruption as key mechanisms in diet-associated neurodegeneration with sex-specific vulnerability.
Mingyu Huang, Defeng Zhao et al.
Autophagy plays a dual role in gynaecological cancers, influencing tumour initiation, progression, immune regulation, and therapeutic resistance, with potential for targeted therapeutic strategies.
Yi Chen, Danru Jin et al.
Gut microbiota dysbiosis mechanistically contributes to type 2 diabetes mellitus by influencing insulin signalling, metabolite production, and inflammation, with altered microbial metabolic output impairing insulin responsiveness and promoting inflammation.
Disha Mukherjee, Sampath Raghul Kannan et al.
N-terminal modifications, including acetylation, methylation, and myristoylation, act as critical fate switches for proteins, influencing their stability, degradation, localization, and aggregation, thereby playing a significant role in the pathogenesis of neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's.
Md Oliullah Rafi, Md Takim Sarker et al.
Six missense single-nucleotide polymorphisms (C358S, C374G, W378G, F379V, S382L, and R400P) within the PHD domain of the p47ING1a isoform are predicted to destabilize the protein, disrupt its interaction with H3K4me3 and the Sin3A/HDAC complex, thereby impairing its tumor-suppressor function.
Christopher Birigwa, Qiang Tong et al.
The gut microbiota influences aging, particularly through chromatin alterations in endocrine and reproductive tissues, with limited direct causal evidence in humans for microbiome-induced endocrine decline.
Cristina Candal-Pedreira, Julia Rey-Brandariz et al.
Okinawa, Ogliastra, and Nicoya are demographically and epidemiologically well-characterized Blue Zones, though some exhibit a recent decline in their longevity advantage, while other regions like Ikaria, Martinique/Guadeloupe, Cilento, a Dutch municipality, and Rugao require further investigation, and Loma Linda and Menorca lack sufficient scientific evidence.
Omid M T Rouzbehani, Marta W Szulik et al.
Epigenetic mechanisms play a critical role in cardiac physiology and pathophysiology, with biological sex significantly influencing disease susceptibility, progression, and therapeutic responses, often conferring a protective advantage in females compared to males.
Bannawich Sapapsap, Wanwarat Aree et al.
In atrial fibrillation patients with advanced chronic kidney disease, both standard- and reduced-dose apixaban demonstrated more favorable outcomes compared to vitamin K antagonists, with standard-dose apixaban showing a trend towards lower all-cause mortality.
Dongquan Gao, Xiaojie Sun et al.
Ballroom dance was positively associated with balance ability in older adults, with physical self-efficacy acting as the largest mediator, followed by fear of falling, and a serial pathway involving both.
Nianci Guo, Shukun Chai et al.
This study protocol outlines a prospective, non-randomized controlled intervention to evaluate an Internet of Things (IoT)-assisted pulmonary rehabilitation model for moderate-to-severe COPD patients over 52 weeks, aiming to assess its efficacy in reducing exacerbations and improving patient outcomes.
Lorin-Manuel Pîrlog, Andreea Cătană et al.
Human longevity is a polygenic and environmentally responsive trait influenced by genetic factors like FOXO3 and APOE, and epigenetic mechanisms that link inherited susceptibility to environmental exposures, with interventions targeting shared pathways but yielding context-dependent effects.
Miguel A Galindo-Campos, Max Hardy-Werbin et al.
Early post-treatment increases in specific peripheral immune cell subsets, such as CD8+CD103+Ki67+ and CD4+Ki67+ T cells, predict improved survival in small cell lung cancer patients treated with chemotherapy and immune checkpoint blockade therapy.
Osman Ertan, Arif Ayar et al.
Belowground extracts of Galanthus elwesii, particularly at subtoxic doses, act as redox modulators, improving oxidative balance and extending lifespan in Drosophila melanogaster, with efficacy driven by redox homeostasis modulation rather than maximal antioxidant capacity.
James K Gibb, Joshua M Schrock et al.
Among young adults with HIV and detectable viremia on ART, epigenetic age acceleration was more strongly associated with HIV infection than with systemic inflammation, with shifts in blood T-lymphocyte composition contributing to epigenetic aging.
Sihui Wen, Yongping Huang et al.
The H3K9me2-FOXG1-microRNA axis modulates autophagy to reduce cochlear hair cell damage in age-related hearing loss by epigenetically repressing FOXG1, which in turn regulates autophagy-related microRNAs to control reactive oxygen species and apoptosis.
Honglin Zheng, Haiyang Luo et al.
Lysosomal rupture caused by ANXA11 amyloid fibrils, particularly the D40G mutant, drives neurodegeneration and propagation in FTLD, with the p38/MK2/HSP27 axis initiating a protective lysophagic response that, when impaired, accelerates disease progression.
