Research Database

NiedrigProspektivMensch2026
Emulating a target trial of early compared with late initiation of appropriate antibiotic therapy for hospital-acquired monobacterial Gram-negative bloodstream infections.
Abdullah T Aslan, Yukiko Ezure et al.
Early appropriate antimicrobial therapy (EAAT) within 24 hours of blood culture sampling was associated with a significantly lower hazard of 14-day and 28-day all-cause mortality in patients with hospital-acquired bloodstream infections caused by Gram-negative bacteria, including those with carbapenem-resistant Gram-negative bacteria.
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Sehr niedrigMaus2026
Dietary Spermidine Mitigates Radiation-Induced Intestinal Injury by Reshaping the Microbiota-Barrier-Inflammation Axis.
Song Li, Yanjiang Liu et al.
Dietary spermidine significantly mitigates radiation-induced intestinal injury by activating the Nrf2 pathway, enhancing intestinal barrier integrity, reducing inflammation, and reshaping the gut microbiota towards beneficial bacteria.
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Sehr niedrigNarrative Review2026
Dietary polyphenols in pediatric obesity and cardiometabolic risk: mechanisms and clinical evidence.
Valeria Calcaterra, Hellas Cena et al.
Dietary polyphenols show promise for pediatric obesity and cardiometabolic prevention, supported by mechanistic evidence and observational/early clinical findings, but direct clinical application is limited by conceptual controversy, methodological weaknesses, and insufficient pediatric-specific evidence, suggesting that promoting polyphenol-rich dietary patterns within lifestyle interventions is the most evidence-based approach.
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Sehr niedrigMensch2026
The influence of C-reactive protein-triglyceride-glucose index (CTI) on the prognosis of heart failure patients with different ejection fractions.
Xinuo Ma, Feng Wang et al.
The C-reactive protein-triglyceride-glucose index (CTI) is an independent predictor of all-cause mortality in chronic heart failure patients across different ejection fraction subtypes, with higher CTI levels indicating increased mortality risk, particularly in HFpEF.
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Sehr niedrigIn vitro2026
Echinocandin tolerance and persistence in vitro are regulated by calcineurin signaling in Candida glabrata .
Abigail A Harrington, Timothy J Nickels et al.
Calcineurin signaling is a major driver of echinocandin tolerance and persistence in *C. glabrata* and *C. albicans*, and its inhibition with FK506 can improve echinocandin efficacy by reducing these mechanisms.
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Sehr niedrigNarrative ReviewMensch2026
Vitamin D as a Lifespan Neuroimmune Signal in Psychiatry: From Developmental Risk to Precision Nutrition.
Czeslaw Ducki, Monika Jach et al.
Vitamin D is not a universal psychiatric treatment, but its relevance is context-dependent, particularly in early neurodevelopmental vulnerability, inflammatory/metabolic depression, psychosis liability, severe mental illness with nutritional deprivation, and frailty/multimorbidity, with clinical management focusing on identifying high-risk patients and correcting deficiency according to established medical guidance.
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Sehr niedrigNarrative Review2026
Promoting tissue repair with plant-derived compounds: evidence and mechanisms from zebrafish studies.
Xiang Meng, Xuting Song et al.
The zebrafish model validates the pro-repair and regenerative effects of plant-derived compounds by modulating conserved mechanisms such as inflammation, oxidative stress, and autophagy, with potential for translation into clinical benefits.
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Sehr niedrigMaus2026
A Primate-Specific lncRNA LINC01021 Contributes to Cellular and Organismal Aging via DAZAP1-Dependent Destabilization of RBMX.
Yan Zhang, Li Hu et al.
The primate-specific long non-coding RNA LINC01021 promotes cellular senescence and aging-like phenotypes by facilitating DAZAP1-dependent destabilization of RBMX mRNA, which activates the P53 pathway.
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Sehr niedrigMaus2026
Dibutyl phthalate induces sarcopenia via TNFα/TNFR1-mediated proteolytic and pyroptotic axes: evidence from NHANES and experimental models.
Xiangjiao Yi, Junyan Li et al.
Combined phthalate exposure, particularly mono-n-butyl phthalate (MBP), is associated with reduced skeletal muscle mass, mediated by inflammation and oxidative stress, with DBP/MBP potentially activating the TNFα/NF-κB axis leading to muscle atrophy and pyroptosis.
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ModeratProspektivMensch2026
Association between the uric acid-to-albumin ratio and risk of all-cause mortality in centenarians: a prospective cohort study.
Xiaofei Liu, Hao Li et al.
Elevated uric acid-to-albumin ratio (UAR) is independently associated with a 28.7% increased risk of all-cause mortality in centenarians.
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NiedrigRCTMensch2026
Maintained diabetes remission among normal BMI individuals achieved without ongoing intervention: a three-year follow-up study of intermittent calorie restriction.
Ruiyu Wu, Xiao Yang et al.
A three-month Chinese Medical Nutrition Therapy (CMNT) intervention led to diabetes remission maintained for three years in 75% of participants with normal BMI, without ongoing structured intervention, and was associated with improved quality of life and reduced complications.
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Sehr niedrigSystematic ReviewMensch2026
Public health policies and interventions to address health inequities in high-income countries: an umbrella review.
Jatinder Hayre, Ellie Canning et al.
Interventions with low agentic demand, such as welfare reform, housing support, and legislative measures, consistently reduce health inequities, while high-demand interventions may exacerbate disparities unless tailored to disadvantaged populations.
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HochRCTMensch2026
Behavior change intervention targeting physical activity and diet improves stress and sleep.
Samuel L Battalio, Bonnie Spring et al.
Interventions targeting diet and activity can lead to collateral improvements in stress and, to a lesser extent, sleep, with the stress/sleep intervention showing statistically larger improvements in sleep duration compared to the diet/activity intervention.
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HochRCTMensch2026
Ivor Lewis minimally invasive oesophagectomy versus McKeown approach: short-term benefits and mid-term equivalence in a randomized trial for oesophageal squamous cell carcinoma.
Ruipu Xiu, Ran An et al.
Ivor Lewis minimally invasive oesophagectomy demonstrated superior short-term outcomes, including reduced operative time and fewer complications, compared to the McKeown approach for mid-lower oesophageal squamous cell carcinoma, with comparable mid-term progression-free survival.
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NiedrigProspektivMensch2026
A genome-wide association study identified 10 novel genomic loci associated with intrinsic capacity.
Melkamu B Beyene, Renuka Visvanathan et al.
This study provides the first comprehensive genetic analysis of intrinsic capacity (IC), demonstrating its heritability (25.2% in UKB, 19.5% in CLSA) and identifying 38 independent SNPs across 10 genomic loci, with a polygenic score significantly associated with higher IC scores.
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ModeratProspektivMensch2026
Sex-specific association between lumbar spine-total hip T-score discordance and all-cause mortality: a prospective cohort study from NHANES.
Rıdvan Erten, Mehmet Poyrazer
In older US adults, a greater difference between lumbar spine and total hip T-scores was associated with higher all-cause mortality in women, but not in men, while the total hip T-score was the strongest single-site predictor for mortality in both sexes.
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HochRCTMensch2026
Diuretic Intensity Score and Mortality in Hospitalized Heart Failure Patients: A Multicenter Propensity-Matched Analysis.
Jianwei Zhou
A higher Diuretic Intensity Score (DIS) was associated with lower 28- and 90-day all-cause mortality in hospitalized heart failure patients across two independent cohorts.
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Sehr niedrigNarrative Review2026
Testosterone Replacement Therapy as a Foundation for Body Composition Remodeling: Synergistic Roles of Resistance Training and Protein Intake.
Luis M Canal de Velasco, José Emiliano González Flores et al.
Testosterone replacement therapy (TRT) can lead to clinically relevant changes in body composition, increasing lean mass by approximately 1-3 kg and reducing fat mass by 1-4 kg, with these effects being amplified by resistance training and adequate protein intake.
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Sehr niedrigRetrospektivMensch2026
Apical myocardial fibrosis burden identifies a high-risk phenotype and predicts cardiac mortality after LVAD implantation.
İbrahim Demir, Bilge Ecemiş et al.
Quantitatively assessed apical myocardial fibrosis burden independently predicts cardiac mortality in LVAD recipients, even after accounting for competing non-cardiac risks.
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Sehr niedrigProspektivMensch2026
Impact of patent foramen ovale on transvenous lead extraction characteristics and outcomes.
Aaron Park, Nolan Martin et al.
Transvenous lead extraction patients with a patent foramen ovale (PFO) had a significantly higher mortality rate (5.41% vs. 0%) compared to those without a PFO, although stroke incidence was not statistically different.
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NiedrigProspektivMensch2026
The impact of multiple long-term conditions on mortality, progression to kidney failure and health-related quality of life among people with chronic kidney disease: a multicentre cohort study (NURTuRE-CKD).
Irene Boateng, Thomas Phillips et al.
A greater comorbidity burden in patients with chronic kidney disease was associated with increased mortality and worse health-related quality of life, but not with the progression of kidney disease.
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Sehr niedrigSystematic ReviewMensch2026
Addressing non-communicable diseases risk factors through innovative and context-sensitive approaches in the eastern Mediterranean region: a systematic review.
Mohammed Elmadani, Godfrey Mbaabu Limungi et al.
Innovative, community-based, culturally responsive, and multisectoral interventions show promise for addressing non-communicable disease risk factors in the Eastern Mediterranean Region, with dietary behaviors and physical activity showing the most consistent improvements.
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NiedrigProspektivMensch2026
Nordic Multimorbidity Index, Charlson, Elixhauser and count-based comorbidity indices for mortality risk: a comparative nationwide cohort study using national health registers in Sweden.
Björn Zethelius, Mats Talbäck et al.
Age and sex alone were better predictors of 5-year mortality than NMI, CCI, or ECI alone, but adding NMI to age and sex provided a modest improvement in predictive performance, while CCI and ECI were less informative.
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ModeratSystematic ReviewMensch2026
Interventions that prolong multidimensional healthspan in humans: a systematic review of randomized controlled trials.
Haoxin Tina Zheng, Aung Zaw Zaw Phyo et al.
Exercise, either alone or as part of multidomain interventions, demonstrates effectiveness in improving intrinsic capacity and quality of life, with limited evidence for caloric restriction and daily supplementation due to small study numbers and heterogeneity.
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Sehr niedrig2026
Dauricine Mitigates Hypoxia Through Targeting ESR1, PIK3CA, and MTOR: A Network Pharmacology and Molecular Dynamics Simulation Investigation.
Zengxun Ni, Zineng Zhou et al.
This study computationally identified ESR1, PIK3CA, and MTOR as core targets for dauricine's anti-hypoxic mechanism, supported by molecular docking and molecular dynamics simulations, suggesting dauricine as a potential multi-target candidate for hypoxia intervention.