Karin de Punder, Malvika Godara et al.
A higher aggregated score of maternal diet, physical activity, and sleep during pregnancy was associated with longer newborn telomere length, and this score mediated the negative relationship between maternal perceived stress and newborn telomere length.
Céline Coquette, Kamar Bouchoucha et al.
Proteostasis decline, indicated by increased SA-β-Gal activity and lysosomal content, emerges as early as age 40 in nasal epithelial cells and correlates with olfactory decline, suggesting proteotoxic stress may play a more prominent role in driving age-associated tissue dysfunction in the upper respiratory tract, while telomere dysfunction-induced foci (TIF) increase significantly only in individuals aged 75 and older in the airway epithelium.
Yirui Chen, Yinuo Qu et al.
In aging Chinese adults, incident diabetes was associated with an 82% higher hazard of progressing to comorbid diabetes-sarcopenia, and incident sarcopenia conferred a 65% elevated risk of subsequent diabetes onset, with these bidirectional associations being time-dependent.
Ye-Seul Lee, Han-Gyul Lee et al.
Acupuncture-related therapies in Parkinson's disease patients were associated with lower levodopa use and a slightly lower long-term risk of all-cause mortality, although they were linked to higher use of medications for nonmotor symptoms like sleep disorders, anxiety, and depression.
Faye Forsyth, Peter Hartley et al.
Patient and public involvement in the PRESERVE-HFpEF doctoral program significantly influenced the intervention content, leading to a more nuanced approach to dietary change, and enhanced researchers' awareness of biases and understanding of patient-centric research practices.
Mufti As Siddiq M Irzal, Tri Yunis Miko Wahyono et al.
Patients with TB-HIV coinfection in Asia and Africa who have a low body mass index (<18.5 kg/m²) have a significantly increased mortality risk, approximately twofold higher (RR=2.01; 95% CI 1.63‐2.48), compared to those with normal or higher BMI.
Xiaolin Wu, Shanglin Cai et al.
The oral microbiota is associated with host lipid metabolism, with Prevotella and Parvimonas being more abundant in hyperlipidemic individuals, and Parvimonas potentially increasing hyperlipidemia risk through sulfur metabolism.
Markus S Brunner, Hansjörg Habisch et al.
Hcy supplementation and genetic SAHH inhibition in yeast and Drosophila lead to SAH accumulation, causing developmental delays, growth defects, and impaired phospholipid and protein methylation, highlighting conserved mechanisms of SAH toxicity.
Daniela Martini, Mariangela Rondanelli et al.
A balanced diet rich in fiber, omega-3 fatty acids, protein, and micronutrients, combined with an active lifestyle, is crucial for maintaining physiological functions and promoting healthy longevity.
Youngjune Bhak, Bruce Guthrie et al.
This study identified significant genetic factors associated with long-term condition burden and their association with lifespan, highlighting the roles of the HLA and LPA regions and suggesting a shared genetic architecture between LTC accumulation and reduced longevity.
Yafang Li, Qinglong Wu et al.
Gut microbial metabolites play a dual role in colitis-associated colorectal cancer (CAC), with protective metabolites like SCFAs and tryptophan derivatives having anti-inflammatory effects, while pathogenic metabolites such as secondary bile acids and TMAO promote carcinogenesis through mechanisms like NF-κB activation and DNA damage.
Qi Huang, Yuesong Pan et al.
Significant and widening discrepancies between cystatin C-based and creatinine-based estimated glomerular filtration rates (eGFRdiff) were independently associated with increased risks of post-stroke disability and mortality.
Ahmed M Omran, Mohamed M Elabd et al.
Early enteral nutrition (EEN) in critically ill pediatric trauma patients is associated with reduced mortality (RR = 0.20), shorter ICU LOS (MD = -4.13 days), shorter hospital LOS (MD = -5.19 days), and improved functional outcomes (OR = 4.79), although the evidence is primarily from observational studies with significant heterogeneity.
Shaymaa Shurrab, Amira Mobarak et al.
Long-term follow-up of two siblings with mitochondrial carbonic anhydrase VA deficiency suggests favorable growth, development, and neurological outcomes are achievable with individualized management, despite significant clinical heterogeneity observed in a literature review of 69 cases.
Hussam Al Hennawi, Muhammad Salman Sabri et al.
The presence of coronary artery calcium (CAC) is significantly associated with increased risks of major adverse cardiovascular events, all-cause mortality, myocardial infarction, and revascularization, and also promotes the initiation and continuation of preventive pharmacologic therapies and lifestyle modifications.
Qian Wang, Jianyao Xue et al.
Elevated plasma cholesterol is associated with improved sepsis outcomes, likely through promoting hepatic metabolic reprogramming.
Xia Zhou, Yun Wang et al.