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ModeratProspektivMensch2026
Association Between Comprehensive Health Assessment and Cardiac Mortality and All-Cause Mortality in Patients With Coronary Heart Disease.
Yanqiong Li, Lixia Yang et al.
A higher Comprehensive Health Assessment Score (CHAS), integrating lifestyle, physical function, metabolic health, and comorbidity/medication adherence, was strongly associated with reduced cardiac and all-cause mortality in U.S. adults with coronary heart disease, with lifestyle factors and comorbidity/medication management being the strongest predictors.
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NiedrigRetrospektivMensch2026
The endothelial activation and stress index (EASIX) predicts hazards of short- and long-term mortality in acute ischemic stroke: a retrospective cohort study.
Antonia Kleeberg, Thomas Luft et al.
The Endothelial activation and stress index (EASIX) independently predicts short- and long-term mortality in acute ischemic stroke patients and improves risk stratification beyond established clinical scores.
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ModeratMetaanalyseMensch2026
Pharmacokinetic interactions and clinical implications of PPIs and CDKIs in breast cancer: a systematic review and meta-analysis.
Agnese Graziosi, Roberto Pane et al.
Proton pump inhibitor (PPI) use significantly reduced palbociclib Cmax and increased CL/F, and was associated with worse progression-free survival and overall survival in HR+/HER2- breast cancer patients, suggesting PPIs should be avoided with palbociclib.
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Sehr niedrigMensch2026
Zero-contrast cardiac resynchronization therapy device implantation in heart failure patients with renal impairment.
Biagio Sassone, Marco Zuin et al.
A zero-contrast strategy for cardiac resynchronization therapy implantation is feasible, safe, and effective in chronic kidney disease patients, leading to better renal preservation compared to procedures using contrast.
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Sehr niedrigQuerschnittMensch2026
Visual acuity and ocular comorbidities in patients aged 100 years and older: A retrospective, crosssectional study.
Takashi Ono, Takuya Iwasaki et al.
Cataract and uveitis were significantly linked to poor visual acuity in patients aged 100 years and older, with cataract surgery improving visual acuity.
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Sehr niedrigProspektivMensch2026
Circulating granzyme A is elevated within the dysregulated host response and associates with mortality in abdominal sepsis.
Galadriel Pellejero-Sagastizabal, Patricia Esteban et al.
Circulating granzyme A (GzmA) concentration and activity were significantly elevated in patients with secondary peritonitis compared to healthy controls, and each doubling of baseline GzmA was associated with a 2.52-fold increase in the odds of in-hospital mortality.
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Sehr niedrigMensch2026
Sex-specific differences in the prognostic value of ischemic pre-hospital ECGs.
L E Sams, L Bachinger et al.
An ischemic prehospital ECG predicts myocardial infarction requiring target lesion revascularization in female patients and identifies high-risk patients for mortality in both sexes.
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ModeratSystematic ReviewMensch2026
Dietary and Nutrition Interventions for Breast Cancer Survivors: An Umbrella Review.
Joan Ern Xin Tan, Mattias Wei Ren Kon et al.
Structured, dietitian-supported, and Mediterranean-style dietary interventions improve diet quality, sustainable weight control, and quality of life among breast cancer survivors.
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NiedrigProspektivMensch2026
Integrative machine learning approach to risk prediction for dementia and Alzheimer's disease.
Amos Stern, Michal Linial
CatBoost models accurately predicted Alzheimer's disease risk using UK Biobank data, achieving a ROC-AUC of 0.773, particularly in females, with the ApoE-ε4 gene being the strongest genetic risk factor, and vascular dementia models showing even higher predictive performance.
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Sehr niedrigRetrospektivMensch2026
Efficacy and Safety of Dual Antiplatelet Therapy in Acute Ischemic Stroke With Recurrent Symptoms Post-thrombolysis: A Retrospective Cohort Study From the TriNetX US Collaborative Network.
Chukwudi Nwogu, James Stupin et al.
In patients with acute ischemic stroke who experienced recurrent symptoms after thrombolysis, dual antiplatelet therapy (DAPT) did not demonstrate a significant advantage over aspirin monotherapy (AM) in reducing recurrent ischemic stroke, symptomatic intracranial hemorrhage, or 90-day mortality.
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Sehr niedrigProspektivMensch2026
Admission Serum Ferritin Levels as a Predictor of Severe Disease in Hospitalized Pediatric Patients in Mexico.
Grecia Abigayl Turrubiates-Hernandez, Jose Eduardo Mares-Gil et al.
Admission serum ferritin levels can predict severe disease and adverse outcomes in hospitalized pediatric patients, with a cut-off of 385 ng/mL indicating a 3.2-fold higher probability of death.
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Sehr niedrigMensch2026
Holter-Derived Mean Heart Rate as a Predictor of Short-Term Clinical Risk in Patients Hospitalized With Acute Heart Failure.
Vu Manh Tan, Pham Xuan Hung et al.
Holter-derived mean heart rate robustly predicted in-hospital mortality in acute heart failure patients, with a heart rate > 100 bpm significantly increasing mortality compared to < 70 bpm (31.3% vs. 4.8%).
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Sehr niedrigMetaanalyseMensch2026
What Are the Optimal Sagittal Alignments in Primary Total Knee Arthroplasty: A Systematic Review and Meta-Analysis.
Guoqing Li, Yong Huang et al.
While optimal sagittal alignment (SA) parameters in total knee arthroplasty (TKA) remain uncertain, favorable SA is hypothesized to improve prognosis and function, with malalignment linked to poorer clinical outcomes and advanced technologies like navigation and robotic-assisted surgery recommended for precise SA tailored to individual needs.
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Sehr niedrigProspektivMensch2026
Three-year outcomes of endovascular repair of descending thoracic aortic lesions with a single-branched endograft for left subclavian artery preservation.
G Chad Hughes, Michael D Dake et al.
At 3 years, the TBE device demonstrated durable outcomes for nondissection descending thoracic aortic disease, with 99% LSA branch patency, 1% lesion-related mortality, and minimal complications.
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Sehr niedrigMensch2026
A Histone Code Functionally Linked to Replicative Senescence.
Thomas Suter, Meyer J Friedman et al.
Promoter loss of H4R3me(2s) and gene body spreading of H3K79me3 are functional features of replicative senescence linked to gene upregulation, particularly in longer genes, and their suppression attenuates senescence and extends cellular lifespan.
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Sehr niedrigRetrospektivMensch2026
Association of endoscopic intervention with mortality in gastrointestinal bleeding after open-heart surgery: a propensity-score cohort study.
Hailin Du, Yamei Sun et al.
In selected patients with postoperative gastrointestinal bleeding after open-heart surgery, those undergoing endoscopic intervention had significantly lower 30-day (26.5% vs. 49.8%) and 1-year (33.8% vs. 57.1%) all-cause mortality rates compared to those who did not receive endoscopic intervention.
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ModeratMetaanalyseMensch2026
Effects of Exercise on Autonomic Cardiovascular Function in Older Adults: A Systematic Review and Meta-Analysis.
Paula Etayo-Urtasun, Mikel Izquierdo et al.
Structured exercise significantly improved parasympathetic modulation (RMSSD, pNN50) and sympathovagal balance (LF/HF ratio) in older adults, with a significant increase in long-term adaptability (SD2).
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Sehr niedrigSystematic ReviewMensch2026
Examining subjective views of the aging process in older adults: a systematic review following the COSMIN methodology.
Enrico Sella, Elena Carbone et al.
A systematic review identified 26 instruments assessing views of aging in older adults, with only a few specifically addressing cognitive changes, and most instruments demonstrated psychometric limitations across various measurement properties.
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ModeratRetrospektivMensch2026
Drug-induced liver injury as a strong independent predictor of in-hospital mortality in tuberculous meningitis: potential age-related effect modification suggested in a large lifespan cohort.
Qiong Wu, Jian Peng et al.
Drug-induced liver injury (DILI) is a strong independent predictor of in-hospital mortality in tuberculous meningitis (TBM), significantly improving mortality risk prediction, with a borderline trend towards age-related effect modification.
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Sehr niedrigFall-KontrollMensch2026
Epigenetic age acceleration in young adults with congenital heart disease.
Parag N Jain, Beryl C Zhuang et al.
Young adults with congenital heart disease who underwent multiple childhood surgeries (Fontan group) showed significantly accelerated epigenetic aging (GrimAge, PhenoAge, DunedinPACE) compared to controls, with inflammation markers (IL-6, CRP) contributing to these differences.
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ModeratMetaanalyseMensch2026
Circulating Level of Growth-Differentiation Factor 15 and Mortality of Patients With Acute Heart Failure: A Meta-Analysis.
Pingkui Jin, Yanjie Geng et al.
Elevated circulating GDF-15 levels at admission were significantly associated with a 2.82-fold increased risk of mortality in patients with acute heart failure.
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NiedrigProspektivMensch2026
Hobby engagement, disability transitions, and life expectancy: a multinational longitudinal study.
Qian Liu, Fan Yang
Hobby engagement is consistently associated with a lower risk of functional disability progression, a higher likelihood of recovery from severe disability, and reduced mortality risk among those with severe disability, leading to significantly longer functional and total life expectancy across diverse global populations.
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Sehr niedrigProspektivMensch2026
Andexanet alfa for the reversal of anticoagulation: Dutch practice data.
Jurjen F Krommenhoek, Wendy Beekman et al.
Andexanet alfa use in the Netherlands was associated with a 4.6% 30-day cumulative incidence of thrombotic events, which was lower than in clinical trials, but a 34% 30-day all-cause mortality rate, reflecting the poor prognosis of the patient population.
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Sehr niedrigNarrative ReviewMensch2026
Abdominal Obesity Phenotypes and Incidence of Type 2 DM, Cardiovascular Outcomes and All-Cause Mortality-A Systematic Review and Meta-Analysis.
Soraya Doustmohamadian, Marjan Momeni et al.
Individuals with a metabolically healthy abdominal obese (MHAO) phenotype did not show significantly elevated risks of type 2 diabetes, cardiovascular disease, or all-cause mortality compared to metabolically healthy, non-abdominally obese controls, although abdominal adiposity itself was associated with adverse changes in blood pressure and cholesterol levels.
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Sehr niedrigNicht-randomisiertMensch2026
The safety and efficacy of human umbilical cord mesenchymal stem cell for acute respiratory distress syndrome: an open-label and multicenter phase 1 clinical trial.
Qinggang Ge, Libo Zheng et al.
Human umbilical cord mesenchymal stem cells (hUC-MSCs) are safe and well-tolerated in patients with mild-to-moderate ARDS, with the middle dose showing promising therapeutic effects, including significant improvements in oxygenation and reductions in lung injury scores.