Cigarette smoke-induced circFOXO3 upregulation contributes to type II alveolar cell senescence by inhibiting autophagy and interacting with E2F1, leading to lung injury.
Yusuf Aggour, Roberto Salguero-Gómez
The proposed 'Aging Onion' framework, integrating evolutionary theories of aging, suggests that the broader efficacy of caloric restriction compared to rapamycin may stem from its wider engagement of both persistent growth signaling (hyperfunction) and suboptimal somatic maintenance axes.
Xiaoya Ren, Xin Zhou et al.
The ubiquitin system, particularly deubiquitinases (DUBs) like USP20, is intricately linked to cellular aging and age-related diseases, presenting significant potential as therapeutic targets.
Liancheng Guan, Fan Yang et al.
Vitamin D receptor (VDR) signaling plays a protective role against inflammatory senescence-associated skin aging by suppressing inflammatory responses and regulating senescence pathways, with VDR modulation offering therapeutic potential for age-related skin conditions.
Ludmila Müller, Svetlana Di Benedetto et al.
Brain aging is a dynamic, interconnected systems process characterized by diverse and asynchronous cellular aging trajectories that vary across cell types and brain regions, involving altered neuronal activity, glial immune states, and vascular regulation that propagate dysfunction across networks.
Kuo-Chuan Hung, Hsiu-Lan Weng et al.
Pre-existing iron deficiency anemia is independently associated with an increased risk of recurrent acute kidney injury (HR, 1.53) and accelerated renal function decline (HR, 1.19) in critically ill patients who survive an initial AKI event.
Rahul Mittal, Farhad Alipour et al.
Immune regulation of cellular identity, driven by transcriptional and epigenetic remodeling, is a fundamental mechanism of tissue control that can lead to functional impairment and chronic disease even before cell loss, as exemplified by metabolic diseases.
Junnan Zhang, Mingyue Gao et al.
Laying hens serve as a valuable and underutilized model for studying female reproductive aging due to conserved features with humans in ovarian aging, endocrine regulation, and oxidative stress, offering a promising framework for understanding reproductive aging and identifying therapeutic targets.
Jieun Seo, Seo-Young Park et al.
Autophagy is a crucial cellular process regulated by a complex interplay of transcription factors and epigenetic modifiers, with context-dependent roles in various diseases, necessitating precision medicine approaches for therapeutic intervention.
Gwendoline Hoslett, Sara Tribble et al.
Nucleophagy, mediated by TEX264 and p97, clears cytotoxic trapped PARP1, and disrupting this pathway increases PARP1 trapping, leading to cell death and re-sensitizing PARPi-resistant cells.
Xinyan Gong, Xiaowei Cheng et al.
In community-dwelling centenarians, serum creatine kinase levels were independently and inversely associated with all-cause mortality in an inverse J-shaped manner.
Yajnaseni Chakraborti, Sunni L Mumford et al.
Minimizing postpartum weight retention was associated with a reduced risk of all-cause mortality over 50 years of follow-up, even in women with a normal pre-pregnancy BMI.
Amina Fallata, Saber Nahdi et al.
Gestational exposure to erythritol disrupts ovarian function across two generations in rats by increasing oxidative stress, suppressing autophagy and PI3K signaling, and reducing AMH levels.
Jérémie Prévost, Sarah J Medina et al.
Both monkeypox virus infection and MVA-BN vaccination lead to declining antibody levels over time, raising concerns about waning immunity and potential reinfection, and suggesting a need for booster doses.
Haiyun Chen, Qinghe Geng et al.
A novel Vdr-spermidine-DNMTs signaling axis is essential for preserving granulosa cell function and maintaining ovarian health, where age-related decline in Vdr leads to GCs aging and ovarian decline, but spermidine and SAM supplementation can counteract these effects.
Holly E Holmes, Kamal Srivastava et al.
Supplementation with nicotinamide riboside and pterostilbene (NRPT) for 7 days safely reduced the frequency and severity of undesirable menopause transition symptoms in symptomatic women, accompanied by a significant increase in the urinary E2/E1 ratio.
Jennifer Nhieu, Fatimah Najjar et al.
CRABP1 signalosomes modulate diverse signaling pathways in a cell type-specific manner, maintaining cellular and organ health, particularly during aging, with disruption contributing to age-related diseases like thyroid dysfunction.
Xiaoyu Zhang, Ai Guan et al.
Elevated homocysteine and reduced methionine/methylation levels are associated with worse cognitive performance and accelerated cognitive decline in Alzheimer's disease patients.
Niloufar Mansooralavi, William E Lowry
MECP2 deficiency impairs DNA repair, leading to genotoxic stress and senescence, which drives the metabolic and neuronal deficits observed in Rett Syndrome.
Guanglei Chen, Yunzhi Chen et al.