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Sehr niedrigProspektivMensch2026
Age-specific patterns of all-cause mortality across COVID-19 booster dose groups in two Japanese municipalities: an exploratory analysis.
Yasushi Iwamoto, Hiroshi Kusunoki et al.
This exploratory study found that in two Japanese municipalities, older adults (65-89 years) showed lower all-cause mortality with more COVID-19 vaccine doses, while younger adults (20-49 years) showed higher mortality with five or more doses, and those aged 50-64 showed higher mortality with six doses, though causality cannot be established due to data limitations.
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Sehr niedrigProspektivMensch2026
Multimorbidity and the Number of Conditions Increase With the Duration of Type 1 Diabetes and Associate With Increased Mortality.
Anni Ylinen, Stefan Mutter et al.
Multimorbidity, defined as the coexistence of two or more chronic conditions, is prevalent in 60.4% of individuals with type 1 diabetes and is strongly associated with a significantly increased risk of all-cause mortality (HR 6.01), with each additional condition further elevating this risk.
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Sehr niedrigNarrative ReviewMensch2026
A shared stress-inflammation signalling architecture underlying chronic disease and multimorbidity.
Wolfgang Kopp
Chronic diseases arise from the persistent activation of a shared stress-response network, involving sympathetic and RAAS signalling, metabolic overload, oxidative stress, and innate immune pathways converging on intracellular hubs, leading to multimorbidity.
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Sehr niedrigMensch2026
Global patterns and inequalities in healthy aging: a multidimensional analysis using composite index and explainable AI.
Sadullah Çelik, Cemile Zehra Köroğlu
Life span, health span, income, environmental performance, and happiness were the primary drivers of healthy aging, with work span having a limited contribution, and moderate disparities in healthy aging index scores were observed across countries (Gini = 0.318).
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ModeratProspektivMensch2026
Prognostic nutritional index at discharge as a practical bedside tool for long-term all-cause mortality risk in pneumonia-induced sepsis survivors.
Zhenwei Zhai, Junyu He et al.
The prognostic nutritional index (PNI) at discharge is a practical bedside tool for estimating long-term all-cause mortality in survivors of pneumonia-induced sepsis, with lower PNI tertiles associated with significantly higher mortality risk.
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Sehr niedrigSystematic ReviewMensch2026
Exploring the effectiveness of physical health check interventions for people with severe mental illness: a systematic review of qualitative and quantitative evidence.
Rachel L Hawkins, Joao Craveiro et al.
While five out of seven interventions showed positive primary outcomes for physical health markers in individuals with severe mental illness (SMI), the results were inconsistent across different markers and interventions, with successful interventions often featuring integrated care models, particularly in US-based settings.
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Sehr niedrigSystematic ReviewMensch2026
Impact of frailty on post-procedural adverse outcomes in older adults aged ≥75 years undergoing percutaneous coronary intervention: a systematic review of observational studies.
Peng Tian, Liping Wang et al.
Frailty in patients aged 75 years or older undergoing percutaneous coronary intervention is associated with significantly increased risks of in-hospital mortality (RR = 3.16), all-cause mortality (RR = 2.51), bleeding (RR = 2.26), and stroke (RR = 1.90), although the evidence quality is low.
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Sehr niedrigMensch2026
Healthy Eating Index, Epigenetic Age Acceleration and Mortality Risk in US Adults.
May A Beydoun, Marie T Fanelli Kuczmarski et al.
Poor diet quality is associated with accelerated biological aging and increased mortality, with GrimAgeEAA identified as the strongest mortality predictor, and epigenetic mechanisms partially mediating the diet-mortality association, although this mediation is attenuated by lifestyle factors, particularly physical activity.
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NiedrigProspektiv2026
Evolutionary Conservation of Lipid-Associated Epigenetic Signatures and Their Distinct Roles in Tissue Identity and Mammalian Aging.
Sun-Young Kang, Jeong-Soo Gim et al.
Lipid-associated epigenetic signatures are highly conserved across mammals, play a role in tissue identity and aging, and blood methylation serves as a reliable proxy for internal metabolic tissue evolution.
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Sehr niedrigNarrative ReviewMensch2026
Effect of Sodium Restriction on Cardiovascular Outcomes in Patients With Hypertension and Heart Failure: A Systematic Review and Meta-Analysis.
Ayman Alqurain, Omer H Al-Hasani et al.
Dietary sodium restriction is effective for hypertension, but strict sodium restriction (<1.5 g/day) is not supported for reducing mortality or hospitalization in established heart failure, with moderate restriction potentially improving symptoms while aggressive restriction could be harmful.
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NiedrigProspektivMensch2026
Association of ultra-processed food consumption with all-cause and cause-specific mortality: population-based cohort study.
Ya-Dong Li, Le-Lan Gong et al.
Higher consumption of ultra-processed food was associated with a 10% higher risk of all-cause mortality, a 9% higher risk of circulatory system diseases mortality, a 20% higher risk of nervous system diseases mortality, and a 28% higher risk of mortality from other causes, with no association found for cancer mortality.
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Sehr niedrigNarrative Review2026
Turning back time: a comprehensive list of interventions that decrease next-generation epigenetic aging clocks in humans.
Adiv A Johnson, David A Sinclair
Next-generation epigenetic aging clocks can be slowed by various interventions including lifestyle changes, pharmaceuticals, supplementation, caloric restriction, and umbilical cord plasma, with some interventions like plasmapheresis accelerating epigenetic aging.
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ModeratRetrospektivMensch2026
Vonoprazan vs Proton Pump Inhibitors for Gastroprotection in Anticoagulated Patients: A Real-World Cohort Study.
Hatem Ahmed, Imad Alabdul Razzak et al.
In anticoagulated patients, vonoprazan use was associated with significantly lower rates of gastrointestinal bleeding, all-cause mortality, and blood transfusions, as well as modestly higher hemoglobin levels compared to proton pump inhibitors over one year.
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ModeratRCTMensch2026
The MetaboHealth Score Enhances Insulin Resistance Metabotyping for Targeted Fat Loss: The PERSON Study.
Jordi Morwani-Mangnani, Fatih A Bogaards et al.
Combining insulin resistance metabotype with the MetaboHealth score identified differential responses in body composition, particularly fat loss, in insulin-resistant adults based on baseline immune-metabolic health status, with individuals in the highest MH tertile experiencing fat loss irrespective of diet or metabotype.
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ModeratProspektivMensch2026
The prognostic value of red cell distribution width-to-albumin ratio for 28-day mortality in sepsis patients: a multicenter analysis based on the eICU Collaborative Research Database.
Mao Ye, Suqi Lv et al.
Elevated red blood cell distribution width-to-albumin ratio (RAR) levels at admission are independently associated with increased 28-day all-cause mortality in sepsis patients, with a non-linear dose-response relationship observed.
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Sehr niedrigMaus2026
Endothelial progenitor cell susceptibility to DNA damaging and DDR-modulating compounds determines endothelial differentiation accuracy.
Sina Federmann, Michelle Westerhoff et al.
Doxorubicin treatment of endothelial progenitor cells (EPC) leads to multiple dysfunctions in their differentiated progeny, including impaired endothelial barrier function, altered cytokine response, and reduced LDL uptake, along with increased senescence.
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NiedrigProspektivMensch2026
Circulating multiple metals and mortality after myocardial infarction: incremental value beyond GRACE.
Minmin Wu, Junhan Chen et al.
Higher plasma levels of copper, lead, and strontium were significantly associated with increased all-cause mortality in patients post-myocardial infarction, and an environmental metal risk score derived from these metals improved risk stratification beyond the GRACE score.
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Sehr niedrigSystematic ReviewMensch2026
The prognostic value of the CALLY index in sepsis: a systematic review and meta-analysis.
Chuangying Xie, Peng Sun et al.
The CALLY index, a composite biomarker, showed a variable association with mortality in sepsis patients across different ethnic groups, suggesting potential as a low-cost biomarker but requiring further validation in large, multinational prospective studies.
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ModeratProspektivMensch2026
Association of high-sensitivity cardiac troponin T with all-cause and cardiovascular mortality in a mobile cohort of older adults aged 70 to 95 years - Results from the AugUR study.
Klaus J Stark, Martina E Zimmermann et al.
Elevated high-sensitivity cardiac troponin T (hsTnT) levels are associated with increased cardiovascular and non-cardiovascular mortality risk in older adults, particularly in those with prevalent cardiovascular disease.
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ModeratMetaanalyseMensch2026
Performance of Malnutrition Screening Tools on People With Chronic Diseases: A Bivariate Meta-Analysis.
Hidayat Arifin, Ruey Chen et al.
The Malnutrition Screening Tool (MST), Malnutrition Universal Screening Tools (MUST), and Nutritional Risk Screening 2002 (NRS-2002) demonstrate good accuracy in detecting malnutrition in patients with chronic diseases, with MST showing a higher area under the curve (AUC).
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Sehr niedrig2026
A Large Lizard in a Small Islet: Abundance, Body Growth, and Diet of Podarcis pityusensis from Es Vaixell (Balearic Islands, Spain).
Valentín Pérez-Mellado, Ana Pérez-Cembranos
The *Podarcis pityusensis* population on Vaixell Islet exhibits large body size, high density, and remarkable longevity, with growth best described by the Gompertz model, indicating intense intraspecific competition and adaptation to extreme islet conditions.
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Sehr niedrigNarrative ReviewMensch2026
Taxonomic and functional remodeling of the gut microbiota during aging and implications for microbiota-derived biomarkers.
Burcu Tekin, Rafig Gurbanov
The gut microbiota undergoes significant taxonomic and functional remodeling during aging, characterized by reduced microbial diversity, loss of beneficial bacteria, and altered metabolic pathways, which are associated with inflammaging and age-related diseases, suggesting its potential as a biomarker for biological aging.
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ModeratProspektivMensch2026
Smoking and mortality risk in COPD patients: a prospective cohort study in Sichuan, China.
Boke Chen, Di Wu et al.
Smoking is an independent risk factor for all-cause, COPD-specific, and CVD mortality in COPD patients in Sichuan, with a dose-response relationship observed for consumption, duration, and age of onset.
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Sehr niedrigQuerschnittMensch2026
Nursing training practices. NIC interventions towards healthy aging.
Mónica Margarita Barón Castro, Angelica María Montoya García et al.
Nursing training practices at the studied university align with regional guidelines for adults and older adults, demonstrating the acquisition of essential competencies for comprehensive care and supporting healthy aging policies, with a notable focus on interventions for individuals from subsidized health regimes and lower socioeconomic strata.
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NiedrigProspektivMensch2026
The efficacy and safety of colistimethate sodium in the treatment of carbapenem-resistant Gram-negative bacilli: a real-world observational study.
Tingyuan Zhang, Fan Zhang et al.