Metabolic reprogramming in COPD leads to protein lysine acylation modifications, such as lactylation and succinylation, which regulate inflammation, senescence, and tissue remodeling, suggesting potential targets for biomarkers and therapeutic interventions.
Ruxia Qiu, Dong Zhang et al.
Immunosenescence, a maladaptive immune remodeling, serves as a unifying mechanism linking frailty and multimorbidity by eroding physiological reserve and promoting disease clustering.
Jamaji C Nwanaji-Enwerem, Dennis Khodasevich et al.
Short-duration spaceflight significantly alters methylation-derived biomarkers of aging and immunity, with notable bidirectional shifts in certain proteins and enrichment in pathways related to endopeptidase activity and cell aggregation.
Beomsu Kim, Joong-Gon Shin et al.
Chlorogenic acid (CGA) and taurine co-treatment in human skin cells identified 62 aging-related differentially expressed genes (AR-DEGs), including key regulators like TGFB2, ETS1, and EGR1, with synergistic effects observed and associations found between AR-DEGs and perceived age and skin pigmentation.
Zhiling Zhang, Huabin Su et al.
Centenarians achieve immune equilibrium through remodeling of cytotoxic immune lineages (NK, CD8+ T, γδ T cells) and fine-tuning of inflammatory responses, rather than generalized immunosuppression, with specific genetic loci identified as potential targets for interventions.
Şebnem Özgen Özkaya, Volkan Özkaya
No significant association was found between dietary diversity and nutritional status, activities of daily living, functional, or cognitive frailty in this Turkish older adult population, although a significant association was observed between DDS and phytonutrient intake.
Haobo Jiang, Yuting Zhang et al.
Osteosarcopenic obesity (OSO) is an immunometabolic disorder driven by chronic inflammation, trained immunity, and senescence, originating from visceral adipose tissue and systemically affecting muscle and bone through a vicious cycle of immune dysregulation.
Yanxia Shang, Yanfeng Shang
Resistance and combined exercise training demonstrate more consistent anti-inflammatory benefits in older adults with sarcopenia compared to aerobic exercise, by suppressing pro-inflammatory pathways and modulating immune responses.
Christopher J Shore, Marc F Österdahl et al.
The COVID-19 pandemic accelerated epigenetic ageing rates (GrimAge acceleration: p=0.002, β=0.99) in individuals between Spring 2020 and Spring 2021, regardless of SARS-CoV-2 infection status.
Shimeng Wang, Jingtian Mu et al.
Oxidative stress-induced senescent macrophages promote squamous cell carcinoma invasion via glutamine metabolic reprogramming and IL-1β secretion, which can be effectively targeted by blocking IL-1β.
Lu Pu, Zhiliang Zuo et al.
ERG forms nuclear condensates via liquid-liquid phase separation (LLPS), which alters chromatin and reduces senescence-related gene expression, thereby attenuating cellular senescence.
Marc Pawlitzki, Patricia Kirschner et al.
In multiple sclerosis patients, a higher brain age gap (BrainAGE) is associated with increased disability and disease duration, but is independent of serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels.
Kai-Le Li, Chen Wang et al.
roX1 and roX2 lncRNAs promote heterochromatinization in intestinal stem cells, leading to gene silencing, stem cell hyperplasia, and reduced lifespan in female Drosophila under stress conditions.
Cornelia M Weyand, Jörg J Goronzy
Aging profoundly impacts the human immune system, leading to a decline in its structural integrity and functional resilience, characterized by compromised hematopoietic stem cells, reduced adaptive immune function, and increased susceptibility to infections and autoimmune diseases, while also promoting chronic inflammation and tissue degeneration.
Ying Wang, Chunli Dong et al.
Polystyrene nanoplastics exposure in young mice significantly increased inflammatory markers and cellular senescence, decreased antioxidant gene expression, and disrupted oral-gut microbiome homeostasis, thereby accelerating aging.
Ke Zhou, Ping Lu et al.
The gut microbiome significantly influences anticancer drug resistance through mechanisms like drug biotransformation, immune modulation, and tumor microenvironment alteration, necessitating personalized microbiome interventions and the development of less susceptible therapies for precision oncology.
Jianbo Cheng, Jing Li et al.
Casein enzymatic hydrolysate (CEH) alleviates Salmonella Typhimurium-induced enteritis in adult mice by modulating the gut microbiota to increase lactate, which activates a GPR81-Wnt3A-ISC axis, promoting intestinal repair and regeneration.
Mónica Margarita Barón Castro, Angelica María Montoya García et al.
Nursing training practices at the studied university align with regional guidelines for adults and older adults, demonstrating the acquisition of essential competencies for comprehensive care and supporting healthy aging policies, with a notable focus on interventions for individuals from subsidized health regimes and lower socioeconomic strata.
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