In Chinese ICU patients with carbapenem-resistant Gram-negative bacilli (CR-GNB) infections, colistimethate sodium (CMS)-based treatment achieved an 82.5% clinical response and 72.8% microbiological eradication, with an acceptable safety profile and a low incidence of adverse events, although baseline renal function may affect the occurrence of CMS-associated acute kidney injury.
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Sehr niedrigRatte2026
Intrinsic exercise capacity is associated with skeletal muscle clock gene and IGF-1 signaling in aged low- and high-running capacity rats.
Hyeon-Ki Kim, Takuji Kawamura et al.
Low intrinsic exercise capacity in aged rats is associated with altered skeletal muscle clock gene expression (higher Cry1 and Bmal1) and an imbalanced IGF-1 signaling pathway (increased Igf1 and Igf1Ec mRNA with reduced JAK2 phosphorylation).
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Sehr niedrigRetrospektivMensch2026
A comparative study of intravenous polymyxin B and colistimethate sodium on efficacy, safety, and cost comparison in treating pulmonary infections: a retrospective cohort study.
Chen Wang, Xing Guo et al.
Intravenous polymyxin B sulfate (PMB) and colistimethate sodium (CMS) showed comparable efficacy in treating pulmonary infections, but PMB was associated with a shorter hospital stay, less hematotoxicity, and a more favorable cost profile.
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HochRCTMensch2026
Metformin and epigenetic age in non-diabetic older people with HIV in Madrid (METFORAGING): a double-blind, randomised, placebo-controlled, pilot trial.
Cristina Marcelo-Calvo, Andrés Esteban-Cantos et al.
In a pilot trial of non-diabetic older adults with HIV, 96 weeks of metformin did not result in statistically significant differences in epigenetic age compared to placebo, although the direction of change favored metformin.
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Sehr niedrigMensch2026
Older adults' acceptability and perceived barriers to digital health tools integrating nutrition and physical activity: a focus group study.
Gioi Spinello, Erica Gobbi et al.
Older adults perceive digital health tools as emotionally distant and impersonal, preferring in-person interactions and social support, and are more receptive to hybrid models that integrate digital tools with human contact for promoting healthy aging.
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NiedrigRetrospektivMensch2026
Prognostic Value of the TAPSE/sPAP Ratio in Patients with Type 2 Respiratory Failure: Insights into Right Ventricular-Pulmonary Arterial Coupling and Clinical Outcomes.
Murat Karamanlıoğlu, Oral Menteş et al.
The TAPSE/sPAP ratio was independently associated with adverse clinical outcomes and mortality in patients with Type 2 Respiratory Failure, reflecting impaired right ventricular–pulmonary arterial coupling.
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ModeratRCTMensch2026
A multidisciplinary intervention targeting pragmatic language and maternal flexibility in Egyptian children with oppositional defiant disorder.
Hoda G Mohammed, Hassnaa O Mohammed
A collaborative intervention targeting pragmatic language skills in children with ODD and psychological flexibility in their mothers led to significant reductions in ODD symptom severity, with effects maintained at a 1.5-month follow-up.
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Sehr niedrigNarrative ReviewIn vitro2026
Non-thermal processing of polyphenol- and carotenoid-rich green leafy vegetables for healthy aging: effects on antioxidant properties and bioavailability.
Marwa Ezz El-Din Ibrahim, Mihriban Elçiçek et al.
Non-thermal processing technologies (HPP, PEF, US, CP) are superior to thermal processing for preserving and enhancing the functional potential of Green Leafy Vegetables (GLVs), improving food safety, releasing bioactive compounds, and maintaining sensory properties, which is crucial for preventive medicine and personalized nutrition in aging populations.
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Sehr niedrigNarrative ReviewMensch2026
Cognition, Utilization and Industrial Development of Sports Nutrition Foods: An Evidence-Based Narrative Review.
Yingqi Yao, Lin Zhu
A disconnect exists between the public's superficial understanding of sports nutrition foods and their actual utilization, negatively impacting athletic performance, with a need for improved cognition, targeted product development, and industry standards.
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Sehr niedrigRCTMensch2026
Comparative effectiveness of tirzepatide versus thiazolidinedione in adults with MASLD: a propensity score-matched cohort study.
Jheng-Yan Wu, Yu-Min Lin et al.
Tirzepatide (TZP) use was associated with a significantly reduced risk of a composite outcome including all-cause mortality, major adverse liver, cardiovascular, and kidney events compared to thiazolidinediones (TZDs) in adults with MASLD.
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ModeratRCTMensch2026
The effect of white noise on sleep quality and fatigue in community-dwelling older adults: a randomized controlled trial.
Seyed Amirhossein Vahhabzadeh Mousavi, Maryam Salehian et al.
For older adults, improvements in sleep medication use, daytime dysfunction, and fatigue were associated with improvements in functional recovery from acute hospitalization to 4-week follow-up.
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ModeratRCTMensch2026
Association between physical activity energy expenditure and markers of healthspan during prolonged calorie restriction in individuals without obesity: observations from the CALERIE™ phase 2 randomized controlled trial.
James L Dorling, Corby K Martin et al.
A smaller decrease in physical activity energy expenditure during prolonged calorie restriction was associated with improvements in grip strength, insulin resistance, HDL-C, and physical activity time in individuals without obesity.
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Sehr niedrigMaus2026
Ligature-induced periodontitis in mice potentially accelerates CD4 + T-cell senescence and exacerbates rheumatoid arthritis.
Jinfeng Li, Terukazu Sanui et al.
Severe periodontal inflammation induces a "senescence-primed" status in helper T cells, which can exacerbate rheumatoid arthritis through a novel cellular mechanism.
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ModeratRCTMensch2026
Revision rate and postoperative volume development of chronic subdural hematomas after burr hole craniotomy in combination with tranexamic acid vs. surgery alone - a single-center propensity score-matched analysis.
Magnus Scheer, Hanno Witte et al.
Postoperative tranexamic acid was associated with a lower rate of revision surgery for chronic subdural hematoma recurrence compared to surgery alone, although it did not significantly impact hematoma volume reduction.
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NiedrigProspektivMensch2026
Does leisure activity matter for epigenetic aging? Analyses of arts engagement and physical activity in the UK Household Longitudinal Study.
Daisy Fancourt, Lehané Masebo et al.
Arts and cultural engagement (ACEng) and physical activity (PA) were associated with slower epigenetic aging, with comparable effect sizes, particularly in adults aged 40 and above, and these effects were observed on second- and third-generation epigenetic clocks.
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Sehr niedrigMaus2026
The GPR17 agonist galinex restores oligodendrocyte maturation under inflammatory conditions.
Juliana Helena Castro E Silva, Davide Marangon et al.
The GPR17 agonist Galinex (GAL) promotes oligodendrocyte maturation and myelination capacity under inflammatory conditions by partially restoring terminal maturation-associated features and oligodendrocyte morphology.
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Association of joint trajectories of dietary diversity and physical activity with cognitive function in older adults: a prospective cohort study.
Chuang Shen, Yifan Yin et al.
Maintaining high dietary diversity with regular physical activity was associated with optimal cognitive function, while physical inactivity was an independent risk factor for cognitive decline that favorable dietary habits could not fully offset.
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ABO Blood Types and Mortality in Patients Undergoing Hemodialysis.
Masafumi Kurajoh, Tetsuo Shoji et al.
Blood type A was associated with significantly lower all-cause and cardiovascular mortality risk compared to blood type O in hemodialysis patients.
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CHA 2 DS 2 -VA score for predicting ventricular arrhythmias and mortality in ICD patients with ischemic heart disease and dilated cardiomyopathy: results from a prospective cohort.
Benjamin Vögeli, Patrick Badertscher et al.
The CHA2DS2-VA score is strongly associated with all-cause and cardiovascular mortality in ICD patients with IHD and DCM, but does not predict ventricular arrhythmia.
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Years of life lost in cutaneous squamous cell carcinoma: analysis of a prospective cohort of 1400 patients.
Klaus Dietz, Thomas K Eigentler et al.
Years of life lost (YLL) in cutaneous squamous cell carcinoma patients were estimated at 5.67 years for the entire cohort, with women and patients exhibiting progression or risk factors experiencing significantly higher YLL, underscoring a clinically relevant reduction in life expectancy despite low disease-specific mortality.
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NiedrigProspektivMensch2026
Comparison of accuracy of acetabular cup placement using manual versus robotic-assistance in the same patient cohort undergoing robotic-assisted total hip arthroplasty.
Adarsh Annapareddy, Tarun Jayakumar et al.
Robotic-assisted total hip arthroplasty achieved significantly greater accuracy and consistency in acetabular cup inclination and anteversion compared to manual impaction, with robotic placement substantially reducing deviation from planned orientation.
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Sehr niedrigProspektivMensch2026
Developmental origins of immune function: Maternal prenatal mood is associated with infant immune cell gene expression.
Gabrielle R Rinne, Christine Dunkel Schetter et al.
Maternal depressive symptom levels during pregnancy were associated with elevated pro-inflammatory (NF-κB) and decreased antiviral (IRF) gene expression in infants at one month of age, while prenatal anxiety symptoms showed no consistent associations with infant immune cell gene expression.
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ModeratRCTMensch2026
Early decompressive hemicraniectomy combined with mild hypothermia treatment for malignant middle cerebral artery infarction.
Junhui Chen, Jiaming Cao et al.
Mild hypothermia combined with decompressive hemicraniectomy was associated with a higher rate of good functional outcomes (mRS 0-2) and lower 30-day mortality compared to decompressive hemicraniectomy alone in patients with malignant MCA infarction, although it also led to significantly more shivering, bradycardia, and electrolyte disturbances.
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Sehr niedrig2026
Plant-based dietary patterns are associated with slower epigenetic aging.
Hyunju Kim, Christina A Castellani et al.
Greater adherence to overall PDI, provegetarian, and healthy PDI is associated with slower epigenetic aging, as measured by GrimAge2 and PhenoAge.
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Development and validation of a Cog-Free risk predicting tool for dementia in a community setting.
Jiwen Che, Na Liu et al.
The developed Cog-Free tool, utilizing routine health examination data without cognitive testing, achieved a significantly higher area under the curve (AUC) of 0.86 compared to three established cognitive-testing-free dementia risk tools, demonstrating its potential as an effective pre-screening and risk stratification tool.
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Sehr niedrigNarrative ReviewMensch2026
Age-related differences and common pathways of lymphocyte subsets in sepsis: a comparative review of elderly and pediatric patients.
Xianwen Wang, Qihang Huang et al.
Sepsis impacts lymphocyte subsets differently in elderly and pediatric patients due to their distinct baseline immune states (immunosenescence vs. immunoimmaturity), leading to divergent pathways of immune dysfunction and recovery potential, although both extremes can converge on an immunoparalysis-like phenotype.
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